가족성 정신분열병 환자에서 임상 특성의 가족내 연관성

최경숙,이유상,장용이,조은영,전현옥,김창현,김상욱,홍경수 大韓神經精神醫學會 2004 신경정신의학 Vol.43 No.5

Objectives : This study aims at examining familial associations of symptoms and clinical characteristics in affected sibling or relative pairs of schizophrenia as an effort to identify genetically homogeneous phenotypes. Methods : Forty-seven relative pairs with DSM-IV diagnosis of schizophrenia from thirty-five Korean families multiply affected with schizophrenia were ascertained. Direct interviews were done using the Korean version of Diagnostic Interview for Genetic Studies (DIGS). The Krawieka Rating Scale and the Schedule for the Deficit Syndrome were also applied for further evaluation of psychopathologies. Intra-familial concordances and correlations of clinical characteristics and symptoms were tested using χ² -test and Spearman's correlation. Results : Significantly high concordance rate within relative pairs was found for the diagnosis of paranoid vs. non-paranoidsubtype (χ²=7.623, P=0.006, df=1). Deficit vs. non-deficit syndrome also showed significant concordance (χ² =3.850, p=0.0497, df=1). Among single symptom items in DIGS, only 'auditory hallucination' showed significant concordance rate ( χ² =5.503, P=0.019, df=1). Factor analysis for symptoms items in the Rrawiecka Rating Scale indicated three symptom dimensions ; negative, psychotic and affective, Psychotic (P =0.442, P=0.003) and affective dimension scores (p =0.427, P=0.004) showed significant intra-familial correlations. Age at onset of recognized psychotic symptoms showed significant correlation only within the male sibling pairs. Conclusion : Familial factors, Possibly genetic factor contribute to the phenotypic characteristics of paranoid vs. non-para-noid subtype, deficit vs. non-deficit syndrome, auditory hallucination, and affective syndrome, It supports their use in the delineation of homogeneous subgroups for future genetic studies.

우리나라 산재보험의 정신질환 인정실태

최경숙,이현주,김세진,이창화 大韓神經精神醫學會 2006 신경정신의학 Vol.45 No.3

Objectives : The purpose of this study was to determine characteristics of work-related psychiatric injuries with Korean Workers' compensation data. Methods : We analyzed the distribution of sex, age, types of work-related psychiatric disorders, type of industry and occupation. Using the data of 3175 Korean workers' compensation cases who were compensated for work-related psychiatric injuries from 2001 to 2003. Results : Work-related psychiatric injuries have increased annually. 897 cases, 1099 cases and 1179 cases were compensated during three years (2001-2003). Men accounted for many more cases than women. The most common age group was 41 -49. The majority of work-related psychiatric injuries were 'organic, including symptomatic, mental disorders', 'neurotic, stress-related and somatoform disorders' and 'mood [affective] disorders'. For accidental psychiatric injury cases construction and manufacturing were the most common industries. Manufacturing, business activities, construction and transport were common in regard to work-related psychiatric disorders. In this study there was a high frequency of craft and related trades workers, elementary occupations and plant and machine operators and assemblers in accidental psychiatric injury cases. Work-related psychiatric disorders were frequent for elementary occupations, plant and machine operators and assemblers, craft and related trades workers, service workers, legislators, senior officials and managers. Conclusion : This investigation provided more information about the psychiatric injuries of Korean workers. These findings should help formulate intervention and prevention strategies of work-related psychiatric disorders.

열안정형 카테콜-O-메틸전이효소 유전자의 클로닝

홍경만,최용복,정갑용,지은정,장현신,박현,백문기 圓光大學校 醫科學硏究所 1998 圓光醫科學 Vol.14 No.2

Catechol-O-methyltransferase (COMT; EC 2.1.1.6) is the enzyme which catalyzes the transfer of methyl group to the catecholamine neurotransmitters from its methyl donor S-adenosyl-L-methionine. Partially purified COMT from rat liver has been used to measure the concentration of catecholamines in the blood through solvent extraction and thin layer chromatography after converting ^3H-methyl derivatives of catecholamines. To improve this inconvenient and fluctuating method, an attempt was made to use COMT gene for the measurement of catecholamines. Specific primers, COMT5P (5'-TGC TCA GAG GTG CTT TGA AG-3') and COMT3P (5'-GGA GCC GCA GAA GGT CA G-3'), were used to amplify COMT gene from human placenta cDNA library. The amplified COMT gene through 35 cycles of polymerase chain reaction was cloned into T-vector and the nucleotide sequences are determined by automatic sequencer. Human COMT has two common variants, a thermostable high activity form which has valine at amino acid 158 and a thermolabile low activity form which Has methionine at the same position. The cloned COMT gene in this study has both variants. Clone 4 and 5 have valine at amino acid 158 (guanine at nucleotide 472) and clone 1-3 have methionine at this site (adenine at nucleotide 472). In addition to this, there are other DNA polymorphisms in COMT gene at nucleotide 101, 102 (amino acid 34, a structural mutation cysteine/serine) and nucleotide 186 (a silent mutation). All of the clones have cysteine at amino acid 34 (guanine and adenine at nucleotides 101 and 102) and cytosine at nucleotide 186 except clone 3 which has thymine at this nucleotide. Clone 4 and 5 are thermostable high activity variants, suggesting being more useful for the measurement of catecholamines after expressing the gene.

