하나로에서의 NTD 조사를 위한 중성자속 평탄화 장치의 최적화를 위한 예비분석

송영동,이헌주,이병택,전병진,김학노 濟州大學校 産業技術硏究所 2001 산업기술연구소논문집 Vol.12 No.1

NTD (Pieutron Transmutation Doping) method has several advantages of high resistivity and uniform doping in comparison with other method. To satisfy those conditions. the flux variations of radial and axial directions should be within ±5 % and ±1.7%. respectively. The NTD facility in HANARO is purposed to irradiate the silicon ingot of 60cm in height. Hence. the flux flattener will be designed for 60cm. In this paper. preliminary study for optimal design is showed and the flux distribution of axial direction is calculated using MCNP4B code. The results show that the flattener model can flatten the flux to 83% of total length.

하나로에서의 NTD조사를 위한 중성자속 평탄화 장치의 최적화를 위한 예비분석

송영동,이헌주,이병철,전병진,김학노 제주대학교 산업기술연구소 2001 尖端技術硏究所論文集 Vol.12 No.1

NTD(Neutron Transmutation Doping) method has several advantages of high resistivity and uniform doping in comparison with other method. To satisfy those conditions, the flux variations of radial and axial directions should be within ±5% and ±1.7%. respectively. The NTD facility in HANARO is purposed to irradiate the silicon ingot of 60cm in height. Hence, the flux flattener will be designed for 60cm. In this paper, preliminary study for optimal design is showed and the flux distribution of axial direction is calculated using MCNP4B code. The results show that the flattener model can flatten the flux to 83% of total length.

Ionized Calcium 및 Chitosan의 혼합처방에 따른 항균효과에 관한 연구

송명수,김미정,김영일,최동성,양재헌 又石大學校 1998 論文集 Vol.20 No.-

The antibacterial effects of chitosan depend on its molecular weight. The inhibition rate of bacteria growth of designated high in Gram positive, which was high in S aurens, S. epidermidis and Bacillus subtilis, low in S. mutans, high in C. albicans in fungi, low in A. niger. The inhibition rate of bacteria growth of chitosan was comparatively high in Gram positive, low in S. mutans and it showed high numerical value in C. albicans of fungi. The rate recorded good result at molecular weight 200,000 relatively, there was no difference, according to the molecular weight. The inhibition rate of bacteria growth according to the concentration of the increased differently between 1,000~10,000㎍/㎖, it showed antibacterial activity close to the inhibition rate of growth of chitosan rather than ionized calcium. The minimum inhibitory concentration marked the highest in the mixture of cihtosan and ionized calcium for all kind of bacteria generally, there was a little difference between yeast and fungi.

