항정신병약물 사용 중인 정신분열병 환자에서 올란자판으로의 교체 방법에 관한 연구(II) : Comparison of Safety 안전성 비교

안용민,권용실,권준수,민성호,박두병,양문정,소형석,송종호,신윤식,우행원,유범희,이홍석,정한용,한창환,김용식 大韓神經精神醫學會 2002 신경정신의학 Vol.41 No.5

연구목적: 이 다기관 공동임상연구는 사용 중인 항정신병약물을 ’직접 교체 방법’또는 ’시작-감량 교체 방법’중 한 가지 방법으로 올란자핀으로 교체한 후, 안정성 측면에서 두 교체 방법 간의 비교와 교체후의 변화를 관찰하기 위한 것이다. 방법: 국내 13개 병원의 입원 및 외래에 내원한 환자들 중 ICD-10 지단기준으로 정신분열병에 해당되며, 임상적으로 항정신병약물 교체가 필요한 환자를 대상으로 하였다. 두 가지 교체 방법 중 한 가지를 무작위로 피험자에 적용하였으며, ’직접 교체 방법’에 배정된 경우에는 사용중인 항정신병약물을 일시에 중단하고 10㎎의 올란자핀을 바로 투여하였고, ’시작-감량 교체 방법’에 배정된 경우는 10㎎의 올란자핀 투여하고 2주에 걸쳐서 기존 약물을 감량하여 중단하였다. 올란자핀 사용기간은 총 6주이며, 용량은 5∼20㎎ 범위로 제한하였다. 한정성 평가를 위해서 체중, 생명징후, 자발적인 이상반응 복, 실험실 검사 그리고 Simpson-Angus Scale(SAS), Barnes akathisia rating scale(BARS), Abnormal involuntary movement scale(AIMS). Liverpool University neuroleptic side effect rating scale(LUNSERS)등을 이용하였다. 결과: 총 103명의 정신분열병 환자를 대상으로 하였다. 사용한 올란자핀의 용량, 벤조디아제핀의 병용률, 탈락률과 탈락 사유, 자발적인 이상반응 보고, 생명징후, 실험실 검사 그리고 대부분의 부작용 척도 상에서 임상적으로 의미 있는 차이를 두 교체 방법간에 발견하지 못하였다. 다만 AIMS의 감소는 ’직접 교체 방법’군에서 보다 적었고, 항콜린제의 병용률은 ’시작-감량 교체 방법’군에서 보다 많았다. 기저 상태에서 전체 피험자의 SAS와 BARS 점수는 각각 3.5점과 1.8점이었으며 70% 이상의 피험자가 고프로락틴 혈증을 보였다. 올란자핀으로 교체한 후, SAS, BARS, AIMS 점수의 유의한 감소가 있었으며 고프로락틴 혈증을 보인 피험자 분율도 약 30%이하로 감소하였다. 그러나 교체 방법과 상관없이 올란자핀 교체 후 유의한 체중 증가가 있었다. 결론: 이 연구를 통해 교체 방법에 관계없이 비교적 안전하고 용이하게 올란자핀으로 교체 할 수 있음을 알 수 있었다. 그리고 기존 항정신병약물을 올란자핀으로 교체함으로써 일부 부작용들을 줄일 수 있음을 간접적으로 관찰할 수 있었다. 하지만 이 연구는 여러 제한점과 문제점을 지니고 있기 때문에 보다 체계적인 연구를 통해 검정이 필요하리라 생각된다. Objectives: This multicenter clinical trial involving 13 hospital sites compared the safely of switching to olanzapine between ’direct switching method’ and ’start-tapering switching method’. Method: This study included both inpatients and outpatients who fulfilled the criteria for schizophrenia as defined in the ICD-10, and were in need to be appropriate for switching antipsychotics. Subjects were randomly assigned to one of the two switching methods. For ’direct switching method’group, previous antipsychotics were abruptly discontinued and 10㎎ of olanzapine was administered, and previous antipsychotics was gradually tapered for 2 weeks. Olanzapine was used for 6 weeks and the dose was adjusted within the range of 5-20㎎. The safety of switching to olanzapine was measured with vital sings including body weight, adverse events reported spontaneously, laboratory tests, and various scales such as Simpson-Angus Scale(SAS), Barnes Akathisia Rating Scale(BARS). Abnormal Involuntary Movement Scale(AIMS), and Liverpool University Neuroleptic Side Effect Rating Scale(LUNSERS). Results: 103 patients were switched to olanzapine in this study. The comparison between two switching methods did not show any significant difference in the dosage of olanzapine used, the concomitant use of benzodiazepine, the rate and reasons of drop-out, the adverse events, vital signs, laboratory tests, and most scales for measuring side-effects. However, the decrease in AIMS scores was significantly lower in ’direct switching method’ group, and the concomitant use of anticholinergics was comparatively greater in ’start-tapering switching method’ group. At baseline, SAS and BARS scores were 3.5 and 1.8 points respectively, and more than 70% of the subjects showed hyperprolactinemia. After switching to olanzapine, SAS, BARS, and AIMS scores were significantly decreased and the proportion of the patients with hyperprolactinemia was also decreased to less than 30%. However significant weight gain after the treatment of olanzapine was observed regardless of switching method. Conclusion: This study may suggest that switching to olanzapine can be done with relatively high safety regardless of switching methods and olanzapine can significantly decrease some side-effects induced by other antipsychotics.

