식도발성에 대한 영상학적, 음향학적 고찰

정은재,정광윤,신동진,서규환,백승국,이남준,진성민 대한이비인후과학회 2004 대한이비인후과학회지 두경부외과학 Vol.47 No.2

Background and Objectives:Advanced laryngeal cancer is frequently treated by total laryngectomy. This operation is effective eech has been employed as a natural and satisfactory means of communication for laryngectomized patients. Unfortunately, during past decades the success rate has ranged 40- 60%. The purpose of this study was to determine which factors contribute to the proficiency of esophageal spech. Materials and Method:Videofluoroscopy and voice analysis of fourteen alaryngeal male patients who had trained esophageal speech were performed. Results:Aerophagia and air ejection were impossible in poor shimmer and harmonic-to-noise ratio. Conclusion:Aerophagia and air ejection are esential for esophageal spech. Short pseudoglottis (less than 2 cm) affords better esophageal speech. Natural repetitive movements of aerophagia and air ejection with accurate articulatory motion can improve the quality of esophageal speech.

Prognostic Factor of Laryngeal Papillomatosis: 20 Years Experience

정은재,홍석진,조재구,백승국,우정수,권순영,정광윤,Chung, Eun-Jae,Hong, Seok-Jin,Cho, Jae-Gu,Baek, Seung-Kuk,Woo, Jeong-Soo,Kwon, Soon-Young,Jung, Kwang-Yoon The Korean Bronchoesophagological Society 2010 大韓氣管食道科學會誌 Vol.16 No.2

Background: Laryngeal papillomatosis, which is cased by human papillomavirus, is the most common benign neoplasm of the larynx. However, the prognosis of this disease remains really unpredictable. The aim of this paper is to determine whether any clinical features at the time of diagnosis could predict its course. Material and Method: Eighty-six patients treated at our institution during the last 20 years were analyzed retrospectively. All patients had microsurgery under general anesthesia. All patients' follow-up period was more than 1 year. We divided the patients into 1) Juvenile versus adult group based on their age 20, 2) single surgical method with laser versus dual surgical method with laser and microdebrider group, and 3) single subsite versus multiple subsites group. And we compared the therapeutic outcome. Results: The recurrence rate was 100% (15 patients) in the JP group and 56% (40 patients) in the AP group. Juvenile versus adult group was the only independent prognostic factor by univariate, and multivariate analysis. Microdebrider resection technique and multiple subsites were not associated with treatment result. Time period from the first surgery to recurrence detection was different statistically only for the age group. The number of surgery in the JP group ranged from 1 to 31 (mean 8.8). In the AP group the number of surgery ranged from 1 to 25 (mean 3.7). It was statistically different. Conclusion: Prognosis for the laryngeal papillomatosis remains unpredictable. Only patients' age was the only independent prognostic factor.

두경부 수술후 발생한 인두피부누공의 치료

정은재,정광윤,Chung, Eun-Jae,Jung, Kwang-Yoon 대한기관식도과학회 2008 大韓氣管食道科學會誌 Vol.14 No.1

Subcutaneous cervicofacial, mediastinal emphysemas are complications associated with head and neck surgery, trauma, infectious processes, tooth extraction. Drill cooling stream and dental syringe air ject are the sources of high pressure air that may enter exposed soft tissue. Since the introduction of the high-speed air turbine drill in the 1960s, The incidence of iatrogenic subcutaneous emphysema has increased. Most cases begin to resolve after 2 to 3 days and residual swelling is usually minimal at the end of 7 to 10 days. Surgical approach is not advised because it is likely to be ineffective. The differential diagnosis of neck swelling after dental procedure includes hematoma, cellulitis, angioedema, allergic reaction, subcutaneous emphysema. We report a rare case of patient with subcutaneous cervicofacial emphysema and mediastinal emphysema secondary to third molar extraction.

