림프종 환자에서의 갈륨, TI-201 그리고 Tc-99m MIBI 섭취의 비교

천경아,조인호,원규장,이경희,이형우,현명수,이재태,이규보 영남대학교 의과대학 2002 Yeungnam University Journal of Medicine Vol.19 No.2

Purpose; Ga-67 scintigraphy has been used for the evaluation of tumors, especially lymphoma. Recently, Tl-201 and Tc-99m MIBI were also used to tumor imaging. Tl-201 and Tc-99m MIBI had better physiologic characteristics than Ga-67, so we studied 32 biopsy proven lymphoma patients (male 24, female 8, mean age 46 years) with Ga-67, Tl-201 or Tc-99m MIBI and compared the scan findings. Materials and Methods: Twenty-three of 32 patients were injected 74-111 MBq (2-3 mCi) of Tl-201, before chemotherapy and imaged with dual-headed SPECT (Prism 2000, Picker, USA) at 30 minutes after injection. Delayed images were obtained after 3 hr in 8 patients. Twenty seven of 32 patients were injected 740 MBq (20 mCi) of Tc-99m MIBI and imaged at 30 minutes after injection. 111-185 MBq (3-5 mCi) of Ga-67 was injected in 12 patients and imaged at 48 and 72 hours after injection. Twenty eight patients were diagnosed as non-Hodgkin's lymphoma and others were Hodgkin's lymphoma. Results: Twenty patients were positive on Tl-201 scan and 3 patients showed negative findings. One of these 3 patients, Tc-99m MIBI and Ga-67 scan were positive. Twenty two patients were positive on Tc-99m MIBI scan and 5 patients showed negative findings. One of these 5 patients, Tl-201 was positive and 2 were positive on Ga-67 scan. Ten of 12 patients showed positive findings on Ga-67 scan. The sensitivity of these agents were 83.3%, 87.0% and 81.5% for Ga-67, Tl-201 and Tc-99m MIBI, respectively. The sensitivity was highest in Tl-201 scan, but there were no significant differences among three tests. In this study, there was no significant difference of uptake ratios between early and delayed images of Tl-201. Conclusion: Scintigraphy with Tl-201 and Tc-99m MIBI in lymphoma patients have similar sensitivity with Ga-67.

ATM망에서 ABR서비스를 위한 효율적인 전송률 할당 알고리즘에 관한 연구

천재호,윤상호,김명균,허정석 울산대학교 1999 공학연구논문집 Vol.30 No.2

ATM망에서 ABR 서비스는 CBR, VBR에 할당된 대역폭을 제외한 나머지를 이용해서 데이터를 전송한다. 오디오 또는 비디오 데이터와 같이 실시간 전송이 필요한 서비스들을 전송지연이 제한되는 CBR이나 VBR 트래픽을 이용하여 제공할 수 있지만, 이런 경우에는 전송 대역폭을 효율적으로 사용하지 못하는 단점이 있다. 본 논문에서는 실시간 데이터를 ABR 서비스를 이용하여 효율적으로 전송하기 위한 ABR 대역폭 할당 알고리즘을 제안한다. 제안된 알고리즘은 MCR을 보장하며, MCR에 비례해 전송률을 할당한다. 그리고 접속의 상태를 만족(satisfied)상태와 불만족(bottlenecked)상태로 구분하고, 만족 상태인 접속이 사용하지 않는 대역폭을 불만족 상태인 접속이 사용할 수 있도록 하여 대역폭 활용도를 높인다. 또한 제안된 알고리즘은 큐 제어 함수를 사용해서 큐 길이를 일정한 범위로 유지함으로써 셀의 전송지연을 일정하게 한다. 본 논문에서는 시뮬레이션을 통해 제안된 알고리즘의 성능을 분석하고, 기존에 제안된 ATM 포럼[1]및 Kalampoukas 알고리즘[2]과 비교를 하였다. On ATM networks, ABR services are provided using the remained bandwidth after allocating CBR and VBR traffic. Realtime services such as transmitting audio or video data may be provided using CBR and VBR which have a constrained transmission delay, but in those cases, the communications bandwidth may be wasted. This paper proposes an efficient ABR rate allocation algorithm to transfer real-time data using ABR service. The proposing algorithm guarantees MCR and allocates bandwidth to each connection proportional to its MCR. The proposing algorithm divides the connections in two groups, a satisfied state group and a bottlenecked state group, and enhances bandwidth utilization by allowing the remained bandwidth after allocating to the connections in the satisfied state to the connections in the bottlenecked state. The proposing algorithm uses the queue control function to keep the queue length within some boundary, which makes the transmission delay constant. We simulate and compare the performance of the proposing algorithm with that of the algorithms proposed by ATM Forum[1] and Kalampoukas[2].

