소세포 폐암의 갑상선전이 1예

장리라,최영식,박요한,문대성,김자경,김성은,최인수,유찬희,남성진 고신대학교 의과대학 2008 고신대학교 의과대학 학술지 Vol.23 No.3

Metastasis to the thyroid gland is usually considered uncommon. The most frequent sites of the primary tumor include the kidney, breast and lung. Its presence often indicates poor prognosis. Metastases represent the advanced stage of the tumors and fine needle aspiration cytology is and important way of diagnosis in thyroid metastasis. we experienced a case of Metastatic Small cell Lung Carcinoma to the Thyroid Gland. A 58-year-old man with Graves' disease diagnosed pulmonary nodule in the left upper lung field on his chest X-ray film. The patient's thyroid gland was diffusely swollen, and elastic to hard. A thyroid ultrasonography showed 1cm sized hypodense nodule on the left thyroid gland. The patient underwent a ultrasonography guided fine needle aspiration cytology of the mass. Cytological diagnosis was a metastatic small cell carcinoma. Then Chemotherapy was administered to the patient. The authors report this rare case of metastatic small cell lung carcinoma to the thyroid with literature review.

Ehlers - Danlos 증후군

주용진,최성문,최영자,성호석 ( Yoing Jin Joo,Sung Moon Choi,Young Ja Choi,Ho Suk Sung ) 대한피부과학회 1990 대한피부과학회지 Vol.28 No.5

A Case of Ehlers-Danlos syndrome Yoing Jin Joo, M.D., Sung Moon Choi, M.D., Young Ja Choi*, M.D., Ho Suk Sung, M.D. Department of Dermatology, Clooego of Medicine, Inje University, Pusan, Korea We presented a case of Ehlers-Danlos syndrome in a 25-year old female, who had hyperextensibility of skin, skin fragility, cigarette paper-like atrophic scar, joint hyperextensibility and skeletal abnormality of scoliosis since birth. There was no family history. Microscopic and electron microscopic examinations of the skin biopsy specimens from normal appearing skin on the forearm and the site of subcutaneous nodule was compatible with finding of Ehlers-Danlos syndrome. Although the manifestations of this case including marked extensibility of skin, joint, skin fraility and atrophic scar might be in accord with type Ⅰ(gravis) Ehlers-Danlos syndrome, skeletal abnormality of scoliosis did not correspond to this type, but to type Ⅳ(hydroxylysine deficient) Ehlers-Danlos syndrome. We consider this case as a type Ⅳ Ehlers-Danlos syndrome.

2003년 국내 중증급성호흡기증후군 진료 현황 및 문제점 분석

이진수,김은실,정문현,백제중,정선화,안주희,최영화,이선희,고철우,김성범,김민자,박승철,기현균,송재훈,최상호,김양수,이상오,조용균,박영훈,정숙인,김연숙,이흥범,손창희,장성희,정희진,김우주 대한감염학회 2004 감염과 화학요법 Vol.36 No.3

