NF-κB 억제를 통한 대회향(大茴香)의 항염증효능

금수연,박상미,제갈경환,황보민,조일제,박정아,김상찬,지선영,Keum, Soo Yeon,Park, Sang Mi,Jegal, Kyung Hwan,Hwangbo, Min,Cho, Il Je,Park, Chung A,Kim, Sang Chan,Jee, Seon Young 대한한의학방제학회 2016 大韓韓醫學方劑學會誌 Vol.24 No.4

Objectives : Illicium verum Hook. f. has been known to possess antimicrobial, antioxidant, antifungal, anti-inflammatory, insecticidal, analgesic, sedative, convulsive activities, it has been rarely conducted to evaluate the immuno-biological activity. The present study was examined to evaluate the anti-inflammatory effects of the Illicium verum Hook. f. water extracts (IVE) in vivo and in vitro. Methods : Cell viability was measured by MTT assay. The relative levels of NO were measured with Griess reagent. iNOS, COX-2, $NF-{\kappa}B$ and target proteins were detected by immunoblot analysis, and levels of cytokines were analyzed by ELISA kit. Anti-edema effect was determined in the carrageenan (CA)-induced paw edema model in rats. Results : All dosages of IVE used in MTT assay had no significant cytotoxicity. The increases of NO production and iNOS expression were detected in LPS-treated cells compared with control. However, these increases were attenuated by treatment with IVE. Also, IVE reduced the elevated production of $TNF-{\alpha}$, $IL-1{\beta}$ and IL-6 by LPS. IVE inhibited the $p-I{\kappa}B$ and translocation of $NF-{\kappa}B$ to nuclear. Furthermore, IVE significantly inhibited the increases of hind paw swelling, skin thicknesses and inflammatory cell infiltrations induced by CA injection. Therefore, IVE will be favorably inhibited the acute edematous inflammations. Conclusion : These results provide evidences that anti-inflammatory effect of IVE is partly due to the reduction of some inflammatory mediators by suppression of $NF-{\kappa}B$ pathway.

미디어, 시각문화와『良友畵報』

金秀姸 한국중국소설학회 2007 中國小說論叢 Vol.25 No.-

?代意味着所?以?角?主的文化,是一??角??的文化,而二十世?是新的?角媒?普遍普及而大?化的?期.中?二十或三十年代作??角?物的印刷文字、照片、?影等?些媒?主?着??中?社?的?通,也支配着?代文化的性?.那?,??作??代?角文化的?合版,是跨越不同媒?的疆界而??出文化信息的一?‘超文本(hypertext)’. 本文?不是想?述『良友??』的具??容和表面?象,而是要借助『良友??』探??志?究特?是???究的方法???.也就是?,本文考???的特性,要考察究竟如何??照片? 在??里,??、?告、漫?和?影等多?多?的文化符?,通?照片媒介如何被建?? ?些又???文字包括文?在?形成?密的?在?系? 等等??.重要的是,在各?媒?相互媒介、相互作用的?程中,文??作方式有什??的?化? 由此可?,中?二十或三十年代?角媒?的???展?致了整?中?文化?域的??.

강서구시설관리공단 운영사례

남형우(南炯祐),김수연(金秀姸) 한국지방공기업학회 2006 한국지방공기업학회보 Vol.2 No.2

서울특별시 강서구시설관리공단은 지방공기업법 제76조 및 서울특별시 강서구시설관리공단설치및운영조례에 의거 서울특별시 강서구에서 자본금 20억원을 전액 출자하여 자치구로서는 전국 최초로 설립된 지방공기업이다. 1996년 5월 6일 공영주차장 5개소와 견인보관소 사업을 시작하였고, 공단의 주요사업으로는 주차사업(공영주차장,거주자우선주차장,견인보관소), 체육사업(강서구민올림픽체육센터, 공항동문화체육센터 수영장, 마곡실내배드민턴장, 마곡테니스장), 공공사업(강서구민회관, 영상미디어센터, 청소년공부방 5개소, 구립어린이집 2개소, 농수축산물상설판매장)이 있다. 21세기 힘차게 비상하는 강서구의 희망으로 교통관련 시설 및 공공시설의 체계적 관리와 효율적 운영으로 경영합리화를 기하고, 공익성과 수익성을 균형 있게 추구하는 지방공기업으로 육성, 구민의 복리증진과 구 재정 확충에 기여하고자 한다.

