Elderly kidney transplant recipients have favorable outcomes but increased infection-related mortality

임정훈,Lee Ga Young,Jeon Yena,Jung Hee-Yeon,Choi Ji Young,CHO, JANG-HEE,Park Sun Hee,김용림,Kim Hyung-Kee,Huh Seung,유은상,Won Dong Il,Kim Chan-Duck 대한신장학회 2022 Kidney Research and Clinical Practice Vol.41 No.3

Background: The number of elderly patients with end-stage kidney disease has been increasing, but the outcomes of kidney transplants (KT) remain poorly understood in elderly patients. Therefore, we evaluated the clinical outcomes of elderly KT recipients and analyzed the impact of elderly donors. Methods: This retrospective cohort study included patients who underwent KT between 2000 and 2019. KT recipients were divided into four groups according to a combination of recipient and donor age (≥60 or <60 years); elderly recipients: old-to-old (n = 46) and young-to-old (n = 83); young recipients: old-to-young (n = 98) and young-to-young (n = 796). We compared the risks of mortality, graft failure, and acute rejection between groups using Cox regression analysis. Results: The incidence of delayed graft function, graft failure, and acute rejection was not different among groups. Annual mean tacrolimus trough level was not lower in elderly recipients than young recipients during 10-year follow-up. Mortality was significantly higher in elderly recipients (p = 0.001), particularly infection-related mortality (p < 0.001). In multivariable Cox regression analysis, old-toold and young-to-old groups had increased risk of mortality (adjusted hazard ratio [aHR], 2.89; 95% confidence interval [CI], 1.14– 7.32; p = 0.03; aHR, 3.06; 95% CI, 1.51–6.20; p = 0.002). However, graft failure and acute rejection risks were not increased in elderly recipients. Conclusion: In elderly recipients, graft survival and acute rejection-free survival were not inferior to those of young recipients. However, mortality, especially risk of infection-related death, was increased in elderly recipients. Thus, low immunosuppression intensity might help decrease mortality in elderly recipients.

Floristic characteristics of vascular plants and first distributional report of Pseudostellaria baekdusanensis M. Kim in Yongneup wetland protected area

Young-Chul Kim,Hyun-Hee Chae,Sang-Heock Oh,Seung-Ho Choi2,Moon-Pyo Hong3,Gi-Heum Nam,Jae-Yoon Choi,Hyun-Sook Choi,Kyu-Song Lee 한국환경생태학회 2015 한국환경생태학회지 Vol.29 No.2

Yongneup wetland protected area, the only high moor in Korea, is a core area to conserve biodiversity. Even though the Yongneup wetland protected area is relatively small, various plant species are distributed in the Yongneup wetland protected area because it includes various habitats showing different environmental gradients. Vascular plants distributed in the Yongneup wetland protected area were identified as a total of 376 taxa that is composed of 73 families, 217 genera, 322 species, 3 subspecies, 44 varieties and 7 forms. For endangered plants designated by the Ministry of Environment, 5 species including Trientalis europaea var. arctica, Lilium dauricum, Halenia corniculata, Lychnis wilfordii and Menyanthes trifoliata were found and 34 taxa were confirmed to be distributed only in the mountainous wetland habitats. Regarding naturalized plants, a total of 11 taxa were distributed, but most of them were distributed in the areas where artificial interference has occurred. And in areas inside the wetlands that are relatively well preserved, 2 species of Bidens frondosa and Erigeron annuus were observed. In this study, the occurrence and distribution of Pseudostellaria baekdusanensis M. Kim, which was recently found in Mt. Baekdu and reported as a new species, were identified in the Yongneup wetland protected area. A wetland is a very vulnerable area to drastic environmental changes and damages to its ecosystem could cause the extinction of rare plant species which are distributed only in the wetlands. Therefore, it is mandatory that current status of the Yongneup wetland protected area is evaluated and actions to prevent rapid environmental changes are taken. Fourteen separate investigations were conducted in 2013 and another four in 2014, to evaluate current status of the Yongneup wetland protected area. These investigations have provided us the basic information for future actions of conservation and restoration.

HPLC를 사용한 쌀 중 잔류농약 동시분석법

최재천,이영자,김소희,최수영,최희주,정성욱,박흥재,김우성 한국환경과학회 2005 한국환경과학회지 Vol.14 No.4

A simple and sensitive analytical method based on RP-HPLC with UV detector(225 nm) and mobile phases using 0.1% phosphoric acid and acetonitrile was developed for simultaneous determination of quinclorac, bentazone, 2,4-D, bensulfuron-methyl, dymuron, capropamide, pencycuron, ethofenprox. This method was resulted in recovery of 78~ 96% with RSD 3.3~7.5%. LODs 0.12~0.84 and LOQs 0.34~1.20 ㎎/L. Calibration curves were linear with r of 0.9995~ 0.9999.

