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ZHEN SUN,Hejun Li,Kezhi Li,QIANGANG FU 성균관대학교(자연과학캠퍼스) 성균나노과학기술원 2014 NANO Vol.9 No.6
Graphene platelets with a large scale have been synthesized by reduction of graphene oxide (GO)in aqueous solution of hydrazine hydrate under microwave irradiation (MWI). Microstructure ofthe graphene was characterized by X-ray di®raction (XRD), Raman spectroscopy, atomic forcemicroscopy (AFM) and transmission electron microscopy (TEM) together with the selected areaelectron di®raction (SAED). The electrochemical properties were evaluated by the analysis ofcyclic voltammetry (CV) and electrochemical impedance spectroscopy (EIS) in 1 M Na 2 SO 4aqueous solution. The results show that the as-prepared materials consist of crumpled, few-layer( ? 3 nm) thick and electronically conductive graphitic sheets. The supercapacitors fabricatedusing this material possess a low equivalent series resistance (ESR) value ? 1.6 ? and a highspeci¯c capacitance of 285 F ? g ? 1 . In addition, the graphene reduced under a diverse duration ofMWI displays a di®erent interlayer spacing, extent of reduction, level of graphitization andspeci¯c capacitances. The duration of MWI and the treatment methods strongly a®ect the mi-crostructure of graphene, and then dominate its electrochemical properties.
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Sun, Jian-Da,Chen, Chuang-Zhen,Chen, Jian-Zhou,Li, Dong-Sheng,Chen, Zhi-Jian,Zhou, Ming-Zhen,Li, De-Rui Asian Pacific Journal of Cancer Prevention 2012 Asian Pacific journal of cancer prevention Vol.13 No.5
Treatment responses of $N_0$ stage nasopharyngeal carcinoma were firstly analyzed comprehensively to evaluate long term outcomes of patients and identify prognostic factors. A total of 610 patients with $N_0$ NPC, undergoing definitive radiotherapy to their primary lesion and prophylactic radiation to upper neck, were reviewed retrospectively. Concomitant chemotherapy was administrated to 65 out of the 610. Survival rates of the patients were calculated using the Kaplan-Meier method and compared by log-rank test. Prognostic factors were identified by the Cox regression model. The study revealed the 5-year and 10-year overall, disease-free, disease-specific, local failure-free, regional failure-free, locoregional failure-free and distant metastasis-free survival rates to be 78.7% and 66.8%, 68.8% and 55.8%, 79.9% and 70.4%, 81.2% and 72.5%, 95.8% and 91.8%, 78.3% and 68.5%, 88.5% and 85.5%, respectively. There were 192 patients experiencing failure (31.5%) after radiotherapy or chemoradiotherapy. Of these, local recurrence, regional relapse and distant metastases as the first event of failure occurred in 100 (100/610, 16.4%), 15(15/610, 2.5%) and 52 (52/610, 8.5%), respectively. Multivariate analysis showed that T stage was the only independent prognostic factor for patients with $N_0$ NPC (P=0.000). Late T stage (P=0.000), male (P=0.039) and anemia (P=0.007) were independently unfavorable factors predicting disease-free survival. After treatment, satisfactory outcome wasgenerally achieved in patients with $N_0$ NPC. Local recurrence represented the predominant mode of treatment failure, while T stage was the only independent prognostic factor for overall survival. Late T stage, male gender, and anemia independently predicted lower possibility of the disease-free survival.