구법(灸法)과 intense pulsed light(IPL)의 특성 비교 및 광선구(光線灸)의 한방임상(韓方臨床) 활용(活用)

장인수,선승호,남동현,금수연,서형식,Jang, In-Soo,Sun, Seung-Ho,Nam, Dong-Hyun,Kum, Su-Eun,Seo, Hyung-Sik 대한한방안이비인후피부과학회 2010 한방안이비인후피부과학회지 Vol.23 No.3

Objectives : The purpose of this study is to compare the principles between moxibustion and the 'Intense pulsed light (IPL)' and to investigate the clinical application of the photo-moxa for the Korean medicine fields. Methods : The characteristics of moxibustion, IPL, parabolic reflector moxa and the dermatology surgical use of moxibustion were reviewed in the literature. Results : IPL is one type of light treatments that is employed by radiating the short-pulse wave, which is transformed from the light of high intensity. There has been used parabolic reflector in Asia for more than 2,000 years, and this hand-held device used for moxibustion in traditional medicine. Moxibustion is one of the treatment tools in Korean medicine using the heat energy. The fluence or energy density of IPL in clinical circumstances is similar to parabolic reflector moxa of moxibustion. IPL and parabolic reflector moxa shared same treatment principle employing the heat energy. Therefore IPL could apply for many indications in Korean medicine as a moxibustion tool and acupuncture. Conclusions: IPL may be plausible to be a fascinate method in phototherapy of Korean medicine.

西瓜皮(서과피)의 전염증성 cytokine 억제효과

손진원 ( Jin Won Son ),지선영 ( Seon Young Jee ),금수연 ( Soo Yeon Kem ) 대구한의대학교 제한동의학술원 2013 제한동의학술원논문집 Vol.11 No.1

Exocarpium Citrulli is the cortex of Fructus Citrulli. In Korean traditional medicine, it has been used to treat edema, dysuria, mouth and tongue sores. Although Exocarpium Citrulli has been known to possess anti-cancer activity, it has been rarely conducted to evaluate the anti-inflammatory activity. The present study was examined to evaluate the anti-inflammatory effects of the Exocarpium Gitrulli EtOH extracts (ECE) in vitro. Inflammatory mediators were detected after the addition of LPS with or without ECE in Raw 264.7 macrophage cell lines. LPS plays a key role in leading to the massive production of pro-inflammatory cytokines, such as TNF-a, 1L-1β and IL-6 in macrophages. In this study, cell viability assay (MTT assay) was conducted to determine the non-cytotoxic concentration of ECE. The dosages (0.1 and 0.3 mg/ml of ECE used in this study had no significant cytotoxicity during the experimental period. The relative level of NO was measured with Griess reagent. Pro-inflammatory cytokines were detected by EUSA assay. The cell was treated with 1 μg/ml of LPS 1 h before adding ECE. The level of NO and cytokines (TNF-a, IL-1β) in culture medium was increased by LPS application. However, these increases were attenuated by treatment with ECE.

척추마취 후 제왕절개술 시행한 산모에 합병된 페전색 1 례

권장연,송종민,박금수,이주용 대한산부인과학회 1996 Obstetrics & Gynecology Science Vol.39 No.8

The maternal mortality rate continued to decline since 1940. However, pulmonary thromboembolism, first identified as the leading cause of maternal death in 1970s, continues to account for an increasing proportion of maternal deaths. The main or major cause of maternal deaths were pulmonary thromboembolism, heamorrhage, ectopic pregnancy, pregnancy induced hypertension complication and infection. Recently, deaths by pulmonary thromboembolism may be becoming more importent as a cause of maternal death. We present a cause of fatal pulmonary emblosim, which was diagnosed by lung-perfusion scan and pulmonary angiography on the postoperative 2 day after cesarean section for which the patient was given a spinal anaesthesia. In our knowledge, we belive it to be the first time this problem case following spinal anesthesia for casarean section has been reported in Korea.

탄소 착상기법이 스텐트 내 재협착에 미치는 영향:다기관 무작위 연구

탁승제,최소연,최병주,김권배,김병옥,김상욱,김종진,박금수,승기배,성인환,양주영,윤정한,이상훈,장양수,정명호,정상식 대한심장학회 2004 Korean Circulation Journal Vol.34 No.5