영구형 항서맥 심박조율기 환자의 장기추적관찰

최현석,이무용,최영진,최성준,김효수,손대원,오병희,이명묵,박영배,최윤식,이영우,이명용 대한순환기학회 1998 Korean Circulation Journal Vol.28 No.5

1~2기 본태성 고혈압 환자들에서 Imidapril 대 Enalapril의 항고혈압 효과를 평가하기 위한 무작위, 이중맹검 임상시험

최영진,손대원,김용진,이홍자,채인호,김효수,김철호,오병희,이명묵,박영배,채윤식,이영우 대한순환기학회 1999 Korean Circulation Journal Vol.29 No.11

미치광이풀 모상근 배양에서 Tropane Alkaloid 생산성 증진을 위한 최적 생물학적 엘리시터 선발

정희영,강승미,강영민,김용덕,양재경,정영관,최명석 Plant molecular biology and biotechnology research 2003 Plant molecular biology and biotechnology research Vol.2003 No.-

Scopolamine and hyoscyamine which belong to tropane alkaloids are the pharmaceutically valuable anticholinergic drugs. In order to increase the productivities, the effects of elicitation were investigated during hairy root cultures of Scopolia parviflora. Biotic elicitors originated from 3 fungi and 1 yeast were prepared as homogenate and supernatant and added to 3-week-old cultures. Both of homogenate and supernatant of Candida albicans elicitors increased the scopolamine production. The production of hyoscyamine was enhanced by homogenate of Fusarium solani and supematant of C. albicans. Most of the other fungal elicitors were also improved on the tropane alkaloid production compared to non-treatment. Among the elicitors tested, C. albicans was proved the optimal biotic elicitor on tropane alkaloids production. These results will be served mass production of tropane alkaloids by large-scale production.

Pseudomonas putida SM25에서의 catBC 유전자의 발현과 catBCA Operon의 Promoter 부위 분석

정영희,민경희,김지영,최순영 숙명여자대학교 자연과학연구소 1997 자연과학논문집 Vol.- No.8

catBCA operon은 catechol로 부터 β-ketoadipate enol-lactone까지 ortho-경로로 분해되는 효소들을 암호하고 있으며, 이들 유전자들은 서로 연관된 전사 조절을 받고 있다. Pseudomonas putida SM25의 염색체로 DHA로 부터 catBCA promoter부위를 pRS415a에 클로닝하여 재조합 plasmid인 pRSB1을 제조하였다. 이 promoter의 작동을 lacZ의 reporter gene인 β-galactosidase의 활성으로 그 발현을 측정하였으며, 그 결과 Escherichia coli내에서의 promoter의 작동은 promoter가 없는 경우의 세표에서 보다 그 활성이 약 10배 높게 나타났다. S1 mapping으로 조사한 결과 catBCA promoter부위는 catB의 번역 개시코돈으로부터 약 45bp upstream부위에 전사개시 부위가 있는 것으로 추정된다. catBC promoter의 작동에 의한 mRNA의 발현은 RT-PCR을 이용하여 간접적으로 조사한 결과, cis, cis-muconate로 유도한 경우 mRNA발현은 현저하게 높게 나타내었으며, P. putida cell에서의 발현이 E. coli cell내에서 보다 높게 나타났다. catBCA genes are encoded for the dissimilation of catechol to β-ketoadipate enol-lactone by ortho-pathway and are regulated under corrdinate transcription regulation. Promoter region of catBCA operon was inserted into a promoter probe vector, pRS415a with lacZ gene, constructing recombinant plasmid pRSB1 carrying pRS415a-catBCA promoter in order to analyze expression from the catBC promoter. The transcription level of pRSB1 was increased 10 fold higher than that of pRS415a. The in vivo transcription initiation site of the catBCA operon was determined by S1 nuclease protection analysis, indicating that it was located on about 45bp upstream from the initiation codon of the translation. Transcription level of the catBCA operon in Pseudomonas putida SM25 was analyzed by RT-PCR indirectly. mRNA of catBC genes was synthesized in both the cells of P.putida PPO200-2 and Escherichia coli NovaBlue under the control of the promoter with induction of cis, cis-muconate.

