조혈모세포이식 환자에서 침습성 진균 감염에 대한 Micafungin의 예방 효과 및 안전성

김시현,이동건,최수미,권재철,박선희,최정현,유진홍,이성은,조병식,김유진,이석,김희제,민창기,조석구,김동욱,이종욱,민우성,박종원 대한감염학회 2010 감염과 화학요법 Vol.42 No.3

Background: Micafungin, a potent inhibitor of 1,3-β-D-glucan synthase, is a novel antifungal agent of the echinocandin class. In vitro study showed that micafungin was effective against Aspergillus species as well as Candida species, but clinical data on the prophylactic efficacy against invasive fungal infections (IFIs) other than candidiasis are still lacking. Materials and Methods: We identified 60 consecutive adult hematopoietic stem cell transplantation (HSCT) recipients who received at least 3 doses of micafungin during neutropenic period. Micafungin was started as an alternative in patients who were intolerant or had adverse events (AEs) to primary prophylactic antifungal agents. We retrospectively reviewed the medical records and analyzed the efficacy and safety of micafungin for prophylaxis against IFIs. Results: The patients either had autologous (n=9) or allogeneic (n=51: 1 syngeneic, 24 sibling, 26 unrelated donor) HSCT. Itraconazole oral solution (n=58) was the most frequently used first line antifungal agent for prophylaxis and was administered for median 11 days. The most frequent cause of switch to micafungin was vomiting (n=42). The duration of neutropenia and micafungin administration was median 13 and 12 days, respectively. A successful outcome was achieved in 45 (75%) patients. Empirical antifungal therapy was initiated in 13 (22%) patients. There were 2 cases (3.3%) of breakthrough fungal infections which comprised a probable invasive pulmonary aspergillosis and a possible invasive fungal sinusitis. There was no case of invasive candidiasis. A total of 53 (88%) patients experienced at least one AE regardless of causality during micafungin administration. The most frequent AEs were hypokalemia, vomiting, diarrhea, and elevated serum aspartate aminotransferase or alanine aminotransferase. Among the aforementioned AEs, only 1 case of diarrhea could be classified as a probable relation with micafungin when causality was assessed. There was no AEs that caused discontinuation of micafungin. Conclusions: Micafungin seems to be a safe and effective agent for prophylaxis of IFIs including aspergillosis as well as candidiasis in HSCT recipients. However, further large, prospective, and randomized comparative studies are warranted for aspergillosis.

20세 전ㆍ후의 남자대학생과 육군장병들의 신체구성 및 생활습관에 관한 비교 연구

유승희,전종목 경희대학교 체육과학연구소 2000 體育學論文集 Vol.28 No.-

From March-25, 2000 to April-2, 2000, we investigated anthropometry, body composition, and general lifestyle of 157 collegiate students in Kyung-Gi province and 106 soldiers of the Korean Army Soldiers in Kang-Won province. The results were as follows : 1.There was no significant difference of the height between the students and the soldiers. The Weight of the students was 64.9±7.8kg compared to 69.3±7.1kg of the weight of the Army soldiers. The percent body fat was 17.0±4.1% and 14.8±3.2% for the students and the sold-iers, respectively. 2.The trend of height is that the most highest population is the under fat groups, with the students 173.8±5.9cm and the soldiers 173.6±6.0cm. The population with obese groups had the lowest height. 3.TBW of the soldiers was 40.9±4.2ℓ, which is about 3.7 ℓ more than TBW of the students. And the soldiers had more protein and mineral of body, about 1.4kg and 0.14kg. respectively. 4.In students, the obese group had the most TBW, 38.0±2.8ℓ. In sold-iers, the under fat soldiers, however, had the most TBW, 41.2±4.2ℓ. 5.The percents of people with the iregular lifestyle were 79% and 17%, the students and soldiers, respectively, and the percent of people drinking three times per week were 29% and 3%, the students and soldiers, respectively. 6.51% in the students and 75% in the soldiers were smokers, and 64% in the students and 85% in the soldiers considered them healthy. 7.65% in the students and 7% in the soldiers have taken an irregular meal and 50% and 15% often had instant food. 8.25% in the students and 100% in the soldiers take an regular exercise, and frequency is 3 times per week and 5 times per week, students and soldiers respectively. 9.In collegiate students, Pearson coefficient correlation between height and weight was proportional with r=0.320, between height and LBM with r=0.565, and also weight and WHR with r=0.490, weight and LBM with r=0.900, weight and percent body fat with r=0.559, WHR and LBM with r=0.311, percent body fat and WHR with r=0.515, smoking amount and lifestyle with r=0.277, smoking amount and frequency of drinking with r=0.370, but height and percent body fat had inverse proportion with r=-0.342. 10.In Amy soldiers, Pearson coefficient correlation between height and weight was proportional with r=0.675, and also between height and LBM with r=0.744, weight and WHR with r=0.298, weight and LBM with r= 0.932, percent body fat and WHR with r=0.284. But Pearson coefficient correlation between percent body fat and smoking amount had inverse proportion with r=-0.240.

