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Vecuronium에 의한 기관내 삽관시 안압 및 심맥관계에 미치는 영향
신용섭,이정은,최세진 충남대학교 의과대학 지역사회의학연구소 1988 충남의대잡지 Vol.15 No.1
The effects of muscle relaxants(vecuronium, pancuronium, d-tubocurarine, and succinylcholine) for endotracheal intubation on intraocular pressure, blood pressure, heart rate, and arrhythmia were studied in 60 patients undergoing general anesthesia, The patients were divided into 4 groups : vecuronium group (0. 1 mg/kg), pancuronium group (0.08 mg/kg), d-tubocurarine group(0.4 mg/kg), and succinylcholine group(1 mg/kg) according to be administrated. Before induction of anesthesia, initial measurement of intraocular pressure (control value) was taken with Schiotz tonometer after instilling of a 0. 5% pontocaine on conjunctival sac. Subsequent measurement were undertaken as soon as the lid reflex was lost after thiopental sodium injection and then at 75-100% depression of first twitch height of train-of-four after intravenous administration of muscle relaxants. It was measured at 1, 3, 5, 10 minutes after endotracheal intubation too. Blood pressure (systolic and diastolic), heart rate, and ECG abnormalities were observed in all cases. The results were as follows; 1. After thiopental sodium injection, intraocular pressure(IOP) decreased than the control value. 2. At 70-100% depression of first twitch height, IOP decreaeed significantly in vecuronium, pancuronium and d-tubocurarine group, but increased significantly in succinylcholine group than the control value. 3. After 1 minute of endotracheal intubation, IOP increased in all groups. There was no stastistical significance in vecuronium group compared with the control value. 4. After 3 minutes of endotracheal intubation, IOP decreased in all groups. 5. The changes of systolic and diastolic blood pressure and heart rate in vecuronium group were the smallest value among all groups. 6. There was no arrythmia in vecurouium group.
Morphine투여시 Fentanyl, Clonidine과의 병용과 투여시기가 수술 후 통증에 미치는 영향
신용섭 충남대학교 의과대학 지역사회의학연구소 1996 충남의대잡지 Vol.23 No.2
The spinal surgical patients were randomly assigned to two groups. One group received fentanyl(3㎍/kg) intravenously during general anesthetic induction, continuous morphine(l.0mg/hr) infusion through the patient-controlled analgesia(PCA) infusion system and a bolus dose of clonidine(3㎍/kg). Another group received a bolus intravenous morphine O.lmg/kg at immediately before the skin closure. Anesthesia was maintained with 50% of nitrous oxide and enflurane or isoflurane in oxygen. Both group received continuous intravenous morphine through the PCA infusion pump(infusion rate 0.5mg/hour, bolus dose 1.0mg) in the postoperative period for 48 hours after operation. Pain scores on Visual Analogue Scale were assessed 1, 2, 6, 24 and 48hour after surgery. There was significant difference between the two groups in VAS at only 1 hour after surgery. In conclusion, intravenous fentanyl administration during tie induction, intraoperative continuous intravenous morphine infusion and sngle dose of intravenous clonidine were effective in reducing postoperative pair immediately after surgery. However, further investigations with regard to of optimization of the agents used, their combination and timing of administration will be necessary.
신용섭 경성대학교 환경문제연구소 2000 環境硏報 Vol.10 No.1
The minimum fluidization velocities of sand/polystryrene mixture in a fluidized bed were measured according to variation of mixing ratio. Particle concentration distributions in the bed were also measured with mixing ratio and superficial air velocity. The mixing index was defined and calculated from the measured particle concentration distribution. As mixing ratio of the sand was increased, voidage of the fixed bed showed trend of concave curve and voidages at minimum fluidization conditions also behaved as those of fixed bed. Based on the measured results, it could be concluded that the minimum fluidization velocities were determined by the components which had high mixing ratio. It was also evident that sand particle took a role of jetsam and polystyrene particle took a role of floatsam and their behavior were independent of mixing ratio and superficial air velocity. As mixing ratio and superficial air velocity were increased, particle concentration distribution in the middle section of the bed was improved. However, particle concentration distributions near the bottom of the bed and especially, near the top section were not improved. The mixing index of the bed was increased with the excess air velocity.
신용섭 충남대학교 의과대학 지역사회의학연구소 1997 충남의대잡지 Vol.24 No.2
This study was designed to compare the incidence and frequency of hypotension and vasopressor therapy after epidural anesthesia and crystalloid, colloid and no prehydration in the elderly patents. Forty-five ASA GRADE 1 or 2 patients, aged 60 years of over, scheduled for orthopedic surgery under epidural anesthesia were randomized to one of three groups. Group 1 received 500 ml crystalloid solution(lactated Ringer's solution), group 2 received 500 ml colloid(6% hydroxyethyl starch) and group 3 received no prehydration over 15 minute prior to epidural anesthesia. Hypotension was defined as 30% decreased form baseline systolic blood pressure of systolic less than 90 mmHg, and was treated with ephedrine 5 mg boluses. The incidence of hypotension was not significantly different between the groups. The incidence of ephdrine use, incidence of nausea/vomiting and median total dose of ephedrine were not significantly different between the groups. The study has demonstrated that, in elderly patients, administration of crystalloid or colloid before epidural anesthesia did not decrease the incidence of degree of hypotension of need for vasopressor therapy compared with withholding prehydration.
Midazolam의 투여가 전신마취시 혈중 Glucose 측정치에 미치는 영향
신용섭 충남대학교 의과대학 지역사회의학연구소 1992 충남의대잡지 Vol.19 No.2
This study examined the effects of midazolam on circulating concentrations of blood glucose and cardiovascular response and compaired with a comparable group of patients receiving thiopental as induction agent only. Twenty patients of ASA class 1 were randomly allocated to Control or Midazolam group. Blood glucose level in reponse to anesthesia and surgery were comparable in the two groups of patients. The use of midazolam as premedicant (0.05 mg/kg, intramuscularly) and intravenous induction agent (0.3 mg/kg) was not associated with significant increase in blood glucose and mean arterial pressure.