목적 : 2002년 말 중국에서 SARS가 발생한 이후 국내에서도 2003년 10월까지 총 3명의 추정환자, 17명의 의심환자가 보고되었다. 향후 추가적인 SARS의 유행이 우려되는 상황에서, 그간의 SARS 환자 진료에 있어서의 실질적인 준비사항, 진료 현황 등에 대한 조사를 통해 문제점을 파악하여, 향후 더 나은 대비가 될 수 있도록 개선점을 제시하고자 하였다. 재료 및 방법 : SARS로 의심되는 환자를 진료 경험이 있는 병원의료진을 대상으로 2003년 10월에 설문조사를 실시하였다. 설문에는 SARS 환자 진료 시의 실질적인 조치, 진료 현황, 병실, 응급실 및 외래에서의 격리 시설과 준비사항, 보건당국의 관리와 지원에 관한 사항을 포함하였다. 결과 : 대상이 되는 22개 병원 중 17개(17/22, 77.2%) 병원이 설문에 응하였다. SARS 환자를 위한 격리실은 응급실, 외래, 일반병실 및 중환자실에서 각각 9개(9/17, 52.9%), 5개(5/17, 29.4%), 15개(15/16, 93.7%), 4개(4/16, 25%) 병원에서 음압처리가 되어있지 않은 일인실 혹은 다인실이 사용되었고, 1개(1/16, 6.3%) 병원에서만 일반병실에서 음압격리실이 운영되었다. 입원환자의 진찰 시 개인보호구의 착용은 거의 모든 의료기관에서 이루어졌다. 보건당국에서 SARS지정병원의 시설 등을 사전에 확인한 곳은 1곳(1/12, 8.3%)이였고, 14개 병원(14/15, 93.3%)에서는 보건당국에 의뢰한 검사결과를 통하 받지 못하였다. 결론 : 의료기관에서 SARS 환자용 격리실뿐만 아니라 기존의 격리실 설비 등이 미흡하였으며, 특히 중환자실 및 외래의 준비가 더욱 부족하였다. 보건당국의 의료기관에 대한 종합적인 지원이 부족하였고, 병원과의 원활한 연계가 잘 이루어지지 않았다. SARS 만이 아닌 격리를 필요로 하는 질환의 적절한 진료를 위해 향후 병원 시설의 정비와 정부차원에서의 보다 구체적이고 실질적인 대책마련이 필요하다. Background : There was an worldwide outbreak of the Severe Acute Respiratory Syndrome (SARS) originated from China in late 2002. During that period three cases of suspected SARS and 17 cases of probable SARS were reported in Korea. With the concerns about the reemergence of SARS-coV transmission, it is important to be prepared for any possibility. So, this study is aimed to analysis the past measures in managing SARS and propose the amendatory plans to improve the preparedness. Materials & Methods : Questionnaires were collected among clinicians with any experience in managing the probable or suspected SARS cases in Oct. 2003. 17 out of 22 hospitals responded to the questionnaire. The contents in the questionnaire were practical activities, personal equipments, response plans, isolation facilities in emergency centers, outpatient clinics, general wards and intensive care units, and relationship with the public health department. Results : The dedicated isolation rooms in emergency centers, outpatient clinics, general wards, and intensive care units were prepared in 9 (9/17, 52.9%), 5 (5/17, 29.4%), 15 (15/16, 93.7%), and 4 (4/16, 25.0%) hospitals, respectively. Except for one hospital that newly made negative pressure room for SARS, single or multi-bed rooms without airborne infection control were used in all the other hospitals. The personal precaution principles were kept quite well in general wards. Before the designation of SARS hospital by the public health department prior evalution to see if the hospital was suitable for managing SARS was conducted in only 1 (1/12, 8.3%) hospital. The results of laboratory diagnosis were reported back in 1 (1/15, 6.6%) hospital. Conclusions : The isolation facilities which can control airborne infection were almost deficient not only for SARS but also for other respiratory transmissible diseases. For the infection control of transmissible diseases including SARS, more investment is needed on medical facilities and comprehensive support from the public health department required.

충남대학교병원 마취발전의 경향에 관한 분석 : 1967년부터 - 1996년까지 from 1967 to 1996

최세진,김상수,정규돈,윤석화,신용섭,손수창,이원형,김혜자,이정은 충남대학교 의과대학 지역사회의학연구소 1998 충남의대잡지 Vol.25 No.2

To evaluate the specificity and historical trends of the anesthesia in Chungnam National University Hospital, anesthetic experiences of 83,572 in total performed at Chungnam National University Hospital from January 1967 to December 1996 were analyzed statistically and clinically according to age, sex, surgical department, physical status, elective and emergency surgery, premedicants, IV anesthetics, anesthetic methods, inhalational anesthetics, muscle relaxants. The results were as follows : 1. The number of cases has been steadily increased year by year. 2. The ratio of male to female was 52.8% : 47.2%. 3. According to the age, There were 44,905 cases (54%) in the group of 13-45 years. 4. According to the ASA classification of physical status, most of the cases were belonged to the class 1 & 2 (72.5%). 5. The ratio of elective to emergency was 79.4% to 20.6%. 6. Recently, glycopyrrolate has been used increasingly. 7. Thiopental sodium has been mainly used for intravenous induction agent. 8. General anesthesia has been used mainly. 9. Enflurane is the most common inhalational anesthetic agent. but Isoflurane has been used increasingly. 10. Most of muscle relaxants are Pancuronium & Vecuronium(84.5%).

시토크롬 C의 전기화학반응에 있어서 프로모터와 전해질과의 영향

최광재,조홍식,이행자,장상목,김영한 동아대학교 환경문제연구소 1999 硏究報告 Vol.22 No.1

The electrochemical reaction of cytochrome C varied with promotors and electrolytes. Among electron transfer carriers, 4-4' bipyridine(PyPy) showed good redox response using 20 mM phosphate solution as electrolyte and the case of Bis(4 pyridyl) bisulphide(PySSPy) as promotor showed same result using 0.2M Sodium cacodylate as electrolyte tested cyclic voltammetry method. Between electrodes, Au electrode is better behaviour than ITO electrode. 0.21M Tris, 0.24M Cacodylate acid showed the most effective electrochemical characteristics as electrolyte.

