키토산 처리포의 괴화 천연염색에 관한 연구(Ⅰ)

전동원,김종준,신혜선 服飾文化學會 2003 服飾文化硏究 Vol.11 No.3

Cotton fabric and nylon fabric were chosen as base fabric speciments for dyeing using Japanese pagoda tree colorants through chitosan treatment. With the chitosan treatment, the dye-uptake of the treated fabric increased. This treatment is also expected to be effective in terms of environment-friendliness. The effect of the dyeing methods, mordanting or non-mordanting, and chitosan treatment on the dye-uptake and air permeability of the treated fabrics was investigated. In case of cotton fabric, Al mordanted dyeing resulted in higher dye-uptake through the chitosan treatment. Therefore, the chitosan treatment is effective in this case. Japanese pagoda tree seems to have direct affinity for nylon fibre without the mordanting treatment. In case of cotton fabric, it seems that the cellulose molecules, colorants, and the chitosan make a complex, thereby the air permeability. In case of nylon fabric, due to the fact the Japanese pagoda tree colorant molecules form direct physical bonding with the nylon molecules, it seems that there is not much of air permeability reduction.

CT flouroscopy를 이용한 중재적 시술의 유용성

전혜정,박정희,서보경,박상우,신현준,최영철,한혜승,이창희 건국대학교 의과학연구소 2004 건국의과학학술지 Vol.14 No.-

Conventional CT-guided needle localization has been reported many times, but a few reports of interventional procedures by using multidetector CT scan with CT-fluoroscopy have been described. We presented 36 cases of CT-fluoroscopy guided interventional procedures focusing on the puncture technique. Two cases of small pneumothorax and one case of pulmonary hemorrhage out of 2lcases after lung biopsy, were not needed any treatments We can easily and accurately access to the lesion by using CT-fluoroscopy and unique our marker system.

n-CdS_(0.46)Se_(0.54)/p-Cu_92-x)S_(0.46)Se_(0.54) 이종접합 태양전지의 제작과 그 특성에 관한 연구

유상하,최승평,이상열,홍광준,서상석,김혜숙,전승룡,윤은희,문종대,신영진,정태수,신현길,김택성,유기수 全北大學校 基礎科學硏究所 1994 基礎科學 Vol.16 No.-

승화방법에 의해 CdS_0.46Se_0.54 단결정을 성장하여 결정구조를 조사하고, Van der Pauw 방법으로 Hall effect를 측정하여 carrier density의 온도 의존성과 mobility의 온도 의존성을 조사하였다. 성장된 CdS_0.46Se_0.54 단결정을 치환반응하여 n-CdS_0.46Se_0.54/p-Cu_2-xS_0.46Se_0.54 이종접합 태양전지를 제작하였다. Spectral response, 전류-전압특성 및 전력변환 효율을 조사하여 그 결과로부터 개방전압은 0.48V, 단락 전류 밀도는 21mA/㎠, fill factor와 전력변환효율은 각각 0.75와 9.5%를 얻었다. CdS_0.46Se_0.54 single crystal was grown by a sublimation method. The crystal structure and the temperature dependence of carrier density and mobility of CdS_0.46Se_0.54 single crystal were studied. Heterojunction solar cells on n-CdS_0.46Se_0.54/p-Cu_2-xS_0.46Se_0.54 were fabricated by the substitution reaction. The spectral response, the J-U characteristics and the conversion efficiency of the n-CdS_0.46Se_0.54/p-Cu_2-xS_0.46Se_0.54 heterojunction solar cells were studied. The open-cricuit voltage, short-circuit density, fill factor and conversion efficiency of n-CdS_0.46Se_0.54/p-Cu_2-xS_0.46Se_0.54 heterojunction solar cells under 80mW/㎠ illumination were found to be 0.48V, 21mA/㎠, 0.75 and 9.5%, respectively.

