한의진단명과 진단요건의 표준화 연구 II (표준화 실례) : 2차년도 연구결과 중간 보고

양기상,최선미,최승훈,안규석,박경모,박종현,김성우,신승호,정우열,전병훈,고현,김정범,신상우,김성훈,김동희,권영규,엄현섭,장혜옥 한국한의학연구원 1996 한국한의학연구원논문집 Vol.2 No.1

The diagnostic requirements were suggested and explained regarding the systems of differentiation of symptoms and signs in the second year study of standardization and unification of the terms and conditions used for diagnosis in oriental medicine. The systems were as follows; - differential diagnosis according to condition of body fluid, differentiation of syndromes according to the state of qi and blood, differential diagnosis according to relative excessiveness or deficiency of yin and yang(氣血陰陽津液辨證) - differentiation of diseases according to pathological changes of the viscera and their interrelation - analyzing and differentiating of febrile diseases in accordance with the theory of the six channels(傷寒辨證) The individual diagnosis pattern was arranged by the diagnostic requirements in the following order : another name(異名), notion of diagnosis pattern, index of differentiation of symptoms and signs(辨證指標), the main point of diagnosis, analysis of diagnosis pattern(證候分析), discrimination of diagnosis pattern(證候鑑別), a way of curing a diseases(治法), prescription(處方), herb in common use(常用藥物), diseases appearing the diagnosis pattern(常見疾病), documents(文獻調査). This study was carried out on the basis of the Chinese documents and references.

야간 응급실 당직의사의 안외상환자 처치의 적절성에 대한 고찰

신환호,온영훈,최병수 순천향의학연구소 1996 Journal of Soonchunhyang Medical Science Vol.2 No.1

Proper management in ocular injured patients is important in prognosis of visual acuity. The authors performed census on the management and treatment of ocular injured patients by 63 doctors in emergency room of 63 hospitas and clinics at night in Seoul. The data were obtained during 2 month period from Nov. 1 1994 to Jan. 31 1995. Interns(62%) were common doctors in emergency room at night. Work period ranged from 1 to 6 months in most cases(33%). Ocular injuries were included: lid laceration(33%), periorbital contusion(24%), corneal laceration(10%), subconjunctiveal hemorrhage(8%). The common management in the emergency room was primar repair(48%). The majority of severe ocular injured patients, such as corneal laceration and scleral laceration, was referred to teh university hospitals(75%). When patients were referred, 8 doctors notified to the ophthalmologist of referred hospitals. The common time inteval between visit of emergency room and transfer of patients was within 30 minutes. These results suggest that doctors in emergency room were passive and inappropriate managements to ocular injured patients. And we think that education is needed to medical students, general physicians, interns and residents.

씀바퀴 성분 중 Cynaroside의 약동태학적 연구

신영희,민병훈,이치호 慶星大學校 1998 論文集 Vol.19 No.1

We isolated cynaroside(luteolin-7-O-glucoside) from the whole plant of Ixeris dentata, and characterized pharmacokinetic properties of cynaroside. It was administered by intravenous injection, intraperitoneal injection and oral routes to male rats, and plasma concentrations of cynaroside were analysed by HPLC method. After iv injection of cynaroside with 5mg, 10mg, and 20 mg per kg of body weight, the area under concentration curve and doses showed a good correlationships. On the other hand, cynaroside hardly absorbed by oral administration route.