채용시 건강진단에서 요ㆍ천추부 단순 방사선 검사의 평가

임현술,김수군,김덕수,이현경,최대섭 대한산업의학회 2000 대한직업환경의학회지 Vol.12 No.2

Objectives : A study was conducted for investigating the status of simple X-rays on lumbo-sacral regions at pre-employment health examination and analysing the effectiveness of simple X-rays on lumbo-sacral regions. Methods : The study data were pre-employment health examination data in a university hospital from Jan 3, 1993 through October of 1997. And, 97 newly employed workers who claimed no low back pawn at pre-employment health examination of a certain company were follow-up survey about low back pain and related factors in April, 1995 and October of 1997. The data were collected by a self-reported questionnaire and a medical examination with a rehabilitation specialist. Results : 1. Taking the simple X-rays on lumbo-sacral regions was 1,591 workers (10.5%) among 15,166 pre-employment health examination from Jan 3, 1993 through October of 1997. And yearly application rates of these X-ray tests have been significantly statistical increasing (p〈0.01). 2. The abnormal findings of simple X-rays on lumbo-sacral regions at pre-employment health examination were 40 workers. But, there was not significantly statistical difference between normal and abnormal group for the complaint rate of low back pain. 3. The number of case with symptoms of low back pain at the follow-up survey were 46, so The incidence density was 37.1 persons/ 100 person-years. And the incidence density was not significantly statistical difference between normal and abnormal group of simple X-rays on lumbo-sacral regions. 4. Through the multivariate logistic regression, significantly associated factors with low back Pain were found to be tenure(OR=0.36, 95%CI : 0.17-0.79), lifting of heavy materials (OR=5.86, 95%CI : 1.58-21.74) . Conclusion : The simple X-rays on lumbo-sacral regions at pre-employment health examination is required further research for utilizing pre-employment health examination according to above results.

크롬 함유 페인트 분무작업자에서 발생한 비중격 천공

정희경,김두희,최병순,임현술,신용철,황보근 東國大學校醫學硏究所 1997 東國醫學 Vol.4 No.-

크롬은 산업에서 널리 사용되고 있으나 접촉성 피부염, 점막 자극, 비중격 천공, 천식, 폐암 등 건강에 영향을 미칠 수 있는데 크롬 및 그 화합물의 원자가, 수용성, 농도, 산성도, 폭로기간 및 경로에 따라 독성이 다르다. 약 5개월간 크롬에 폭로된 2명의 근로자에서 비중격 천공이 발생하여 35명 근로자의 작업조건과 건강상태를 조사하였다(페인트 분무 판넬부서 14명, 서스부서 16명, 기타 부서 5명). 공기 중 총크롬의 농도는 0.103-0.318 mg/m³이었고, 6가 크롬농도는 자동분무 중에 0.001-0.060 mg/m³, 수동분무 중에 0.029-0.226 mg/m³이었다. 모든 근로자에서 소변의 크롬농도는 50㎍/L를 넘지 않았으나, 혈액의 크롬농도는 3명에서 3㎍/dL를 초과하였다. 서스부서보다 판넬부서 근로자에서 비강의 미란이나 가피가 더 많이 발견되었다(교차비 7.0). 부서별로는 소변이나 혈액의 크롬농도가 차이가 없었고 비강소견에 따라서도 소변의 크롬농도가 차이가 없었으나, 혈액의 크롬농도는 비강의 미란이나 가피가 있는 경우 유의하게 높았다. 비중격 천공이 발생한 2명의 근로자에서 크롬에 의해 발생할 수 있는 폐나 비갑개, 간 및 신장의 이상소견과 천식은 발견되지 않앗다. 본 사업장에서 크롬에 의한 건강장애를 예방하기 위해서는 수동분무를 자동분무로 바꾸고 분무한 페인트가 완전히 건조한 후 다음 작업을 하여야 한다. 또한 크롬 미스트가 흡입되지 않도록 적절한 호흡기 보호구를 철저히 착용하여야 한다. After discovery, chromium has been widely used in industry. Health hazards of chromium and its compounds are contact dermatitis(allergic and irritant), mucosal irritation, nasal septal perforation, asthma, and lung cancer. Their toxicity depends on valency, solubility, concentration, PH, exposure duration and route. Nasal septal perforation was developed in two workers exposed to chromium for about 5 months, so we surveyed the working condition and health status of 35 workers(14 workers in paint spraying panel line, 16 in sus line and 5 in other line). Air concentration was as follows: total chromium 0.103-0.318 mg/m³, Cr(VI) 0.001-0.060 mg/m³in automatic spraying and 0.029-0.226 mg/m³in manual spraying. Urine chromium concentration was not over 50 ㎍/L in all workers, but blood chromium concentration was over 3 ㎍/dL in 5 workers. Erosion or crust of nasal cavity was detected more frequently in panel line workers than sus line workers(odds ratio=7.0). But blood or urine concentration of chromium was not different according to the job. Urine concentration of chromium was not different irrespective of nasal cavity finding, but blood concentration was high in the workers with erosion or crust of nasal cavity. Two workers with nasal septal perforation did not have any other diseases which can be developed by chromium exposure. To prevent health hazards of chromium in this factory, manual spraying process has to be changed to automatic process, the next process done after paint was absolutely dried, and respiratory protector should be weared to prevent inhalation of chromium mist effectively.

