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Zhou Wenxian,Shi Yifeng,Wang Hui,Chen Linjie,Yu Caiyu,Zhang Xufei,Yang Lei,Zhang Xiaolei,Wu Aimin 생화학분자생물학회 2022 Experimental and molecular medicine Vol.54 No.-
Intervertebral disc degeneration (IVDD) is a major cause of low back pain (LBP), and excessive senescence and apoptosis of nucleus pulposus (NP) cells are major pathological changes in IVDD. Physical exercise could effectively delay the process of intervertebral disc degeneration; however, its mechanism is still largely unknown. Irisin is an exercise-induced myokine released upon cleavage of the membrane-bound precursor protein fibronectin type III domain-containing protein 5 (FNDC5), and its levels increase after physical exercise. Here, we show that after physical exercise, FNDC5/irisin levels increase in the circulation and NP, senescence and apoptosis are reduced, autophagy is activated in NP tissue, and the progression of IVDD is delayed. Conversely, after knocking out FNDC5, the benefits of physical exercise are compromised. Moreover, the overexpression of FNDC5 in NP tissue effectively alleviated the degeneration of the intervertebral disc (IVD) in rats. By showing that FNDC5/irisin is an important mediator of the beneficial effects of physical exercise in the IVDD model, the study proposes FNDC5/irisin as a novel agent capable of activating autophagy and protecting NP from senescence and apoptosis.
Bao, Xiukun,Wang, Xiaolei,Zhou, Xinao,Shi, Guimei,Xu, Ge,Yu, Jin,Guan, Yinyan,Zhang, Yajing,Li, Da,Choi, Chuijin Elsevier 2018 JOURNAL OF ALLOYS AND COMPOUNDS Vol.769 No.-
<P><B>Abstract</B></P> <P>FeCo/ZnO composites have been successfully prepared through liquid-phase reduction process for the formation of FeCo polyhedrons and sequentially thermal decomposition of colloidal mixture of FeCo and Zn(Ac)<SUB>2</SUB>·2H<SUB>2</SUB>O under nitrogen atmospheres. ZnO nanoparticles are homogeneously deposited on the surface of FeCo polyhedrons and the level of oxygen-vacancy defects in ZnO can be elevated with the increase of ZnO content. By comparison with FeCo polyhedrons, FeCo/ZnO composites exhibit excellent microwave absorption. The optimal RL value can reach −34.8 dB at 14.8 GHz and effective bandwidth (RL < −10 dB) is 5.1 GHz in the frequency range of 12.4–17.5 GHz with a matching thickness of 1.5 mm. The integrated bandwidth with RL < −10 dB can reach 14.1 GHz covering 3.4–17.5 GHz. Theory analysis demonstrates the interfacial polarization, dipole polarization and high conductivity due to oxygen-vacancy defects in FeCo/ZnO composites contribute to enhancement of dielectric loss capacity, which is more favorable for impedance matching.</P> <P><B>Highlights</B></P> <P> <UL> <LI> The preferable impedance matching of FeCo/ZnO composites can be achieved by regulating the ZnO content. </LI> <LI> The optimal reflection loss (RL) can reach −34.8 dB with a matching thickness of 1.5 mm. </LI> <LI> The effective bandwidth with RL < −10 dB achieve 14.1 GHz covering 3.4–17.5 GHz with integrated thickness of 1.5–5 mm. </LI> </UL> </P> <P><B>Graphical abstract</B></P> <P>[DISPLAY OMISSION]</P>
Yunpeng Sun,Yipeng Lan,Xiaolei Shi,Zelai Xu,Cheng Lei 대한기계학회 2023 JOURNAL OF MECHANICAL SCIENCE AND TECHNOLOGY Vol.37 No.11
In the high-speed and high-precision magnetic suspension linear synchronous motor, the non-linear coupling between armature current, suspension height and horizontal velocity, as well as the uncertain factors such as load disturbance, which will have many adverse effects on the control system. To solve these problems, this paper uses a feedbacklinearized control method. Through coordinate transformation and state feedback, the nonlinear model of motor affine is decoupled and linearized into three independent linear subsystems of straight axis current subsystem, horizontal speed subsystem and suspension height subsystem. In order to reduce the dependence of feedback linearization control on linear motor mathematical model and improve the robustness of servo system, so as to realize decoupling control of magnetic suspension linear synchronous motor, a variable speed reaching law sliding mode controller is designed on the basis of linearization model. Simulation and experimental results show that the dynamic and static performance of the system is enhanced significantly by using the proposed control strategy.