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现代汉语位移动词“走”与“去”的认知对比研究 ― 以“前往、离开”义为中心
ZHEN SUN 한국중국언어학회 2023 중국언어연구 Vol.- No.104
‘QU’ and ‘ZOU’ are two commonly used verbs in modern Chinese, they are used very frequently, and the basic semantics of the two words are relatively complicated. For Korean learners, part of the semantics of ‘QU’ and ‘ZOU’ are similar to Korean ‘ka-ta(가-다)’ has overlapping parts, many learners are confused when using it, and various errors will also occur in practical application. This paper mainly uses the relevant theories of cognitive linguistics to compare and analyze the similarities and differences of the place-moving words ‘QU, ZOU’ from the four elements of displacement events, such as moving body, displacement, path, reference body, and scanning method. The moving body of the two word is generally a living body, but some inanimate bodies, such as vehicles or machinery, can also be used as moving bodies. When ‘QU’ is used in the sense of ‘go;, its end point are generally clear, and when it is used in the sense of ’leave for‘, the end point is implicit. When ‘ZOU’ is used in the sense of ‘leaving’, the start point is exact, but the end point is not necessarily clear, and the emphasis is on the start point. When ‘ZOU’ is used in the sense of ‘moving’, the start point and end point may be implicit, but the focus is on the via and process. From the point of view of dynamic observation, ‘去’ is a SUMMARY scanning, regardless of whether the start point/end point is highlighted, the focus of its displacement meaning is whether it reaches the end point. However, the displacement pattern of ‘走’ is a SEQUENTIAL scanning , without highlighting the end point or goal, and the focus is on whether to leave the start point to start the next stage. “去”和“走”是现代汉语两个常用的动词,使用频率非常高,而且二词的基本语义也比较复杂,对韩国学习者来说,“去”和“走”的部分语义和韩语“가다”有交叉、重合部分,很多韩国学习者在使用时会产生困惑,在实际应用中,也产生了各种偏误。本文主要从位移事件的四个要素动体、位移、路径、参照体等方面,对比分析了位移动词“去、走”的异同点。二词的动体一般是有生命体,但也有无生命体,如交通工具或机械等也可以作为动体。当“去”用作“前往”义时,其源点和终点一般是明确的,用作“离开”义时,终点可能是隐性的,但一定是明确存在的。而“走”作“离开”义或“移动”义时,源点是确切的,终点则不一定明确,侧重是源点或经由、过程。从位移和路径“去”和“走”都是一维线型的,一般来说是离开说话者所在的源点,准确表达的话是远离说话时所选择的参照点,。从动态的观察方式上来看,“去”是一个总括扫描,无论是否凸显源点/终点,其位移义的重点在于是否到达终点。而“走”的位移图式是顺序扫描,不凸显终点或目标,重点在于是否离开源点开始下一个阶段或过程。在实际应用中,除了其语法意义和结构外,还应该注意两者不同的认知方式。
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Significance of HPV Infection and Genic Mutation of APC and K-ras in Patients with Rectal Cancer
Sun, Zhen-Qiang,Wang, Hai-Jiang,Zhao, Ze-Liang,Wang, Qi-San,Fan, Chuan-Wen,Kureshi, Kureshi,Fang, Fa Asian Pacific Journal of Cancer Prevention 2013 Asian Pacific journal of cancer prevention Vol.14 No.1
Background: Significance of HPV infection and genic mutation of APC and K-ras in rectal cancer has been investigated but not clarified. The objective of our study was to investigate these parameters in patients with rectal cancer to analyze correlations with biological behaviour, to determine relationships among the three, and also to demonstrate survival prognosis effects. Methods: From December 2007 to September 2008, 75 rectal cancer cases confirmed by histopathology in the Tumor Hospital of Xinjiang Medical University were enrolled. The control group consisted of normal rectal mucous membrane taken simultaneously, a least 10 cm distant from the carcinoma fringe. HPV DNA, the MCR of APC and exon-1 of K-ras were detected by PCR and PCR-SSCP. All results were analyzed in relation to clinical pathological material, using chi-square and correlation analysis via SPSS.13 and Fisher's Exact Probability via STATA. 9.0. All 75 patients were followed up for survival analysis using Kaplan-Meier and Log-rank tests. Results: 55 out of 75 cases demonstrated gene HPV L1 while it was notdetected in normal rectal mucosa tissue. HPV infection was correlated with age and lymphatic metastasis (P<0.05) but not other characteristics, such as ethnicity, tumor size, histological type, tumor type, Duke's stage and infiltration depth. Some 43 cases exhibited APC genic mutation (57.3%) and 34 K-ras genic mutation (45.3%). APC genic mutation was correlated with gender(P<0.05), but not age, histological type, infiltration depth, lymphatic metastasis and Duke's stage. In 55 cases of rectal cancer with HPV infection, there were 31 cases with genic mutation of APC (56.4%) and 24 with genic mutation of K-ras (43.6%). For the 20 cases of rectal cancer with non-HPV infection, the figures were 12 cases (60%) and 10 (50.0%), respectively, with no significant relation. Survival analysis showed no statistical significance for K-ras genic mutation, APC genic mutation or HPV infection (P>0.05). However, the survival time of the patients with HPV infection was a little shorter than in cases without HPV infection. Conclusions: Our results suggest that HPV infection might be an important factor to bring about malignant phenotype of rectal cancer and influence prognosis. Genic mutation of APC and K-ras might be common early molecular events of rectal cancer, but without prognostic effects on medium-term or early stage patients with rectal cancer.
