정신분열병에 대한 리스페리돈의 효과 및 안정성

이민수,김용구,김영훈,연병길,오병훈,윤도준,윤진상,이철,정희연,강병조,김광수,김동언,김명정,김상훈,김희철,나철,노승호,민경준,박기창,박두병,백기청,백인호,손봉기,손진욱,양병환,양창국,우행원,이정호,이종범,이홍식,임기영,전태연,정영조,정영철,정인과,정인원,지익성,채정호,한상익,한선호,한진희,서광윤 大韓神經精神醫學會 1998 신경정신의학 Vol.37 No.1

연구목적 : 본 시험의 목적은 임상시험 시작전에 연구자들을 대상으로 PANSS Workshop을 통하여 PANSS, ESRS에 대한 국내에서의 표준화 작업을 구축하고 새로운 정신병 치료제인 리스페리돈의 효과와 안정성을 재확인하여 리스페리돈 사용에 대한 적정화를 이루는데 있다. 연구방법 : 1996년 4월부터 1996년 9월까지 국내 39개 대학병원 정신과에 입원중인 혹은 증상이 악화되어 입원하는 정신분열병 환자 377명을 대상으로 다시설 개방 연구를 시행하였다. 1주일간의 약물 배설기간을 가진후, 리스페리돈을 8주간 투여하였고, 기준점, 1주, 2주, 4주, 그리고 8주후에 평가되었다. 용량은 제1일에는 리스페리돈 1mg씩 1일 2회, 제2일에는 2mg씩 1일 2회, 제3∼7일에는 3mg씩 1일 2회 투여하였다. 이후 환자의 임상상태에 따라 임의로 증량할 수 있으며, 최대 일일 16mg을 초과하지 않도록 하였다. 추체외로 증상을 조절하기 위한 투약을 허용하였다. 임상증상 및 부작용의 평가는 PANSS(Positive and Negative Syndrome Scale), CGI(Clinical Global Impression) 그리고 ESRS(Extrapyramidal Symptom Rating Scale)을 사용하였다. 연구결과 : 377명중 343명(91%)이 8주간의 연구를 완결하였다. 치료 종결시점인 8주후 PANSS 총점수가 20% 이상 호전된 경우를 약물 반응군으로 정의할때, 약물반응군은 81.3%였다. 리스페리돈에 반응하는 예측인자로는 발병연령, 이전의 입원 횟수, 유병기간이 관련 있었다. 리스페리돈은 1주후부터 PANSS양성, 음성, 및 일반정신병리 점수상에 유의한 호전을 보여 효과가 빨랐다. CGI의 경우도 기준점에 비해 1주후부터 유의한 감소를 나타내었다. ESRS의 경우, 파킨슨 평가점수는 기준점과 비교해 투여 1주, 2주, 4주후 유의하게 증가되었다가 8주후 기준점과 차이가 없었다. Dystonia 평가점수는 1주후만 유의한 증가를 보였으며, dyskinesia 평가점수는 유의한 차이가 없었다. 혈압, 맥박수의 생명징후 및 일반 혈액학 검사, 생화학적 검사, 심전도 검사에서 유의한 변화는 없었다. 결 론 : 이상의 다시설 개방 임상 연구를 통해 리스페리돈은 정신분열병 환자에서 양성증상뿐만 아니라 음성증상 및 전반적인 증상에도 효과적인 것으로 사료된다. 보다 명확한 평가를 위해서는 다른 항정신병약물과의 이중맹검 연구가 필요할 것으로 생각되며, 또한 장기적 치료에 대한 평가도 함께 이루어져야 하겠다. Objective : The purpose of this study was to investigate the efficacy and safety of risperidone in the treatment of Korean schizophrenic patients. Method : This multicenter open study included 377 schizophrenic patients drawn from 39 university hospitals. After a wash-out period of 1 week, the schizophrenic patients were treated with risperidone for 8 weeks and evaluated at 5 points ; at baseline, and 1, 2, 4 and 8 weeks of treatment. The dose was increased from 2mg/day(1mg twice daily) to 6mg/day(3mg twice daily) during the first week and adjusted to a maximum of 16mg/day over the next 7 weeks according to the patient's clinical response. Medication to control extrapyramidal symptoms was permitted. The psychiatric and neurological status of the patients was assessed by PANSS, CGI, and ESRS scales. Results : 343(91%) of 377 patients completed the 8-week trial period. Clinical improvement, as defined by a 20% or more reduction in total PANSS score at end point, was shown by 81.3% of patients. The predictors of response to risperidone were associated older age, shorter duration of illness, fewer previous hospitalization. Risperidone had rapid onset of action ; a significant decrease of the total PANSS and three PANSS factor(positive, negative, general), and CGI was already noticed at the end of first week. For the ESRS, parkinsonism rating scores were significantly increased until week 4 comparing with baseline. Dystonia rating scores were significantly increased until week 1, and dyskinesia rating scores were not significantly changed during the study. Laboratory parameters including vital sign, EKG, hematological, and biochemical values showed no significant changes during the trial. Conclusions : This study suggests that risperidone is generally safe and effective against both the positive and negative symptoms in our group of patients.