위암 환자의 복강내 투여를 위한 Activated Charcoal-Alginate Bead 제형으로부터 Mitomycin C의 용출 거동

이진호,최선웅,서중기,김동민,정경수,오정연,김진향,노승무,민병무,김용백,김창식,박근성,강대영,송규상,양준묵,조준식,정현용,김학용,인현빈 충남대학교 의과대학 지역사회의학연구소 1998 충남의대잡지 Vol.25 No.1

Locoregional recurrence is the most common type of recurrence in surgical operation of gastric adenocarcinoma, and peritoneal dissemination is one of the most difficult problems in advanced gastric adenocarcinoma treatment. Because the peritoneal cavity is the most common site of the first recurrence after gastric cancer resection, intraperitoneal chemotherapy seems a logical choice for cancer chemotherapy. In this study, Mitomycin C (MMC)-activated charcoal (CH)-alginate (ALG) beads were prepared by the mixtures of CH particles adsorbed with MMC as an anti-cancer drug and aqueous alginate solution. The alginate is recognized as biodegradable, nontoxic, and biocompatible. The release of MMC from the beads in 0.1 M Tris buffer was stable and continuous until about 1 week. The MMC-CH-ALG beads can be applied in the peritoneal cavity for intraperitoneal chemotherapy since they provide a good adhesiveness on the tissue and controlled release pattern of the drugs.

미취학 아동에 있어 신체발달, 손목 골밀도 및 영양섭취와의 상관성

명금희,나현주,최미경,김애정 동아시아식생활학회 2004 동아시아식생활학회지 Vol.14 No.2

This study was conducted to examine the correlation among growth development, bone mineral density, and nutrient intakes in preschool children. A total of 62 preschool children measured the anthropometric characteristics and the bone mineral density of carpus using DEXA. The questionnaires categorized to determine health status, life style, dietary behaviors, and dietary intakes were filled out by children's mothers. The average ages of the study subjects were 62.4 months in boys and 62.1 months in girls. The birth height and weight of the subjects were 50.9 ㎝ and 3.4 ㎏ in boys and 50.3 ㎝ and 3.3 ㎏ in girls, respectively. The average height, weight, % body fat, and obesity index were 111.7 ㎝, 19.6 kg, 15.0%, -2.1% in boys and 109.4 ㎝, 18.7 ㎏, 17.5%, 0.2% in girls, respectively. The bone mineral density in carpus was 0.25 g/㎠ in boys and 0.24 g/㎠ in girls. Proportions of children having regular meals were 69.0%, 94.7% and 69.0% for breakfast, lunch, and dinner, respectively. The major reasons for irregular meal were poor appetite and lack of time for breakfast and snacks for dinner. Most of the children(52.6%) had breakfast with the whole family together, and all the children had lunch and dinner with a part of the family. Most of the children answered they had snack more than once a day, and 64.3% had an unbalanced diet. The intakes of energy, calcium, iron, zinc, vitamin A, vitamin B₁, niacin, and vitamin C did not meet the Korean RDAs. The intakes of energy, calcium, iron, zinc, vitamin A, vitamin B₁, niacin, and vitamin C did not meet the Korean RDAs. Average bone mineral density in carpus was positively correlated to the body weight, the total body water, the lean body mass, and obesity index, respectively(p<0.01, p<0.01, p<0.01 and p<0.01). The body weight, the total body water, and the lean body mass showed the significant negative correlation with the animal iron intake(p<0.05, p<0.01 and p<0.01). The bone mineral density the distal carpus was negatively correlated to the animal protein intake and the animal iron intake(p<0.05 and p<0.05). And the bone mineral density in the ultradis carpus and the average bone mineral density in the carpus were positively correlated to the plant calcium intake(p<0.05 and p<0.05). Therefore, more systematic studies to investigate the roles of protein, iron, and calcium in growth development of preschool children were required.

