Tropane Spirohydantoin들의 합성 및 구조분석

정대일,이도훈,송주현,이용균,최순규,박유미,한정태 동아대학교 환경문제연구소 2006 硏究報告 Vol.28 No.1

The tropane ring system is an important substructure in a number of natural products and synthetic compounds of biological and medicinal importance. As a result of the significance of the tropane ring system, the purpose of this study is the synthesis of anticonvulsant compounds of new s tructure anticipated anticonvulsant activity. After we first synthesized the various N-substituted nortropinone derivatives, we prepared new nortropane alkaloids and nortropinone derivatives. Substantially, we tried several experiments to optimize reaction condition. The tropane spirohydantoins 17, 18, 19, 20, 21 were respectively synthesized by the treatment of corresponding N-substituted nortropinone with potassium cyanide and ammonium carbonate.

Castleman 씨 병에 동반된 신유전분증

김연수,한진석,이정상,김병국,이중건,정윤철,이진학,최영진,안규리,김성권,이현순 대한내과학회 1994 대한내과학회지 Vol.46 No.2

Castlemam's disease is an asymptomatic and benign lymph node hyperplasia which is frequently manifested as mediastinal mass in over 70% of cases. Amyloidosis is rarely associated with Castleman's disease. Recently we experienced a patient with nephrotic syndrome due to renal amyloidosis who had been previously diagnosed as Castleman's disease of retroperitoneal lymph node enlargement. A 47-year old woman was admitted because of generalized edema and chest tightness. Five months ago she diagnosed as Castlman's disease-plasma cell type, of retroperitoneal lymph node enlargement. The patient was followed up through outpatient department without any specific medication. Physical examination showed pale conjunctivae, palpable mass on epigastric area and pretibial pitting edema. The hemoglobin, leukocyte count and erythrocyte sedimentation rate were 96 g/L, 5.9×109/L and 127 mm/hour, respectively. The blood urea nitogen was 3.6 mmol/L and creatinine was 88 umol/L. The urinalysis showed 3 positive for albumin. Twentyfour hour urine contained 16.6 grams of protein. A computerized tomographic (CT) scan of the abdomen disclosed multiple lymph node enlargement at mesentery. Percutaneous needle biopsy of kidney showed massive infiltration of pale pinkish amorphous material in the glomerular tuft forming large nodules. Ultrastructural examination exhibited heavy deposition of amyloid fibrils in the mesangium and perpendicular to glomerular basement membrane. Polarizing microscopy with Congo-red stain revealed prominent yellow green birefringence in glomeruli, tubules and interstitium.

플라즈마질화 및 침질탄화처리한 탄소강의 경도와 내마모특성

정병호,이재식,김무길,박화순,이병찬,신성하 한국열처리공학회 1999 熱處理工學會誌 Vol.12 No.2

Commercial carbon steels containing 0.2∼0.55wt.%C were plasma-nitrided or plasma nitrocarburized at 550℃ for 21.6Ks using H₂-N₂or H₂-N₂-CO mixed gas respectively. The characteristics of hardening and wear-resistance of each treatment were studied and compared. And also microstructure of nitrided layer and nitrides formed in compound layer near surface were studied. All plasma-nitrided steels investigated showed remarkable increase of surface hardness with the increase of carbon content. But nitrocarburized steels resulted in higher surface-hardness than plasma-nitrided steels, which means that nitrocarburized has higher surface-hardening effect. Plasma-nitrided steels showed hardness increase in through-thickness direction near surface. And also nitrocarburized steels showed similar hardness distribution in through-thickness direction to that of plasma-nitrided steel. However, nitrocarburized steels had higher cross-sectional maximum-hardness than plasma-nitrided steels as much as 100Hv. Wear test showed that the amount of specific wear was reduced by both plasma-nitriding and nitrocarburized, showing that the amount of specific wear was not related to the hardness. But non-treated specimen showed that the amount of specific wear was related to the hardness.