한의진단명과 진단요건의 표준화 연구 II (표준화 실례) : 2차년도 연구결과 중간 보고

양기상,최선미,최승훈,안규석,박경모,박종현,김성우,신승호,정우열,전병훈,고현,김정범,신상우,김성훈,김동희,권영규,엄현섭,장혜옥 한국한의학연구원 1996 한국한의학연구원논문집 Vol.2 No.1

The diagnostic requirements were suggested and explained regarding the systems of differentiation of symptoms and signs in the second year study of standardization and unification of the terms and conditions used for diagnosis in oriental medicine. The systems were as follows; - differential diagnosis according to condition of body fluid, differentiation of syndromes according to the state of qi and blood, differential diagnosis according to relative excessiveness or deficiency of yin and yang(氣血陰陽津液辨證) - differentiation of diseases according to pathological changes of the viscera and their interrelation - analyzing and differentiating of febrile diseases in accordance with the theory of the six channels(傷寒辨證) The individual diagnosis pattern was arranged by the diagnostic requirements in the following order : another name(異名), notion of diagnosis pattern, index of differentiation of symptoms and signs(辨證指標), the main point of diagnosis, analysis of diagnosis pattern(證候分析), discrimination of diagnosis pattern(證候鑑別), a way of curing a diseases(治法), prescription(處方), herb in common use(常用藥物), diseases appearing the diagnosis pattern(常見疾病), documents(文獻調査). This study was carried out on the basis of the Chinese documents and references.

Nontuberculous Mycobacterial Lung Diseases Caused by Mixed Infection with <i>Mycobacterium avium</i> Complex and <i>Mycobacterium abscessus</i> Complex

Shin, Sun Hye,Jhun, Byung Woo,Kim, Su-Young,Choe, Junsu,Jeon, Kyeongman,Huh, Hee Jae,Ki, Chang-Seok,Lee, Nam Yong,Shin, Sung Jae,Daley, Charles L.,Koh, Won-Jung American Society for Microbiology 2018 Antimicrobial Agents and Chemotherapy Vol.62 No.10

<P>Mycobacterium avium complex (MAC) and M. abscessus complex (MABC) comprise the two most important human pathogen groups causing nontuberculous mycobacterial lung disease (NTM-LD). However, there are limited data regarding NTM-LD caused by mixed NTM infections. This study aimed to evaluate the clinical characteristics and treatment outcomes in patients with NTM-LD caused by mixed infection with these two major NTM pathogen groups. Seventy-one consecutive patients who had been diagnosed with NTM-LD caused by mixed infection with MAC (M. avium or M. intracellulare) and MABC (M. abscessus or M. massiliense) between January 2010 and December 2015 were identified. Nearly all patients (96%) had the nodular bronchiectatic form of NTM-LD. Mixed infection with MAC and M. massiliense (n = 47, 66%) was more common than mixed infection with MAC and M. abscessus (n = 24, 34%), and among the 43 (61%) patients who were treated for NTM-LD for more than 12 months, sputum culture conversion rates were significantly lower in patients infected with MAC and M. abscessus (25% [3/12]) than in patients infected with MAC and M. massiliense (61% [19/31, P = 0.033]). Additionally, M. massiliense and M. abscessus showed marked differences in clarithromycin susceptibility (90% versus 6%, P = 0.001). Of the 23 patients who successfully completed treatment, 11 (48%) redeveloped NTM lung disease, with mycobacterial genotyping results indicating that the majority of cases were due to reinfection. Precise identification of etiologic NTM organisms could help predict treatment outcomes in patients with NTM-LD due to mixed infections.</P>

Anti-inflammatory activity of Motherwort (Leonurus sibiricus L.).

Shin, Hye-Young,Kim, Sang-Hyun,Kang, Sin-Myoung,Chang, Ik-Jun,Kim, Sang-Yong,Jeon, Hoon,Leem, Kang-Hyun,Park, Won-Hwan,Lim, Jong-Pil,Shin, Tae-Yong Marcel Dekker 2009 Immunopharmacology and immunotoxicology Vol.31 No.2

<P>Motherwort (MW), a Korean folk medicine, has been applied to treat inflammatory disease. However, its effect on inflammatory cytokine release from mast cells is not well known. We investigated the anti- inflammatory effect of MW on the secretion of inflammatory cytokine such as tumor necrosis factor (TNF)-alpha and interleukin (IL)-6 and IL-8 in human mast cell line (HMC-1). MW was treated in vitro before activation of HMC-1 cells with phorbol 12-myristate 13-acetate (PMA) plus calcium ionophore A23187. MW had no cytotoxic effects on HMC-1 cell viability. MW (1 mg/ml) inhibited PMA plus A23187-stimulated gene expression and production of TNF-alpha, IL-6, and IL-8. Stimulation with PMA plus A23187 induced NF-kappaB activation in HMC-1 cells, which was inhibited by MW (1 mg/ml). MW inhibited secretion of TNF-alpha, IL-6, and IL-8 possibly by inhibiting NF-kappaB activation. These results indicate that MW may be helpful in regulating inflammatory diseases.</P>