추체 사대부 종양에 대한 개두술을 시행하지 않는 변형된 후경추체 경천막접근법 : Technical Note

유헌,정희원,양희진,김종선 대한신경외과학회 1999 Journal of Korean neurosurgical society Vol.28 No.3

치과의사의 근골격계 장애에 관한 연구

유종희,정성창 대한 두개하악장애학회 1994 대한두개하악장애학회지 Vol.6 No.2

The purpose of this work is to study the frequency of pain and discomfort in the musculoskeletal system among dentists, above all concerning head, neck and shoulder pain and to find possible correlations between these symptoms and various working positions and different working actions. A questionnaire was answered by 425 dentists with more than one year working experience (80% male, 20% female). The age varied from 25 to 67 years and mean age was 34.8 years. The dentists had worked on the average for 9.1 years. The obtainded results were as follows. 1. Dentists usually were at 10, 11, 9 o'clock position in treating upper and lower teeth, and 40% of dentists suffered from pain and discomfort in the neck were at 10 o'clock position in treating lower teeth (p<0.05). 2. During the past 12 months, 152 dentists(35.5%) suffered from headache, 208(48.9%) from pain and discomfort in the neck, 208(48.9%) from pain and discormfort in the shoulders and 188(44.2%) from pain in the lower back. 3. During the past one week, 50 dentists (11.8%) suffered from headache, 91(21.4%) from pain and discomfort in the neck, 86(20.2%) from pain and discomfort in the shoulders and 80(18.8%) from pain and discomfort in the lower back. 4. During the past 12 months, female dentists had a higher frequency of the pain and discomfort in the head, neck and shoulders than male dentists. During the past 1 week, female dentists had more lower backache additionally. 5. During the past 12 months the frequency of pain and discomfort in the head (p<0.05) and neck (p<0.01), during the past 1 week the frequency of pain and discomfort in the neck(p<0.01) and shoulders (p<0.05) had a tendency to decrease with age and the number of practice.

고령토로부터 알루미나 추출에 관한 연구(Ⅰ) : 황산에 의한 추출

유대선,윤종석,이희수 연세대학교 산업기술연구소 1990 논문집 Vol.22 No.1

The preparation conditions of alumina powder extracted by sulfuric acid were investigated. The raw material was domestic San-Cheong Kaolin. The experimental conditions which have an effect on the yield of alumina were varied as follows; the calcination temperature and time, the reaction temperature and time, and the acid concentration. The agglomeration of aluminum hydroxides precipitated by ammonia water was controlled by various drying methods. And the dried power was heated to obtain α-Al₂O₃for 1 hour at 1200℃. The yield of alumina was up to 58 percent under the optimum condition and its purity was 96.4 percent. The alumina particles prepared by the freeze drying method revealed narrower size distribution and less agglomerate than others.

