2009년 유행 신종인플루엔자 A(H1N1)의 한약 및 기타 비전형적 치료에 대한 고찰

선승호,장인수,백유상,배선재,한창호,Sun, Seung-Ho,Jang, In-Soo,Baik, You-Sang,Bae, Sun-Jae,Han, Chang-Ho 대한한방내과학회 2009 大韓韓方內科學會誌 Vol.30 No.3

Background : Since March 2009, when the first patient of novel influenza A (H1N1) was reported, many deaths have occurred in North and Central America. The start of the 2009 influenza pandemic was declared by WHO Director-General Dr. Margaret Chan on 11 June 2009, and the level of influenza pandemic alert raised from phase 5 to phase 6. There was no vaccine yet developed, and many experts worried that the novel H1N1 virus could kill as many or more as did the influenza pandemic in 1918-1919. Objective : To evaluate the possibility of treatment for 2009 novel influenza A (H1N1) using herbal remedies and other non-conventional therapies. Methods : We researched the clinical studies for novel H1N1 influenza virus-related herbal medicine or non-conventional medicine treatment using internet search engines including PubMed and CNKI. In addition, we reviewed many reports and clinical practice guidelines (CPG) for influenza A (H1N1). Results : Two case series were selected after reviewing 701 papers, and two CPG published by the Chinese government and Jilin province identified. They reported that the clinical symptoms were no more significant than seasonal influenza, and the condition of patients more than 45 years old was milder than those less than 45 years old. There are no patients with gastric problems, and oseltamivir has been used at the same time in all patients. Conclusion : The efficacy and effectiveness of herbal medicine and other non-conventional treatments for the novel influenza A (H1N1) is questionable, and more studies are needed to draw a firm conclusion. However, in the severe acute respiratory syndrome (SARS) experience in 2002/2003, it was demonstrated that herbal medicine can relieve all symptoms of SARS patients, promote absorption of lung inflammation, improve the degree of blood oxygen saturation, regulate immunological functions, reduce the required dosage of glucocorticoid and other medicines, and reduce case fatality rate. In light of the current situation that there is no vaccine or conventional treatment yet available, the study of herbal medicine and other non-conventional therapies are also necessary for appropriate evaluation.

한약을 사용하는 아시아권 국가의 유해사례 보고 양식에 관한 비교 연구

선승호,이은경,장보형,박선주,고호연,전찬용,고성규,Sun, Seung-Ho,Lee, Eun-Kyoung,Jang, Bo-Hyoung,Park, Sunju,Go, Ho-Yeon,Jeon, Chan-Yong,Ko, Seong-Gyu 대한예방한의학회 2015 대한예방한의학회지 Vol.19 No.3

Objective : The purpose of this study is to find out the possibility of application to herbal medicine's report form for adverse drug reaction (ADR) by reviewing and analyzing Asian countries's ADR report forms. Method : We investigated, compared, and analyzed ADR report forms (ADR-RF) of Asian countries's ADR institutions (ACAI), such as, Korea institute of drug safety & risk management and Dongguk university Ilsan oriental hospital (DUIOH) in Korea, national center for ADR monintoring (NCAM) in China, pharmaceuticals and medical devices agency (PMDA) in Japan, Ministry of Health and Welfare (MOHW) in Taiwan, and drug office, department of health, the government of the Hong Kong special administrative region (GHKSAR) in Hong Kong. Results : ADR-RF for ACAI included common contents, such as, patients information (name(initial), gender, age, weight), adverse event (AE)'s report information (Recognition and report for AE occurrence, first or follow up report, Severe AE), the detailed information of AE (the title of AE, onset & closing date of AE symptoms, the progress & results detailed test of AE), the information of AE's medicine (the types of medicine, product name, ingredient name, suspected or combination drug, single dose & frequency, dosage form, administration route, dealing for AE-suspected medicine), and AE reporter's information (reporter's information, institution's information). Taiwan had ADR-RF and the department exclusively for herbal medicine (HM), but others (except DUIOH) had not only no ADR report form but also contents for HM. Conclusion : ADR-RF for HM have to include the common contents of ACAI at least, as well as HM information related to ADR, such as the title, composition and types of HM, history related to HM's ADR, and the contents of drug-induced liver injury and so on. In addition, the main department of government for HM's ADR will be needed.

