알코올이 Dynamic Posturography에 미치는 영향

이진춘,고의경,장민호,이병주,백무진,노환중,왕수건,전경명 대한이비인후과학회 1999 대한이비인후과학회지 두경부외과학 Vol.42 No.2

안구적출에 따른 위둔덕의 Calbindin D-28k과 c-fos의 변화에 관한 연구

김명,김기훈,김주영,하현철,안명수,김장민,조향훈,정명섭,장인엽 朝鮮大學校 附設 醫學硏究所 2005 The Medical Journal of Chosun University Vol.30 No.2

Changes of Calbindin D-28k- and c-fos-immunoreactivities in the superior collicuclus after Eye Enucleation. Objective and methods: Calcium-binding proteins (CBPs) play an important role in the protection, differentiation and reorganization of the central nervous system. The effects of neonatal retinal deafferentation on a CBPs, calbindin D-28k were examined immunohistochemically in the superficial layer of the rat superior colliculus. Also early gene familly c-fos was examined to evaluate the neuronal characteristics in the superior colliculus after monocular enucleation. Results: On the experimental side of superior colliculus, the number of calbindin D-28k-immunoreactive (IR) cells was reduced (77.4% compared to control), but not fibers. Appearance of c-fos-like immunoreactivity was represented much more in the ipsilateral superior colliculus than contralateral side within 24h after eye enucleation. Conclusion: These results suggest that the changes of retinotectal projection may alter the expressional pattern of calbindin D-28k and c-fos expression.

채널 식각형 비정질 실리콘 박막 트랜지스터에서 배면에 수소 이온 도핑효과

장진,최종현,이경하,임병천,김창수 慶熙大學校 레이저 工學硏究所 1997 레이저공학 Vol.8 No.-

We have studied the effect of the hydrogen ion doping on the free surface of back channel etched a Si:H TFTs. The hydrogen ion doping on the back channel etched TFT reduces the off-state photo leakage current by one order of magnitude. The reduction of the photo-leakage current is due to the creation of defect states at the free surface by hydrogen ion doping. After hydrogen ion doping on the free surface, the field effect mobility change little, but the threshold voltage increases, which is due to the state creation in a-Si:H by ionized H ions. Furthermore, the off-state leakage current under frontlight illumination can be reduced by 2 orders magnitude by hydrogen ion doping on the back channel of a Si:H TFT.

수용성 키틴이 백서 창상치유에 미치는 영향

강장석,조용남,정상훈,유 결,임진수,권 호,조용우,고석원 大韓成形外科學會 2001 Archives of Plastic Surgery Vol.28 No.1

유온감압법에 의한 슬러지의 탈수에 관한 연구

장성호,박진식,성낙창,김수생 동아대학교 환경문제연구소 1996 硏究報告 Vol.19 No.1

This study was to experiment, through sewage sludge treatment by Vacuum Frying Method, the effects of reaction condition come up to sludge water content. The results are as follows 1) On accassion the sewage sludge treatment by Vacuum Frying Method, the effect of pressure come up to water content, the water content decreased when the same reaction temperature and time was lower pressure more than the normal pressure(760㎜Hg), particularly. Since pressure 280㎜Hg increased water content decrease range. Since pressure(250㎜Hg) the water boiling point down sharply a phenomenon and the lower pressure lowered the water boiling point a phenomenon, the same sewage sludge water content evaporated rapidly the lower pressure more than the normal pressure. Accordingly, a close vacuum(40㎜Hg), showed very lower water content when a short reaction temperature and reaction time. 2) On accassion the sewage sludge treatment by vacuum Frying Method, the effect of reaction time come u to sludge water content, at the same reaction pressure and temperature, relatively the water content at a low reaction temperature(90℃, 120℃) decreased small in case of a long reaction time, the water content at a high reaction temperature(150℃, 180℃) decreased rapidly in case of a short reaction time. 3) On accassion the sewage sludge treatment by Vacuum Frying Method, the effect of come up to sludge water content, at the same reaction time and pressure, increase of reaction temperature decreased rapidly the water content.

학사 데이타베이스 구축을 위한 논리적 설계에 관한 연구

장수진,이중인,진성일 충남대학교 자연과학연구소 1992 忠南科學硏究誌 Vol.19 No.1

In this thesis, we deisign the logical database model by relational database design tool. We used the E-R model in a conceptual step. We used the mapping rule and BCNF algorithm for the normalization, and describe the implementation of the educational information by these methods.