유전성 대사질환에서의 동종조혈모세포이식 : 단일 기관에서의 경험 A single center experience

유건희,김흥렬,이지은,이호영,천정미,성기웅,구홍회,이문향,진동규,김종원,김대원,김형록 대한조혈모세포이식학회 2001 대한조혈모세포이식학회지 Vol.6 No.2

배경: 유전성 대사질환의 치료로서 효소 요법 및 유전자 치료가 제한적인 현실에서 동종 조혈모세포이식이 현재로선 가장 중요한 치료가 될 수 있다. 본 연구에서는 단일 기관에서 유전성 대사질환에 대해 동종 조혈모세포이식을 시행한 경험을 보고하고자 하였다. 방법: 삼성서울병원 유전성 대사질환 조혈모세포이식팀에서는 1999년 12월부터 2001년 3월까지 총 6례의 유전성 대사질환을 대상으로 동종 조혈모세포이식을 시행하였다. 대상 질환은 Hunter 증후군 3례, galactosialidosis 1례, 이염성 백질이영양증 1례, 부신백질이영양증 1례였으며 성별 분포는 남아가 5명, 여아가 1명이었으며 연령 분포는 2년 9개월에서 15년 9개월이었다. 5례는 HLA 일치 혈연간 골수이식이었으며 1례는 HLA 불일치 T 림프구 제거 말초혈액 조혈모세포이식이었다. 전처치는 모두 BuCy를 사용하였으며 이식편대숙주반응의 예방에는 cyclosporine을 사용하였다. 이식된 세포는 유핵세포가 4.81×10^(8)(2.40~7.01×10^(8))/kg이었으며 CD34+ 세포는 3.65×10^(6)(0.88~10.72×10^(6))/kg이었다. 결과: 이식 후 조혈기능의 회복은 모두 조기에 달성되었으며(ANC>500: 정중 9.5일, 범위 9~14일; PLT>50K: 정중 32일, 범위 23~34일) 이식과 관련된 합병증은 Gr I의 aGVHD 3례, 국한성의 cGVHD 1례, 경증의 간정맥 폐쇄성 질환이 1례이었다. 모든 환자에서 직간접적으로 이식 후 효소의 생산이 증가함이 확인되었으며 임상적인 호전을 보인 경우가 4례, 질병 진행이 중단된 경우가 1례, 질병이 진행된 경우가 1례이었다. 질병 진행이 중단되었던 1례는 면역억제제 투여 중 수두 감염에 의한 폐출혈로 사망하였다. 결론: 유전성 대사질환에서 동종 조혈모세포이식이 가장 중요한 치료법으로 사용될 수 있고 중추신경계 증상이 나타나기 전, 가능한 조기에 조혈모세포이식을 시행하는 것이 바람직할 것이며 적극적인 지지 요법이 필요하다. 향후 더 많은 임상 경험이 필요하리라 사료된다. Background: Allogeneic hematopoietic stem cell transplantation (HSCT) may be the most important treatment modality to cure a number of genetic metabolic disorders because of the limitation of enzyme replacement or gene therapy. In this study, we report our single center experience about HSCT in several genetic metabolic disorders. Methods: We performed 6 cases of HSCT for genetic metabolic disorders from December 1999 to March 2001. Patients' diagnoses were Hunter syndrome (3), galactosialidosis (1), metachromatic leukodystrophy (1), and adrenoleukodystrophy (1). Stem cell sources were bone marrow from HLA matched sibling donors in 5 patients and mother's peripheral blood stem cells in one patient who did not have HLA matched donors. Busulfan and cyclophosphamide for conditioning, and cyclosporine for the prevention of graft versus host disease were used in all patients. Transplanted total nucleated cell counts were median 4.81×10^(8)(2.40~7.01×10^(8))/kg , and CD34+ cells 3.65×10^(6)(0.88~10.72×10^(6))/kg. Results: All patients achieved early hematologic recovery (median 9.5 days, range 9~14 days for ANC>500/μL; median 32 days, range 23~34 days for PLT>50,000/μL). Transplant-related complications were 3 cases of grade 1 acute GVHD, a case of limited chronic GVHD, and a case of mild hepatic veno-occlusive disease. Enzyme levels were normalized in 4 patients evaluated and there were indirect evidences of enzyme production in the other 2 patients after HSCT. Four of the 6 patients showed symptomatic improvement, 1 patient (galactosialidosis) experienced disease stabilization without progression before he eventually died due to pulmonary hemorrhage, and the other 1 patient deteriorated progressively even after HSCT. Conclusions: Allogeneic HSCT can be done as the only curative treatment in a number of genetic metabolic disorders. It seems desirable to perform HSCT as early as possible before the onset of central nervous system symptoms. More experience and long term follow up is needed to evaluate the efficacy and to monitor the long term transplant-related complications.