Characteristics of Korean Employees Without Depression but Having Suicidal Ideation

Jeon Hye Jeong,Oh Kang Seob,Shin Young-Chul,Shin Dong-Won,Cho Sung Joon,Jeon Sang Won 대한신경정신의학회 2023 PSYCHIATRY INVESTIGATION Vol.20 No.7

Objective The aim of this study was to identify the factors related to suicidal ideation targeting the risk group showing suicidal ideation despite the absence of depression in Korean workers.Methods The data of 14,425 participants who were employees aged of 18 to 75 years who attended a mental health checkup program at the Workplace Mental Health Institute, Kangbuk Samsung Hospital from June 2015 to October 2019 were analyzed. A self-report questionnaire consisting of sociodemographic factors, suicidal ideation, job stress, levels of depression and anxiety, and resilience was administered. A Hierarchical logistic regression model was used with suicidal ideation as dependent variable. Separate analyses were conducted according to depressive symptoms using the 20-item Center for Epidemiological Studies Depression (CES-D) scale.Results Being women, older, and having low resilience, more perceived stress, more severe anxiety and less sleeping hours were associated with suicidal ideation in no-depression group (CES-D <16). In the subcategories of job stress, lack of reward was significantly associated with suicidal ideation in no-depression group.Conclusion This study identified the characteristics of a group that has no depression but has suicidal ideation in Korean workers. Among job stress items, lack of reward is a clear characteristic to be considered with caution in this group.

Right hepatic vein stenosis at anastomosis in patients after living donor liver transplantation: optimal Doppler US venous pulsatility index and CT criteria--receiver operating characteristic analysis.

Hwang, Hye Jeon,Kim, Kyoung Won,Jeong, Woo Kyoung,Song, Gi-Won,Ko, Gi-Young,Sung, Kyu Bo,Shin, Yong Moon,Kim, Pyo Nyun,Ha, Tae-Yong,Moon, Deok-Bog,Kim, Ki-Hun,Ahn, Chul-Soo,Hwang, Shin,Lee, Sung-Gyu Radiological Society of North America 2009 Radiology Vol.253 No.2

<P>PURPOSE: To establish optimal Doppler ultrasonographic (US) venous pulsatility index and computed tomographic (CT) criteria for right hepatic vein (RHV) stenosis after living donor liver transplantation (LDLT) and to compare accuracies of these methods by using receiver operating characteristic (ROC) analysis. MATERIALS AND METHODS: This retrospective study was approved by an institutional review board; informed consent was waived. Eighty patients (48 men, 32 women; mean age, 51.5 years +/- 9.2 [standard deviation]) underwent Doppler US and CT within 8 days of hepatic venography following right lobe LDLT between October 2006 and September 2008. At venography, RHVs were classified into a stenosis or nonstenosis group. At Doppler US, venous pulsatility index was defined as the difference between maximum and minimum frequency shifts divided by maximum frequency shift. At CT, diameters of anastomosis and RHV were measured; percentage of stenosis was calculated. Mean Doppler US and CT parameters in the two groups were compared; ROC analysis was performed. RESULTS: There were 30 stenotic and 50 nonstenotic RHVs. Mean venous pulsatility index and mean anastomosis diameter were significantly lower and mean percentage of stenosis was significantly higher in the stenosis than the nonstenosis group (P < .001 each). Optimal cutoffs for venous pulsatility index, anastomosis diameter, and percentage of stenosis were 0.16, 3.7 mm, and 47%, respectively. Sensitivity and specificity were 86.7% and 68.0% for venous pulsatility index, 96.7% and 88.0% for anastomosis diameter, and 96.7% and 86.0% for percentage of stenosis, respectively. At ROC analysis, anastomosis diameter (P = .002) and percentage of stenosis (P = .003) were significantly more accurate than venous pulsatility index. CONCLUSION: CT is more accurate than Doppler US for RHV stenosis after LDLT, with venous pulsatility index as the sole sonographic criterion. Patients suspected of having RHV stenosis at Doppler US may benefit from CT to reduce unnecessary venography.</P>

안와 종괴 생검으로 첫 진단된 소세포폐암 1예

전혜신(Hye shin Jeon),조명호(Myung Ho Cho),최희영(Hee Young Choi) 대한안과학회 2017 대한안과학회지 Vol.58 No.4