Branch-Line Slit 을 갖는 이중 대역 PIFA의 설계 및 제작

장수영,윤진호,김보미,김석현,이영순 금오공과대학교 2005 論文集 Vol.26 No.-

A PIFA(Planar Inverted-F Antenna) which can be used in GSM/IXS dual band mobile phone has been designed and fabricated. In particular, in order to reduce the required top patch dimensions, the patch of the present PIFA has been designed as a type of an asymmetric branch line slit in which the excited patch surface currents can be meandered. By use of the HFSS, important design parameters such as the position of feed point and the length of slit were simulated and determined. In the present study, the design procedure by which the exact operating frequency and the proper band width can be obtained, are discussed. In order to check the validity of the present study, some simulated and measured results are presented.

일부 소규모 시계조립 사업장의 상지 누적외상성장애의 유병률

장은철,김현주,권영준,박시복,이수진,송재철 大韓産業醫學會 2000 대한직업환경의학회지 Vol.12 No.4

목적 : 단순 반복작업을 하는 시계조립 사업장 근로자를 대상으로 상지 누적외상성장애의 자각증상 유병률과 상지 누적외상성장애 유병률을 파악하고자 하였다. 방 법 : 인구학적 특성, 상지의 자각증상, 사회심리적 요인은 자가 설문지법으로, 인간공학적 특성은 점검표를 이용한 면담법으로 조사하였다. 상지의 자각증상 조사와 사회심리적 요인은 각각, N10SH (1993) 설문지와 Karasek(1979)의 Job strain model을 번역하여 조사하였다. 상지 누적외상성장애 판정은 의사가 작업 현장에서 직접 환자 면담과 이학적 검사를 수행한 후, 연구에서 규정한 증례정의에 의해 수행하였다. 수집된 자료는 x2 teat와 exact test로 단별량 분석을 하였고, 이중 의미있는 변수와 위험 인자로 알려진 변수들로 다중 로지스틱 회귀분석을 시행하였다. 결 과 : 대상자들의 자각증상 유병률은 54.2 %였고, 부위별로는 목 34.9 %, 손/손목 31.3 %, 어깨 30.1 %, 팔/팔꿈치 18.0 %순이었다. 상지 누적외상성장애의 유병률은 45.8 %였고, 근막동통증후군이 26명으로 가장 많았고, De Quervain씨 병 8명, 수부/전완부의 건염 및 건활막영 8명, 수근관 증후군 5명, 이두건염 5명, 척골 신경병증 5명, 내상과 염 4명, 외상과염 2명, 경추 디스크 질환 2명, 흥곽 출구 증후군 1명순으로 나타났다. 단변량 분석시 자각증상 유병률은 작업부서 중 완성 부에서, 상지 누적외상성장애 유병률은 여자와 완성 부에서 통계학적으로 유의하게 높았다. 다중 로지스틱 회귀분석 결과 완성부와 근무긴장도가 높은 군이 상지 누적외상 성장애와 통계학적으로 유의한 결과를 보였다. 결 론 : 이 연구에서 상지 누적외상성장애 유병률은 45.8 %으로서 저강도의 단순 반복작업을 하는 시계조립 사업장 근로자에서도 누적외상성장애의 위험이 있는 것으로 생각된다. 또한, 사회심리적 요인과 작업 부서별 공정 및 환경이 유병률에 영향을 미치는 주요 요인으로 생각되며, 향후 이들에 관한 다양한 연구가 진행되어야 할 것이다. 산업보건 현장에서는 시계조립 사업장과 같이 저 강도의 단순 반복작업을 위주로 하는 사업장에 대한 지속적인 관심과 각 사업장별 위험요인을 파악하여 적절한 예방 및 관리 대책을 세워야 할 것이다. Objectives : The prevalence of cumulative trauma disorders of upper extremities mons watch assembly workers in small-scaled industry was studied. Methods. In 83 workers at five watch assembly factories, symptoms and psychosocial questionnaire, ergonomic Interview, physical examination were conducted. Results : Prevalence of self-reported symptoms was 54.2% and neck 34.9%, wrist/hand 31.3%, shoulder 30.1%, elbow/arm 18.0% by anatomical site. Prevalence of cumulative trauma disorders was 45.8%. Most common disease was myofascial pain syndrome (31.3%). The other diseases were De Quervain disease (9.6%), tenosynovitis/tendinitis at wrist/hand (9.6%), bicipital tendinitis(6.0%), fat. epicondylitis(4.8%), meIn. epicondylitis(2.4%), and cervical disc disease(2.4%). As result of ergonomic interview, repetitiveness was 79(98.8%). There were no differences in the prevalence of self-reported symptoms and cumulative trauma disorders for age, sex, marital status, duration of work In the study, The significant factors of cumulative trauma disorders were occupational task and psychosocial stress in the study. The prevalence of cumulative trauma disorders in high strain group was hlgher (68.4%) than other three groups. The prevalence of self-reported symptoms and cumulative trauma disorders in assembly task was higher (70.0%, 64.0%) than other two tasks. Conclusions : Prevalence of self-reported symptoms was 54.2%, prevalence of cumulative trauma disorders was 45.8% in watch assembly workers. In this study, factor related to self-reported symptoms was occupational task and factors relaxed to cumulative trauma disorders were occupational task and psychosocial stress. This results suggest that differences of ergonomics and environment in occupational task cause differences of prevalence of self-reported symptoms and cumulatlve trauma disorders.