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Association Between GSTM1 Polymorphism and Nasopharyngeal Cancer Susceptibility: a Meta-analysis
Sun, Zhen-Feng,Zhang, Jia,Xu, Hong-Ming,Wang, Guo-Liang,Dong, Pin Asian Pacific Journal of Cancer Prevention 2012 Asian Pacific journal of cancer prevention Vol.13 No.11
Background/Aims: Glutathione S-transferase M1 (GSTM1) is a multifunctional enzyme that plays a critical role in the detoxification of varieties of carcinogenic metabolites. Many studies have been conducted to investigate the association between GSTM1 polymorphism and nasopharyngeal cancer (NPC) risk, but the findings among those studies are inconsistent. To assess this relationship more precisely, we performed a meta-analysis of all available studies on the subject. Methods: Case-control studies were identified by searching Pubmed, Embase, ISI Web of Science, and Wanfang databases through September 6, 2012. We used the pooled odds ratio (OR) with its corresponding 95% confidence interval (95%CI) to evaluate the association of GSTM1 polymorphism with NPC susceptibility. Subgroup analyses by pathological types, sex and smoking status were performed to further identify the association. Results: Overall, 11 published studies with 1,513 cases and 2,802 controls were finally included into this meta-analysis according to the inclusion criteria. Meta-analysis of total studies showed that the null genotype of GSTM1 was significantly associated with increased risk of NPC, when comparing with the non-null genotype (OR=1.51, 95%CI=1.33-1.72, POR<0.001). The association was still statistically significant in subgroup analysis of patients with nasopharyngeal squamous cell carcinoma (OR=1.73, 95%CI=1.24-2.42, POR=0.001). Males with the null genotype of GSTM1 were more likely to subject to NPC than females. In addition, the association between the null genotype of GSTM1 and NPC risk was strongest in individuals with exposure to smoking. Sensitivity analysis by sequential omission of any individual studies one at a time further demonstrated the significant association. Conclusions: The findings suggest that the null genotype of GSTM1 is a risk factor for NPC, and there is a gene-smoking interaction in this association.
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Development of New Endovascular Devices for Aneurysm Treatment
Zhen Yu Jia,Hai Bin Shi,Shigeru Miyachi,Sun Moon Hwang,Jae Jon Sheen,Yun Sun Song,Joong-Goo Kim,Deok Hee Lee,Dae Chul Suh 대한뇌졸중학회 2018 Journal of stroke Vol.20 No.1
Since the first use of the Guglielmi detachable coil system for cerebral aneurysm embolization in 1990, various endovascular methods have been developed to treat large numbers of aneurysms. The main strategic and technical modifications introduced to date include balloon-assisted coilembolization, stent-assisted coil embolization, flow diverters, and flow disrupters. The development and introduction of such devices have been so persistent and rapid that new devices are being approved worldwide even before the earlier ones become available in some countries. However, even if some patient populations may possibly benefit from earlier introduction of new devices, the approval authorities should balance the available evidence of the safety and effectiveness of novel devices. This review aims to provide an overview of the recent innovations in endovascular treatment of cerebral aneurysms and a brief review of market access policies and regulations for importing high-risk medical devices, such as those used for endovascular aneurysm management, which correspond to class III devices, as defined by the U.S. Food and Drug Administration. We focus on the current situation in Korea and compare it with that in other Asian countries, such as China and Japan.
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Zhen Sun,Guofeng Liu,Zuoling Fu,Xiangtong Zhang,Zhijian Wu,Yanling Wei 한국물리학회 2017 Current Applied Physics Vol.17 No.2
Yb3þ/Tm3þ co-doped BaGd2ZnO5 phosphors have been effectively synthesized by traditional sol-gel method. The graph of X-ray diffraction (XRD) exhibited that the obtained phosphors were pure orthorhombic phase. The morphology and composition of the samples were obtained by field emissionscanning electron microscope (FE-SEM) and the energy dispersive spectrometry (EDS). From upconversion luminance (UCL) emission spectra, the two strong blue emissions were obviously observed at 478 and 485 nm under the excitation of 980 nm. The possible energy diagram and UC mechanism were explained in detail. Optical temperature (T) sensing performances were evaluated in the temperature ranging 313 K - 573 K. And the highest sensor sensitivity calculated was 0.0055 K『1 at 323 K. Additionally, the laser excitation heating effect was also explored. The results indicated that Yb3þ/Tm3þ codoped BaGd2ZnO5 phosphors could be applied on optical temperature sensors and optical heater.
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