Background and Objectives :Heavy metal ions released from a stainles stel stent can induce an inflammatory reaction that might be associated with in-stent restenosis. A carbon ion implantation technique, which physi -and improve the biocompatibility. This study was designed to evaluate the eficacy of a carbon ion implanted Arthosinert stent on the reduction of in-stent restenosis and the improvement in the clinical outcomes. Subjects and Methods :193 de novo coronary lesions in 191 anginal patients at 14 centers, with reference diameters from 2.75 to 4.5 mm, were randomly assigned to either an Arthosinert (10 patients, 102 lesions) or an Arthos (9 1 pa -tients, 9 1 lesions) stent. The lesion length was 14.1± 5.7 mm. The ACC/AHA (American College of Cardio -logy/American Heart Association) lesion classifications were A :1 1:36.8%, B2 :35.8% and C :12.4%. The study end points are angiographic restenosis, during a six-month folow-up, and Major adverse cardiac event. In-stent restenosis was defined as a diameter of stenosis ≥50%. Results:A six-month angiographic fol -low-up was obtained for 72.3% ( 138/191) of the subjects. There were no significant differences between the Arthosinert and Arthos groups in the rates of restenosis ( 17.8% vs. 3 1.8%, p=0.055) and Target vessel revascula -rization (7.0% vs. 11.0%, p=0.476). There were no deaths or non-fatal myocardial infarction in either group. Conclusion :The treatment of de novo coronary stenosis, with carbon ion implanted stents, showed a tendency 16L stainless steel stents. A larger tr -ial will be needed to confirm the efficacy of the carbon ion implanted stent. 배경 및 목적: 금속 재질의 스텐트 표면에서 방출 되는 몇 가지 중금속 이온들이 주위 조직의 염증 반응을 일으키며 스텐트 재협착과 관련이 있을 것으로 생각 되고 있다. 스텐트 표면에 특수한 방법으로 탄소 입자를 코팅할 경우 표면에서 방출 되는 중금속 이온을 줄여 생물학적 적합성을 향상 시킬 수 있다. 본 연구는 스텐트 표면을 특수한 방법으로 탄소화한 Arthosinert스텐트를 사용하여 스텐트 재협착 및 임상 경과에 미치는 영향을 평가 하고자 하였다. 방 법: 191명 협심증 환자를 대상으로 14개 기관이 연구에 참여 하였다. 참조 혈관 내경이 2.75~4.5 m인 193개의 de novo 병변에 대해 Arthosinert(10명, 102병변)와 Arthos(91명, 91병변) 스텐트를 무작위로 선택하여 시술하였으며 병변의 길이는 14.1 ± 5.7 mm, ACC/ AHA병변 분류는 A:15.0%, B1:36.8%, B2:35.8%, C:12.4%였다. 연구 종말점은 6개월 추적 관동맥 조영의 스텐트 재협착과 중대한 심장 관련 합병증(사망, 심근 경색, 표적 혈관 재관류술)으로 하였다. 스텐트 재협착은 내경 협착이 50% 이상인 경우로 하였다. 결 과: 6개월 추적 관동맥 조영술이 72.3%(138/191)에서 시행 되었다. Arthosinert와 Arthos 스텐트 군 사이에 스 텐트 재협착(17.8% vs 31.8%, p=0.055), 표적 혈관 재관류술(7.0% vs 11.0%, p=0.476)의 유의한 차이 가 관찰 되지 않았다. 두 스텐트 군에서 심근 경색이나 사망은 한 건도 발생하지 않았다. 결 론: de novo 관동맥 병변의 치료에 있어서 탄소 착상 스 텐트는 316L stainless 스텐트에 비해 스텐트 재협착률 이 낮은 경향을 보였으며 향후 더 큰 규모의 연구가 필 요 하다고 생각 되었다.

산전 진단된 좌측 신장 무형성증 및 흔적요관 1예

김주현,한금수,고식봉,이태성,홍성연 대한산부인과학회 2006 대한산부인과학회 학술대회 Vol.92 No.-

사물인터넷(IoT) 기반 해양구조물 모니터링 시스템

박수열,강성민,여금수,원병연 해양환경안전학회 2016 해양환경안전학회 학술발표대회 논문집 Vol.2016 No.04

등부표용 파랑발전시스템 개발

박수열(Soo-Yeol Park),원병연(Byung-Yeon Won),여금수(Keum-Soo Yeo),지창환(Chang-Hwan Ji),오영민(Young-Min Oh) 한국연안방재학회 2016 한국연안방재학회지 Vol.3 No.3

Light beacon structures are very essential to the maneuvering of ship especially in the night. The power is usually from the rechargeable battery connected to solar panel which generates electricity from the sunlight. There are two types of structures, one is floating and the other is fixed. In this study, we are dealing with the new power generation system motivated by the wave motion for the floating light beacon. The basic principle of new system is transforming wave motion into electricity by the solenoid that composed of circular tube coiled around and magnetic inside. We succeeded in generating electricity in the lab test using the motion actuator. On the basis of lab test experience it is applied to the real field, Samchuk port. The power unit is installed in the floating light buoy and generating electricity when the inclination of the buoy is beyond the certain limit. The amount of electricity depends on the wave height and wave period. The purpose of field test is to clarify the relationship between the wave condition and electricity.