죽순의 화학적 특성 및 염장 죽순 제조과정 중 성분 변화

유맹자,정희종 한국식품영양학회 1999 韓國食品營養學會誌 Vol.12 No.6

죽순의 가공 식품으로서의 적합성을 규명하고 염장죽순에 대한 과학적 자료를 마련하기 위차여 왕죽, 분죽, 맹종죽 죽순의 화학적 특성과 염장 죽순 제조 과정에서의 화학적 성분변화를 검토하였다. 수분. 조지방 함량은 염장기간에 따라 서서히 감소하였고 조단백. 회분의 함량은 증가하였으며 pH는 염장 80일째까지 감소하였다가 80일 이후부터는 다시 증가하였고 염 농도는 맹종죽 죽순이 가강 높은 염 농도를 보였으며 숙성이 진행되는 60일째 최고 염 농도를 보였다가 그 이후는 조금씩 감소하였다. 탄닌과 아스코르브산 함량은 염장 중에 계속 완만한 감소를 보였다 유리 아미노산의 조성은 세린 아르기닌. 알라닌. 로이신. 티로신이 주요 아미노산으로 분석되었고, 숙성이 진행됨에 따라 총 유리아미노산 함량은 염장 120일째까지 지속적으로 감소하였다 특히 아르기닌이 가장 빠른 감소 폭을 보였으며 세린. 알라닌. 로이신 등은 서서히 감소하였다 총 유리아미노산의 함량은 원료 죽순 중 왕죽 죽순이 1.060.18㎎/100g으로 가장 높은 함량을 나타냈고 다음으로 맹종죽 죽순이 612.29㎎/100g. 분죽 죽순이 539.76㎎/100g의 순으로 나타났으며 염장 죽순은 맹종죽 죽순이 76.60㎎/100g으로 가장 높았고 분죽 죽순이 44.43㎎/100g.왕죽 죽순이 43.70㎎/100g 나타나 염장 중 유리 아미노산의 감소가 큰 것을 알 수 있다. 무기성분의 경우 Mg, Ca. Na을 제외한 대두분이 원료 죽순에서 높은 함량이 분석되었는데 윈료 죽순은 K>P>Na>Ca>Mg>Fe>)Zn>Mn>Ge>Gu의 순으로 K의 함량이 가장 높았으나 숙성이 진행됨에 따라 P. Fe. Zn. Mn, Ge, Gu의 함량은 서서히 감소하고 K, Mg. Na. Ca의 함량은 증가하여 염장 l20일째에」Na>K>Ca>P>Fe>Ge>Mn>Zn의 순으로 Na 함량이 크게 증가하였다. In result of chemical properties of bamboo shoots and changes of chemical components of salted bamboo shoots during 120 days salting, the contents of moisture, crude fat, tannin and ascorbic acid were decreased but those of crude protein, crude ash and salt concentration were increased during salting. The pH was decreased in 80days-past of salting and after that, gradually increased. The main free amino acids of bamboo shoots were serine, arginine, alanine, leucine, and tyrosine. The content of total free amino acid was rapidly decreased in 80days-past of salting and after that, slowly decreased. Wang bamboo shoots was the highest as 1060.18㎎/l00g in content of total free amino acid. The main mineral elements were K, P, Na, and Mg. The contents of Fe and K were the highest among them. The contents of P, Fe, Zn, Mn, Ge and Cu were decreased but K, Mg, Na and Ca were increased during salting. When fresh bamboo shoots were compared with salted bamboo shoots, fresh bamboo shoots contained the contents of moisture, crude protein, crude fat, tannin and ascorbic acid more than salted bamboo shoots did, but the less the contents of ash, fiber and salt concentration.