산소 소모법에 의한 액체 연료의 열발생율 평가

한용식,김명배,최준석 韓國火災ㆍ消防學會 1998 한국화재소방학회논문지 Vol.12 No.3

액체연료들의 열발생율이 산소 소모법에 의해 측정되었다. 산소 소모법은 화재 시에 경험되어지는 대부분의 연료에 대해서 소모된 산소단위 질량당 발생된 열량이 근사적으로 같다는 원리에 기초하고 있다. 산소농도의 측정에는 상자성 방식의 가스 분석기가 사용되었고, CO_2 및 CO가스 농도 측정은 적외선 방식의 분석기에 의해 이루어졌다. 가스 분석기들의 시간지연은 고려하지 않았다. 배기가스 측정방법에 따른 결과들을 비교 검토하였다. The heat release rate of liquid fuels is estimated by oxygen consumption technique. This method is based on the generalization that the heat release rate of combustion per unit of oxygen consumed are approximately the same for most fuels commonly encountered in fires. The oxygen concentration is measured by analyzer of paramagnetic type. The concentrations of CO_2 and CO gas are measured by analyzer of Infra-Red type. Time delays of analyzers are ignored. Results acqired from measuring techniques of exhaust gas concentrations are compared with each other.

인체 방광암에서 p33^ING1의 발현 변화

이석영,신관희,한광희,이상철,김용태,김원재 大韓泌尿器科學會 2001 Korean Journal of Urology Vol.42 No.7

감성돔, Acanthopagrus schlegeli의 종묘생산 및 성분화에 미치는 영향

한종석,김용구,라성주,윤호섭,이원교,김정,최상덕 國立 麗水大學校 環境問題硏究所 2002 環境硏究論文集 Vol.5 No.-

This study was carried out to produce the seeding of the larvae and juvenile of black sea bream, Acanthopagrus schlegeli in terms of artificial hatching, feeding behavior and growth rate in each factor. Total length of black sea bream larvae hatched was 2.57±0.35mm and after 50 days, total length was 22.08±3.74mm, 49.7% in survival rate. This research was conduced to confirm the effect of tributyltin and 2,4-dinitrophenol on the sex differentiation in Black Sea bream, Acanthopagrus schlegeli. Fish were reared of oral administration of tributyltin at 0.05, 0.5, 5㎍/g and 2,4-dinitrophenol at nominak concentration of 0.05, 0.5, 5, 50㎍/g diet from 156 days to 185 days after hatching. In the process of the differentiation until 156 days after hatching, gonads were composed testis. In contrast, 185 days after hatching, testis were composed of a number of spermatogonia and sperm duct. The female in the control in which sex differentiation of Acanthopagrus schlegeil was normally conducted was 100%. The experimental unit of estradiol-17β, it was 100% in 0.05㎍/g diet concentration, which was similar to the sex ratio of the control. And it was 100% in 0.5㎍/g diet concentration. In each experimental unit with 5, 50㎍/g diet concentrations, every individuals of them differentiated to males. About the experimental unit of tributyltin, the females were 100%, 100%, 100%, 100% and 100% in 0.05㎍/g, 0.5,㎍/g, 5㎍/g and 50㎍/g diet concentrations, respectively. About the experimental unit of 2,4-dinitrophenol, the males were 100% tn 0.05, 0.5, 5, 50㎍/g diet concentrations, respectively.

