A Case of Ocular Myasthenia Gravis Presenting as Double Depressor Palsy

이관복,김응수 대한안과학회 2014 Korean Journal of Ophthalmology Vol.28 No.2

A 65-year-old man who had been experiencing diplopia in front and down gaze for 15 days visited ourhospital. Hypertropia was noted in the patient’s left eye, and limitation of depression was found in theadduction, primary gaze, and abduction. Brain magnetic resonance imaging showed no remarkablefindings. Two weeks after the first visit, the patient complained of ptosis in the left eye. An ice test wasperformed and the ptosis was resolved after the test. Then, anti-acetylcholine receptor binding antibodylevels were checked and found to be slightly elevated. We prescribed methylprednisolone per os 24 mg for2 weeks, and his symptoms improved after the 2-week treatment. Five weeks after his first visit, the patientshowed an ortho result in the alternate prism cover test and normal ocular movements. This may be thefirst case in which ocular myasthenia gravis presented as double depressor palsy, and in such cases, thepossibility of ocular myasthenia gravis should be considered to rule out double depressor palsy.

무방류식 자연발효화장실에서 배양가능한 혐기성 세균

이관복,신광수,박성주 대전대학교 기초과학연구소 2002 自然科學 Vol.13 No.1

혐기성 소화 방식으로 분뇨를 처리하는 무방류식 자연발효화장실의 혐기성 세균을 연구하기 위하여 모형 화장실을 제작 가동하면서 혐기성 소화가 일어나는 발효조의 분뇨를 채취하여 모두 19개의 혐기성 세균 균주를 순수 배양하였다. 이들에 대하여 생화학적 특성을 조사하였으며 이를 기초로 한 표현형적 동정과 이와 동시에 165 rRNA 유전자의 염기서열 분석으로 동정을 실시하였다. 19개의 분리균주 가운데 3개는 분뇨의 주성분인 탄수화물 분해능이 거의 없었으며, 8개는 15℃에서도 생장 가능하였다. 표현형 및 유전자 동정이 모두 실시된 10개의 균주가 동일한 동정 결과가 나타난 것은 하나도 없었다. 유전자 동정 결과 9개가 Low G+C gram-positive bacteria 즉 Bacillus/Clostridium group에 속하였으며 이 가운데 8개가 Enterococcus 속이었다. The model human manure digestion tank without effluent was constructed and operated for studying anaerobic bacteria participating in anaerobic digestion of human manure. A total of 19 anaerobic bacterial pure isolates were obtained from human manure samples in the digestion chamber. Their phenotypic characteristics were examined by various biochemical tests, by which the isolates were identified. In addition. their genotppic identification were carried out by the 16s rDNA base sequence analysis. Three culturable isolates did not ferment carbohydrate compounds which are main constituents of human manure. Eight isolates grew at 15-C. None of ten showed the same identification results by phenotypic and genotypic tests. The 16s rDNA base sequence analyses showed that nine isolates of ten belong to Low G+C gram-positive bacteria, and eight of which belong to genus Enterococcus.

한우의 간이물질 대사효소의 활성도

이관복,박승춘,한경오,윤호인 충남대학교 수의과대학 동물의과학연구소 1994 動物醫科學硏究誌 Vol.1 No.-

It is important to study the activity of drug biotransformation enzymes, because from a pharmacological and therapeutic point of view these enzymes are resposible for eliminating most drugs. Their level is ciritical when deciding the dose regimen. (From a toxicological perspective, the role of these enzymes varies, with some of them being directly responsible for activation of certain chemicals to reactive intermediates with deleterious consequence to the animal.) Experiments were designed to measure in vitro, the activity of drug metabolizing enzymes in liver of Korean native cattle. The microsomal monooxygenase activities were evaluated utilizing specific substrates. The activities of BPDM and TST 6β-hydroxylase were seemed to be high level relatively to other monooxygenzses such as ECOD, EROD and AH. Interestingly, TST 16α-hydroxylase which is a maker enzyme for CYP ⅠLA was not detected in Korean native cattle. These results sugest that Korean native cattle have high contents of CYP IIB1 and CYP IIIA.