연조직 측모에 관한 분석

장영일,최희영,신수정 대한치과교정학회 1995 대한치과교정학회지 Vol.25 No.5

본 연구에서는 단정한 측모를 지니고 교합이 양호한 성인을 대상으로 몇 가지 연조직 분석을 시행하고, 이를 여러 다른 연구에서의 기준치와 비교하여, 향후 교정치료 계획시에 도움이 되고자 하여 시행하였다. 측모가 단정하고 교합이 양호한 성인 남, 녀 각 25명(총50명)을 대상으로 촬영한 측모 두부X선계측사진에서 연조직 측모의 각도, 거리 계측을 시행하여 facial convexity angle, nasolabial angle, H-angle, Z-angle, E-line to upper lip, lower lip과 Sn-Pog´to upper lip, lower lip에 대한 남녀의 평균과 표준편차를 구하였고, 국내의 다른 연구와 비교하여 다음과 같은 결과를 얻었다. 모든 항목에 대해 백인에 비해 전방 돌출된 안모의 특징을 보였으며, 국내의 다른 연구의 수치에 비해서도 본 연구의 표본의 안모는 전방 돌출되어 있었다. The purpose of this study to analyze characteristics of soft tissue profile in Korean young adults. The sample consisted of 50 young adults (25 males and 25 females) who had pleasing and normal occlusion. Soft tissue analysis (facial convexity angle, nasolabial angle, H-angle, Z-angle, E-line to upper lip, lower lip, Sn-pog´to upper lip, lower lip) was performed on lateral cephlograms. Mean and standard deviation was obtained. When compared by other studies, mean profile of this sample was relatively straighter and both the upper and lower lips was more protrusive.

자가 산부식 프라이머의 적용시간이 상아질의 미세인장 결합강도에 미치는 영향

조영곤,이영곤,김종욱,박병철,김종진,최희영,진철희,유상훈 大韓齒科保存學會 2004 Restorative Dentistry & Endodontics Vol.29 No.5

This study evaluated the influence of application time of self-etching primers on microtensile bond strength (μTBS) to dentin using three self-etching primer adhesive systems. Dentin surfaces were exposed from forty-eight human molars. They were conditioned with three self-etching primers (Clearfil SE Bond [SE], Unifil Bond [UF], Tyrian SPE + One Step Plus [TY]) and different primining times (10s, 20s, 30s and 40s). Composite resins were bonded to dentin surfaces and specimens were made. μTBS was tested and statistically compared using by one-way ANOVA and Tukey's Test. The results of this study presented that priming time for 10s in SE and UF groups and for 30s and 40s in TY group was highly decreased μTBS to dentin.

열공형과 비열공형 피질하 혈관성 치매에서 위험인자의 차이에 관한 비교 연구

배희준,정지향,유경호,나덕렬,김상윤,최경규,양동원,손의주,이상도,김재우,박경원,김응규,이재홍,박미영,한일우,함동석,최문성,하충건,최성혜,이애영,이병철,한설희 대한치매학회 2003 Dementia and Neurocognitive Disorders Vol.2 No.2

Backgrounds and Objectives: Vascular dementia is a group of dementing disoders arising from various stroke syndrome. Among these. subcortical ischemic vascular dementia (SIVD) is regarded as a relatively distinct clinical entity. However, MRI patterns of SIVD are not homogenous. In some patients, lacunes are dominant, and in others, subcortical white matter changes are. This study was designed to compare risk factor profiles between SIVD with and without multiple lacunes. Methods: We divided 47 subjects (22 males, mean age. 68 years) recruited from VADAPET (Multicenter Trial For Evaluation Of The Changes In the PET Images Of Subcortical Vascular Dementia Patient) study into two groups one with more than 5 lacunes in deep gray matter (lacune group) and the other with 5 or less(non-lacune group) Clinical characteristics and laboratory findings of two groups were compared. Results: Nineteen of 47 patients (40%) belonged to the lacune group. The lacune and non-lacune groups d d not differ in the following variables: age, hypertension, diabetes mellitus, hyperlipidemia heart disease, history of stroke or TIA, history of trauma or major surgery, family history of hypertension stroke, or dementia, age at diagnosis of dementia, body mass index, white blood cell count, ESR, CRP, fibrinogen, hemoglobin A1C, total cholesterol. LDL cholesterol creatinine, proteinuria, glucosuria, and microhematuria. However, male sex, smoking alcohol. hemoglobin, and HDL cholesterol were possibly associated more with lacune group SIVD than with non-lacune group (p<0 1) Multivariate analyses revealed that smoking, hemoglobin, and HDL cholesterol were independent predictors of SIVD with multiple lacunes Conclusion: Our study suggests that SIVD with multiple lacunes may be significantly different in smoking habits hemoglobin, and HDL cholesterol from SIVD without multiple lacunes.