S. cerevisiae와 A. pullulans를 이용한 중금속 제거에 있어 중금속의 선택도에 관한 연구

김동석,서정호,이종헌,송승구 대구효성가톨릭대학교 응용과학연구소 1997 응용과학연구논문집 Vol.6 No.1

폐수중에 함유한 중금속을 처리하기 위하여 미생물을 이용한 중금속 제거공정의 응용가능성을 알아보고자 하였다. Cd, Cr, Ni, Pb을 사용하여 균류인 S. cerevisiae와 A. pullulans의 각 단일 중금속에 대한 제거 선택도와 혼합 중금속의 제거 선택도를 관찰하였고, Pb에 대한 2가지 미생물의 제거특성을 고찰함으로써 각 제거기작에 대한 기초연구를 하였다. 1) S. cerevisiae와 A. pullulans에 대한 단일 중금속(Cd, Cr, Ni, Pb)의 선택도는 다음과 같다 Pb>Cr>Ni>Cd (S. cerevisiae) Pb>Cr>Cd>Ni (A. pullulans) 2) S. cerevisiae와 A. pullulans에 대한 혼합 중금속(Cd, Cr, Ni, Pb)의 선택도는 다음과 같다. Pb>Cr>Ni>Cd (S. cerevisiae) Pb>Cr>Ni>Cd (A. pullulans) 3) 본 실험에서의 선택 순서는 중금속의 원자반경의 크기에 따라 나타났다. 4) S. cerevisiae의 Pb 제거 특성에 있어 초기 PB의 농도가 증가할수록 단위 미생물당 중금속 제거량은 증가하였으며 평형에 도달하는 시간도 증가하는 것으로 나타나, Pb의 세포내 침투가 발생함을 간접적으로 알 수 있었다. 5) A. pullulans는 Pb의 제거에 있어 S. cerevisiae와 마찬가지로 초기 Pb의 농도가 증가할수록 단위 미생물당 중금속 제거량은 증가하였으나, 평형에 도달하는 시간은 초기 Pb의 농도에 거의 무관하였다. 그러므로 A. pullulans의 Ph 제거기작에서는 Pb의 세포내 침투가 발생하지 않음을 간접적으로 알 수 있었다. 6) 2종류 미생물의 PB에 대한 제거능을 비교해보면 초기 Pb의 농도가 96 mg/l 정도인 경우에 A. pullulans에서는 단위 미생물당 흡착량이 120 mg Pb^2+/g로 나타났으나, S. cerevisiae의 경우에서는 70 mg Pb^2+/g로 나타나, 미생물을 이용한 중금속 제거공정을 실용화하고자 할 경우에는 A. pullulans가 보다 유리할 것으로 판단되었다. Waste heavy metals which have a reputation of detrimental effect on the environment through the food chain are generated from mining, dyestuff, material, electric, and petroleum industries. In this study, the feasibility a heavy metal removal process using microorganisms which is an alternative method to remove and recover heavy metals was examined, in order to treat the heavy metal in waste water. The removal selectivity about single and mixed heavy metals(Cd, Cr, Ni, Pb) using Saccharomyces cerevisiae and Aureobasidium pullulans, and the effect of initial heavy metal concentration on the removal of heavy metal were determined. The order of selectivity were Pb〉Cr〉Ni〉Cd(S. cerevisiae) and Pb〉Cr〉Cd〉Ni(A. pullulans) in single metal solution and Pb〉Cr〉Ni〉Cd(S. cerevisiae and A. pullulans) in mixed metal solution. The order of selectivity was mainly depended on the ionic radius. The amounts of heavy metal removal and the time required to the equilibrium state were increased according to the increase of initial heavy metal concentration in S. cerevisiae, but the time to reach equilibrium state was independent of initial concentration in the case of A. pullulans. These facts show that the penetration of heavy metal into the inner cellular part was occured in S. cerevisiae and it cannot be done in A. pullulans.

측두하악장애 환자 중 하악과두의 퇴행성 골 변화를 보이는 환자의 분포 및 임상적 특징

임용규,김민지,김연중,송윤헌,이동렬 대한치과교정학회 2006 대한치과교정학회지 Vol.36 No.6

측두하악장애 환자 중 하악과두의 퇴행성 골 변화를 보이는 환자의 분포와 임상적 특징을 규명하고자 측두하악장애로 진단받은 6,070명의 환자들을 대상으로 연구를 시행하였다. 환자들의 초진 시 파노라마와 TMJ 파노라마 사진을 관찰하여 하악과두의 퇴행성 골 변화 유무를 기준으로 환자들을 퇴행성 골 변화를 보이는 군(DJD군)과 골 변화를 보이지 않는 군(non-DJD군)으로 나누고, 환자들의 초진 의무기록을 바탕으로 두 군 간의 특징을 비교, 분석하였으며, 각종 변수들이 DJD 발병에 미치는 상대적 위험성을 측정하기 위하여 로지스틱 회귀분석을 시행하였다. 연구 결과 전체 환자 중 DJD군에 속한 환자는 31.7%였고, non-DJD군에 속하는 환자는 68.3%였다. DJD군은 성별에 따라 다른 분포를 보여 남자보다 여자의 이환율이 높았고, 10대와 20대에서 가장 높은 분포를 보였다. 환자의 내원 주소 중에서는 전치부 개방교합, 턱의 후퇴감, 안모 비대칭, 개구장애를 주소로 내원한 환자가 다른 주소로 내원한 환자들에 비해 DJD를 보일 위험성이 높았으며, 교정치료 경력이나 중심위-중심교합위 변위 그리고 염발음을 보이는 환자도 DJD군에 속할 위험성이 큰 것으로 나타났다. 따라서 측두하악장애를 가진 환자 중 30세 이하의 여성이 위와 같은 임상적 특징을 보이는 경우, 교정치료를 계획할 때 DJD에 이환 되었을 가능성에 대하여 충분히 주의를 기울여야 할 것으로 생각된다. (대치교정지 2006;36(6):402-11) Objective: This study was carried out to evaluate the distribution and clinical features of patients with degenerative change of the mandibular condyle. Methods: Six thousand and seventy patients with TMD (temporomandibular disorder) were selected for this study, who had complete initial clinical records and radiographs. Panorama and TMJ panorama radiographs were used to screen the degenerative change in the condyle, and the patients were divided into DJD (degenerative joint disease) and non-DJD groups. Results: The distribution and clinical features of the two groups were compared. Out of the total number of patients, 31.7% were in the DJD group, and 68.3% were in the non-DJD group. The portion of females was larger in the DJD group (80.8%) than in the non-DJD group (67.5%), and the DJD group had high prevalence in the second and third decades. Lack of incisal contact, retrusive chin, facial asymmetry, and mouth opening limitation were the chief complaints of the patients who had positive relation to DJD. Conclusion: Patients with an orthodontic treatment history, CO-CR discrepancy and crepitation were at possible risk of having DJD. (Korean J Orthod 2006;36(6):402-11)