전치부 개교를 동반한 골격성 Ⅲ급 부정교합 환자의 악교정 수술 후 교합평면의 변화와 안정성에 관한 연구

신수정,황병남,이정근,이승훈 대한치과교정학회 1999 대한치과교정학회지 Vol.29 No.1

악골의 골격적 부조화를 가진 환자의 교정치료는 악교정 수술을 필요로 하고, 악교정 수술에 의해 교합평면각은 변화된다. 특히 전치부 개교를 동반한 III급 부정교합 환자에서 치아안면 기형을 치료하기 위한 교합평면각의 변화에 대하여 많은 논란이 있어 왔다. 교합평면각을 증가시키는 하악골의 시계 방향 회전(clockwise rotation)은 전치부 개교에 대한 적절한 치료법으로 추천되어 왔고 하악골의 반시계 방향의 회전(counterclockwise rotation)은 하악지 고경을 증가시키는 방향으로 하악골을 회전시킨다는 개념으로 인해 재발(relapse)을 유발하는 불안정한 수술 방법으로 인식되어 왔다. 본 연구는 전치부 개교를 동반한 골격성 Ⅲ급 부정교합 환자에서 교합평면의 반시계 방향회전을 동반한 하악지시상분할 골절단술 시행 후 교합평면각의 변화와 술후 안정성과의 관계를 평가하고자 하였다. 하악지 시상분할 골절단술과 rigid fixation으로 치료받은 환자 25명(평균연령 20.6세)을 대상으로 하여 수술 작전(T1), 술후 2주내(T2), 그리고 술후 6개월 이후(T3)에 촬영한 측모 두부계측 방사선 사진을 통계분석한 결과 (Paired t-test, Pearson correlation analysis), 다음의 결론을 얻었다. 1. 악교정 수술 후 (T2) 하악평면각은 2.9° 감소하였고 SN평면에 대한 하악 교합평면의 각도는 2.7°감소하였다. 술후 6개월경과 후 (T3)후안면 고경의 감소로 인해(P<0.01) 하악 평면각은 1.0° 증가하였으나 하악 교합평면의 경사도는 변화되지 않았다. 2. 악교정 수술 후 시간 경과(T3)에 의해 발생한 수평적 개발은 하악골의 전방 이동량이 B점에서 1.6mm로 수술시 전체 후방 이동량의 약 22%였다. 전안면 고경에서는 수직적 재발이 발생하지 않았으나, 후안면 고경은 감소하였다(P<0.01). 3. 수평적 재발과 상관관계를 보이는 항목은 하악평면각 이었고(P<0.01) 수술 6개월경과 후 후안면 고경의 감소와 상관관계가 있는 요소로는 수술시 하악골의 후방 이동량(P<0.01), 하악지 고경의 증가량(P<0.01), 그리고 하악평면각의 감소량(P<0.01) 등이 있었다. 4. 수술시 하악 교합평면 경사도의 변화량과 술후 재발과는 상관관계가 없었다. The purpose of this study is to investigate the stability of counterclockwise rotation of mandible by sagittal split ramus osteotomy to correct the skeletal Class Ⅲ malocclusion with anterior open bite. Twenty five skeletal Class Ⅲ open bite patients(mean age 20.6 years) who were treated by the sagittal split ramus osteotomies with rigid fixation were examined in this study. Cephalometric radiographs were taken for each patients preoperative (T1), early postoperative(T2), and late postoperative period(T3). Mean postoperative period was 8.0 months. Cephalometric analysis was done and data from T1, T2, T3 were analyzed statistically by Paired t-test and Pearson correlation analysis. The following results were obtained. 1. Mandibular plane angle decreased 2.9° and mandibular occlusal plane angle related to SNplane decreased 2.7° after orthognathic surgery(T2). At 6 months after orthognathic surgery(T3), mandibular plane angle increased 1.0°, but mandibular occlusal plane angle did not changed. 2. The amount of horizontal relapse long time after orthognathic surgery(T3) was 1.6mm at B point and it was 22% of the total posterior movements. There was no vertical relapse in the anterior facial height. 3. The related factor with horizontal relapse at late postoperative period was mandibular plane angle(p<0.01). The related factors with decreasing posterior facial height were amount of mandibular setback(p<0.01), increasing of mandibular ramus height(p<0.01), and decrease of the mandibular plane angle during operation(p<0.01). 4. There was no relationship between the amount of changes in mandibular occlusal plan angle during operation and the amount of relapse after surgery.