B 형 간염 Virus-Associated Hemophagocytic Syndrome 1 예

김진우,임경수,최영미,정인석,박두복,김호균,정영기 대한내과학회 1991 대한내과학회지 Vol.40 No.6

Virus-associated hemophagocytic syndrome (VAHS) is a nonneoplastic generalized histiocytic proliferation with marked hemophagocytosis associated with systemic viral infections such as Epstein-Barr virus, cytomegalovirus, adenovirus, herpes virus. etc. High fever, liver dysfunction, coagulation abnormality, and peripheral blood cytopenias are characteristic findings. Hepatosplenomegaly, lymphadenopathy, bilateral pulmonary infiltrations, and skin rash are often present. We report a case of Hepatitis B virus-associated hemophagocytic syndrome with a brief review of literature.

변형된 트랜스듀서 및 FM을 이용한 이식형 인공중이 시스템의 전력효율 개선

윤영호,원철호,송병섭,정영숙,김명남,박세광,이상흔,조진호 경북대학교 전자기술연구소 1997 電子技術硏究誌 Vol.18 No.2

In design of implantable middle ear system, it is necessary that the system has a high power-transfer efficiency because die internal circuit of the system has no power source. The FM transmission method transfers the signal power more efficiently than AM method because AM signal has large carrier component which act as the loss. Therefore, an implantable middle ear system using FM transmission and receiving method is proposed. And the new shape of vibrating transducer which vibrate more efficiently than the conventional type was designed. This tranducer is consisted of coil and small T-type cylindrical permanent magnet. The differences between conventional methods and proposed methods are investigated and compared through quantitive analysis. The advantages of proposed methods are proved by experiments.

제 2 형 당뇨병에서 미세혈관 합병증과 대혈관 합병증의 대비

강문호,이기영,정연실,김홍규,서찬종,송광식,박혜영,이원기 대한당뇨병학회 2001 Diabetes and Metabolism Journal Vol.25 No.2

Background: Type 2 diabetes is a heterogeneous disease. As to its complications, microangiopathy predominantly develop in some patients while macroangiopathy is more predominant in others. Therefore, this study was performed to identify the factors associated with such dissociation. Methods: Type 2 diabetic patients were classified into the macro and microangiopathy groups by carotid intima-medial thickness (IMT) and the presence of severe diabetic retinopathy. Patients with IMT ≤ 0.83 mm and severe NPDR or PDR were assigned to microangiopathy group; those with IMT 0.84 mm and no diabetic retinopathy were assigned to macroangiopathy group. Of 95 patients studied, 14 were classified as microangiopathy group and 20 as macroangiopathy group. Results: When the microangiopathy and macroangiopathy groups were compared, the microangiopathy group were significantly younger at the time of examination and at the onset of diabetes, and had longer duration of diabetes. Percentage of patients receiving insulin treatment was significantly higher and plasma C-peptide significantly lower in the microangiopathy group. However, HDL-cholesterol levels were significantly lower in the macroangiopathy group. Furthermore, the multiple logistic regression analyses revealed that younger onset of type 2 diabetes was an independent factor that was associated with the acceleration of microangiopathy. Conclusion: This study suggests that the age at onset of diabetes is an important independent risk factor that is associated with predominant development of microangiopathy in type 2 diabetic patients.

