Tropane Spirohydantoin들의 합성 및 구조분석

정대일,이도훈,송주현,이용균,최순규,박유미,한정태 동아대학교 환경문제연구소 2006 硏究報告 Vol.28 No.1

The tropane ring system is an important substructure in a number of natural products and synthetic compounds of biological and medicinal importance. As a result of the significance of the tropane ring system, the purpose of this study is the synthesis of anticonvulsant compounds of new s tructure anticipated anticonvulsant activity. After we first synthesized the various N-substituted nortropinone derivatives, we prepared new nortropane alkaloids and nortropinone derivatives. Substantially, we tried several experiments to optimize reaction condition. The tropane spirohydantoins 17, 18, 19, 20, 21 were respectively synthesized by the treatment of corresponding N-substituted nortropinone with potassium cyanide and ammonium carbonate.

Castleman 씨 병에 동반된 신유전분증

김연수,한진석,이정상,김병국,이중건,정윤철,이진학,최영진,안규리,김성권,이현순 대한내과학회 1994 대한내과학회지 Vol.46 No.2

Castlemam's disease is an asymptomatic and benign lymph node hyperplasia which is frequently manifested as mediastinal mass in over 70% of cases. Amyloidosis is rarely associated with Castleman's disease. Recently we experienced a patient with nephrotic syndrome due to renal amyloidosis who had been previously diagnosed as Castleman's disease of retroperitoneal lymph node enlargement. A 47-year old woman was admitted because of generalized edema and chest tightness. Five months ago she diagnosed as Castlman's disease-plasma cell type, of retroperitoneal lymph node enlargement. The patient was followed up through outpatient department without any specific medication. Physical examination showed pale conjunctivae, palpable mass on epigastric area and pretibial pitting edema. The hemoglobin, leukocyte count and erythrocyte sedimentation rate were 96 g/L, 5.9×109/L and 127 mm/hour, respectively. The blood urea nitogen was 3.6 mmol/L and creatinine was 88 umol/L. The urinalysis showed 3 positive for albumin. Twentyfour hour urine contained 16.6 grams of protein. A computerized tomographic (CT) scan of the abdomen disclosed multiple lymph node enlargement at mesentery. Percutaneous needle biopsy of kidney showed massive infiltration of pale pinkish amorphous material in the glomerular tuft forming large nodules. Ultrastructural examination exhibited heavy deposition of amyloid fibrils in the mesangium and perpendicular to glomerular basement membrane. Polarizing microscopy with Congo-red stain revealed prominent yellow green birefringence in glomeruli, tubules and interstitium.

제 2 형 당뇨병에서 미세혈관 합병증과 대혈관 합병증의 대비

강문호,이기영,정연실,김홍규,서찬종,송광식,박혜영,이원기 대한당뇨병학회 2001 Diabetes and Metabolism Journal Vol.25 No.2

Background: Type 2 diabetes is a heterogeneous disease. As to its complications, microangiopathy predominantly develop in some patients while macroangiopathy is more predominant in others. Therefore, this study was performed to identify the factors associated with such dissociation. Methods: Type 2 diabetic patients were classified into the macro and microangiopathy groups by carotid intima-medial thickness (IMT) and the presence of severe diabetic retinopathy. Patients with IMT ≤ 0.83 mm and severe NPDR or PDR were assigned to microangiopathy group; those with IMT 0.84 mm and no diabetic retinopathy were assigned to macroangiopathy group. Of 95 patients studied, 14 were classified as microangiopathy group and 20 as macroangiopathy group. Results: When the microangiopathy and macroangiopathy groups were compared, the microangiopathy group were significantly younger at the time of examination and at the onset of diabetes, and had longer duration of diabetes. Percentage of patients receiving insulin treatment was significantly higher and plasma C-peptide significantly lower in the microangiopathy group. However, HDL-cholesterol levels were significantly lower in the macroangiopathy group. Furthermore, the multiple logistic regression analyses revealed that younger onset of type 2 diabetes was an independent factor that was associated with the acceleration of microangiopathy. Conclusion: This study suggests that the age at onset of diabetes is an important independent risk factor that is associated with predominant development of microangiopathy in type 2 diabetic patients.

