노인성 안질환의 관리대책 (5) - 예방

온영훈 한국만성질환관리협회 1995 월간성인병 Vol.179 No.-

일부 농촌지역 주민들에 있어서 혈중 카드뮴 및 아연과 요중 N-acetyl-β-D-glucosaminidase활성도와의 관계

온영훈,박정덕,최병선,홍연표,장임원 중앙대학교 의과대학 의과학연구소 1995 中央醫大誌 Vol.20 No.4

In order to identify the reference value and distribution of blood cadmium, zinc and urinary NAG activity and analyze relationship among them, this study was performed in 102 subjects (male : 35, female : 67) aged 25 to 95 who had not been exposed to cadmium in rural area. The mean values of blood cadmium and zinc were 2.04±0.72 ㎍/ℓ and 5.56±0.97 mg/ℓ, and urinary NAG activity was 2.16±2.66 U/ℓ, 2.38±2.31 U/g creatinine and 2.11±2.60 U/S.G., There were no difference between both sexes in blood cadmium and urinary NAG activities, but blood zinc level was significantly higher in male. Blood cadmium and zinc level were relatively constant by the age, but urinary NAG activity had tendency increasing with the age. Blood cadmium and urinary NAG activity showed log normal distribution while blood zinc showed normal distribution. There were no relation between blood cadmium or blood zinc and urinary NAG activity, but urinary NAG activity in 3 groups classified by the blood cadmium level had increasing tendency with cadmium level. These results suggest that urinary NAG activity can be used as an useful indicator of early changes of kidney function induced by low dose cadmium exposure in cadmium exposed group.

뇌성마비환자의 안과적 장애에 관한 조사

온영훈,구본술 중앙대학교 의과대학 의과학연구소 1985 中央醫大誌 Vol.10 No.4

Ophthalmological examinations were carried out on the 67 cerebral palsy patients of Korean children and adults (Holt Ilsan center), and the ocular disorders were classified and evaluated. In view of rarity of previous report on the ocular disorders in this important non­progressive brain disorder with resultant abnormality of motility and posture as well as the considerably serious disturbances of visual functions, the outcome of this survey was analyzed and results were as follows. 1. The incidence of nonrefractive ocular disorders was 47.8% of all cerebral palsy patients. 2. The strabismus was the most prevalent nonrefractive disorder of 20 cases (29.9%) with 19.4% of exotropia and 10.5% of esotropia. 3. The optic nerve atrophy was found in 14 cases (20.9%) consisting of four binocular and six monocular cases. 4. Of 64 eyes in which E­game vision was elicited, 40 eyes (62.5%) had uncorrected vision of 0.6 or worse. 5. The refractive error occupied 57.7% (60 eyes in 104 eyes) including 42 myotic eyes (40.4%) and 18 hyperopic eyes (17.3%).

Stargardt씨 병 1예와 Fundus Flavimaculatus 1예

온영훈 순천향의학연구소 2004 Journal of Soonchunhyang Medical Science Vol.10 No.2

Stargardt disease was first recognized in 1909. Stargardt's description of this disease included a juvenile onset of poor central vision with distinctive macular changes, bilaterality, slow progression, and hereditary. In 1963, Franceschetti et al drew attention to the presence of pisciform flecks in the macula and midperiphery, and named this phenotype "Fundus Flavimaculatus". The macular region can be detected in almost 50% of the fundus flavimaculatus. However, these diseases are considered one disease-category at now. We have recently seen macular dystrophy occuring in a 13-years-old boy, whose chief complaints was the severe decrease of the vision for 2 years. A dilated fundus examination was reveled a definitely atophic macular lesion("Bull's eye") surrounded by many yellow flecks in the paracentral region in the both eyes. A fluorescein angiogram demonstrated the hypofluorescence in the center and the multiple fluorescent spots with outlines. Based on these results, a diagnosis of Stargardt disease was made. In other hands, we coudln't find any specific findings in his past and family histories. But the inheritance of Stargardt disease is mostly autosomal recessive, despite some reports of dominantly-inherited or sporadic Stargardt disease. So the fact of the abscence of family history can't exclude the Stargardt disease. We experienced another case, a 45-years-old female. She visited our hospital for general work-up of body. We noticed her fundus abnormalities, but her best corrective visual acuity was 1.0 in the both eyes. A dilated fundus examination was revealed multiple yellow flecks in the midperipheral retina, but no macular lesion. A fluorescein angiogram demonstrated the multiple granular hypofluorescence spots corresponding the fundus findings. The results of the visual field test, electroretinogram, multifocal electroretinogram were normal. This case was diagnosed to fundus flavimaculatus. The purpose of this article are to report of a case of Stargardt disease and a case of fundus flavimaculatus, and to review the disease.

