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        • KCI등재

          임상연구방법론에서 귀무가설과 대립가설, 귀류법에 대한 고찰과 한방이비인후과에서 베이지안 통계학의 활용

          남승표,배재민,권강 대한한방안이비인후피부과학회 2019 한방안이비인후피부과학회지 Vol.32 No.4

          Background : The current medical statistics used in clinical research are the results of Fisher's significance test and the Neyman-Pearson hypothesis test, which were combined by psychologists. Also, in the philosophical background, it is related to Popper's falsificationism based hypothesis-deductive method and reduction to absurdity. Objectives : This study was designed to find complementary and alternative methods of null hypothesis and alternative hypothesis used for the clinical research methodology of Korean medicine otolaryngology. Methods : The body of this paper was divided into seven part. These are historical background, hypothesis test, hypothesis test method used in the design of clinical study, falsificationism and reduction to absurdity, problem and alternative method of the Neyman-Pearson hypothesis test, diagnosis example of sinusitis differentiation syndromes by Bayesian statistics. Through this process, we found out problems of frequentist statistics and suggested alternative methods. Result & Conclusion : As a solution to the problems of the null hypothesis and the alternative hypothesis, there are effects size, confidence interval, Bayesian statistics and Lakatos methodology of scientific research programmes.

        • KCI등재

          경증의 아토피 환자에서 한약 추출물 함유 외용제에 대한 임상 연구

          강민서,김정범,김희택,Kang, Min-Seo,Kim, Jeung-Beum,Kim, Hee-Taek 대한한방안이비인후피부과학회 2014 한방안이비인후피부과학회지 Vol.27 No.3

          Objectives : The purpose of this study is to confirm the effects of external applications(CLANCHE SM A Clinic) containing herbal extracts on patient with atopic dermatitis. Methods : A total of 24 patients who visited Semyung Oriental Medical Center from January 15th, 2014 to February 20th, 2014 were included in the study. In this study, the patients were treated with external applications(CLANCHE SM A Clinic) containing herbal extracts. For 4 weeks of gross examination and instrumental assesment were made before and after the study. Results : 1. In the primary endpoint, SCORAD index showed a statistically significant decline. 2. In the secondary endpoint, index of skin hydration and index of TEWL showed statistical significance. 3. In the secondary endpoint, index of skin pH showed no statistically significant result. 4. To evaluate the safety of the products for the human body, vital sign check were conducted and showed no statistically significant result. And There were no severe adverse events during this study. Therefore, it is suggested that the safety of the products, if used for certain period, should be safe for the human body. 5. In global assesment of efficacy, both experimenter and subjects evaluated external applications were effective. Conclusions : According to the above experiments, it is suggested that external applications(CLANCHE SM A Clinic) containing herbal extracts should be effective for the atopic dermatitis.

        • KCI등재

          모르타르로 인한 직업성 알레르기성 접촉성 피부염 치험 1례

          엄예진,홍철희,Eom, Ye-Jin,Hong, Chul-Hee 대한한방안이비인후피부과학회 2014 한방안이비인후피부과학회지 Vol.27 No.4

          홍반과 소양감을 주증으로 하는 모르타르로 인한 직업성 알레르기성 접촉성 피부염 환자 1례에서 한약치료, 침 치료, 약침치료 및 외치요법 등의 한방치료만으로 양호한 치료효과를 확인하여 이를 보고하는 바이다. Objectives : The purpose of this study is to report the effect of Korean medicine treatment on occupational allergic contact dermatitis caused by mortar. Methods : The patient treated by herbal medicine, acupuncture, pharmacopuncture and external therapy. The progress is evaluated by Numerical Rating Scale(NRS) and Dermatology Life Quality Index(DLQI). Results : NRS and DLQI score were significantly decreased as a result of Korean medicine treatment. Conclusions : Korean medicine treatment should be effective for the occupational allergic contact dermatitis caused by mortar. More studies are needed to confirm stability of these treatment.