묵은 김치 제조과정에서의 이화학적 및 미생물학적 특성 변화

유맹자,김형량,정희종 한국식생활문화학회 2001 韓國食生活文化學會誌 Vol.16 No.5

To develop the low-temperature and long-term fermented kimchi, kimchi was prepared according to the recipe of a specific ratio of major and minor ingredients and adjusted its salinity to 3.7%. Prepared kimchi fermented at 15±1℃ for 24 hours and transferred and fermented in a refrigerator only used to make low-temperature and long-term fermented kimchi at -1±1℃ for 30 weeks. During 30 weeks of fermentation the changes in physicochemical and microbiological properties of low-temperature and long-term fermented kimchi were studied. The initial pH of 6.47 decreased gradually and dropped to pH 4.0 after 14 weeks of fermentation, and then it maintained at same level. Acidity increased to 0.49% on 2 weeks of fermentation and kept at 0.47∼0.50% during 2 to 30 weeks fermentation. Salinity was slightly increased at early stage and started to decrease on 4 weeks of fermentation, and then it did not change. The change of reducing sugar content was closely related to the trend of pH change with a very high correlation coefficient(r=0.912). Lactic acid, citric acid, malic acid, succinic acid and acetic acid were major organic acids contained in low-temperature and long-term fermented kimchi. Vitamin C content decreased at initial stage of fermentation and then slightly increased up to the maximum of 22.3㎎% on 8 weeks of fermentation. In color measurement, L value continued to increase during the fermentation and reached at the highest of 55.45 on 22 weeks of fermentation, and a and b values of 3.62 and 4.54 also increased to 31.26 and 37.32 on 30 weeks of fermentation, respectively. Total microbial count increased slowly from beginning and was the highest on 4 weeks of fermentation, and then began to decrease slowly. Count of lactobacillus spp. was highest after 6 weeks, but count of Leuconostoc spp. was highest on 2 weeks of fermentation, and then both showed a slow decrease. Yeast count wasn't increased until 4 weeks of fermentation and then increased rapidly to get the highest on 10 weeks of fermentation.

폐기물매립지 적지선정을 위한 GIS 활용

유환희,김종오,김의명 경상대학교 환경보전연구소 1996 環境保全硏究所報 Vol.4 No.1

This study represents the present situation and the future prospect of waste management, the regulations for environmental protection, and the criteria and procedure for selecting the waste landfill sites using GIS. The criteria for selecting the waste landfill sites composes of 8 items ; topography, hydrology, geology, ecology, location, landuse, society, and others. In order to secure the accuracy and objectivity for selection of suitable waste landfill sites, individual weights of 8 items were introduced using the concept of fuzzy set. Also, unacceptable conditions were described for deciding which sites should not be selected because of environmental concerns. As showed in the result obtained by the case study in Chinju, GIS technology was demonstrated as a useful tool for the management and analysis of environmental data in the suitability analysis for the waste landfill sites.

최대운동부하시 단련자와 비단련자의 호흡순환기능 비교연구

유승희,김복현,송종국,윤형기,박찬호 경희대학교 체육과학연구소 1996 體育學論文集 Vol.24 No.-

We studied the differences of cardiorespiratory function of the untrained group and the trained group. The findings are following: 1.In ventilation, trained group was higher than untrained group. In addition, there was significant difference(p〈.001) at 60% and 85% exercise levels and All-out time. 2.In respiratory rate, tranined group was higher than untrained group. In addition, there was significant difference(p〈.01)at 85% exercise level and All-out time. 3.In respiratory gas exchange, trained group was lower than untrained group. In addition, there was significant difference(p〈.01) at All-out time. 4.In oxygen intake per weight, trained group was higher than untrained group. In addition, there was significant difference(p〈.001) at 40%, 60%, and 85% excercise levels and All-out time. 5.In heart rate, trained group was lower than untrained group. In addition, there was remarkable difference(p〈.0901) at rest.