노인에 흔한 안질환

온영훈 대한임상노인의학회 2000 대한임상노인의학회지 Vol.1 No.2

명음성반응(Photopic Negative Response; PhNR)의 원리와 임상

온영훈,김훈동,박주연 순천향대학교 의학연구소 2009 Journal of Soonchunhyang Medical Science Vol.14 No.3

.

Multifocal Electroretinogram의 원리와 임상

온영훈 순천향의학연구소 1999 Journal of Soonchunhyang Medical Science Vol.5 No.2

Purpose: To compare the Multi-focal electroretinogram(ERG) system to conventional Ganzfeld and focal ERGs obtained from patients with known retinal diseases in order to assess its clinical applicability. Methods: A multi-input system analysis was used to explore the field topography of ERG responses to local luminance modulaton in patients with retinitis pigmentosa, pericentral pigmentary retinal dystrophy, branch retinal arterial occlusion or idiopathic macular hole. Results: The dysfunctional areas measured by multifocal ERG were well compatible to those assumed by combined findings of Ganzfeld and focal ERGs However, the wave shapes of multi-focal ERG in the retina with arterial occlusion differed from those of conventional focal ERG, suggesting that the negative and negative and positive deflections shown in the first order kernel of multi-focal ERG may not correspond to conventional a - and b- waves of ERG. Conclusions: The multi-focal ERG system is available for electroretinographic field mapping at the clinical level.

다국소 망막전위도검사의 임상적 응용

온영훈 ( Young Hoon Ohn ),안용석 ( Yong Suk Ahn ) 대한안과학회 2002 대한안과학회지 Vol.43 No.10

Argon laser photocoagulation 의 결막표층 색소종양에 대한 임상효과

온영훈(Young Hoon On),신환호(Hwang Ho Shin) 대한안과학회 1984 대한안과학회지 Vol.25 No.2

알코올성 간경화에서 발생한 망막출혈 2예

온영훈(Young Hoon Ohn),박태관(Tae Kwann Park),한정우(Jung Woo Han),서두리(Du Ri Seo),김영신(Young Shin Kim) 대한안과학회 2015 대한안과학회지 Vol.56 No.8

목적: 알코올성 간경화에서 발생한 빈혈과 혈소판감소증으로 망막출혈 2예를 경험하였기에 이를 보고하고자 한다. 증례요약: (증례 1) 알코올성 간경화로 소화기내과에 입원 치료 중 양안의 시력저하가 발생한 45세 여자로, 안저검사상 양안의 황반부를 포함하는 다수의 망막전출혈 및 망막하출혈이 관찰되었다. 혈액학적 검사상 심한 빈혈과 혈소판감소증이 관찰되었다. 수혈로 혈액학적 이상을 교정하였고, 증상 발생 후 1개월째 시력은 호전되고, 망막출혈은 감소되었다. (증례 2) 알코올성 간경화로 간 이식을 시행받은 후 3일 뒤 호소한 좌안 시력저하로 의뢰된 47세 남자 환자로, 안저검사상 좌안 황반부를 포함하는 다수의 망막전출혈이 양안에서 관찰되었다. 간 이식 당시 심한 빈혈과 혈소판감소증이 관찰되어 수혈로 이를 교정하였다. 증상 발생 후 3개월째 좌안 시력이 호전되었고, 망막출혈은 대부분 흡수되었다. 결론: 알코올성 간경화로 인해 발생하는 혈액학적 이상으로 망막출혈이 발생할 수 있다. 정기적인 경과관찰로 망막출혈의 감소와 시력의 회복을 확인하였다. Purpose: To report 2 cases of retinal hemorrhage due to anemia and thrombocytopenia in patients with alcoholic cirrhosis. Case summary: (Case 1) A 45-year-old female with alcoholic cirrhosis who was treated in the gastroenterology department pre-sented with reduced vision in both eyes. Fundus examination showed multiple preretinal and subretinal hemorrhages with mac-ular involvement in both eyes. Hematological findings revealed severe anemia and thrombocytopenia. One month after the transfusion treatment her visual acuity was improved and retinal hemorrhages resolved. (Case 2) A 47-year-old male presented with painless loss of vision in the left eye 3 days after orthotopic liver transplantation for the treatment of alcoholic cirrhosis. Fundus examination showed preretinal hemorrhages in both eyes with macular involvement in the left eye. During the trans-plantation, hematological findings revealed severe anemia and thrombocytopenia. Three months after the transfusion treatment his visual acuity was improved and retinal hemorrhages nearly completely resolved. Conclusions: Hematological abnormalities due to alcoholic cirrhosis can cause retinal hemorrhage. In the present cases the reti-nal hemorrhages were resorbed and the visual acuity recovered.