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피치각 조정형 송풍-역풍 겸용 축류팬에서 배연용 피치각 선정을 위한 실험적 연구
장택순(Taek-Soon Chang),허진혁(Jin-Huek Hur),문승재(Seung-Jae Moon),이재헌(Jae-Heon Lee),유호선(Ho-Sun You),임윤철(Yun-Chul Im) 대한설비공학회 2008 대한설비공학회 학술발표대회논문집 Vol.2008 No.2
In this study, the experimental study has carried out to select pitch angle on the backward flow in an axial fan that has adjustable pitch blades. With the change of pitch angle of axial fan with adjustable blade, air flow rate, pressure and air flow direction can be changed. Because of this merit, adjustable axial fan can be used in the backward flow. For the selection of the backward flow pitch angle, fan performance test method is selected by KS B 6311. Dynamic pressure, static pressure, electric current and voltage are measured in each pitch angles of axial fan that are 36°, -16°, -21°, -26°, -31° and -36°. In the result of test, fan performance curves at several pitch angle has been investigated. Finally, pitch angle of -26° has been selected to get largest flow rate at backward flow situation.
( Soon-hyo Kwon ),( Jung-im Na ),( Chang-hun Huh ),( Kyoung-chan Park ) 대한피부과학회 2021 Annals of Dermatology Vol.33 No.6
Background: Melasma shows characteristic histological features of photoaged skin. Objective: We evaluated the effect of dermal rejuvenation using a temperature-controlled continuous non-invasive radiofrequency (RF) device on melasma. Methods: Continuous skin heating at the temperature of 43℃ for 20 minutes was performed in ten subjects with melasma who underwent 3 tri-weekly RF sessions. Pigmentation was evaluated with Mexameter<sup>®</sup> and investigator’s global assessment (IGA). Immunohistochemical staining and image analysis was performed to evaluate biopsies from melasma skin before and after the treatment. Results: The lesional melanin index was decreased by 13.7% at week 9. IGA score was improved from 3.50 at baseline to 2.95 at week 9. No significant adverse event was reported. Histologic analysis revealed reduced melanin and increased collagen density and thickness. The expression of procollagen-1 and type IV collagen was increased after the treatment. The number of p16<sup>INK4A</sup>-positive senescent fibroblasts was reduced after the treatment, while the expression of heat shock protein 70 and 90 was increased. Stromal derived factor-1, a senescence-associated anti-melanogenic factor secreted from the fibroblasts, was up-regulated after the treatment, while the level of c-kit was not changed. Conclusion: Thermal skin stimulation by the temperature-controlled continuous RF device improved melasma through dermal rejuvenation.
A preliminary study in melasma following INMODE forma procedure
( Soon-hyo Kwon ),( Je-byeong Chae ),( Jung-won Shin ),( Jung-im Na ),( Chang-hun Huh ),( Kyoung-chan Park ) 대한피부과학회 2018 대한피부과학회 학술발표대회집 Vol.70 No.2
Background: Melasma is a common hypermelanosis that frequently appears on the face. In recent studies, it is suggested that dermal structural alteration, including solar elastosis and basement membrane disruption, may have an important role in the pathogenesis of melasma. Forma device (InMode Inc, Richmond Hill, ON, Canada, North America) is a radiofrequency dermal heating device used on facial wrinkles and rhytides. Objectives: The aim of this study was to evaluate the effects of Forma device on melasma in a small group of volunteers. Methods: All volunteers were treated 4 times at 3 weeks intervals. Every visit, melanin index and erythema index was measured to assess the improvement in hyperpigmentation and erythema. Clinical photos were evaluated to estimate the degree of skin changes. Results: Clinical and instrumental evaluation showed that melasma improved after INMODE forma treatment. Conclusion: We suggest that treatment with Forma device may have beneficial effects on melasma by dermal remodeling and direct heat delivery on melanocytes.
이임순,장진영,이정재,이순곤,이권해,이해혁,김승형 순천향의학연구소 1997 Journal of Soonchunhyang Medical Science Vol.3 No.2
Purpose: We have evaluated the compliance of hormone replacement therapy. Method: There are 185 climacteric women who are divided into three groups (Group I, Group II, Group III). Group I is given conjugated equine estrogen(CEE, 0.625mg, day 1-30) plus medroxyprogesterone acetate(MPA, 5mg, day 1-12). Group II is given conjugated equine estrogen (CEE, 0.625mg, day 1-30) plus medroxyprogesterone acetate (MPA, 2.5mg, day 1-30), Group III is given only conjugated equine estrogen(CEE, 0.625mg, day 1-30). Results: 1) The compliance rate of hormone replacement therapy during three months is 77.9% including each Group I : 77.7%, Group Ⅱ : 76.1%, Group Ⅲ :80.4%. 2) The compliance rate of hormone replacement therapy during six months is 60.7% including each Group Ⅰ:52.9%, Group Ⅱ: 56.4%, Group Ⅲ: 79.5%. 3) The compliance rate of hormone replacement therapy during nine months is 49.7% including each Group Ⅰ: 45.5%, Group Ⅱ:41.7%, Group Ⅲ: 64.3%. 4) The compliance rate of hormone replacement therapy during a year is 44.4% including each Group Ⅰ: 40.2%, Group Ⅱ:35.3%, Group Ⅲ: 59.5%. Conclusion : It is vital that we maximize compliance if patients are to receive the full benefits from hormone replacement therapy. We think that physicians who prescribe hormone replacement therapy for climacteric women should enough explain the purpose, risks, and side effect of treatment for maximizing compliance of hormone replacement therapy.