社會體育 活動의 滿足度 評價

한이석,신용업 龍仁大學校 1991 용인대학교 논문집 Vol.7 No.-

The purpose of this study was to examine and explicate the concept of Recreation satisfaction and to describe the development and adequacy of an instrument to measure it. Examination of the concept of Recreation satisfaction is relatively new and research reports on the topic only recently have begun to appear fine the literature. yet, despite the recent and increasingly frequent research efforts, knowledge of this subject remains limited. A major goal of recreation services and Leisure service is to contribute to individuals' satisfaction and pursuit of happiness. In addition, researchers have expressed the importance of Recreation as an aid in the process of "need gratification". However, the research of Recreation satisfaction as a concept has had little attention. Recreation satisfaction, therefore, appears to be a potentially important concept for Recreation researchers as well as practitioners.

직업적 연폭로에서 혈중 연량 수준에 따른 선별검사로서의 혈중 ZPP 검사의 타당도

한구석,안현철,김용배,리갑수,김화성,황규윤,장봉기,이성수,안규동,이병국 순천향대학교 산업의학연구소 1999 순천향산업의학 Vol.5 No.1

In order to evaluate the validity of current screening criteria of lead exposure and to provide effective information for the better health management of lead workers, author investigated the interrelationship between blood lead and blood zinc protoporphyrin(ZPP) and evaluate the validity of blood zinc protoporphyrin as the screening test and blood lead as gold standard of diagnostic test. The total of 2245 lead workers (male workers: 1982, female workers : 263) from 12 lead using industries were studied. Blood lead, ZPP, hemoglobin and hematocrit were selected as lead exposure variables. Personal information on sex, age and work duration were also checked. Blood lead was measured with flameless atomic absorption spectrometry (model: Hitachi 8100) using standard addition method. Blood ZPP was measured with portable hematoflurometer (model: Aviv 206). The results obtained were as follows: 1. The mean blood lead of all lead workers were 0.7±14.3㎍/㎗(Male: 31.0±14.4㎍/㎗, Female: 28.2±12.9㎍/㎗), whereas the mean blood ZPP of those were 68.1±47.5㎍/㎗(Male: 63.9±43.7㎍/㎗, Female: 100.1±61.0㎍/㎗). The mean value of hemoglobin and hematocrit of all lead workers were 14.5±1.5g/㎗(Male: 14.7±1.3g/㎗, Female: 12.3±1.2g/㎗) and 45.4±3.6(Male: 46.2±2.8, Female: 39.5±3.1) respectively. 2. Validity of test using blood zinc protoporphyrin as screening test for blood lead levels of 30㎍/㎗ as gold standard of diagnostic test revealed that the highest validity value for male and female lead workers were 50 and 90 ㎍/㎗ of ZPP respectively, showing 50 and 60 ㎍/㎗ of ZPP for all lead workers. While those test for blood lead levels of 40㎍/㎗ as gold standard of diagnostic test revealed that the highest validity value for male and female lead workers were 60 and 90 ㎍/㎗ of ZPP respectively, showing 60 ㎍/㎗ of ZPP for all lead workers, those test for blood lead levels of 50 and 60㎍/㎗ as gold standard of diagnostic test revealed that the highest validity value for male and female lead workers were 60 or 70 and 100 ㎍/㎗ ZPP respectively, showing 60and 70 or 80 ㎍/㎗ of ZPP for all lead workers. 3. Predictive value of test using blood zinc protoporphyrin as the screening test for different blood lead levels of 30, 40, 50 and 60㎍/㎗ as gold standard of diagnostic test revealed that positive predictive value of screening test were decreased by the increase of blood lead level regardless of csreening criteria value ZPP and negative predictive value of screening test were increased accordingly regardless of screening criteria value of ZPP. On the other hand, within same blood lead level as a gold standard positive predictive values were inceased by the increase of screening criteria value of ZPP, whereas the negative predictive value were decreased accordingly by the the increase of screening criteria value of ZPP. 4. The correlation analysis of all lead workers among study variables revealed that CPbB and natural log transformation ZPP(LZPP) were better correlated with other variables and found to be better estimate than PbB and ZPP themselves. The age was correlated with all other variables, but the work duration was not. The correlation analysis of male and female workers among study variables revealed the same results with all lead workers. 