이중 셀 구성에 의한 셀룰라 이동통신 시스템의 채널용량 개선

신창윤,우병훈,조성준 한국항공대학교 1994 論文集 Vol.32 No.-

본 논문에서는 셀에서의 용량 증대를 위하여 셀을 내부 셀과 외부 셀로 나누어 구성하는 이중셀을 적용하였을 경우 반송파 대 동일채널간섭비와 채널용량을 산출하고 분석하였다. 이를 위하여 셀룰라 육상이동통신 시트테에서 규칙적인 주파수재사용 패턴 N을 도출하여 무지향성 안테나 사용시와 지향성 안테나 사용시 셀 패턴에 따른 반송파 대 동일채널간섭비를 계산하였다. 이중 셀을 구성하였을 때 내부 셀에 주파수 재사용 패턴 N을 작게하여 내부와 외부 셀의 주파수 재사용 패턴을 다르게 하면 채널용량이 크게 개선되었다. 실제적인 통화품질 기준인 반송파 대 동일채널간섭비가 24dB 이상이 되는 경우 가장 용량면에서 우수한 주파수 재사용 패턴은 N=7인 3 섹터 셀이었고 이중 셀로 구성하였을 경우 내부 셀 패턴이 N=3, 외부 셀 패턴이 N=7인 3 섹터 셀의 경우였다. 이 경우 이중 셀을 구성하지 않은 N=5인 주파수 재사용 패턴과 같은 용량을 가질 수 있었다. 이것은 이중 셀을 상용하므로서 한정된 주파수의 수용 용량을 1.4배 높일 수 있음을 알 수 있다. In this paper, when the dual cell, a cell which is divided into the inner cell and outer cell, is employed to increase the channel capacity, the carrier power to co-channel interference power ratio (C/I) and channel capacity are evaluated and analyzed. For this evaluation, the regular frequency reuse pattern factor N is calculated and them the C/I is calculated according to the cell pattern when the isotropic antenna is used and the directional antenna is used, respectively. In a dual cell, the channel capacity is incrased by making the frequency reuse pattern factor N of inner cell smaller than that of outer cell. In the case of nondual cell, the channel capacity is the largest when the frequency reuse pattern factor N is 7 in the 3 sector cell on the condition of the C/I is over the 24dB of standard call quality. In the case of dual cell, the channel capacity is the largest when the frequency reuse pattern facotr N is 3 for inner cell and N is 7 for outer cell. In this case, the cell has the same capacity as the frequency reuse pattern factor N=5 of nondual cell. This result shows that the channel capacity with dual cell can be incrased in the limited available frequency by 1.4 times more than the capacity with nondual cell.

瓦松이 家兎의 腎機能에 미치는 影響

申炳勳,金光鎭 충남대학교 의과대학 지역사회의학연구소 1986 충남의대잡지 Vol.13 No.1

Orostachys malacophyllus Fischer(Tsume renge) is a plant to grow on the tiled roof of the house, and in the field or the mountain. And the compositions of the plant have not been known yet. But it has transmitted to this time as a kind of medical plant from remote antiquity. Sometimes, it is used in the folk remedies for the treatment of the malignant diseases. But it is not clear in the therapeutic effect. This study was attempted to investigate the effect of the water extract of Tsume renge on the renal function of rabbits. Physiological saline was infused into the jugular vein for the hydration of rabbit(30ml/hr), and the urine and blood were collected to take the control values after the steady state. Samples were collected by the regular interval of time during the infusion of 0.5% solution of Tsume renge water extract in the physiological saline. The results obtained were summarized as follows: 1. The urine volume, glomerular filtration rate, and renal plasma flow were 0.095±0.013 ml/min. 5.66±0.39 ml/min. and 21.01±1.52 ml/min, respectively. But their flow rates were decreased significantly during the infusion of the solution of water extract. 2. The water extract of Tsume renge had no any effects on the renal tubular reabsorption of the osmolar substances and the electrolytes. 3. The negative free water clearance was decreased significantly during the infusion of the water extract of Tsume renge. From the above results, it was suggested that the water extract of Tsume renge affected to the renal hemodynamics and the mechanism of water reabsorption in the renal tubules.

반건식-백필터에 의한 소각배가스 중의 HCI, SOx 제거 (Ⅱ)

배병훈,신남철,조정구,문종익,임경택 동아대학교 환경문제연구소 1998 硏究報告 Vol.21 No.2

A combination of process modification and various additives to a lime-based spray-dryer/fabric-filter system was evaluated for its value in promoting sorbent utilization and simultaneous removal of HC1 and SO₂ from waste incineration flue gas. The variety of operating conditions were tested to evaluate important factors such as spray drying reactor(SDR) outlet temperature, retention time, molar equivalence ratio( MER ), fabric filter velocity, etc. For the sorbent activity enhancement, additives such as KmnO₄, NaOH, NaHCO₃, CaCl₂, a mixture of NaOH and CaCl₂ were added to Ca(OH)₂ at optimum operating condition. The mixture of NaOH and CaCl₂ ( 2 : 1 by weight ) was found to be the best economic additive. When that additive, 10% of Ca(OH)₂ by weight, was added, under the condition of Ca(OH)₂ of MER 1.0, HCl/SO₂ removal efficiencies at fabric filter were 98.3% and 97.1%, respectively.