흰쥐 내측 전정신경핵 뉴론의 자발적 활동성의 발생에 관여하는 이온전류에 관한 연구

이형재,최정희,천상우 원광대학교 치의학연구소 2003 圓光齒醫學 Vol.12 No.2

Medial vestibular nucleus (MVN) neurons are found to have spontaneous electrical activity in the absence of any detectable synaptic input. To investigate the contributions of intrinsic mechanisms to the spontaneous activity of MVN neurons, we examined the effects of various channel blockers on spontaneous firing by means of patch clamp recordings. Coronal slice (400 ㎛) of the vestibular nucleus region was sequentially treated with pronase 0.2 ㎎/㎖ and thermolysin 0.2 ㎎/㎖, then single neurons were mechanically dissociated. Almost all the MVN neurons recorded in neonatal rat were shown to have spontaneous resting activity. In 300 nM TTX, spontaneous firing was blocked in all cells tested. In 8 of 11 cells, underlying fluctuation or oscillations in membrane potential was not remained, and hyperpolarization did not produce rebound low-threshold calcium spikes. Although MVN neurons possessed hyperpolarization activated cation current (Ih), cesium had no effect on firing rates. The spike afterhyperpolarization (AHP) is calcium dependent. When Ca^2+ influx was blocked in external Ca^2+ free solution, repetitive firing was abolished and the cell rested at depolarized membrane potentials. Application of apamin (300 nM) caused a profound reduction in the amplitude of the AHP and produced rhythmic burst firing. These findings suggest that the spontaneous activities of MVN neurons is regulated by interactions between the membrane depolarization mainly due to a persistent sodium conductances and hyperpolarization due to the calcium-activated potassium conductances.

30-60대 건강한 서울시민의 脚筋伸展파워 및 신체작업능력 : 동경 및 북경시민과의 비교 Comparison of Tokyo and Peking Residents

서재균,김승일,최영렬,방영진,김형돈,전병관,선우섭,손두옥 한국학교체육학회 1999 한국학교 체육학회지 Vol.9 No.1

본 연구는 한국인의 삶의 질 향상을 위한 국민 생활체육 진흥정책 수립에 필요한 기초자료를 제공하기 위하여, 건강한 30-60대 서울시민(313명)의 체격과 근력, 전신지구력 등의 체력을 측정하여 문화, 경제생활수준이 서로 빠른 동경시민(509명) 및 북경시민(160명)과 비교 검토하는 것을 목적으로 하였다. 각국의 연구대상에 대한 측정은 사전에 협의한 동일한 방법(동경대학 체육과학실법)과 기기를 이용하였다. 체격요인으로는 신장과 체중을, 체력요인으로는 트레드밀 보행시 (90m/분)의 심박수와 보폭 그리고 자전거 에르고미터 운동시의 PWC75%HRmax와 脚筋伸展파워를 측정하였다. 신장 및 체중, 신체질량지수는 남녀 모두 북경, 서울, 동경시민순으로 높게 나타났다. 트레이드밀 보행시의 심박수는 남녀 모두 북경, 동경, 서울시민 순으로 낮은 값을 보였으며, 신장에 대한 보폭비율은 남자의 경우에는 북경, 서울, 동경의 순으로, 여자는 북경, 동경, 서울의 순으로 높았다. 脚筋伸展파워는 60대 여자를 제외한 남녀 모두 북경, 서울, 동경시민의 순으로 높았으며, PWC75%Hrmax는 남자 40대 와 여자 30대를 제외한 모든 연령 대에서 서울시민이 동경시민 보다 높은 경향을 나타냈다. 한편 모든 피검자를 대상으로 연령과 脚筋伸展파워와의 회귀식은 남녀 각각 Y=-0.30X+28.88(n=230, r=0.61, p<.001), Y=-0.l0X +12.49(n=611, r=0.32, p<.001), PWC75%HRmax와의 회귀식은 남녀 각각 Y=-0.01+ 2.50(n=116, r=0.29, p<.01), Y=-0.l0X+1.89(n=461, r=0.20, p<.001)이였다. 따라서 30~60대 서울시민의 체격 및 脚筋伸展파워는 북경시민 보다 낮게 나타나 삶의 질 향상을 위해 보다 적극적인 사회체육 활성화 방안 마련이 요망된다. The purpose of this study was to serve as a basis for making a health promotion policy for better quality of Korean life, by examining 313 citizens of Seoul's physical and leg extension power, physical working capacity who were in their thirties to sixties, enjoying good health, and by making a comparison of tile result with that of 509 citizens of Tokyo and 160 citizens of Peking who lived in different culture and living environment. The findings of this study were as below: First, the male citizens of Peking, who were in their forties to sixties, and the female citizens of the same city, who were in their fifties to sixties, were significantly higher in height, body weight and body mass index. Second, the male citizens of Peking, who were in their thirties and sixties, and the female citizens of the same city, who were in their thirties to forties, were significantly lower in heart rate in walking in the treadmill(90n/min). And there was a tendency that the citizens of Peking showed a higher ratio of stride to height. Third, the male citizens of Peking, who were in their fifties, and the female citizens of the same city, who were in their thirties to forties, had a significantly better leg extension power. As a result of examining all the subjects, there was a negative correlation between leg extension power and age. Fourth, all age groups of Seoul citizens, except males in their forties and females in their thirties, fended to be better in PWC75%HRmax than the citizens of Tokyo. When all the subjects were examined, there was a negative correlation between PWC75%HRmax and age. Consequently, there was a need to prepare more active plan to step up sports fur all successfully in order to improve the quality of life, as the citizens of Seoul who were their thirties to sixties appeared to be inferior in physical physique and leg extension power to the citizens of Peking.