최대운동시 항산화제 투여와 운동처지가 대사 및 근피로도에 미치는 영향

정성태,정덕조,전태원,최명동,이왕록 한국운동과학회 2000 운동과학 Vol.9 No.1

최대운동시 항산화제 투여와 운동처치가 대사 및 근피로도에 미치는 영향. 운동과학, 제 9권 제 1호. (137)-(148), 2000. 본 연구는 6주간의 항산화제 투여와 운동처치가 대사반응 및 하지근육의 근 피로도에 미치는 영향을 규명하는 것이었다. 본 연구의 목적을 달성하기 위하여 중학교 학생 27명을 대상으로 6주간의 항산화제 투여(비타민 E+C, 위약)와 운동처치(처치집단, 통제집단)를 실시하였다. 이상의 연구 절차를 통해 얻은 연구결과는 다음과 같다. 첫째, 6주간의 항산화제 투여(비타민 E+C, 위약)와 운동처치(처치집단, 통제집단)를 실시한 후, 각 집단간 운동지속시간을 비교한 결과는 항산화제를 투여한 집단에서 위약을 투여한 집단에 비해서 통계적으로 유의한 차이를 나타내었다(P<0.05). 둘째, 6주간의 합산화제 투여(비타민 E+C, 위약)와 운동처치(처치집단, 통제집단)를 실시한 후, 각 집단간 최대산소섭취량을 비교한 결과는 항산화제를 투여한 집단에서 위약을 투여한 집단에 비해서 통계적으로 유의한 차이를 나타내었다(P<0.05). 세째, 6주간의 항산화제투여(비타민 E+C, 위약)와 운동처치(처치집단, 통제집단)를 실시한 후, 각 집단간 근피로도(평균파워주파수)을 비교하였다. 각 집단간 평균파워주파수는 통계적으로 유의한 차이는 없었다. 이상의 결론을 종합해보면, 항산화 비타민 복합섭취는 운동수행력에 있어서 약간의 효과가 있는 것으로 나타났으나, 좀 더 정확한 결론을 내리기 위해서는 세포수준에서의 세일한 측정과 연구가 더 필요할 것이라고 제안한다.

확률론적 안전성평가를 위한 일반 기기 신뢰도 데이타 베이스 구축 절차와 적용

김길유,김태운,정원대,황미정,임태진 한국산업안전학회 1997 한국안전학회지 Vol.12 No.4

건설중이거나 기기 이력이 부족한 원자력 발전소에 대한 확률론적 안전성평가에 사용되는 일반 기기 신뢰도 데이타를 기 개발된 일반 데이타 및 발전소 데이타를 취합하여 구한다. 이를 위해 본 논문에서 사용한 계산 Code는 모수적 선험적 베이지안 방떱에 근거하여 3단계 베이지안 방법으로 한국원자력연구소에서 개발한 MPRDP Code이다. 일반 자교원에서 주로 자료를 취합하였으므로 각 문헌들 사이에 존재할 수 있는 종속성을 고려하여 Code에서 처리하였다. 본 논문에서는 결과로 얻어진 기기 신뢰도 자료표의 일부분을 보여준다. This paper presents the development procedure and application of the generic component reliability data base considering the dependency among dependent generic compendia in NPPs (Nuclear Power Plants) PSA (Probabilistic Safety Assessment) under construction or without operating history. We use MPRDP (Multi-Purpose Reliability Data Processor) code developed in KAERI (Korea Atomic Energy Research Institute) based on a PEB (Parametric Empirical Bayesian) procedure to estimate the reliability. The employed model in this study accounts for the relative credibility as well as the dependency among generic estimates. Numerical examples and the part of summarized reliability data table are provided as the application.

차동 플로팅매스형 전자 트랜스듀서를 이용한 이식형 인공중이의 실험적 평가

송병섭,김명남,조진호,정주영,김동만,이건일 경북대학교 전자기술연구소 2001 電子技術硏究誌 Vol.22 No.2

Recently, implantable middle ear hearing system have attracted hearing impaired person's attention because it can overcome the disadvantages of conventional hearing aids such as sound distortion, sound feedback and howling effect. In this study, implantable middle ear hearing system, using DFMT(differential floating mass type) transducer that has two magnets glued with the same pole facing was evaluated by performing several experiments. The results of vibration experiments using DFMT transducer showed several advantages such as high vibration efficiency, good frequency response, minimal influencing by external magnetic flux, etc. And the results of the ABR(auditory brainstem response) test using guinea pig proved the performance of transducer in the animal's body and the possibility of clinical application of the implantable middle ear system for mild to severe hearing loss patients.

당뇨병 환자에서 발생한 감염증의 임상적 고찰

김형길,이상용,안혜진,박찬근,방규태,정동균,최조영 대한당뇨병학회 1990 Diabetes and Metabolism Journal Vol.14 No.2