Changes in Tear Volume after 3% Diquafosol Treatment in Patients with Dry Eye Syndrome: An Anterior Segment Spectral-domain Optical Coherence Tomography Study

이관복,고경민,권영아,송상률,김병엽,정재림 대한안과학회 2017 Korean Journal of Ophthalmology Vol.31 No.4

Purpose: To evaluate changes in the tear meniscus area and tear meniscus height over time in patients withdry eye syndrome, using anterior segment spectral-domain optical coherence tomography after the instillationof 3% diquafosol ophthalmic solution. Methods: Sixty eyes from 30 patients with mild to moderate dry eye syndrome were included. Tear meniscusimages acquired by anterior segment spectral-domain optical coherence tomography were analyzed usingNational Institutes of Health’s image-analysis software (ImageJ 1.44p). Tear meniscus area and tear meniscusheight were measured at baseline, 5 minutes, 10 minutes, and 30 minutes after instillation of a drop of diquafosolin one eye and normal saline in the other eye. Changes in ocular surface disease index score, tear filmbreak-up time, corneal staining score by Oxford schema, and meibomian expressibility were also evaluated atbaseline, and after 1 week and 1 month of a diquafosol daily regimen. Results: Sixty eyes from 30 subjects (mean age, 29.3 years; 8 men and 22 women) were included. In eyes receivingdiquafosol, tear volume was increased at 5 and 10 minutes compared with baseline. It was also higherthan saline instilled eyes at 5, 10, and 30 minutes. Changes in tear volume with respect to baseline were notstatistically different after the use of diquafosol for 1 month. Ocular surface disease index score, tear filmbreak-up time, and Oxford cornea stain score were significantly improved after 1 week and 1 month of dailydiquafosol instillation, but meibomian expressibility did not change. Conclusions: Topical diquafosol ophthalmic solution effectively increased tear volume for up to 30 minutes,compared to normal saline in patients with dry eye syndrome.

『잡보장경』과 중한 민간이야기 관련 양상 연구

이관복 대각사상연구원 2011 大覺思想 Vol.16 No.-

불경은 불교문화의 중요한 캐리어며 동방문화의 귀중한 유산으로서 중 국 문학과 한국 문학에 막대한 계발과 주입을 했다. 그중 잡보장경은 문 학성이 뛰어난 이야기 문집이며 중국, 한국, 인도의 문화교류에 심원한 영향을 끼쳤다. 논문은『고려대장경』제30권에 실린 잡보장경의 121개 이야기 속에서 “기로국연(棄老國緣)”, “왕자가 제 살로 부모를 구원한 인 연(王子以肉濟父母緣)”, “부처님의 아우 난타가 부처님의 핍박을 받고 집 을 떠나 도를 얻은 인연(佛弟難陀爲佛所逼家得道行)”, “바라내국의 어떤 장자의 아들이 천신과 함께 왕을 감동하게 해 효도를 한 인연(波羅奈國 有一長者供天神感王行孝緣)”, “사라나 비구가 악생왕에게 고뇌를 당한 인 연(娑羅那比丘爲惡生王所苦腦緣)”, “바사닉왕의 추한 딸 뇌제의 인연(波 斯匿王醜女賴提緣)” 등 사람들의 입에 자주 오르내리는 기이한 착상의 이야기를 통해 중한 민간이야기 및 소설과 인도문화의 연관성을 연구하 고자 한다. 이는 불경과 동방 문학의 연관성을 연구하는데 도움이 되며 문화유산의 계승과 동방의 문화를 널리 알리고 발전시키는데 유리하다. As a main carrier of Buddhist culture and an important oriental cultural heritage,Buddhist scripture gives Chinese literature and Korean literature utmost enlightenments. Zabaozhangjin, a book of stories with enormous literariness, has a considerable hold over the cultural exchanges among China, India and Korea. This paper features some widely loved and strange-imagined stories from Zabaozhangjin which is recorded from volume thirty of Gaoli Tripitaka. By the research on the spreading of Zabaozhangjing, we can explore the link between Sino-Korean folktales and Indian culture. This research is not only beneficial to studying the relationship between Buddhist scripture and Oriental literature, but also to inheriting traditional culture and enlarging the ancient orient culture.