PTA 법에 의한 스텔라이트 12 합금 육성층의 조직과 경도에 미치는 전류와 예열온도의 영향

정병호,김민영,김무길,김규덕,이성열 한국열처리공학회 2000 熱處理工學會誌 Vol.13 No.4

Stellite 12 alloy-powder was overlaid on 410 stainless steel valve seat using plasma transferred arc(PTA) process. Variation of characteristic of microstructure and hardness of deposit with current(90-150A) and preheat temperature(R.T.∼400℃) was investigated. Important conclusion obtained are as follows; All welding conditions used produced a sound deposit layer with no defect in single pass welding. The maximum deposit had 4.0∼4.8㎜ in thickness and its bead width was increased with increase of current and preheat temperature. The deposit showed hypoeutectic microstruture, which was consisting of primary cobalt dendrite and networked M_7C₃type eutectic carbides. The amount of eutectic carbides was decreased and its dendritic secondary arm spacing was increased with increase of current. Hardness of the deposit was decreased with increase of current. Preheat temperature up to 400℃, however, showed little influence on the hardness and microstructure. The hardness was also influenced by diluted Fe content near the interface in addition to microstructure and dendritic secondary arm spacing. Hot hardness at 500℃ showed higher than 300HV.

변형된 트랜스듀서 및 FM을 이용한 이식형 인공중이 시스템의 전력효율 개선

윤영호,원철호,송병섭,정영숙,김명남,박세광,이상흔,조진호 경북대학교 전자기술연구소 1997 電子技術硏究誌 Vol.18 No.2

In design of implantable middle ear system, it is necessary that the system has a high power-transfer efficiency because die internal circuit of the system has no power source. The FM transmission method transfers the signal power more efficiently than AM method because AM signal has large carrier component which act as the loss. Therefore, an implantable middle ear system using FM transmission and receiving method is proposed. And the new shape of vibrating transducer which vibrate more efficiently than the conventional type was designed. This tranducer is consisted of coil and small T-type cylindrical permanent magnet. The differences between conventional methods and proposed methods are investigated and compared through quantitive analysis. The advantages of proposed methods are proved by experiments.

전남대학교병원 응급실을 통한 급성중독 실태조사

이용복,주은희,서세민,고익배,김미숙,정영녀 전남대학교 약품개발연구소 1996 약품개발연구지 Vol.4 No.1

This study was aimed to take the available informations about the acute poisoning, its prevention and therapy. This survey was accomplished with acute intoxicated patients in the ER(emergency room) of Chonnam National University Hospital during 42 months from Jan.1986 to June 1989. The intoxicated patients occupied 5.8% of total ER patients (47007 cases). The average of intoxicated patients per day in ER was 2.13. On sex analysis, males occupied 49.3% and females 50.7%. On the motive of poisoning, intoxication by accident occupied 42.1%, by suicide attempt 39.4%, and by the others 18.5%. Poisoning substances included CO poisoning(23.9%), agricultural agents (22.8%), drugs(15.4%), chemicals(14.6), bites, rodenticides and food poisoning. The mortality of intoxicated patients was 8% (216 cases) and the major death-inducing substance was paraquat(39.8%). To decrease and prevent these acute poisonings, we suggest, first, that agricultural agents and psychotropic drugs must be carefully controlled by authorities, second, the informations on the acute poisoning continuously collected, third, poison control center established as soon as possible.