Synthesis and charaterization of indenofluorene-based white-emitting copolymers

정은재,우한영 한국고분자학회 2008 한국고분자학회 학술대회 연구논문 초록집 Vol.33 No.2

The Utility of $^{18}F$-FDG PET/CT for Following Up Head and Neck Cancer

정은재,백승국,우정수,권순영,정광윤,Chung, Eun-Jae,Baek, Seung-Kuk,Woo, Jeong-Soo,Kwon, Soon-Young,Jung, Kwang-Yoon The Korean Society for Head and Neck Oncology 2010 대한두경부 종양학회지 Vol.26 No.2

서 론 : 두경부암의 예후에 가장 중요한 인자는 진단시 병기와 치료 후 재발의 유무이다. 따라서, 재발 병변을 조기에 발견하는 것이 매우 중요하다. 본 연구에서는 두경부암 환자의 추적 관찰에서 $^{18}F$-FDG PET/CT의 유용성에 대해 알아보고자 하였다. 대상 및 방법 : 2004년 4월부터 2008년 8월까지 고려대 안암병원에서 두경부암으로 치료를 완료한 후 추적관찰이 가능하였던 88 예의 환자를 대상으로 하였다. 환자는 본원의 두경부암 추적관찰 양식에 따라 술 후 6, 12개월째 $^{18}F$-FDG PET/CT를 시행하였으며, 원발부위 및 경부 재발, 원격전이와 중복암의 진단에 있어 $^{18}F$-FDG PET/CT의 민감도, 특이도, 양성예측율, 음성예측율을 평가하였고, 기존의 추적관찰 방법과 이를 비교하였다. 결 과 : 원발부위 재발의 진단에 있어 민감도, 특이도, 양성예측율, 음성예측율은 각각 95%, 97%, 90%, 98% 였다. 경부전이 재발의 진단에 있어서는 각각 94%, 98%, 83%, 99%였으며, 원격전이 및 이차암 진단에 있어서는 94%, 100%, 100%, 99%였다. 원발부위 재발은 고식적인 진단 방법, 원격전이와 이차암은 $^{18}F$-FDG PET/CT가 진단에 의미있게 유리하였다. 결 론 : $^{18}F$-FDG PET/CT는 두경부암의 추적관찰 과정에서 재발 여부를 판정하는데 있어 매우 유용하며, 특히 원격전이 및 이차암의 발견에 있어 유용하다. 그러나, 위양성 및 위음성의 가능성으로 고식적인 진단 방법과 병행해야 진단의 효과를 높힐 것으로 생각된다.

Clinical Efficacy of Primary Tumor Volume Measurements: Comparison of Different Primary Sites

정은재,이남준,백승국,권순영,우정수,정광윤 대한이비인후과학회 2009 Clinical and Experimental Otorhinolaryngology Vol.2 No.2

Objectives. The purpose of study was to determine the clinical efficacy of primary tumor volume measurements of different primary sites in the oropharynx compared to the oral cavity. Methods. A retrospective analysis of 85 patients with oral cavity or oropharynx cancer. The tumor area was manually outlined from axial magnetic resonance (MR) series. The software calculated the tumor volumes, automatically. The values of the primary tumor volumes were then subdivided into separate groups (≤3,500 ㎣, >3,500 ㎣). Results. The prognostic indicators were the cT and cN (oral cavity); age, primary site, cT, cN, and primary tumor volume (oropharynx) on the univariate analysis. There was no significant prognostic factor for oral cavity cancer on the multivariate analysis. Primary site, cN, and primary tumor volume were independent prognostic indicators for oropharynx cancer by multivariate analysis. Conclusion. Primary tumor volume measurement is a reliable way to stratify outcome, and make up for the weak points in the American Joint Committee on Cancer staging system with oropharynx cancer. Objectives. The purpose of study was to determine the clinical efficacy of primary tumor volume measurements of different primary sites in the oropharynx compared to the oral cavity. Methods. A retrospective analysis of 85 patients with oral cavity or oropharynx cancer. The tumor area was manually outlined from axial magnetic resonance (MR) series. The software calculated the tumor volumes, automatically. The values of the primary tumor volumes were then subdivided into separate groups (≤3,500 ㎣, >3,500 ㎣). Results. The prognostic indicators were the cT and cN (oral cavity); age, primary site, cT, cN, and primary tumor volume (oropharynx) on the univariate analysis. There was no significant prognostic factor for oral cavity cancer on the multivariate analysis. Primary site, cN, and primary tumor volume were independent prognostic indicators for oropharynx cancer by multivariate analysis. Conclusion. Primary tumor volume measurement is a reliable way to stratify outcome, and make up for the weak points in the American Joint Committee on Cancer staging system with oropharynx cancer.