5. The slope of simple linear regression of CPbB (independent variable) with ZPP in female workers(3.223)was steeper than in male workers(2.144). That of lead workers with work duration of less than 1 year was steeper than that of lead workers whose work duration was more than 1 year. But there was no slope difference between two groups divided by their work duration of 2 years less and more. The slope of simple linear regression of CPbB lead (independent variable)with ZPP in lead workers whose blood lead were higher than 30㎍/㎗and 40㎍/㎗ were steeper than those whose blood lead were less than 30㎍/㎗ and 40㎍/㎗. 6. The slope of simple linear regression of CPbB (independent variable) with ZPP in lead industries with low mean blood lead were less steeper than those with high mean blood lead. 7. The slope of simple linear regression of CPbB (independent variable) with LZPP in female workers(0.0308was steeper than in male workers(0.0253). That of lead workers with work duration of less than 1 year was steeper than that of lead workers whose work duration was more than 1 year. But where was no slope difference between two groups divided by their work duration of 2 years less and more. While the slope of simple linear regression of CPbB lead (independent variable) with LZPP in lead workers whose blood lead were hogher than 30㎍/㎗ was not steeper than those whose blood lead were less than 30㎍/㎗, there was no slope difference between two groups whose blood lead were less than 40㎍/㎗ and more than 40㎍/㎗. 8. The slope of simple linear regression of CPbB (independent variable) with LZPP in lead industries with low mean blood lead were less steeper than those with high mean blood lead, but the difference was not significant then that of CPbB and ZPP. With above results, it is recommended that the screening criteria value of ZPP should be down to 60-70㎍/㎗ from 100㎍/㎗ for male lead workers and screening criteria of ZPP for female lead workers was all right with current value of 100㎍/㎗. So it is recommended to make different screening criteria of ZPP for male and female workers like the hemoglobin and hematocrit screening criteria. It is also preferable to use CPbB and LZPP rather than uncorrected PbB and ZPP in the evaluation of lead exposure for lead workers.

평면 다수 입출력 전력 분배/결합회로의 2 GHz에서의 구조 수정 연구

한용인,조치성,김인석 한국항행학회 2002 韓國航行學會論文誌 Vol.6 No.4

본 논문에서는 하나의 입력과 다수의 출력을 가지는 [10]에서에서 제시한 평면 Taper 형의 전력 분배/결합기를 2GHz대역에서 수정한 구조를 제안한다. 제안하는ㄱ n조의 전기적 특성을 결정하는 파라메터들을 HFSS시뮬레이션을 이용하여 분석하였다. 입력 정합 그리고 각 출력 단에서 출력 신호의 균형과 위상의 선형성을 위해 회로의중앙에 하나의 원형 모양을 애칭 제거하였다. 또 본 논문에서 제안한 구조의 1:2와 1:3의 전력 분배/결합기외 [10]의 구조와 S-Parameter를 비교?분석하였다. 결과적으로 본 연구에서 제시하는 수정된 형태를 적용할 경우 기존의 전력 분배/결합기의 반사손실 특성이 2 GHz에서 20dB이상 개선되었고 대역폭 또한 증가되는 것을 확인하였다. In this paper, tapered shape of multiport power divider/combiner modified for 2 GHz range from the model published by [10] is proposed. Parameters determining electrical property of the circuit structure have been analyzed by HFSS simulation. For input matching, balance of output signals and phase linearity at each output port, one circular hole has been etched out on the circuit surface. 1:2 and 1:3 power dividers/combiners designed by this study have been compared with the same circuits designed by the method of [10] in terms of S-parameters. As a result, it has been found that the modified structure of power divider/combiner have improved return loss more than 20 dB and another 18 dB, respectively, at 2 GHz.