기계적 합금법으로 제조된 Al-Nb 합금 및 Al-Al3Nb 복합재료 압출재의 인장 특성

김상식,박민우,정광철,안인섭,류영빈,이광민 대한금속재료학회(대한금속학회) 1999 대한금속·재료학회지 Vol.37 No.12

Tensile behavior of mechanically alloyed(MA) Al-5 wt.%Nb alloy extrusion was examined at various temperatures and strain rates. The tensile ductility of MA Al-5wt.%Nb alloy extrusion was greatly reduced with increasing temperature and/or decreasing strain rate. The SEM observations of side and fracture surfaces of tensile fractured specimens demonstrated that the overall void density formed during deformation was considerably reduced, along with the sign of decreased plasticity around the dimples on the fracture surface. To understand the effect of grain size on the deformation behavior of submicron grain sized alloys, Al-5 vol. %Al₃Nb composite extrusions with different grain sizes were fabricated and tensile tested at different temperatures. The present study confirms that the reduction in tensile ductility of submicron grain sized alloys at elevated temperatures are undoubtedly related to the grain size. Fast dynamic recovery rates, due to the lack of dislocation substructures, in submicron grain sized alloys appears to be responsible for the elevated temperature reduction in tensile ductility.

B 형 간염 Virus-Associated Hemophagocytic Syndrome 1 예

김진우,임경수,최영미,정인석,박두복,김호균,정영기 대한내과학회 1991 대한내과학회지 Vol.40 No.6

Virus-associated hemophagocytic syndrome (VAHS) is a nonneoplastic generalized histiocytic proliferation with marked hemophagocytosis associated with systemic viral infections such as Epstein-Barr virus, cytomegalovirus, adenovirus, herpes virus. etc. High fever, liver dysfunction, coagulation abnormality, and peripheral blood cytopenias are characteristic findings. Hepatosplenomegaly, lymphadenopathy, bilateral pulmonary infiltrations, and skin rash are often present. We report a case of Hepatitis B virus-associated hemophagocytic syndrome with a brief review of literature.

확률론적 안전성평가를 위한 일반 기기 신뢰도 데이타 베이스 구축 절차와 적용

김길유,김태운,정원대,황미정,임태진 한국산업안전학회 1997 한국안전학회지 Vol.12 No.4

건설중이거나 기기 이력이 부족한 원자력 발전소에 대한 확률론적 안전성평가에 사용되는 일반 기기 신뢰도 데이타를 기 개발된 일반 데이타 및 발전소 데이타를 취합하여 구한다. 이를 위해 본 논문에서 사용한 계산 Code는 모수적 선험적 베이지안 방떱에 근거하여 3단계 베이지안 방법으로 한국원자력연구소에서 개발한 MPRDP Code이다. 일반 자교원에서 주로 자료를 취합하였으므로 각 문헌들 사이에 존재할 수 있는 종속성을 고려하여 Code에서 처리하였다. 본 논문에서는 결과로 얻어진 기기 신뢰도 자료표의 일부분을 보여준다. This paper presents the development procedure and application of the generic component reliability data base considering the dependency among dependent generic compendia in NPPs (Nuclear Power Plants) PSA (Probabilistic Safety Assessment) under construction or without operating history. We use MPRDP (Multi-Purpose Reliability Data Processor) code developed in KAERI (Korea Atomic Energy Research Institute) based on a PEB (Parametric Empirical Bayesian) procedure to estimate the reliability. The employed model in this study accounts for the relative credibility as well as the dependency among generic estimates. Numerical examples and the part of summarized reliability data table are provided as the application.

차동 플로팅매스형 전자 트랜스듀서를 이용한 이식형 인공중이의 실험적 평가

송병섭,김명남,조진호,정주영,김동만,이건일 경북대학교 전자기술연구소 2001 電子技術硏究誌 Vol.22 No.2

Recently, implantable middle ear hearing system have attracted hearing impaired person's attention because it can overcome the disadvantages of conventional hearing aids such as sound distortion, sound feedback and howling effect. In this study, implantable middle ear hearing system, using DFMT(differential floating mass type) transducer that has two magnets glued with the same pole facing was evaluated by performing several experiments. The results of vibration experiments using DFMT transducer showed several advantages such as high vibration efficiency, good frequency response, minimal influencing by external magnetic flux, etc. And the results of the ABR(auditory brainstem response) test using guinea pig proved the performance of transducer in the animal's body and the possibility of clinical application of the implantable middle ear system for mild to severe hearing loss patients.