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Zheng Liu,Jianjun Chen,Lei Cheng,Huabin Li,Shixi Liu,Hongfei Lou,Jianbo Shi,Ying Sun,Dehui Wang,Chengshuo Wang,Xiangdong Wang,Yongxiang Wei,Weiping Wen,Pingchang Yang,Qintai Yang,Gehua Zhang,Yuan Zhan 대한천식알레르기학회 2020 Allergy, Asthma & Immunology Research Vol.12 No.2
The current document is based on a consensus reached by a panel of experts from the Chinese Society of Allergy and the Chinese Society of Otorhinolaryngology-Head and Neck Surgery, Rhinology Group. Chronic rhinosinusitis (CRS) affects approximately 8% of Chinese adults. The inflammatory and remodeling mechanisms of CRS in the Chinese population differ from those observed in the populations of European descent. Recently, precision medicine has been used to treat inflammation by targeting key biomarkers that are involved in the process. However, there are no CRS guidelines or a consensus available from China that can be shared with the international academia. The guidelines presented in this paper cover the epidemiology, economic burden, genetics and epigenetics, mechanisms, phenotypes and endotypes, diagnosis and differential diagnosis, management, and the current status of CRS in China. These guidelines—with a focus on China—will improve the abilities of clinical and medical staff during the treatment of CRS. Additionally, they will help international agencies in improving the verification of CRS endotypes, mapping of eosinophilic shifts, the identification of suitable biomarkers for endotyping, and predicting responses to therapies. In conclusion, these guidelines will help select therapies, such as pharmacotherapy, surgical approaches and innovative biotherapeutics, which are tailored to each of the individual CRS endotypes.
Two Types of Immunoassay Based on Nile Blue Labeling Polydopamine Nanospheres
Lili Liu,Wenbo Lu,Chang Liu,Ying Wang,Jian Dong,Weiping Qian 성균관대학교(자연과학캠퍼스) 성균나노과학기술원 2017 NANO Vol.12 No.8
The sandwich-type immunoassays have been developed by using electrochemical and surface-enhanced Raman scattering (SERS) techniques for the detection of carcinoembryonic antigen (CEA). Nile blue as a kind of Raman dye has been decorated on nanospheres with polydopamine resin (PDR) via π-stacking interaction. The Nile blue displays the strong SERS signals as well as a characteristic electrochemical reduction peak at -0.33V (versus Ag/AgCl). The implementation of the PDR nanospheres mixing with Au nanoparticles (AuNPs/PDR) exhibits a better electrical conductivity and large SERS enhancement. The immunoassays based on Nile blue-labeled AuNPs/PDR nanospheres have been fabricated by using electrochemical and SERS techniques for the detection of CEA. The proposed immunoassay shows higher sensitivity, high selectivity, lower detection limit and long-term stability. The performances of the electrochemical immunoassay are better than that of SERS immunoassay. For the electrochemical immunoassay, the linear range occurs from 1 pg/mL to 100 ng/mL (R = 0.995) with a detection limit of 0.68 pg/mL and signal-to-noise ratio of 3 in the detection of CEA. The data for the analysis of human serum samples by using the electrochemical method are acceptably consistent with those obtained from the enzyme-linked immunosorbent assay (ELISA). The proposed immunoassay exhibits a promising potential for application in clinical diagnosis.
Weiping Luo,Jun Sun,Jun Ye,Wei Deng,Qiang Liu,Cancheng Guo 한국공업화학회 2014 Journal of Industrial and Engineering Chemistry Vol.20 No.5
The liquid-phase catalytic aerobic oxidation of toluene by [T(p-Cl)PPFe]2O was studied in a series of three stirred tank reactors. The effects of operation mode (including semi-batch and continuous operation), reaction temperature, catalyst concentration, average residence time, and air flow rate on the oxidation process were examined. The experimental results showed that continuous oxidation had no advantage over the total yield and selectivity of benzaldehyde and benzyl alcohol in comparison with semi-batch oxidation. And the reaction temperature was the most significant factor influencing on continuous oxidation of toluene. It is also found that adopting sequentially decreased temperature in the three series reactors could improve the yield and selectivity of benzaldehyde and benzyl alcohol in this process. Under which at the higher conversion of toluene, the total yield to benzaldehyde and benzyl alcohol increased 17.05% or 43.62% respectively in comparison with adopting sequentially increased or same temperature in the three series reactors.