지난 2년간의 학회지 "신경정신의학" 심사 평가보고

김찬형,김세주,김도관,김성곤,박원명,송동호,박용천,이영문,오강섭,정영철,이상열,김주한,이동영,이헌정,함병주,김율리,김문두,김정진,이강욱,천근아,김재진,홍진표,홍승철 大韓神經精神醫學會 2007 신경정신의학 Vol.46 No.6

In situ intestinal permeability and in vivo oral bioavailability of celecoxib in supersaturating self-emulsifying drug delivery system

Song, Woo Heon,Yeom, Dong Woo,Lee, Dong Hoon,Lee, Kyung Min,Yoo, Hyun Joon,Chae, Bo Ram,Song, Seh Hyon,Choi, Young Wook 대한약학회 2014 Archives of Pharmacal Research Vol.37 No.5

In order to characterize the in situ intestinal permeability and in vivo oral bioavailability of celecoxib (CXB), a poorly water-soluble cyclooxygenase (COX)-2 inhibitor, various formulations including the self-emulsifying drug delivery system (SEDDS) and supersaturating SEDDS (S-SEDDS) were compared. The S-SEDDS formulation was obtained by adding Soluplus as a precipitation inhibitor to SEDDS, composed of Capryol 90 as oil, Tween 20 as surfactant, and Tetraglycol as cosurfactant (1:4.5:4.5 in volume ratio). An in situ single pass intestinal perfusion study in rats was performed with CXB-dissolved solutions at a concentration of $40{\mu}g/m$. The effective permeability ($P_{eff}$) of CXB in the control solution (2.5 v/v% Tween 20-containing PBS) was $6.39{\times}10^{-5}cm/s$. The $P_{eff}$ value was significantly increased (P<0.05) by the lipid-based formulation, yielding 1.5- and 2.9-fold increases for the SEDDS and S-SEDDS solutions, respectively, compared to the control solution. After oral administration of various formulations to rats at the equivalent dose of 100 mg/kg of CXB, the plasma drug level was measured by LC-MS/MS. The relative bioavailabilities of SEDDS and S-SEDDS were 263 and 355 %, respectively, compared to the CXB suspension as a reference. In particular, S-SEDDS revealed the highest $C_{max}$ and the smallest $T_{max}$, indicating rapid and enhanced absorption with this formulation. This study illustrates the potential use of the S-SEDDS formulation in the oral delivery of poorly water-soluble compounds.

Impacts of Irradiation Sources on Quality Attributes of Low-salt Sausage during Refrigerated Storage

Dong-Heon Song,Hyun-Wook Kim,Ko-Eun Hwang,Yong-Jae Kim,Youn-Kyung,Ham,Yun-Sang Choi,Dong-Jin Shin,Tae-Kyung Kim,Jae Hoon Lee,Cheon-JeiKim,Hyun-Dong Paik 한국축산식품학회 2017 한국축산식품학회지 Vol.37 No.5