유량지속곡선을 이용한 한강수계 총량관리 단위유역 오염기여도 분석

이한필 ( Han Pil Rhee ),최재호 ( Jaeho Choi ),이성준 ( Yong Seok Kim ),김용석 ( Sung Jun Lee ),황하선 ( Ha-sun Hwang ) 한국물환경학회 2017 한국물환경학회·대한상하수도학회 공동 춘계학술발표회 Vol.2017 No.-

PC통신 온라인 구매특성에 관한 실증적 연구

손용석,한부학 한국인터넷비즈니스학회 2001 인터넷비지니스연구 Vol.2 No.2

본 연구는 소비자가 PC통신을 사용한 결과 발생한 부산물인 클릭스트림 테이터(clickstream data)를 이용하며 온라인(on-line) 상에서 발생되는 구매자와 비구매자간의 차별적 특성에 관하여 파악하고자하는 의도에서 시작되었다. 클릭스트림 데이터는 온라인 네트웍 상에서 사용자가 방문한 페이지들외 순차와 각 페이지에 소비된 시간들을 포함하므로, 사용자들에 대한 정보탐색정보를 제공한다. 따라서 일정한 기간의 데이터를 확보한다면 특정한 사이트를 방문하는 소비자의 행위를 분석라여 특정 제품의 구매를 예측하는 연구가 가능하리라 생각된다. 이 논문에서는 클릭스트림 데이터 사용의 중요성을 강조하기 위한 시금석적인 실증 연구를 시도한다. 즉, PC통신의 현황, 서비스 내용, 사용자수 및 매출액규모 등을 시장성(marketability)의 관점에서 분석하기 위해 PC통신 사용자 중에 온라인 비구매자로부터 온라인 구매자로 전판을 예측하게 하는 변수를 파악하기 위해, PC통신 사용자들을 온라인 상에서 제품을 구매라는 집단과 구매하지 않는 집만으로 나누어 인구통계변수 및 PC통신을 사용하는 정보탐색변수를 중심으로 두 집단간의 차이를 분석하는 이분화 연구(dichotomous study)를 시도한다. 방법론으로 두 집단간의 평균차이를 비교하는 일변량 분석과 로지스틱 회귀분석을 사용한다. We began the study in order to analyze characteristics differentiated between on-line and off-line purchases by using the clickstream data occurring as a byproduct resulting from consumers' usage of PC telecommunication. The clickstream data includes information on the sequence of pages visited and time consumed on each page, which is expected to provide demand forecasting on the particular product if consumer behavior visiting a particular site is studied. We have performed an empirical study with demographics and information search variables to characterize a difference between on-line and off-line purchase3. Univariate and logistic regression analyses are employed.

리눅스를 기반으로 한 홈오토메이션 서버의 구현

성한용,김규칠,방철원,김용석 江原大學校 産業技術硏究所 2002 産業技術硏究 Vol.22 No.B

It becomes common to use computers to control electronic devices and security facilities in newly constructed buildings and house. There are many home application devices in the market which can be controlled by computers. But they are expensive and managed by specialized companies. This paper is focused on personal computers which are available in most homes and can be used to control home electronic appliances and home security facilities. We implemented a home automation server based on Linux. The standard parallel port of personal computer is used to connect sensors and actuators. Therefore, the cost of the server is very low. Moreover, the server is connected to Internet and anywhere we can control and monitor the home security facilities and home automation systems.