수막종의 Flow Cytometry 및 Nucleolar Organizer Regions(NORs)에 관한 비교연구

韓東錫,蔡暘錫,金仁仙,白承龍 고려대학교 의과대학 1990 고려대 의대 잡지 Vol.27 No.1

The flow cytometric DNA analysis and the Ag-NORs staining method have been reported to reflect the cellular activities and the proliferative rates of the normal and the neoplastic cells. Currently, these methods have attracted many interests from clinical fields in evaluating the patient regarding on the prognosis and the responsiveness to therapy of human tumors. The author analyzed thirty eight meningiomas(meningothelial 5, transitional 7, fibrous 5, psammomatous 2, atypical 11, hemangiopericytic 6 and hemangoblastic 2 cases) using flow cytometry and Ag-NORs staining in the paraffin embedded tissues. The results are summarized as follows : 1. In flow cytometric study, twenty eight cases were diploid and the remaining 10 cases were aneuploid. The latter included meningothelial 3, atypical 3, hemangiopericytic 2 and hemangioblastic 2 cases. 2. In Ag-NORs study, the mean mumber of Ag-NORs had a significant difference between classical types(1.46±O.21) and atypical meningiomas(1.88±0.36) including hemangiopericytic one(1.74±0.38) (P<0.05). 3. The cytometric S phase, G_(0)/G₁ phase and proliferation index and the mean number of Ag-NORs had a significant difference between classical diploid and atypical diploid meningiomas(P<0.005). 4. There was no significant relationship between cytometric S phase and the mean number of Ag-NORs in classical meningiomas.

체력검사의 종목별기록 예측을 위한 추정방안

채한승 서원대학교 응용과학연구소 2002 응용과학연구 Vol.11 No.1

The purpose of this study was to examined the test battery validity and reliability of the applicants physical fitness test for male in high school student, with multiple correlation. The primary purpose of this study was to formulated regression equation of each test. The subject of this were 732 male applicants in high school who participated the physical education practical examination in Seowon University during the 1997-1999 academic years. To achieve this purpose, the SPSS software package was used for the statical analysis. Statistics employed in this study were multiple correlation analysis and partial correlation analysis. The major findings obtained from this were following; First, the analyze of the relationship between sargent jump test and other tests( side step test, dipping test, handball throw test, shuttle run test ) showed that most variables used in this study had significant correlations each other. The correlation coefficients were 0.27, 0.24, 0.28, -0.33, respectively, but correlation coefficients were shown to be low. Second, regression equation was formulated by the results of correlation among tests. 1) prediction formula of sargent jump record = ( 0.240 × side step test record ) + ( 0.138 × dipping test record ) + ( 0.383 × handball throw test record ) + ( -3.327 × shuttle run test record) +77.045. 2) prediction formula of side step test record = ( 0.326 × sargent jump test record ) + ( 0.235 × handball throw test record ) + 17.114. 3) prediction formula of dipping test record = ( 0.214 × sargent jump test record ) + ( -1.810 × shuttle run test record) + 22.608. 4) prediction formula of handball throw test record = ( 0.154 × sargent jump test record ) + ( -6.239E-02 × side step test record ) + ( -1.084 × shuttle run test record ) 5) prediction formula of shuttle run test record = ( -1.952E-02 × sargent jump test record ) + ( -7.049E-03 × dipping test record ) + ( -1.688E-02 × handball throw test record ) + 11.895.