한의학교육평가원 2주기, 세계의학교육연합회(WFME)의 의학기본교육, WHO 서태평양 지역지부(WHO/WPRO) 인증 기준 간의 비교 연구

선승호 대한예방한의학회 2019 대한예방한의학회지 Vol.23 No.3

Objective : The purpose of our study is to compare and analyze the standards for the 2nd cycle of Evaluation and Accreditation system on institute of Korean Medicine Education & Evaluation (2nd IKMEE standards) and WHO guidelines for quality assurance of Traditional Medicine Education in the Western Pacific Region (WHO/WPRO guidelines) around the global standards of World Federation for Medical Education for basic medical education (WFME standard) to identify the shortcomings and improvements of 2nd IKMEE standards. Method : Each article of 2015 revised WFME standard was translated and summarized with focus on its core content. The next step was to review and analyze the corresponding contents of 2nd IKMEE standards in 2016 and the WHO/WPRO guidelines in 2005 for each item, focusing on the WFME standards. Results : All items in the fields of 3. assessment of students and 7. program evaluation in the WFME domain were absent from the 2nd IKMEE standards, and almost none of the WHO/WPRO guidelines. Most items in 1. the mission and outcomes domain, except for some items in the 1.1 mission field, the items of 2.6~2.8 fields in 2. education program domain, the items of 4. student domain except for the items of 4.3 student counseling and support field, and almost all items about quality development in WFME standards did not have a corresponding item in both the 2nd IKMEE standards and the WHO/WPRO standards. Conclusion : 1. The WFME standards are applicable to the criteria development of IKMEE standards. Several items of the WFME standards may need to be modified to apply the educational characteristics of Korean medicine, but consensus or further study is required. 2. Both the 2nd IKMEE standards and the WHO/WPRO standards are very insufficient to meet the WFME standards. In particular, 3. assessment of students and 7. program evaluation in the WFME domain were not in the 2nd IKMEE standards. This standard needs to be supplemented.

암환자의 방사선 요법 및 화학요법 치료 후 발생된 백혈구감소증의 치료에 관한 중의학 임상논문의 문헌적 고찰

선승호,고성규,정용수,부송아,박경훈 대한한방내과학회 2002 大韓韓方內科學會誌 Vol.23 No.1

Effects of costunolide derived from Saussurea lappa Clarke on the apoptosis in AGS Stomach Cancer Cell Lines

선승호,고승규 대한한의학회 2006 대한한의학회지 Vol.27 No.4

Costunolide is an active sesquiterpene lactone isolated from the root of Saussurea lappa Clarke and is known to exhibit a variety of biological activities, including anti-carcinogenic and anti-inflammatory effects. Nevertheless, the pharmacological pathways of costunolide have not yet been fully elucidated. In this study, its cytotoxic effects were examined using AGS gastric cancer cells. Its treatment resulted in apoptosis in a dose- and time-dependent manner. The effects were attributed to the regulation of pro-apoptotic molecules and suppression of anti-apoptotic molecules. These results suggest that costunolide may be a candidate to deal with gastric cancers by chemopreventive agents.

휴대 전화용 안테나의 지향성에 관한 연구

선승호,박수봉,김재이,고영혁 한국정보통신학회 2001 한국정보통신학회논문지 Vol.5 No.6

본 논문에서 이동통신 전화기에 의해 인체두부에 유기된 전계 분포와 지향성을 분석하였다. 계산된 모델은 인체 두부모델을 구성하고 안테나는 휴대폰 크기와 같은 그라운드판위에 올려놓았다. 이동 통신 전화기의 안테나로 전기력선이 제한 받지 않는 용량을 장하한 QMSA를 활용하였다. 안테나는 2㎓ 부분의 주파수 대역에서 동작하도록 설계하였고, 인체 두부로 터의 거리에 따른 변화와 안테나 복사 특성을 고찰하였다. In this paper, the electric field distribution and directivity on human head caused by portable phone is analyzed. An analysis model is composed of a human head model and the antenna mounted on the same ground plane as portable telephone size. The QMSA to load a capacitor without limitation of the electric force is used In the computational model to apply to the antenna mounted on portable phone. This antenna is designed to operate in the near of frequency 2.0㎓, is observed the radiation characteristics of the antenna and their variations as a function of distance from the human head.