목적: 안와에 발생한 종괴의 조직검사 결과 소세포폐암의 안와 전이로 진단된 1예를 문헌고찰과 함께 보고하고자 한다. 증례요약: 당뇨와 고혈압의 병력이 있는 66세 남자 환자가 좌안의 시력 저하 및 안구 돌출을 주소로 내원하였다. 우안은 13년 전 나이 관련황반변성으로 진단 받았으며 1개월 전부터 폐렴으로 진단 받고 치료 받은 과거력이 있었다. 최대교정시력은 우안 안전수동, 좌안 0.04였고 좌측 안저에서 시신경유두의 부종 및 출혈 소견을 보였으며 좌안의 안구돌출 및 안구운동의 제한을 보였다. 안와 자기공명 영상에서 좌측 안와 근원추 내 종괴가 관찰되어 시행한 병리조직검사에서 작고 둥근 모양의 종양세포가 관찰되었다. 면역조직화학염색 결과에 따라 전이성 종양을 의심하였으며 전신 평가 실시 후 원발성 소세포폐암 및 다발성 전이로 진단되었다. 이후 항암 치료를 시작하였으나 2개월 후 시력은 안전 수동으로 감소하였으며 안구돌출은 호전되지 않았다. 결론: 안와 종괴가 발생하여 내원한 환자에서 감별 진단 시 전이성 종양의 가능성도 염두에 두어야 하며 조기에 적극적인 조직검사를 시행하여야 한다. Purpose: To report a case of an orbital mass diagnosed as metastasis from small cell lung cancer and to provide a review of the literature. Case summary: A 66-year-old male with a history of diabetes mellitus and hypertension presented with decreased visual acuity and exophthalmos in his left eye. He had been diagnosed with age-related macular degeneration 13 years prior and had a history of pneumonia that was treated for one month. The best corrected visual acuity was hand-motion in the right eye and 0.04 in the left eye. Optic disc swelling and splint hemorrhage of the left eye was observed on fundus examination. The left eye was protruded and eye movement was limited. On orbital magnetic resonance imaging, an irregular mass in the left intraconal space was found. Incisional biopsy was performed, and histopathologic examination revealed a small round tumor. According to the results of immunohistochemical staining, metastatic tumors were suspected. After systemic evaluation, the patient was diagnosed with primary small cell lung cancer with multiple metastases. After 2 months, the visual acuity was hand-motion and proptosis was not resolved. Conclusions: In patients with orbital masses, the possibility of metastatic tumors should be considered during differential diagnosis and early biopsy should be performed.

Long-term efficacy and safety of intravenous injection of clonal mesenchymal stem cells derived from bone marrow in five adults with moderate to severe atopic dermatitis

( Seon Bok Lee ),( Hye Won Hwang ),( Ji Hye Heo ),( Hee Seong Yoon ),( Yun-kyoung Cho ),( Eunkyung Chung ),( Myung-shin Jeon ),( Si Hyub Lee ),( Hyun-tae Shin ),( Ji Won Byun ),( Jeonghyun Shin ),( Su 대한피부과학회 2020 대한피부과학회 학술발표대회집 Vol.72 No.1

Background: Atopic dermatitis(AD) is a chronic and relapsing inflammatory skin disease that is treated with immunosuppressants. However, long-term use of immunosuppressants may cause toxicity and severe side effects. Objectives: This study aimed to confirm the long-term efficacy and safety of clonal mesenchymal stem cell therapy in adult patients with moderate to severe AD that was refractory to conventional treatments. Methods: A single-center, open-labeled investigator-initiated clinical trial for the therapeutic use of allogeneic bone marrow-derived clonal MSCs in five adults with moderate to severe AD was conducted intravenously. Eczema Area and Severity Index (EASI), Severity Scoring for AD and Investigator Global Assessment scale were used to evaluate the effectiveness of the therapy. Results: The clinical response assessment values such as EASI improved significantly at 16 weeks, and 80% (4/5) of the patients achieved EASI-50 after one or two treatment cycles. Patients were observed for long-term efficacy and safety for an average of 38 weeks and showed no serious side effects. Among the cytokines tested, CCL-17, IL-13 and IL-22 significantly decreased at the endpoint of the five participants, two patients who maintained good clinical response over 84 weeks showed increased IL-17 cytokine levels in the blood. Conclusion: This study suggests that clonal mesenchymal stem cell therapy could be safe and effective treatment option for chronic refractory AD.