韓國 스포츠의 近代化 過程

蔡漢承 서원대학교 응용과학연구소 1997 응용과학연구 Vol.6 No.1

The purpose of this study was investigate modernization in Korean sport. I investigated Korean sport's modernization which was related with the process of Korea's modernization ranging from the opening-harbour(1876) to the period 1920 before and after Western sports were introduced and settled. The approaching method is to unfold and suggest the periodic situations and features of sports which are based phililogical study used in historical science, and based on the first materials(newspapers and historical books) published before and after Gab O Kyung Chang(Political Reform) in 1894, the second materials are books that deal with the history of Korea's modernization. In 1883 Won San Hak Sa was established, which was the first modern school in the opened harbour city, Won San. After that various kinds of subjects were introduced by foreign missionaries, and above all, physical education was firstly started with gymnastics. In KoJong's 32nd year, on 2nd February, 1895, Emperor Ko Jong declared to all people that the true meaning of education is in the development of virtue, body and wisdom. Starting with this declaration physical education was involved in school education.

韓國 近代體育에 있어서 各種 體育大會의 性格에 關한 考察

蔡漢承,高成植 서원대학교 응용과학연구소 1994 응용과학연구 Vol.3 No.1

This study aims to investigate how various athletic meetings have been developed in the introduction and settlement of Korean modern physical education and how the characters appeared according to the period have been. As there was a quickening of modern physical education, and various athletic meetings were held giving the first consideration to athletic sports, the athletic meetings were at the height of prosperity and the modern athletic sports were practiced, spread by missionaries. These athletic meetings contributed to not only performing the education like the import and introduction of modern culture and the inspiration of patriotic sentiment, including games, amusements and speech meetings. It was the bitters of our physical education to be modernized by the need of Japanese exploitation of the colony for 35 years of Korean and Japanese annexation. In the athletic sports at that time, overseas brethrens and students studying abroad attended and spread the skills to Korean society and athletes. And introducing new sports, they performed great services in the promotion of domestic physical education. On the other hand, our athletes won prizes at the international Olympic games, and Son, Kee-Jeong, a marathon runner won a gold medal at the Berlin Olympic games. So it contributed to the inspiration of our national consciousness in the gloomy period. When Japan invaded the continent in 1930, they revised physical education with the kinds of fight training, in other to strengthen the policy of physical education to militaristic war structure. Therefore, it was very hard time in our physical education. As the autonomy at physical education was restored with liberation in 1945, every physical education organization was adapted for the international situation through the medium of sports and activated domestically international athletic meetings and each sort of athletic meetings in other to improve competition power. Also internationally, they sent athletes to various international tournaments including Olympic games and Asian games, and enhanced the nation's prestige abroad. The epoch-making promotion of physical education was made at the height of Seoul Olympic games in 1988.

해군장병의 여가조건과 직무만족의 관계

채한승,정희석 한국스포츠리서치 2003 한국 스포츠 리서치 Vol.14 No.6

The purpose of this study was to examine the relations between the leisure condition of the military personnel in the Korean Navy and the duty stress of them. The subjects are present on duty military personnel in the navy and they are selected by the stratified random sampling. Among 950 subjects, 933 responded the questionnaire. The number of 913 subjects are finally accepted as insincere or insufficient questionnaire are eliminated among 933. Data have been processed by SPSS and especially the frequencies, the one and two way ANOVA, Duncan analysis are used as tools for this study. After the procedures, through the methods and analysis, the results are followed by; First, after the analysis of the differences among the duty satisfaction according to the population-socialistic traits of navy personnel, the duty satisfaction by the age, the rank, the education level, the health condition, the household income and the number of vacation days have the significant difference statistically. But the duty satisfaction by the duty area do not have the significant difference statistically. Second, after the analysis of the differences of the duty satisfaction by the leisure condition of the navy personnel, there is a significant effect statistically on the duty satisfaction by the weekday leisure time. Also, the differences of the duty satisfaction by the leisure cost have the significant effect statistically.