두경부암 환자에서 내시경적 연하검사의 유용성

정은재 대한연하장애학회 2012 대한연하장애학회지 Vol.2 No.1

Dysphagia is an important symptom of head and neck cancer, as well as representing a significant complication of its treatment. Surgical interventions for cancers of the head and neck result in specific anatomic or neurologic insults with site-specific patterns of dysphagia and aspiration. Fiberoptic endoscopic evaluation of swallowing (FEES) is an imaging procedure that is generally well tolerated and therefore frequently repeatable to evaluate swallowing function. The FEES procedure allows for dynamic examination of the anatomy and physiology of pharyngeal and laryngeal structures at the level of the soft palate and below. It can be performed at the bedside like a usual clinical examination, and has a similar sensitivity and specificity for detecting signs of dysphagia. This article reviews the effect of the various treatment modalities in head and neck cancer on the swallowing mechanism, and the usefulness of FEES after head and neck cancer surgery. (JKDS 2012;2:1-7)

Synthesis and characterization of donor-acceptor copolymers based on 2,5-di(thiophen-2-yl)thiazolo[5,4-d]thiazole for polymeric solar cells

정은재 한국고분자학회 2010 한국고분자학회 학술대회 연구논문 초록집 Vol.2010 No.10

연구생산성 측정을 위한 DEA접근과 비율 ( Ratio ) 분석

정은재,김지수 한국경영과학회 1999 한국경영과학회 학술대회논문집 Vol.- No.1

Moderately Differentiated Neuroendocrine Carcinoma of the Larynx

정은재,백승국,권순영,우정수,정광윤 대한이비인후과학회 2008 Clinical and Experimental Otorhinolaryngology Vol.1 No.4

Neuroendocrine neoplasm of the larynx is a morphologically heterogeneous group of tumors. This unusual neoplasm includes the four different type of tumors. Paraganglioma is the best-known neural origin tumor. The epithelial origin tumor is further divided based on the degree of differentiation into well, moderately, and poorly differentiated carcinoma. The diverse biological behavior of neuroendocrine neoplasm of larynx makes an accurate diagnosis of paramount importance, since treatment depends on diagnostic accuracy. The diagnosis is based primarily on light microscopy, and immunohistochemical and/or ultrastructural investigations are needed to diagnose correctly. The mainstay of treatment of moderately differentiated neuroendocrine carcinoma of the larynx is surgery. Elective neck treatment should be performed considering the high likelihood of cervical lymph node metastases. The 5-yr survival rate approximates 50%, and 10-yr survival rate is only 30%. Neuroendocrine neoplasm of the larynx is a morphologically heterogeneous group of tumors. This unusual neoplasm includes the four different type of tumors. Paraganglioma is the best-known neural origin tumor. The epithelial origin tumor is further divided based on the degree of differentiation into well, moderately, and poorly differentiated carcinoma. The diverse biological behavior of neuroendocrine neoplasm of larynx makes an accurate diagnosis of paramount importance, since treatment depends on diagnostic accuracy. The diagnosis is based primarily on light microscopy, and immunohistochemical and/or ultrastructural investigations are needed to diagnose correctly. The mainstay of treatment of moderately differentiated neuroendocrine carcinoma of the larynx is surgery. Elective neck treatment should be performed considering the high likelihood of cervical lymph node metastases. The 5-yr survival rate approximates 50%, and 10-yr survival rate is only 30%.