        • KCI등재

          계지작약지모탕(桂枝芍藥知母湯)이 Acetic Acid에 의한 통증에 미치는 영향

          노희엽,김연섭,김도훈,Noh, Hee-Youb,Kim, Youn-Sub,Kim, Do-Hoon 대한한방안이비인후피부과학회 2016 한방안이비인후피부과학회지 Vol.29 No.3

          Objectives : We want to know the effect of Gyejakjimo-tang in mice model of acute pain.Methods : We investigated writhing reflex in mice with acetic acid-induced abdominal pain using mice, we observed c-Fos protien expression by immunohistochemistry dyeing method in the paraventricular nucleus(PVN) and supraoptic nucleus(SON) of the hypothalamus.Results : All of Gyejakjimo-tang treated group suppressed acetic acid-induced writhing response as acetic acid injuction group, but in 100㎎/㎏ Gyejakjimo-tang treated group and 200㎎/㎏ Gyejakjimo-tang treated groups represernted significance. All of Gyejakjimo-tang treated groups(50, 100 and 200㎎/㎏ Gyejakjimo-tang-treated group), Fos-positive cells in PNV significantly decreased as acetic acid injuction group, and All of Gyejakjimo-tang-treated groups Fos-positive cells in SON significantly decreased as acetic acid injuction group.Conclusions : The present results showed that the mice pre-treated with the aqueous extract of Gyejakjimo-tang showed analgesic effect on acetic acid-induced abdominal pain.

        • KCI등재

          전신소양감을 동반한 심상성 천포창 치험 1례

          이성은,윤화정,고우신,Lee, Sung-Eun,Yoon, Hwa-Jung,Ko, Woo-Shin 대한한방안이비인후피부과학회 2016 한방안이비인후피부과학회지 Vol.29 No.2

          Objectives : The purpose of this report is to know the effect of Korean medical treatments on pemphigus vulgaris with generalized pruritus. Methods : We treated a 44-years-old woman patient with pemphigus vulgaris on the whole body with Korean medicine. After Korean medical treatment for 17 weeks, we measured the extinction of blisters and decrease of pruritus. We recorded pictures of changes on symptoms. Results & Conclusions : The symptoms of pemphigus vulgaris were significantly improved. The blisters and itching were decreased and skin damages were almost recovered. Thus Korean medical treatments are effective on pemphigus vulgaris.

        • KCI등재

          중증 아토피피부염 환자 89명의 한의학적 치료 효과에 대한 후향적 연구

          조아라,한수련,박건,서산,Cho, Ah-Ra,Han, Su-Ryun,Park, Gun,Seo, San 대한한방안이비인후피부과학회 2016 한방안이비인후피부과학회지 Vol.29 No.2

          Objectives : The purpose of this study is to report the effectiveness of a Korean Medicine Treatment on 89 severe atopic dermatitis patients all through 12 months. Methods : The degree of atopic dermatitis was measured in Objective SCORAD Index (OSI) with photos of patients. Then, the OSI score was estimated according to gender, age and intensity. Results : 1. The ratio of male to female was 41.57 : 58.43. The 24.72% of patients were in 0~11 year-old group, 16.85% were in 12~18 year-old group and 58.43% were in the group above 19 years old. 2. The initial OSI score was 64.43 and the final was 37.03 after 12 months. After 3, 6, 9, 12 months, the OSI score was significantly lower than the initial visit. 3. There was no significant difference between male and female patients on age, OSI scores and OSI improvements. 4. The patients who treated acupuncture were significantly older then who not treated. The OSI improvement had no significant difference whether treated with acupuncture or not. 5. There was no significant difference among 3 different age groups on initial OSI scores. The OSI improvement of 0~11 year-old group was significantly higher than the other groups after 12 month treatment. 6. The OSI score of 97.75% was decreased after 12 month treatment compared to initial visit. 7. After 12 month treatment, the distribution of severe atopic dermatitis was decreased from 100% to 37.08%. 8. There was no significant difference betweent steroid group and non-steroid group on OSI scores at initial visit and after 12 month treatment. Conclusions : The OSI Score of severe atopic dermatitis patients was decreased on the significant rate with Korean medicine treatment for 12 months.

        • KCI등재

          수족농포증에 목초액 사용 후 발생한 자극 피부염 치험 1례

          김경한,홍지희,정훈,정현아,Kim, Kyung-Han,Hong, Jee-Hee,Jung, Hoon,Jung, Hyun-A 대한한방안이비인후피부과학회 2014 한방안이비인후피부과학회지 Vol.27 No.2