감귤류 종자 추출물의 N-nitrosodimethylamine 생성억제에 관한 연구
오혁수,안용석,나임순,오명철,오창경,김수현 한국조리과학회 2003 한국식품조리과학회지 Vol.19 No.5
The effect of inhibition on N-nitrosodimethylamine (NDMA) formation by methanol extracts from 6 kinds of citrus seed (Citrus sunki, Citrus natsudaidai, Citrus suleata, Citrus tangerina, Citrus grandis and Citrus obovoidea) were investigated. The contents of moisture, crude protein, crude fat, carbohydrate, ash, flavonoid and totat phenol in citrus seeds were 4~6, l1~15, 32~46, 22~45, 2~4%, 12~24mg% and 53~133㎎%, respectively. The solid contents and yield of citrus seed extracts were 0.8~1.0 and 0.7~1.1%, respectively. Nitrite-scavenging activity by methanol extracts from citrus seeds increased with increasing extract dosage. Furthermore, the nitrite scavenging activity was pH dependent being the highest at pH 1.2 (42.7~96.9%) and the lowest at pH 6.0 (19.9~62.6%). Scavenging effects of nitrite by reaction time showed high effects under 3hr reaction time. The inhibition effect of NDMA formation by the citrus seed was strengthened as the amount of extract increased. The inhibition rate of methanol extracts from citrus seeds on NDMA formation showed 1.2~39.8%, 21.3~60.1% and 47.4~94.0%, according to add 1, 3 and 5㎖, respectively. Therefore, the inhibition effect of NDMA formation by the citrus seed was strengthened as the concentration of extract increased.
서울의 Penicillinase Producing Neisseria Gonorrhoeae 발생빈도(1996)
김재홍,황동규,전재홍,김윤석,김중환,김용준,이창균,임동진,김현수,조창근,김경문,박상훈,전우형,김희성,이호정,차명수,김갑형,김형석,김석우,황지환,박병순,권오상,이민수,송기훈,성소영,이인섭,부태성 대한화학요법학회 1999 대한화학요법학회지 Vol.17 No.2
Background : In recent years, gonorrhea has been panedemic and remains one of the most commom STDs in the world, especially in developing countries. Objective & Methods: For the detection of a more effective therapeutic regimen and assessing the prevalence of PPNG, we have been trying to study the patients who have visited the VD Clinic of Choong-Ku Public Health Center in Seoul since 1980 by means of the chromogenic cephalosporin method. Results: In 1996, 139 strains of N. gonorrhoeae were isolated, among which 53(39.0%) were PPNG. Conclusion: Our results suggests that after a peak of 74.3% in 1993, the prevalence of PPNG in Seoul is gradually declining.
Chang, Young-Ja,Kim, Yu-Lee,Jo, Ji-Yeong,Kim, Kye-Ok,Kim, Hyo-Lim,Im, Dong-Soon 대한약학회 2008 Archives of Pharmacal Research Vol.31 No.5
Previously, we suggested that dioleoyl phosphatidic acid (PA) and lysophosphatidic acid (LPA) increased $[Ca^{2+}]_i$ through endogenous LPA receptors coupled to pertussis toxin-sensitive G proteins in rat C6 glioma cells. In the present report, we investigated morphological changes and cytotoxicity induced by PA and LPA in C6 glioma cells. Isoproterenol treatment led to changes in the cell morphology of rat C6 glioma cells, which were reverted by the addition of PA and LPA. PA- and LPA-induced morphological reversions were inhibited by treatment with Ki16425, an $LPA_1/LPA_3$ receptor antagonist. VPC32183, another $LPA_1/LPA_3$ receptor antagonist with a different structure, only inhibited PA-induced morphological reversion but not LPAinduced reversion. However, the reversions were not inhibited by treatment with pertussis toxin, a specific inhibitor of $G_{i/o} $proteins. In addition, cytotoxicity was only induced by LPA but not by PA in C6 glioma cells. Our results suggest that PA may act as a partial agonist at endogenous LPA receptors, which are sensitive to Ki16425 and coupled to PTX-insensitive G proteins, to evoke morphological changes in C6 glioma cells.