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화영지통탕(和營止痛湯)의 혈관신생억제효과(血管新生抑制效果)에 관한 실험적(實驗的) 연구(硏究)
김인석,박준혁,강희,김성훈,유영법,심범상,최승훈,안규석,Kim, In-Seok,Park, Joon-Hyuck,Kang, Hee,Kim, Sung-Hoon,Yu, Young-Beob,Shim, Bum-Sang,Choi, Seung-Hoon,Ahn, Koo-Seok 대한암한의학회 2001 大韓癌韓醫學會誌 Vol.7 No.1
The purpose of this study is to prove the angiogenesis effects of WhaYoungJiTongTang (hereinafter referred to as the 'WYJTT'). For the study, by utilizing liver cancer cell line; SK-HEP-1, lung cancer cell line: A549, stomach cancer cell line: AGS and bovine capillary endothelial cell: BCE, the effects of the WYJTT on toxicity and proliferation ability of cells and the effects on anti-angiogenesis of bovine capillary endothelial cell and of mice's aorta were studied. 1. Cell viability assay In comparison with the control group, when $100{\mu}g/ml$ of WYJTT was injected, the viability was reduced in SK-Hep-1, $400{\mu}g/ml$ in A549 and $200{\mu}g/ml$ in AGS. 2. Cell proliferation assay In comparison with the control group, when $600{\mu}g/ml$ of WYITT was injected, DNA synthesis was reduced to 35.1% in the SK-Hep-1, 56.0% in A549, and 25.8% in BCE (bovine capillary endothelial cell); and when $400{\mu}g/ml$ was injected, DNA synthesis was reduced to 12.1 in AGS. 3. Tube formation assay In the event that BCE is injected with WYJTT in each of its content gradient, the anti-angiogenesis was effective in amounts of $400{\mu}g/ml$ with 6 hours of the treatment. 4. Aortic ring assay In comparison with the control group, the angiogenesis was restricted to the remarkable degree in amount of $200{\mu}g/ml$: 10% in $400{\mu}g/ml$; and fully inhibited in each of $800{\mu}g/ml$ and $1600{\mu}g/ml$. As a result of the experiments mentioned above, WYJTT showed its anti-angiogenesis effects against cancer cell line.
컴퓨터 기저 영어 평가 테스트의 국내·외 연구 동향과 수행형 초등영어 CALT 듣기 평가도구 개발 방향의 제시
김인석 동덕여자대학교 인문과학연구소 2003 人文科學硏究 Vol.9 No.-
The digital technology has made an unprecedented impact on foreign language education over last several decades. These can be categorized as two kinds of development which have entered foreign language classroom: intranet/internet-based English education and computer-assisted English testing. In recent years foreign language instructors began to use CD-ROM titles as well as internet programs as supplements to their existing teaching materials in order to improve instructional efficiency of foreign language. More and more foreign language instructors have become aware of the importance of computer-assisted language testing which will save them time and energy, when they use it properly. This paper purports to overview current research on computer-assisted language testing and suggest specific procedures that are needed to develop a performance-based English testing program for elementary school students. The paper consists of the following six sections. In the first section, the paper will address the reason why computer-assisted English testing need to be developed. In the second section, the paper will introduce several testing related terminologies such as CBT, CAT/CALT, WBT, and WAT and define each. The third and fourth section of the paper will be dedicated to summarizing recent computer testing research which were conducted by Korean and overseas researchers, respectively. In the fifth section, the paper will explain the specific procedures that are needed to develop a performance-based English testing program for Korean elementary school children. These include items bank construction, calibration of proficiency guidelines, and sample items. The paper will conclude by calling for a necessity to develop a full scaled computer-adaptive testing program which can be used to measure Korean elementary school children`s English proficiency.