유산균(L.lactis CBT-8)및 발효 추출물의 Helicobacter pylori 억제 능력

진춘조,박형석,이혜운,김성렬,강동구,이준상,이재동,왕준호 건국대학교 의과학연구소 2002 건국의과학학술지 Vol.12 No.-

Helicobacter pylori infection was the cause of chronic gastritis, duodenal ulcer and gastric MALT lymphoma. The eradication rates of H. pylori using antibiotics are around 80%. Lactobacilli have been demonstrated to have in vivo and in vitro inhibitory effects on H. pylori infection. We aimed to evaluate the inhibitory effect of L. lactis CBT-8 and its extract on H. pylori in human stomach. Thirty-five H. pylori-infected volunteers(30-49 yr)were randomized into two groups which were treated with L. lactis CBT-8 and its extract(Group A n=17) or milk containing L. lactis CBT-8(Group B, n=18). They underwent 13C-urea breath tests before and after treatment. The DOB30 of group A(n=14) was decreased 41.0% after treatment(26.0±4.9 before, 15.3±2.1 after treatment)(p<0.05). the DOB30 of group B(n=13) was decreased 22.3% after treatment(22.0±2.2 before, 17.1±1.7 after treatment)(p<0.05). In conclusion, L. lactis CBT-8 was effective in suppressing H. pylori infection in human stomach.

환경 오염물질의 진보된 독성 평가 기법

류재천,최윤정,김연정,김형태,방형애,송윤선 한국환경독성학회 1999 환경독성보건학회지 Vol.14 No.1

Recently, several new methods for the detection of genetic damages in vitro and in vivo based on molecular biological techniques were introduced according to the rapid progress in toxicology combined with cellular and molecular biology. Among these methods, mouse lymphoma thymidine kanase (tk) gene forward mutation assay, single cell gel electrophoresis (comet assay) and transgenic animal and cell line model as a target gene of lac I (Big Blue) and lac Z (Muta Mouse) gene mutation are newly introduced based on molecular toxicological approaches. The mouse lymphoma tk^(+/-) gene assay (MOLY) using L5178Y tk+i- mouse lymphoma cell line is one of the mammalian forward mutation assays, and has many advantages and more sensitive than hprt assay. The target gene of MOLY is a heterozygous tk^(+/-) gene located in 11 chromosome, so it is able to detect the wide range of genetic changes like point mutation, deletion, rearrangement, and mitotic recombination within tk gene or deletion of entire chromosome 11. The comet assay is a rapid, simple, visual and sensitive technique for measuring and analysing DNA breakages in mammalian cells. Also, transgenic animal and cell line models, which have exogenous DNA incorporated into their genome, carry recoverable shuttle vector containing reporter genes to assess endogenous effects or alteration in specific genes related to disease process, are powerful tools to study the mechanism of mutation in vivo and in vitro, respectively. Also in vivo acridine orange supravital staining micronucleus assay by using mouse peripheral reticulocytes was introduced as an alternative of bone marrow micronucleus assay. In this respect, there was an International workshop on genotoxicity procedure (IWGTP) supported by OECD and EMS (Environmental Mutagen Society) at Washington D, C, in March 25-26, 1999. The objective of IWGTP is to harmonize the testing procedures internationally, and to extend to finalization of OECD guideline, and to the agreement of new guidelines under the International Conference of Harmonization (ICH) for these methods mentioned above. Therefore, we introduce and review the principle, detailed procedure, and application of MOLY, comet assay, transgenic mutagenesis assay and supravital staining micronucleus assay.

