약물로 인한 눈의 장애

申桓澔 藥業新聞社 1986 (月刊) 醫藥情報 Vol.1986 No.4

Behcet 증후군의 역학조사 (제1보)

신환호 순천향대학교 1983 논문집 Vol.6 No.2

Management of ill-health in the community as a whole requires a community diagnosis which rests on epidemiological information. For this purpose the recurrent uveitis that the cause is not known has been a concern for a long time. The Behcet disease has not been managed epidemiologically yet in Korea. This preliminary report about the Behoet disease is in order that we may know the geographical distribution, the incidence, the characteristics of individuals, the recurrent rate with environmental factors, and the therapeutic regimens and its response. 16 cases of questionnaires, 41 cases in the Korean Ophthalmological journal, and 70 cases in the Korean Dermatologic journal, totaling 127 cases of Behcet diseases have been studied here. The incidence of this disease is more frequent in male adults from ophthalmological aspects but more frequent in female adults in dermatological aspects. The frequency of recurrent attacks is twice a month in 62.5% of the questionnaires at the beginning of the onset. The attacks are related with intake of oily food substances in 50% of the questionnaires. The season related recurrency is strictly more frequent in winter in 87.5% of the questio nnaires. The therapeutic regimens are not effective to prevent the attacks. The corticosteroid preparations for this disease are not effective and have harmful responses to the visual prognosis. Immunosuppressive drugs and colchicine may be helpful for the inhibiton of attack. The prodromal symptoms of attacks are fatigue and headaches in 56.3% of questionnaires. Folk medicines in 75%, body weight control in 68.8%, and diet control in 68.8% have been tried without any effect on the recurrency. Referrences for the Behoet disease were compared with this study. The further investigation of these problems should be continued for emancipation of blindness.

광화학 공기 공해가 눈에 미치는 영향, 특히 누액의 pH변화와 공해의 비교 상관관계

신환호 순천향대학교 1985 논문집 Vol.8 No.2

이 논문은 대기오염도가 눈에 미치는 영향 중 누액 pH변동에 대한 역학조사와 월별, 지역별 대기오염도와 누액 pH변동의 상관관계를 주요 조사 연구과제로 하였다. 특히 공해도가 가장 높은 계절을 선택하여 누액 pH변동의 변화곡선과 대기오염의 변화곡선을 비교했으며 대기오염에 의한 눈의 자극이 누액 pH의 산성화를 촉진 시킴을 알았다. 아울러 대기오염의 주범인 자동차 배기가스의 불완전 산화물등 혼합가스에 의한 실험적 안 자극 증상 발현을 분류하였으며, 자극 후의 누액 pH를 조사하였다. The tear pH was measured in 669 inhabitants(1,338 eyes) with BTB pH paper(5.8∼8.2) aged 10 to 69 years regionally and monthly, and also an investigation of photochemical oxidant(sulfur dioxide) in ambient air by acdimetric method at 49 sites of Seoul area was carried out. The photochemical oxident in the commercial and industrial region was a excess rate of 0.080±0.045ppm but a less rate of 0.74±0.046 in the residental and the rural region. The tear pH in the commercial and the industrial region was a less rate of 7.03±0.23 that was a significant acidic shift. So the value of lysozyme in tears seemed to be decreased significantly. Ocular surface pH means are affected to acidic shift by the concentration rate of polluted air. On December and January which was the highest concentration of air pollution, the photochemical oxidant was 0.092±0.061ppm and 0.094±0.056 ppm and the ocular surface pH means was 7.14±0.19 and 6.99±0.23. The rate of air pollution was in parallel with the acidic shift of the ocular surface pH. Experimental research of eye irritation with automobile emitted gases was only a preliminary study without any significant results. The normal human tear pH range established by this study was 6.8 to 7.6, the mean value was 7.28±0.190. It is concluded that ocular surface pH varies significantly in both healthy and disease states. Understanding of the surface pH could have therapeutic and diagnostic significance and might help in the understanding of complexities of disease process.

