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Peihe Zheng,Yinbin Chen,Yangyang Fu,Hecheng Wang,Jia Wang,Siwen Zheng,Shengyuan Xiao,Yingping Wang 한국식품영양과학회 2017 Journal of medicinal food Vol.20 No.11
After cultivation of ginseng, ginsenosides, which are the major active ingredients of gingeng, were approved for use by the food industry, and began to be used as added functional ingredients to try to improve the quality and price of functional foods. However, the interaction between different types of ginsenosides and nutrients needs further study. We investigated the effect of B-complex vitamins (which are essential nutrients) on the pharmacokinetics of the ginsenosides protopanaxatriol-type saponin Rg1, protopanaxadiol-type saponin Rb1, and oleanolic acid-type saponin Ro after oral administration. Ginsenosides Rg1, Rb1, and Ro, with or without B-complex vitamins, respectively, were administered orally to rats to evaluate their pharmacokinetics. The concentration of ginsenosides in plasma was determined by liquid chromatography/tandem mass spectrometry. Pharmacokinetic parameters were fitted using WinNonlin v6.2. After oral coadministration with B-complex vitamins, the area under the concentration–time curve from zero to infinity (AUC0–∞) of ginsenoside Rg1 was reduced by 70%, that of ginsenoside Rb1 was reduced by 43%, and that of ginsenoside Ro was reduced by 34%. The AUC0–∞ of ginsenosides Rg1 and Rb1 showed significant differences between different treatments, but the AUC0–∞ of ginsenoside Ro did not. These results suggest significant ginsenoside-nutrient interactions between ginsenosides Rg1, Rb1, and B-complex vitamins.
HALF-METALLIC SILICENE AND GERMANENE NANORIBBONS: TOWARDS HIGH-PERFORMANCE SPINTRONICS DEVICE
YANGYANG WANG,JIAXIN ZHENG,ZEYUAN NI,RUIXIANG FEI,QIHANG LIU,RUGE QUHE,CHENGYONG XU 성균관대학교(자연과학캠퍼스) 성균나노과학기술원 2012 NANO Vol.7 No.5
By using first-principles calculations, we predict that an in-plane homogenous electrical ¯eld can induce half-metallicity in hydrogen-terminated zigzag silicene and germanene nanoribbons (ZSiNRs and ZGeNRs). A dual-gated ¯nite ZSiNR device reveals a nearly perfect spin-¯lter e±ciency (SFE)of up to 99% while a quadruple-gated ¯nite ZSiNR device serves as an effective spin ¯eld e®ect transistor (FET) with an on/o® current ratio of over 100 from ab initio quantum transport simulation. This discovery opens up novel prospect of silicene and germanene in spintronics.
Yangyang Zhang,Yixiao Qin,Jinpeng Gu,Qianqian Jiao,Feng Wang,Zhenshan Guo,Hao Zhang,Jianjun Wang,Chenghong Mi,Huaipeng Zheng 대한기계학회 2021 JOURNAL OF MECHANICAL SCIENCE AND TECHNOLOGY Vol.35 No.8
Unsymmetrical complex plate and shell structure is one of the common engineering structures. In practice, more redundant materials exist because of the irrationality of this kind of structure with heavy load and multiple working conditions, and the study of its topology optimization has become an engaging topic. Using the SIMP model, topological results show that one side of the main web is a hollow structure, and the other side of the auxiliary web is a truss structure. According to the topological results and considering manufacturable processing, a new structure is redesigned, the size and shape of the redesigned structure is secondary optimized, and the final structure is obtained. The method in this paper not only meets the performance requirements of the unsymmetrical complex plate and shell structures, but also realizes the topology and lightweight. The effectiveness scientific research value of the proposed method is verified by engineering examples.
Performance of a modified alkaline lignin towards copper adsorption under different conditions
Chunli Zheng,Qiaorui Wang,Yujie Dai,Bo Zu,Yangyang Zhang,Tian C Zhang 대한환경공학회 2022 Environmental Engineering Research Vol.27 No.3
Polyethyleneimine and carbon disulfide were employed to modify alkaline lignin (AL) in order to introduce -NH, -NH₂ and -CSS- groups. Its adsorption performance towards Cu(II) was evaluated based on the residual concentration (Cr) against the discharge permissible concentration for Cu(II) (2.0 mg/L) established by the World Health Organization. The evaluation was operated under different conditions such as adjusting the solution pH, Cu(II) coexisting with K(I), Na(I), Ca(II) or Mg(II), changing the contact time (t) and initial concentration of Cu(II) (C0), as well as regeneration. When t and C0 equaled to 180 min and 50 mg/L, Cr was less than 2.0 mg/L at pH of 5.03 to 5.65. Under the situation of Cu (II) coexisting with 50 mg/L of K(I), Na(I), Ca(II) or Mg(II), Cr was as low as 1.96, 1.53, 1.97 or 1.55 mg/L (t = 180 min, C0 = 50 mg/L), respectively. Even the modified AL was regenerated and reused four times, Cr was closed to 2 mg/L for each time (t = 180 min, C0 = 51 mg/L). By comparing with other lignin-based materials according to the adsorption equilibrium time, the maximum adsorption capacity, and Cr, the modified AL exhibited higher application potential in copper-loaded water treatment.
