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Jiaxin Pi,Xu Gao,Yue Yu,Yin Zheng,Zhuangzhi Zhu,Yajing Wang 대한약학회 2021 Archives of Pharmacal Research Vol.44 No.9
Bakuchiol (BAK), isolated from the seeds ofPsoralea corylifolia L., recently presents a variety ofpharmacologic activities. However, the poor oral bioavailabilitylimits its further development and clinical use. The purpose of this study was to establish a self-microemulsifying(SME) formulation for oral deliveryimprovement of BAK. The optimized liquid SME formulationwas comprised of BAK (40 %), Cremophor RH 40(30 %) and Labrasol (30 %). The emulsion droplets werespherical in shape, and particle size and zeta potential weredetermined. The in vitro dissolution test of BAK-SMEformulation illustrated faster dissolution rate than the bulkdrug. The permeabilities of 40 lg mL-1 BAK-SME formulationin rat intestinal segments of duodenum, jejunum,ileum and colon were 30.91 9 10-3, 23.61 9 10-3,29.43 9 10-3 and 23.62 9 10-3 cm min-1, respectively,exhibiting 3.99 times in duodenum, 2.59 times in ileum and 2.31 times in colon greater than BAK perfusate. The oralbioavailability of BAK-SME formulation at a dose of150 mg kg-1 was determined in rats. The Cmax and theAUC(0–24h) were 515.4 ng mL-1 and 4,327.2 h ng mL-1,respectively, which were 1.90 fold and 1.73 fold greaterthan the value of BAK suspension. All these results clearlystated that BAK-SME formulation performed wellimprovementon oral bioavailability of BAK.
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HALF-METALLIC SILICENE AND GERMANENE NANORIBBONS: TOWARDS HIGH-PERFORMANCE SPINTRONICS DEVICE
YANGYANG WANG,JIAXIN ZHENG,ZEYUAN NI,RUIXIANG FEI,QIHANG LIU,RUGE QUHE,CHENGYONG XU 성균관대학교(자연과학캠퍼스) 성균나노과학기술원 2012 NANO Vol.7 No.5
By using first-principles calculations, we predict that an in-plane homogenous electrical ¯eld can induce half-metallicity in hydrogen-terminated zigzag silicene and germanene nanoribbons (ZSiNRs and ZGeNRs). A dual-gated ¯nite ZSiNR device reveals a nearly perfect spin-¯lter e±ciency (SFE)of up to 99% while a quadruple-gated ¯nite ZSiNR device serves as an effective spin ¯eld e®ect transistor (FET) with an on/o® current ratio of over 100 from ab initio quantum transport simulation. This discovery opens up novel prospect of silicene and germanene in spintronics.
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Fast Response Research of Magnetically Controlled Reactor
Chen Feng,Wang Jun,Zheng Hao,Lu Wenhua,Tian Cuihua,Yuan Jian,Chen Baichao,Yuan jiaxin 보안공학연구지원센터 2015 International Journal of Smart Home Vol.9 No.10
As a kind of reactive power compensation equipment with control flexibility and high reliability, magnetically controlled reactor (MCR) is widely used in reactive power compensation, over-voltage limitation and other aspects. However, low responding speed has severely limited the application of MCR. Especially when applied to suppress voltage flicker and arc suppression coil, the slow response of MCR will decrease the stability of control system, even causing the system shock. To improve the response performance of MCR, in this paper, the working principle of MCR has been analyzed, and a fast response structure of MCR has been designed with the novel fast response structure, fast excitation and rapid demagnetization can be achieved. According to the simulation and experiment results, the effectiveness of the proposed structure is verified by limiting the response time in 30ms.
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