Weiping Zhang,Hui Liu,Yong Zhou,Kaixing Liao,Ying Huang Korean Nuclear Society 2023 Nuclear Engineering and Technology Vol.55 No.6
The aggregate-forming minerals in concrete undergo volume swelling and microstructure change under neutron irradiation, leading to degradation of physical and mechanical properties of the aggregates and concrete. A comprehensive investigation of volume change and elastic property variation of major aggregate-forming minerals is still lacking, so molecular dynamics simulations have been employed in this paper to improve the understanding of the degradation mechanisms. The results demonstrated that the densities of the selected aggregate-forming minerals of similar atomic structure and chemical composition vary in a similar trend with deposited energy due to the similar amorphization mechanism. The elastic tensors of all silicate minerals are almost isotropic after saturated irradiation, while those of irradiated carbonate minerals remain anisotropic. Moreover, the elastic modulus ratio versus density ratio of irradiated minerals is roughly following the density-modulus scaling relationship. These findings could further provide basis for predicting the volume and elastic properties of irradiated concrete aggregates in nuclear facilities.
A Novel Algorithm for Efficiently Sequential Pattern Mining
Weiping Wang,Lei Liu 인하대학교 정석물류통상연구원 2009 인하대학교 정석물류통상연구원 학술대회 Vol.2009 No.10
this paper proposed an IESE-Span algorithm using frequent itemsets to mine sequential patterns. This algorithm redefines the length of sequence and increases the granularity of mining sequential patterns. At first, this algorithm mines all the frequent itemsets as the increasing unit in the process of sequential pattern mining. Position information of frequent 2-itemsets (or sequences) is represented by frequent 2-itemsets (or sequences)-adjacency matrix and support degree of sequence is calculated by positions sets. Experiments show that the proposed algorithm is better in both time and space performance compared to traditional sequential pattern mining algorithm.
Diantong Liu,Weiping Guo,Wei Wang 대한기계학회 2013 JOURNAL OF MECHANICAL SCIENCE AND TECHNOLOGY Vol.27 No.1
For the piezoelectric actuator model with hysteretic nonlinearity, a second-order sliding mode tracking controller is proposed. First, a second-order nonlinear dynamic model is introduced for the piezoelectric actuator. Next, a second order sliding mode control law with dual-phase sliding movement is designed. Then, the system stability is proved with a theorem. From theoretical analysis, the feedback control system is stable in the sense that all signals involved are bounded. The simulation results show the validity of the proposed method for this kind of nonlinear dynamic model of the piezoelectric actuator.
Substrate-Immersed Solvothermal Synthesis of Ordered SiO2/Ag Arrays as Catalytic SERS Substrates
Chang Liu,Qianqian Su,Li Li,Jie Sun,Jian Dong,Weiping Qian 성균관대학교(자연과학캠퍼스) 성균나노과학기술원 2018 NANO Vol.13 No.5
In this work, we designed a simple substrate-immersed solvothermal route for the one-step synthesis of novel ordered SiO2/Ag arrays, employing SiO2 colloidal crystals as templates and alcohol as reducing agent. The Ag nanoparticles were uniformly deposited in situ onto SiO2 colloidal crystals, which exhibited high surface enhanced Raman spectroscopy (SERS) activity and uniform SERS intensity. It was found that ordered SiO2/Ag arrays could rapidly scavenge the absorbed-Nile blue A (NBA) molecules from the surfaces with the assistance of H2O2, while the SERS signals of NBA decreased sharply and almost completely disappeared within four minutes. This can be attributed to the superior catalytic activity of Ag nanoparticles. After five times of re-immersion and re-absorbing process of NBA, the substrates could still keep ~74.8% SERS intensity versus the original. The high activity and durability of the as-prepared SiO2/Ag SERS substrate endow them as a promising candidate for trace detection.
Dynamics and GA-Based Stable Control for a Class of Underactuated Mechanical Systems
Diantong Liu,Weiping Guo,Jianqiang Yi 대한전기학회 2008 International Journal of Control, Automation, and Vol.6 No.1
The control of underactuated mechanical system is very complex for the loss of its control inputs. The model of underactuated mechanical systems in a potential field is built with Lagrangian method and its structural properties are analyzed in detail. A genetic algorithm (GA)-based stable control approach is proposed for the class of under actuated mechanical systems. The Lyapunov stability theory and system properties are utilized to guarantee the system stability to its equilibrium. The real-valued GA is used to adjust the controller parameters to improve the system performance. This approach is applied to the underactuated double-pendulum-type overhead crane and the simulation results illustrate the complex system dynamics and the validity of the proposed control algorithm.