반건식-백필터에 의한 소각배가스 중의 HCI, SOx 제거 (Ⅰ)

배병훈,신남철,고경숙,김춘희,문종익,임경택 동아대학교 환경문제연구소 1997 硏究報告 Vol.20 No.1

This study has been carried out to investigate the removal efficiencies of HCl/SOx in a Spray-Dryer/Fabric-Filter system. In HCl/SOx removal, we could identify the key factors such as spray dryer outlet temperature, molar equivalence ratio(MER) and fabric filter velocity, but we couldn't find out the correlation of HCl and SOx. The removals of HCl/SOx were inversely proportional to spray dryer outlet temperature(l30~170℃) and filter velocity(l.0~1.5 m/min), at the MER, HCl removal efficiency was strongly proportional to MER, but SOx, removal efficiency was not particularly increased by MER over 1.5. The removal efficiencies of HCl/SOx were improved over 10% at the fabric filter. In this Spray-Dryer/Fabric-Filter system, HCl/SOx removal efficiencies were about 99%, 96% respectively.

들잔디 성숙종자로부터 캘러스배양 및 식물체 재분화에 미치는 몇 가지 요인의 영향

이상훈,김범수,원성혜,조진기,김기용,박근제,성병렬,이효신,이병현 Plant molecular biology and biotechnology research 2004 Plant molecular biology and biotechnology research Vol.2004 No.-

In an effort to optimize tissue culture responses of zoysiagrass (Zoysia japonica Steud.) for genetic transformation, factors affecting callus induction and plant regeneration were investigated. MS medium containing 3 ㎎/L 2,4-D was optimal for embryogenic callus induction from mature seed. The plant regeneration frequency of 73.3% was observed when embryogenic calli induced in this medium were transferred to N6 medium supplemented with 0.1 ㎎/L 2,4-D and 5 ㎎/L BA. Among several basic media, MS and N6 medium were optimal for callus induction and plant regeneration, respectively. Regenerated plants were grown normally when shoots transplanted to the soil. A rapid and efficient plant regeneration system established in this study will be useful for molecular breeding of turfgrass through genetic transformation.

말기신부전 환자에서 심혈관계 합병증 예측인자로서의 호모시스테인의 의의

정종훈,신병철,김현리 朝鮮大學校 附設 醫學硏究所 2008 The Medical Journal of Chosun University Vol.33 No.2

Backgroud: Thromboembolic phenomena are major cause of morbidity and mortality in patients with end-stage renal disease (ESRD). In the last years, the accumulation of evidence coming from studies in patients with chronic renal failure have demonstrated an increased relative risk of coronary artery disease (CAD) in association with hyperhomocysteinemia. We elucidate the effects of homocysteine on diagnostic marker of cardiovascular risk factor of patients with ESRD. Methods: One hundred thirty-three patients were enrolled in the study performed at a Chosun university hospital. Ninety patients were on dialysis (58 hemodialyzed patients and 32 peritoneal dialyzed patients). Hyperhomocysteinemia was defined as a fasting plasma homocysteine level more than 15 μmol/L. Results: A total 71 patients (53.4%) had hyperhomocysteinemia. The prevalence of hyperhomocysteinemia was 60.3%, 46.9%, 48.8% among hemodialysis, peritoneal dialysis and kidney transplantation, respectively. CAD was present in 40.6% of patients (54 patients). The mean homocysteine concentration was 22.35 ± 5.94 μmol/L and 15.07 ± 5.45 μmol/L in patient with (n=54) and without (n=79) CAD, respectively (p<0.01). There was significant difference including age, serum creatinine, cardiac troponin-T (cTn-T), homocysteine level, total cholesterol, CRP in the two group (p<0.05). Plasma homocysteine concentration showed significant positive correlations with age (r= 0.261, p<0.05), cTn-T (r= 0.244, p<0.05), CRP (r= 0.422, p<0.01) in overall and negative correlations with hemoglobin (r= -0.240, p<0.05) in dialysis patients. Conclusion: Hyperhomocysteinemia, elevation of cTn-T, and elevation of CRP were diagnostic markers of ischemic heart disease of ESRD patients undergoing hemodialysis and peritoneal dialysis. The homocysteine is more potential diagnostic marker than cTn-T and CK-MB in ischemic heart disease with ESRD patients.