뇌혈관질환의 한의학적 접근

선승호,Seon, Seung-Ho 한국산업간호협회 2006 한국산업간호협회지 Vol.13 No.4

청심연자탕가미방의 효과에 대한 증례군 보고 - 9명의 두통 환자를 중심으로 -

선승호,Sun, Seung-Ho 대한한방내과학회 2009 大韓韓方內科學會誌 Vol.30 No.3

Objectives : The purpose of this case series was to investigate the effectiveness of Chengsimyeonjatang-gamibang for headache. Methods : The case subjects were nine patients who were diagnosed as Taeumin from the Department of Sasang Constitutional Medicine. They were selected among outpatients who visited Sangji Oriental Medical Hospital with complaint of headache from October 2007 to January 2008 through chart reviews. They were treated with Chengsimyeonjatang-gamibang without other treatments. Relative seriousness of headache was determined by Headache Impact $Test^{TM}$(HIT-$6^{TM}$) questionnaire. Results of before and after therapy were evaluated and scored using Visual Analogue Scale (VAS). The results were analyzed using statistical methods. such as Friedman test, Wilcoxon signed-rank test, and Mann-Whitney U Test. Results : The study showed that the VAS score significantly decreased after treatment (P<0.05). Conclusions : In summary, this case report suggests that Chengsimyeonjatang-gamibang appears to be effective in the treatment of headache.

Single-dose Intramuscular Injection Toxicology of Danggui Pharmacopuncture (DGP) in Sprague-Dawley Rats

선승호,정종진,박선주,이광호,유준상,서형식,권기록 대한약침학회 2015 Journal of pharmacopuncture Vol.18 No.1

Objectives: The purpose of the study is to assess both the approximate lethal dose and the single dose intramuscular injection toxicity of Danggui (Angelica gigantis radix) pharmacopuncture (DGP) in Sprague-Dawley (SD) rats. Methods: The experiments were conducted at the good laboratory practice (GLP) laboratory, Biotoxtech Co., which is a laboratory approved by the ministry of food and drug safety (MFDS). The study was performed according to the GLP regulation and the toxicity test guidelines of the MFDS (2009) after approval of the institutional animal care and use committee of Biotoxtech. Single doses of DGP were injected intramuscularly into the rats in three test groups of 6 week old SD rats (5 male and 5 female rats per groups) in the amounts of 0.1, 0.5, and 1.0 mL/animal for groups 2, 3, and 4, respectively, and normal saline solution in the amount of 1.0 mL/animal was injected intramuscularly into the rats (5 male and 5 female rats) in the control group. Observations of the general symptoms and weight measurements were performed during the 14 day observation period after the injection. Hematologic and serum biochemical examination, necropsy, and a local tolerance test at the injection site were done after the observation period. Results: No death was observed in three test groups (0.1, 0.5 and 1.0 mL/animal group). In addition, the injection of DGP had no effect on general symptoms, weights, hematologic and serum biochemical examination, and necropsy. The results from the local tolerance tests at injection site showed no treatment related effects in the SD rats. Conclusion: The results of single dose intramuscular injection of DGP suggest that the approximate lethal dose is above 1.0 mL/animal for both male and female SD rats and that intramuscular injection of DGP may be safe.

Single-dose Intravenous Toxicology Testing of Daebohwalryeok Pharmacopuncture in Sprague-Dawley Rats

선승호,박선주,정종진,이광호,유준상,서형식,권기록 대한약침학회 2015 Journal of pharmacopuncture Vol.18 No.2

Objectives: The aims of the study were to test the single- dose intravenous toxicity of Daebohwalryeok pharmacopuncture (DHRP) in Sprague-Dawley (SD) rats and to estimate the crude lethal dose. Methods: The experiments were conducted at Biotoxtech Co., a Good Laboratory Practice (GLP) laboratory, according to the GLP regulation and were approved by the Institutional Animal Care and Use Committee of Biotoxtech Co. (Approval no: 110156). The rats were divided into three groups: DHRP was injected into the rats in the two test groups at doses of 10 mL/kg and 20 mL/kg, respectively, and normal saline solution was injected into the rats in the control group. Single doses of DHRP were injected intravenously into 6 week old SD rats (5 male and 5 female rats per group). General symptoms were observed and weights were measured during the 14 day observation period after the injection. After the observation period, necropsies were done. Then, histopathological tests were performed. Weight data were analyzed with a one-way analysis of variance (ANOVA) by using statistical analysis system (SAS, version 9.2). Results: No deaths and no statistical significant weight changes were observed for either male or female SD rats in either the control or the test groups during the observation period. In addition, no treatment related general symptoms or necropsy abnormalities were observed. Histopathological results showed no DHRP related effects in the 20 mL/kg DHRP group for either male or female rats. Conclusion: Under the conditions of this study, the results from single-dose intravenous injections of DHRP showed that estimated lethal doses for both male and female rats were above 20 mL/kg.