Bo-Chao Zheng,Lina Guo,Yangyang Zhao,Xiaoguang Liu,Zhou Gu 제어·로봇·시스템학회 2022 International Journal of Control, Automation, and Vol.20 No.12
Robust security problem for uncertain cyber-physical systems (CPSs) subject to periodic denial-ofservice (DoS) jamming attacks is investigated based on event-triggered (ET) sliding-mode control (SMC) approach in this paper. First, a new type of SMC approach driven by ET mechanism is constructed using the property of the period DoS jamming attacks. Then, sufficient conditions for robust stabilization of dynamical systems constrained by system parameters and attacks period are proposed. Further, it is proved that the execution time interval of the proposed ET-based SMC strategy has a positive lower bound, and thus Zeno-free behavior occurs during system evolution. Finally, comparisons results show the effectiveness and superiority of this methodology.
Plasma-catalytic decomposition of ethyl acetate over LaMO3 (M = Mn, Fe, and Co) perovskite catalysts
Yuxiang Cai,Xinbo Zhu,Wenshuo Hu,Chenghang Zheng,Yangyang Hu,Menghan Chen,Xiang Gao 한국공업화학회 2019 Journal of Industrial and Engineering Chemistry Vol.70 No.-
Plasma-catalytic decomposition of low concentration ethyl acetate with LaMO3 (M = Co, Mn and Fe)perovskite catalyst was investigated in a coaxial dielectric barrier discharge (DBD) reactor. Thecombination of perovskite catalyst and plasma enhanced ethyl acetate decomposition, and the activitysequence was LaCoO3> LaMnO3> LaFeO3. Characterizations results indicated that the activation ofsurface oxygen species and amount of oxygen vacancies contributed to ethyl acetate decompositionremarkably. FT-IR analysis demonstrated that the employment of LaCoO3 catalyst also reduced theamount of unwanted by-products. Based on these results, reaction mechanism of ethyl acetate plasmacatalyticdecomposition process was proposed.
SWIPT in MISO Full-Duplex Systems
Alexander Akpofure Okandeji,Muhammad R. A. Khandaker,Kai-Kit Wong,Gan Zheng,Yangyang Zhang,Zhongbin Zheng,Ruopeng Liu 한국통신학회 2017 Journal of communications and networks Vol.19 No.5
This paper investigates a multiuser multiple-input singleoutput(MISO) full-duplex (FD) system for simultaneous wirelessinformation and power transfer (SWIPT), in which a multiantennabase station (BS) simultaneously sends wirelessly informationand power to a set of single-antenna mobile stations (MSs) usingpower splitters (PSs) in the downlink and receives informationin the uplink in FD mode. In particular, we address the joint designof the receive PS ratio and the transmit power at the MSs, andthe beamforming matrix at the BS under signal-to-interferenceplus-noise ratio (SINR) and the harvested power constraints. Usingsemidefinite relaxation (SDR), we obtain the solution to theproblem with imperfect channel state information (CSI) of the selfinterferingchannels. Furthermore, we propose another suboptimalzero-forcing (ZF) based solution by separating the optimizationof the transmit beamforming vector and the PS ratio. Simulationresults are provided to evaluate the performance of the proposedbeamforming designs.
CDH17 nanobodies facilitate rapid imaging of gastric cancer and efficient delivery of immunotoxin
Jingbo Ma,Xiaolong Xu,Chunjin Fu,Peng Xia,Ming Tian,Liuhai Zheng,Kun Chen,Xiaolian Liu,Yilei Li,Le Yu,Qinchang Zhu,Yangyang Yu,Rongrong Fan,Haibo Jiang,Zhifen Li,Chuanbin Yang,Chengchao Xu,Ying Long,J 한국생체재료학회 2022 생체재료학회지 Vol.26 No.4
Background: It is highly desirable to develop new therapeutic strategies for gastric cancer given the low survival rate despite improvement in the past decades. Cadherin 17 (CDH17) is a membrane protein highly expressed in cancers of digestive system. Nanobody represents a novel antibody format for cancer targeted imaging and drug delivery. Nanobody targeting CHD17 as an imaging probe and a delivery vehicle of toxin remains to be explored for its theragnostic potential in gastric cancer. Methods: Naïve nanobody phage library was screened against CDH17 Domain 1-3 and identified nanobodies were extensively characterized with various assays. Nanobodies labeled with imaging probe were tested in vitro and in vivo for gastric cancer detection. A CDH17 Nanobody fused with toxin PE38 was evaluated for gastric cancer inhibition in vitro and in vivo. Results: Two nanobodies (A1 and E8) against human CDH17 with high affinity and high specificity were successfully obtained. These nanobodies could specifically bind to CDH17 protein and CDH17-positive gastric cancer cells. E8 nanobody as a lead was extensively determined for tumor imaging and drug delivery. It could efficiently co-localize with CDH17-positive gastric cancer cells in zebrafish embryos and rapidly visualize the tumor mass in mice within 3 h when conjugated with imaging dyes. E8 nanobody fused with toxin PE38 showed excellent anti-tumor effect and remarkably improved the mice survival in cell-derived (CDX) and patient-derived xenograft (PDX) models. The immunotoxin also enhanced the anti-tumor effect of clinical drug 5-Fluorouracil. Conclusions: The study presents a novel imaging and drug delivery strategy by targeting CDH17. CDH17 nanobodybased immunotoxin is potentially a promising therapeutic modality for clinical translation against gastric cancer.