          목초액 외용 후 발생한 자극 피부염에 의한 홍반, 소양감, 통증 및 수장족저 농포증의 악화를 보인 환자에게 한방치료를 통해 유의성 있는 치료 효과를 확인할 수 있었으며 활발한 사례보고를 통해 부적절한 민간요법의 시행에 의한 폐해로부터 예방이 필요할 것으로 사료된다. Objectives : The purpose of this study is to report the oriental treatment on Irritant Dermatitis Caused by Wood Vinegar on Pustulosis Palmaris et Plantaris. Methods : After using Wood Vinegar, a patient suffers from erythema, pruritus, pain, desquamation of skin and degeneration of Pustulosis Palmaris et Plantaris. The patient was admitted to Dunsan oriental hospital for 15 days and took an oriental(venesection, herbal-medicine, and vapor treatment) treatment. To evaluate the results of this treatment, the improvement of symptoms(vesicles, pruritus, pain) was identified by patient's subjective expression and in lesion-symptom improvement. Results : The symptoms caused by Wood vinegar on both palms and soles were improved but the desquamation of skin remained. Conclusions : This study shows that the oriental medical treatment effects on the irritant dermatitis caused by Wood Vinegar. Also, the public should be aware of indiscreetly-used, natural herbal products as a folk remedy.

        • KCI등재

          한방 외용제 개발을 위한 건강한 성인 남녀 25명의 피부 특성 분석

          엄예진,홍철희,Eom, Ye-Jin,Hong, Chul-Hee 대한한방안이비인후피부과학회 2014 한방안이비인후피부과학회지 Vol.27 No.4

          Objectives : The aim of present study was to investigate the skin characteristics of twenty-five healthy Korean subjects. These results can be used as basic data for the development of future herbal applications. Methods : Skin type, hair and scalp condition, water content, sebum content were investigated through the measurement of skin conditions and subjective questionnaire survey to know the skin characteristics of subjects. Results : Most of subject has 'Dry Skin' and they have trouble about their keratin(dandruff), scalp itching, alopecia, hair texture, scalp moisture. Conclusions : More studies are needed to investigate the skin characteristics of healthy Korean subjects.

        • KCI등재

          소양인 수부 백반증 한방치험 4례

          홍요한,김성원,조영천,Hong, Yo-Han,Kim, Sung-Won,Cho, Young-Chen 대한한방안이비인후피부과학회 2015 한방안이비인후피부과학회지 Vol.28 No.1

          Purpose : This rearch aims to prove effects of an oriental medical complex therapy on vitiligo patients who have the symptoms in the hands. Method : The rearch conducted its investigation targeting these four patients who have the symptoms in the hands. The study resolved the findings through the comparison on the pictures before and after the therapy. Result : After making a comparison on the pictures, the study confirmed positive changes in the conditions of the patients. The oriental medical complex therapy turned out to be effective enough to treat the patients who have the symptoms in the hands. Conclusion : Such result leads the study to a conclusion that the oriental medical complex therapy can be an effective method to treat these patients who have the symptoms in the hands. In addition, more case studies and research will be necessary. 저자는 본 증례에서 한방치료를 통해 사지말단부인 손의 증상이 호전된 백반증 환자 증례를 경험하였기에 보고하는 바이다. 하지만 4례의 증례만으로 부족한 점이 많고 앞으로 더욱 많은 임상 증례와 연구가 필요할 것으로 사료된다.

        • KCI등재

          여드름 변증 유형 도구 개발을 위한 전문가 설문조사 연구

          신준혁,정우열,문영균,남혜정,김윤범,이준희,김규석,Shin, Jun-Hyuk,Jeong, Woo-Yeol,Moon, Young-Kyun,Nam, Hae-Jung,Kim, Yoon-Bum,Lee, Jun-Hee,Kim, Kyu-Seok 대한한방안이비인후피부과학회 2015 한방안이비인후피부과학회지 Vol.28 No.2

          Objective : The purpose of this study was to develop a Pattern Diagnosis Instrument of Acne in traditional Korean Medicine. Methods : Data was collected by structured survey papers from 20 professors of The Korean Oriental Medical Ophthalmology & Otolaryngology & Dermatology Society(Delphi method). We investigated importance rates of the symptoms of each Pattern in the survey papers, then calculated Weighted Value of the symptoms. Results : Nine objective symptoms and nine subjective symptoms were selected by investigated importance rate in the survey from 20 professors of The Korean Oriental Medical Ophthalmology & Otolaryngology & Dermatology Society. In Wind-Heat pattern(WHP, 風熱型), inflammatory lesion of acne was the most important symptom. Oily skin, nodule and effect of menstruation are the most important symptoms in Dampness-Heat pattern(DHP, 濕熱型), Phlegm-Stasis pattern(PSP, 痰瘀型) and Disharmony of the thoroughfare and conception vessels pattern(DTCVP, 衝任不調型) each. Conclusions : The results might provide backgrounds and methods for clinical care of acne and follow-up study.

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