외안부 감염증에 대한 Garasone^(�)의 임상효과

신환호,이희라,이미리 최신의학사 1987 最新醫學 Vol.30 No.6

포도막염을 일으킨 양안에 발생한 Mooren's ulcer의 조직병리학적 소견

차인식,김지한,신환호 순천향대학교 1984 논문집 Vol.7 No.4

Mooren's ulcer is a chronic, painful corneal ulceration of unknown etiology. Its spread occurs in three directions: round the periphery, in towards the cornea, and occasionally into the sclera. We experienced a case of Mooren's ulcer in 77-year-old female, in which chronic granulomatous uveitis was complicated along with rubeosis iridis, pars planitis, and peripheral retinal vasculitis. Mooren's ulcer appears to be a distinct entity clinically and a distinct entity by gross pathologic examination but a nonspecific process histologically.

약물을 이용한 상안검 Mueller씨근의 기능에 관한 연구

김준순,신환호 순천향의학연구소 1996 Journal of Soonchunhyang Medical Science Vol.2 No.1

Mueller's superior tarsal muscle and the levator palpebrae superioris act together to elevate the upper lid. Mueller's muscle consists of nonstriated muscle fibers supplied by the sympathetic nerve system, whereas the levator consists of striated muscle. The superior tarsal muscle provides approximately 2mm of lift for the upper eyelid. The function of the sympathetically innervated superior tarsal muscle was defined in 35 young adults by stimulating this muscle pharmacologically in randomized study. The drugs used topically were sympathomimetics (2.5% and 10% phenylephrine HCL) for muscle stimulation. This study provides basic data on the sympathetic tarsal muscle function in young normal subjects by measurement of the MRO (margin-reflex distance). The mean maximum lid elevation was 1.83 mm with 2.5% phenylephrine and was 2.15mm with 10% phenylephrine. The mean of the differences between two concentrations was 0.32 mm. By paired t-test, this difference was not statistically significant (p>0.05).

후 모양동맥 색전증 1예

남기룡,박성희,신환호 순천향대학교 1988 논문집 Vol.11 No.1

The clinical picture of central retinal artery occlusion is well known. Little is known, however, about the clinical picture of occlusion of the various posterior ciliary arteries individually or together in rhesus monkey. The authors have experienced a case of 21 old women with the visual field defects developed by the humen posterior ciliary artery occlusion via a pathologic embolic process. A brief review of the related literatures is presented.

특발성 시신경염환자에서 컴퓨터 단층촬영 소견

박민영,김재호,신환호 순천향대학교 1992 논문집 Vol.15 No.2

There are many causes for thickening and enlargement of optic nerve. Optic neuritis and papilledma are most common causes of enlargement of optic nerve. In many patients with a single episode of optic neuritis, the actual cause is never established. We expereinced a 29-year-old man who complaints of sudden visual loss and mild ocular pain in left eye. It was diagnosed as idiopathic optic neuritis through the clinical sign, fundus appearence and visual field defect. The orbital CT scan showed diffuse enlargement and thickening of introrbital portion of left optic nerve, homogenous enhancement after contrast injection. The thickened left optic nerve was normalized gradually.

상각막윤부 각결막염

김준순,김재호,신환호 순천향대학교 1990 논문집 Vol.13 No.3

Superior limbic keratoconjunctivitis is a chronic and recurrent inflammatory disease of the superior tarsal, bulbar and limbal conjunctiva associated with superior limbal pannus, superficial punctate keratopathy and filament formation. Remissions and exacerbations occur, and the process usually resolves without visual compromise. We have recently experienced a case of superior limbic kerato conjunctivitis with borderline thyroid hyperfunction and characteristic clinical findings. The lesion showed improvement after resection of superior bulbar conjunctiva.

제6 뇌신경 마비시의 Modified Jensen Procedure 1례

김재호,신환호 순천향대학교 1982 논문집 Vol.5 No.3

Because of the long intracranial course, the 6th nerve is vulnerable to increased intracranial pressure, trauma to the cranial floor, meningeal edema, inflammation in the base of the skull, and any displacement of the brain stem. The authors had experienced a case of abducens nerve palsy resulting non-concomittent esotropia and lateral gaze palsy due to brain trauma by traffic accident. We had performed modified Jensen procedure that had good result. That procedure is presented to aid in preserving the anterior segment blood supply. The anterior ciliary artery in the lateral rectus is not included in the union. The case report is reviewed with the pertinent literature.