This study was performed to investigate the impacts of irradiation sources on quality attributes of low-salt sausage during refrigerated storage. Control sausage was prepared with 1.5% sodium chloride (NaCl), whereas low-salt sausage was formulated with 0.75% NaCl (a 50% reduction; L-control). Sausage samples were vacuum-packaged, and low-sausages were irradiated with gamma-ray, electron-beam and X-ray at 5 kGy, respectively. The samples were stored at 4°C for 28 d to determine changes in quality attributes. The pH of low-salt sausages was unaffected by irradiation at 5 kGy (p>0.05). Higher redness values were found at irradiated low-salt sausages compared to control (p<0.05). The hardness, gumminess and chewiness of control sausage were higher than those of low-salt sausages (p<0.05). However, there were no significant differences in the textural parameters between low-salt sausage treatments. The overall sensory acceptability score of irradiated/low-salt sausages were lower than L-control due to decreased scores for cooked meat flavor but increased radiolytic off-flavor (p<0.05). The initial 2-thiobarbituric acid-reactive substances (TBARS) values of irradiated/ low-salt sausages were higher than control and L-control (p<0.05). However, the TBARS values of irradiated treatments were significantly lower than control at the end of storage. Irradiation could effectively inhibit the microorganism growth (total aerobic bacteria, coliforms, Enterobacteriaceae, and Pseudomonas spp.) in low-salt sausages (p<0.05). Therefore, our findings show that irradiation could be to improve microbial safety of low-salt sausages, and suggest that further studies should be necessary to reducing radiolytic off-flavor of irradiated/ low-salt sausages.

Effects of Mechanically Deboned Chicken Meat (MDCM) and Collagen on the Quality Characteristics of Semi-dried Chicken Jerky

Dong Heon Song,Ji Hun Choi,Yun Sang Choi,Hyun Wook Kim,Ko Eun Hwang,Yong Jae Kim 한국축산식품학회 2014 한국축산식품학회지 Vol.34 No.6

This study was conducted to determine the effects of using mechanically deboned chicken meat (MDCM) and collagen on quality characteristics of semi-dried chicken jerky. In experiment I, semi-dried chicken jerky was prepared with the replacement of chicken breast with MDCM (0, 10, 20, and 30%). The pH value of the jerky formulated with only chicken breast was 5.94, while the replacement of chicken breast with MDCM significantly increased the pH (p<0.05). The protein content and shear force of the jerkies decreased with increasing amounts of MDCM, whereas the fat, ash content and processingyield showed the opposite tendency (p<0.05). Replacement with up to 10% MDCM had no adverse effects on the sensory characteristics of the semi-dried chicken jerky. In experiment II, four levels of pork collagen (0, 1, 2, and 3%) were added to the semi-dried chicken jerky formulated with 90% chicken breast and 10% MDCM. The addition of collagen increased the moisture content, but decreased the ash content of the jerkies produced (p<0.05). The processing yield of the jerkies increased with increasing added amounts of collagen (p<0.05). It was found that the jerkies formulated with 0-2% collagen had significantly higher overall acceptance score than those prepared with 3% collagen (p<0.05). In conclusion, MDCM and collagen could be useful ingredients to reduce the production cost and improve the processing yield of semidried chicken jerky. The optimal levels of MDCM and collagen which could be added without adverse effects on the sensory characteristics were up to 10% and 2%, respectively.

Asymptomatic Solitary Renal Metastasis Detected during Surveillance after Curative Surgery for Squamous Cell Carcinoma of Lung

Song, Sung-Heon,Jun, Young-Jin,Paik, Seung-Sam,Kwak, Hyun-Jung,Kim, Sang-Heon,Kim, Tae-Hyung,Sohn, Jang-Won,Shin, Dong-Ho,Park, Sung-Soo,Yoon, Ho-Joo The Korean Academy of Tuberculosis and Respiratory 2011 Tuberculosis and Respiratory Diseases Vol.71 No.6

Non small cell lung cancer (NSCLC) frequently metastasizes to brain, bone, liver, and adrenal glands. While an autopsy of NSCLC reveals some cases of metastasis to the kidney, clinical detection of renal metastases is extremely rare. Furthermore, metastases to the kidney usually present as multifocal or bilateral lesions and solitary renal metastases are usually suspected to be renal cell carcinoma. We now report a case of asymptomatic solitary renal metastasis from a primary squamous cell carcinoma, which was detected by routine surveillance with abdominal CT after curative surgery.