대학생의 생활체육수업 수강에 따른 참여동기와 여가몰입경험과의 관계

채한승,이종호 서원대학교 2001 교육논총 Vol.5 No.-

The purpose of this study was to examine the influence of college students' participation in sports activity classes on their participation motivation and flow experience. To accomplish the purpose of this study, 646 college students who participated sports activity classes from seven randomly selected universities were surveyed by means of both the revised questionnaires, initially used and developed by Min, B. (1997) and Csikszentmihalyi(1975). The content validity and reliability of both the questionnaires were determined by conducting a pilot study. The used statistical methods for the data analysis were t-test, one-way ANOVA, Pearson's correlation, and multiple regression analysis. The major findings obtained from this study were following: First, there was significant difference between male and female students who participated sports activity classes with respect to participation motivation and flow experience. The male students rated participation motivation and flow experience significantly higher in perception than did the female. Second, there was significant difference among the four different college student groups as freshman, sophomore, junior, and senior students who participated sports activity classes with respect to participation motivation and flow experience. The sophomore, junior, senior students rated participation motivation and flow experience higher in perception than did the freshman students. Third, there was significant difference among the three different groups as one, two, and three times who participated sports activity classes with respect to participation motivation and flow experience. The over two times croups in participating sports activity classes rated participation motivation and flow experience significantly higher in perception than did the one time croup. Fourth, there was significant difference among the six different groups as wolf, bowling, table tennis, swimming, tennis classes with respect to Participation motivation and flow experience. The students who took tennis and swimming classes rated participation motivation and flow experience significantly higher in perception than did the students who took other sports activity classes. Fifth, there was significant casual relationship among sender, rear in college, frequency of participation, six different sports activity classes, participation motivation and flow experience. Among them, gender, year in college, six different sports activity classes, and participation motivation in sport activity classes significantly influenced the flow experience.

체력검사의 구성요인과 상호관계 분석

채한승 서원대학교 응용과학연구소 2001 응용과학연구 Vol.10 No.1

The purpose of this study was to examine the relationship between practical skill tests of the university entrance examination. The population for this study consisted of 722 male and 94 female applicants who participated the practical skill tests of the university entrance examination during the 1997-1999 academic years, S University. To accomplish the purpose of this study, the central tendence scores and variability were computed in order to compare characteristic scores of male and female applicants. Also, statistic employed in this study were multiple correlation analysis and partial correlation analysis. The major findings obtained from this study were following: First, as for the male applicants, there was significant casual relationship between five practical skill tests as shuttle run test, handball throw test, and sargent jump test, dipping test, and side step test. Second, as for the female applicants, there was significant casual relationship between shuttle run test and handball throw test. And there was significant casual rlationship between shuttle run test and sargent jump test. Third, as controlling for academic year, there was significant casual relationship between five practical skill tests as shuttle run test, handball throw test, and sargent jump test, dipping test, and side step test.

환기역치로서 심박수 역치의 적용가능성

채한승,고성식 서원대학교 응용과학연구소 2003 응용과학연구 Vol.12 No.1

The purpose of this study was to verified the availability of the heart rate threshed (HRT) as the ventilatory threshold. Subjects were consisted of the college-aged male(N=8) sports students. Subjects were performed an incremental exercise test on a bicycle ergometer starting with an initial power output of 40W with intensity increments of 20W/min until the subjects were exhausted, showing a heart rate deflection point. Subjects then in random order performed two(speed/grade) treadmill tests, respectively. The HRT determination was done by computer aided deflection point regression analysis from dependence of functional measures on work road. The same computer algorithm(1) or visual analysis(4) were used for VT determination from the relationship between ventilation and oxygen uptake. The results of this study as follow: First, all subjects demonstrated an heart rate threshold on the tests. Second, there were no significant differences inside test protocols of the HR and VO_2 at the HRT. Third, heart rate at the ventilatory parameters (HR_VT) showed significant correlations with HR_HRT. These results suggest that HRT could be used as an method of determining ventilatory threshold in sports students. Specially, HR_VT method is the preferred method to predict heart rate threshold during treadmill incremental exercise. Thus, This HRT method may be attractive for the application in training intensity.

近代 Europe의 國家主義 體育에 關한 硏究

蔡漢承 西原大學校 1990 西原大學 論文集 Vol.25 No.-

Toward the close of the 18th century, the French Revolution and the Industrial Revolution of England brought about great changes in modern Europe. At that time the modern structure of democracy was established as the result of the abolishment of the absolute monarchy and nobility. At the same time the notion of nationalism newly originated from modern Europe to unite a people and to protect a nation from the domination of Napoleon. Strong centripetal force and unification was required to keep the nationalism and the nation. For the establishment of the centripetal force and national unification, many leaders required the development of patriotism and physical strength through a physical education. Then they enforced their people to develop physical strength as follows. First, by means of the characteristics of the nationalism : the unity of race, nation, language, culture and religion, nationalists tried to preserve their nation and protect it from the out side force. Second, they tried to get the unity, physical strength and some skills from the physical education. Third, owing to their the physical education of German, Sweden, and Denmark made a great contribution to the development of modern physical deucation. Especially, under the difficult situation of that time, the studies on physical education by Jahn, Ling, and Nachtegall remarked immortal achivements in the history of physical education.