난관 페쇄증으로 인한 불임 여성에 있어서 미세수술과 육안적 수술의 비교 관찰에 의한 임상적 연구

이관복,유정옥,박철순,이지성,박영선 대한산부인과학회 1983 대한산부인과학회 학술대회 Vol.51 No.-

학술발표(學術發表) 연제(演題) 및 초록(抄錄) 제사부(第四部): 공중위생(公衆衛生),생리(生理),어병(魚病),법령(法令),분야(分野) : 19. 불임유우의 혈청화학치에 관한 연구

이관복,신창호,김선희,임종묵,최원식,박현기 한국가축위생학회 1997 학술대회논문집 Vol.1997 No.-

한우와 돼지에서 간의 약물 대사효소의 활성 비교

이관복,윤효인,박승춘,김민규,이내경,조준형,이동우,Lee, Gwan-bok,Yun, Hyo-in,Park, Seung-chun,Kim, Min-kyu,Lee, Rae-kyung,Cho, Joon-hyung,Lee, Dong-woo 대한수의학회 1998 大韓獸醫學會誌 Vol.38 No.1

Drug-metabolizing activities of Korean native cattle and swine were investigated from viewpoints of the cytochrome P-450's level, their dependent mixed function oxidase activities, the reactive oxygen species formation and cytosolic enzyme acitivities from each liver homogenates. Level of cytochrome P-450 in the liver microsome of Korean native cattle was $0.28{\pm}0.05nmole/mg$ and that in pigs $0.35{\pm}0.03nmole/mg$. Level of cytochrome $b_5$ of Korean native cattle was $0.24{\pm}0.06nmole/mg$, and that of pigs $0.2{\pm}0.05nmole/mg$, showing no difference between two species. NADPH P-450 reductase were higher in Korean native cattle ($58.3{\pm}5.3nmole/mg/min$) than in pigs ($29.9{\pm}3.8nmole/mg/min$)(p<0.01). The activities of cytochrome P-450 dependent monooxygenases such as ethoxyresorufin O-deethylase (cattle, $96.5{\pm}12.5nmole/mg/min$ ; pigs, $13.6{\pm}2.1nmole/mg/min$), N-benzphetamine N-demethylase (cattle, $5.23{\pm}0.82nmole/mg/min$ ; pigs, $0.76{\pm}0.3nmole/mg/min$) and aniline hydroxylase (cattle, $0.95{\pm}0.1nmole/mg/min$ ; pigs, $0.33{\pm}0.08nmole/mg/min$) were much higher in Korean native cattle than in swine(p<0.01). However, the activity of testosterone $7{\alpha}$-hydroxylase was higher in swine ($90.4{\pm}1.2nmole/mg/min$) than cattle (cattle, $32.8{\pm}1.2nmole/mg/min$). Interestingly, testosterone $16{\alpha}$-hydroxylase, a marker enzyme for P-450 IIA was not detected in both animal species. These results suggest that Korean native cattle and pigs have high contents of P-450 IA1 and P-450 IIIA. Total sulfhydryl compound (cattle, $10.3{\pm}1.1nmole/mg$ ; Pigs, $14.5{\pm}1.8nmole/mg$) and glutathione related enzymes except glutathione reductase (cattle, $38.1{\pm}7.9nmole/mg/min$; swine, $22{\pm}3.6nmole/mg/min$) showed higher levels in swine than in Korean native cattle. Superoxide dismutase (cattle, $7.64{\pm}0.84nmole/mg/min$ ; pigs, $4.47{\pm}0.94nmole/mg/min$) and catalase (cattle, $30.4{\pm}3.7nmole/mg/min$ ; pigs, $17.2{\pm}1.8nmole/mg/min$) were remarkably higher in Korean native cattle than in swine (p<0.05).

중국과 한국에서의 『백유경』 이야기의 傳播와 變形

이관복,김동훈 한국어문교육학회 2005 어문학교육 Vol.31 No.-

Mayer - Rokitansky - Kuster - Hauser 증후군 2 례의 치험

이관복(KB Lee),신수은(SE Sin),김명근(MK Kim),임헌방(HB Lim),민부기(BG Min) 대한산부인과학회 1984 Obstetrics & Gynecology Science Vol.27 No.15

저자들은 을지병원 산부인과에서 선천적 질결원증 2례를 치험하였기에 문헌적 고찰과 함께 증례보고를 하는 바이다. The Mayer-Rokitansky-Kuster-Hauser Syndrome refers to the Clinical entity consisting of; normal female Secondary Sex Characteristics, normal external genitalia absence of the vagina, a rudimentary uterus in the form of bilateral noncanaliculated muscular buds, and normal tubes and ovaries with normal cytogenic and endocrine evaluation. Two cases of mayer-Rokitansky-Kuster-Hauser syndrome were reported brief review of the literatures.