一部 農村地域 住民의 여름철 營養攝取狀態에 대한 調査

崔京子,宋東彬,李幸子,李成東 高麗大學校 倂設 保健大學 保健科學硏究所 1985 保健科學論集 Vol.14 No.1

In order to obtain basic information on nutrient intake of residents in rural community during the summer that can be used as reference material for making health policy in the future, a three day survey has been conducted at Jeomdong-Myun, Yeoju-Gun, Kyunggi province which is the pilot project area for the project implemented by the Community Health Development Committee, Korea University. The sample size was 46 households and the major findings were as follows; 1. The number of foods they were taking totalled 16 categories and 152 kinds. 2. Average amount of daily intake was 1,124 grams per person of which 93% was vegetable food, and animal food occupied only 7%. Amongst the animal foods, the intake amount of fishes and milk was lower than the national average. 3. The nutrient intake except fatty substance and calcium, namely protein, carbohydrate, phosphorus, iron and vitamines, was exceeding the recommended daily allowance for adult. The same fact was also found in terms of the total calorie intake. 4. The problems on the nutrient intake arisen from the study in this area were; a. The proportion of animal protein occupies 24% of the total protein intake whereas the national average of rural community stood at between 32.5%∼33.5% as a results of 1981∼1984 National Nurition survey. b. Insufficient intake of fat and oil, and c. Calcium intake occupies only 72% of the recommended daily allowance and 84.5% of the calcium intake was depending upon vegetable, which has a low absorbability. As described above, the intake of animal protein, fatty substance and calcium was low because of the high dependency on vegetable food in this community.

Diammonium Acetyl Phosphate의 합성에 관한 연구

崔聖澔,金秀子 慶熙大學校 1989 論文集 Vol.18 No.-

Acetyl phosphate (diammonium salt) as a terminal phosphate donor of ATP regenerating system was synthesized by acetylation of 100% phosphoric acid followed by the reaction with saturated NH_3-CH_5OH solution. The yield of acetyl phosphate (diammonium salt) was 90% and the purity was 85% by the enzymatic determination. The optimum condition for synthesis is 0℃, 90 mm reaction, acetic anhydride: phosphoric acid molar ratio of 2:1 and ethylacetate as solvent.

타액선 세포에서 내인성 산화질소에 의한 칼슘유입 조절기전

최경자,정성수 전남대학교 치과대학 1996 전남치대논문집 Vol.8 No.1

Nitric oxide (NO) has been known to function as a cellular signaling messenger in various tissues and organs. The present study was aimed to investigate whether the regulatory mechanisms of calcium influx are mediated by the endogenous NO in submaxillary acinar cells. Effects of agents which stimulate or inhibit the NO-cGMP pathway on the calcium influx and potassium efflux were examined in submaxillary cells of the rat in vitro. 1) In the submandibular slices, carbachol (10^-5 mol/L) increased the NO_2 contents, which was prevented by pretreatment with L-NAME. 2) In the submandibular slices, K^+ efflux in response to carbachol (10^-5 mol/L) was significantly inhibited by pretreatment with L-NAME (10^-4 mol/L) which was attenuated by L-arginine (10^-5 mol/L). 3) L-NAME (10^-4 mol/L) did not affect the transient K^+ efflux in response to carbachol (10^-5 mol/L), but decreased the sustained K^+ efflux. 4) In the isolated submandibular acini, calcium influx by carbachol (10^-5 mol/L) was reduced by L-NAME or L-NMA. 5) In the isolated submandibular acini, calcium influx induced by sodium nitroprusside (10^-6 mol/L) was attenuated by pretreatment with hemoglobin (10^-4 mol/L) or methylene blue (10^-4 mol/L). 6) Calcium influx by 8-Br-cGMP (10^-4 mol/L) was inhibited by H8, (10^-4 mol/L). 7) Calcium influx by 8-Br-cGMP was not affected by nifedipine or verapamil (10^-5 mol/L) but was slightly decreased by reduction of extracellular sodium concentration. These results suggest that endogenous NO stimulates Ca^2+ influx through activating a cGMP-dependent protein kinase-activated nonselective cation channel in submandibular acinar cells.

튀김 기름의 저장 기간에 따른 향신료 및 허브류 첨가에 의한 항산화 효과 `

최은미,윤혜경,윤기주,구성자 동아시아식생활학회 2000 동아시아식생활학회지 Vol.10 No.4

The effect of heated oil on human nutrition has recently become of great interest to nutritionists and food chemists, However, the detrimental effect of heated oil has been hardly studied extensively and many problems have still remained unsolved. This study was carried out to investigate the storage stability of the heated oils at room temperature (25±5℃), with the variation in storage conditions (addition of spices and herbs) for 7 weeks period. The rancidity of the oils according to storage time and condition was measured and compared with TBA, ferric thiocyanate, and DPPH method. For fresh oil, when stored for 7 weeks at room temperature, there was no significant change in the degree of oxidation. But for the heated oil with frying materials, the degree of oxidation significantly increased at 5 weeks(p<0.05), When stored with spices and herbs, the degree of oxidation significantly decreased with storage period(p<0,05), Antioxidative activity of herbs, especially sage group was higher than that of any other group.

물세척법에 의한 결장루관리 실태에 관한 조사

최상경,박희자,김채숙,서문숙 대한대장항문학회 1992 Annals of Coloproctolgy Vol.8 No.2