무증상군의 요추부 유연성과 그라프 불안정 정도

강재도,김광열,김형천,정경칠,유호섭 침례병원 1998 浸禮病院學術誌 Vol.14 No.-

서울의 Penicillinase Producing Neisseria Gonorrhoeae 발생빈도(1996)

김재홍,황동규,전재홍,김윤석,김중환,김용준,이창균,임동진,김현수,조창근,김경문,박상훈,전우형,김희성,이호정,차명수,김갑형,김형석,김석우,황지환,박병순,권오상,이민수,송기훈,성소영,이인섭,부태성 대한화학요법학회 1999 대한화학요법학회지 Vol.17 No.2

Background : In recent years, gonorrhea has been panedemic and remains one of the most commom STDs in the world, especially in developing countries. Objective & Methods: For the detection of a more effective therapeutic regimen and assessing the prevalence of PPNG, we have been trying to study the patients who have visited the VD Clinic of Choong-Ku Public Health Center in Seoul since 1980 by means of the chromogenic cephalosporin method. Results: In 1996, 139 strains of N. gonorrhoeae were isolated, among which 53(39.0%) were PPNG. Conclusion: Our results suggests that after a peak of 74.3% in 1993, the prevalence of PPNG in Seoul is gradually declining.

酸素活性汚泥工程에 의한 皮革廢水의 生物學的 處理에 관한 硏究

김재형,양천회 大田産業大學校 1996 한밭대학교 논문집 Vol.13 No.0201

This study was performed to evaluate the form of leather industrial wastewater treatment by Oxygen and Air activated sludge process. 1. BOD was removed 93% by air activated sludge process that was operated in 1.46~3.20 volumetric loading, 0.3~0.65 sludge loading (F/M) and 95% by oxygen activated sludge process. That was operated in 2.2~5.6 volumetric loading 0.45~ 1.13 sludge loading. In spite of BOD sludge loading keeping high about 2 times the oxygen process was got equal result than the air process. 2. COD removal efficiency were 69% and 72% by air activated sludge process that was operated in 0.7~1.05 volumetric loading, 0.15~0.30 sludge loading and by oxygen activated sludge process that was operated in 1.25~ 1.65 volumetric loading, 0.23~0.40 sludge loading. The water quality of oxygen process was stable than the air process for COD concentration by COD volumetric load.

흰쥐 십이지장 점막의 Polyamine 대사, [^(14)C]Spermine 단백 결합능 및 [³H]Thymidine DNA 섭취에 대한 Calcitriol과 Prednisolone의 상호작용

최상현,이영재,정휘정,김형건,신경호,천연숙,전보권 고려대학교 의과대학 1997 고려대 의대 잡지 Vol.34 No.1

Calcitriol has been shown to induce the duodenal synthesis of the spermine-binding protein. and hydrocortisone was reported to increase the intestinal polyamine contents. This study examined whether prednisolone might enhance or reduce the calcitriol effects on the polyamine contents, [^(14)C]spermine-protein binding activity, and [^(3)H] thymidine DNA synthesis of the rat duodenum. The mucosal contents of putrescine. spermidine. and spermine were increased by 198.8%, 84.0%, and 78.3%, respectively, within 6 hours after calcitriol. 5 ㎍/kg (CT) and fell down to the control values at 12 hours. And prednisolone. 10 mg/kg (PD) also increased the polyamine contents in similar patterns. They did not counteract each other in the polyamine metabolism. CT increased the [^(14)C]spermine-binding activity of the cytosol protein fraction from the duodenal mucosa by 71.1%. But PD increased the binding activity by 28.0% and did not affect the CT-induced increase. CT increased the [^(3)H]thymidine DNA synthesis of the duodenal mucosa by 42.3%. but PD reduced it slightly. The CT-dependent increase of the synthesis was significantly inhibited by PD. These results suggested that the inhibitory effect of glucocorticoids on the vitamin D dependent increases of the duodenal calcium absorption and mucosal proliferation seems not to be associated with the metabolic changes of polyamines in the duodenal mucosa.