Rat의 복강에 삽입한 Fluorouracil-Polyglycolic acid 제형의 Fluorouracil 용출에 관한 연구

노승무,정경수,오정연,김진향,양준묵,강대영,송규상,최정목,최선웅,이진호,조준식,민병무,김용백,김창식,박근성,김승영,김학용,인현빈 忠南大學校 癌共同硏究所 1998 癌共同硏究所 硏究誌 Vol.2 No.1

A common form of relapse in adenocarcinoma of the stomach is intraperitoneal dissemination, in fact, among gastric adenocarcinoma patients who have undergone surgery intended to cure, approximately 50% of the patients develope initial recurrence in the peritoneal cavity regardless of the anatomic site of the primary tumor within the stomach. The efficacy of systemic postoperative chemotherapy to prevent peritoneal recurrence of gastrric adcnocarcinoma is not satisfactory. There is still a great need for improved therapeutic strategies on the disseminated microscopic disease and small miliary nodules remaining on the peritoneal surface or lymphatics after operation. The authers have made fluorouracil-polyglycolic acid composite disks(Fu-PGA disks) with fluorouracil and biodegradable polymer: polyglycolic acid for more effective intraperitoneal chemotherapy. We inserted the Fu-PGA disk(s) in the peritoneal cavity of rat and pharmacokinetic study was performed to measure fluorouracil concentration in the peritoneal fluid, plasma, liver, kidney and heart tissue at 24 hour, 72 hour and 168 hour after insertion of Fu-PGA disk(s). Myelosuppressive action of this composite also was determined following its administration. The data of this study suggested that Fu-PGA composite will be a new device releasing drugs in a controlled manner and having targetability to peritoneum, and this device will be improving the efficacy of intraperitoneal chemotherapy for gastric adenocarcinoma.

백서의 복강내에 투여한 Mitomycin-C-Polyglycolic acid 제형이 장기에 미치는 영향에 관한 연구

송규상,강대영,최정목,노승무,정경수,오정연,김진향,양준목,최선웅,이진호,조준식,민병무,김용백,김창식,박근성,김승영,김학용,인현빈 충남대학교 의과대학 지역사회의학연구소 1998 충남의대잡지 Vol.25 No.1

To evaluate the in-vivo effects of mitomycin-C-polyglycolic acid composite(MMC-PGA) the disk: shaped composite were implanted into the peritoneal cavity of the Sprague-Dawley rats. The pathologic changes were examined at various time points up to 12 weeks. Initially the soft tissue around the inserted disks showed capillary congestion at 3 days. Inflammatory infiltrates with foreign body giant cells appeared from the 2nd week and reached peak response at 6-8 weeks. These reaction diminished prominently at 12 weeks. No specific pathologic change was found in the liver, the kidneys, and the heart. The above results suggest that the MMC-PGA composite can serve as a new device for intraperitoneal chemotherapy of various types of cancers.

신라대학교 주변 백양산의 동물상

노치권(외 6명) 신라대학교 자연과학연구소 2012 自然科學論文集 Vol.22 No.-

To study fauna of Silla University located in Mt. Baek-yang, we conducted six surveys from 29 May 2011 to 28 April 2012. We found five phyla 41 orders 197 species of animals inhabiting in this area: four phyla 27 orders 163 species of invertebrates and in vertebrates one order six species of fishes, three orders nine species of amphibians and reptiles, six orders 14 species of aves, and four orders five species of mammals. Of these species, some Korean endemic species were included: a fish of Rhodeus uyekii in a pond near main gate of this university, a frog of Rana coreana in a creek near a dormitory, and a rabbit of Lepus coreanus and a water deer of Hydropotes inermis in a grass region near a main stadium. A kind of hawk, Falco tinnunculus as a natural monument (animal) of no. 323-8, was observed on a building of medical and life science. A blue frog of Hyla japonica as a variation was found near a spring resort. Therefore, this area is considered an ecologically important area having a high animal diversity.