비소세포 폐암 환자의 이차 치료로서 Gemcitabine과 Vinorelbine 혼합 요법의 효과

장필순,강현모,이정은,권선중,안진영,이연선,정성수,김주옥,김선영 충남대학교 암공동연구소 2006 암공동연구소 업적집 Vol.5 No.

Background : Both gemcitabine and vinorelbine are effective anticancer drugs with mild toxicity on non-small cell lung cancer, and monotherapy of these drugs are effective as a second-line chemotherapy. The aim of this trial was to assess the response and toxicity of a combination of gemcitabine and vinorelbine in patients of previously treated for non-small cell lung cancer. Materials and Methods : 24 patients, initial stage III A/B,IV and previously treated with platinium and taxane based regimens, were enrolled from June 2000 to March 2004. The regimens consisted of vinorelbine 25mg/㎡ followed by an infusion of gemcitabine 1000mg/㎡ on day 1 and day 8 every three weeks. This course was repeated more than twice. Results : Twenty-four patients were analyzed for the response, survival rate, and toxicities. The overall response was 17% with a complete remission rate of 4%. The median time-to progression (TTP) was 3.1 months (95%, CI l-10months), and the survival time was 8.2 months (95%, CI 1-23 months). The grade 3/4 toxicities encountered were neutropenia (12.5%), anemia (0%), thrombocytopenia (0%). Non-hematological 3/4 toxicities were not observed. Conclusion : A combination of gemcitabine and vinorelbine in patients previously treated for non-small cell lung cancer provides a relatively good response rate, and a low toxicity profile. However, further study will be needed to confirm its effectiveness. (Tuberc Respir Dis 2005; 58: 344-351) 배경 : Gemcitabine, paditaxel, docetaxel, vinorelbine, ir-rinotecan 새로운 항종양제의 출현으로 일차 치료의효과가 증대 되고 있고 재발시에도 좋은 신체 활동도를 보이고 있어서 이차 치료의 대상군도 늘어나는 효과를 보이고 있다. 치료의 필요성은 증대 되고 있지만 현재까지 표준 치료가 확립되지 않은 상황에서 Gem-citabine과Vinorelbine모두 독성이 강하지 않아서 혼합 요법이 가능한 장점이 있고 비소세포 폐암에 대한효과도 입증이 되어있어서 본 연구는 반응이 없거나 반응을 보인후에 재발된 진행된 비소세포 폐암에 ge-mdtabine과 vinorelbine 흔합 요법을 시행하여서 치료 반응률과 생존율 그리고 부작용을 평가하였다. 대상 및 방법 :2000년 6월부터 2004년 3월까지 충남대학교병원에내원하여 진행성 비소세포 폐암 IIIA/IIIB, IV로 진단을 받고 일차 항암화학요법치료를 받은 환자중에 초기 치료에 반응이 없거나, 치료에 반응이 있었으나 병이 진행된 환자로 추적 관찰 기간이 6개월 이상인 환자를 대상으로 생존율과 반응률 그리고 독성을 분석하였다. 결과 : 총 치료 반응률은 17%. 반응 유지기간의 중앙값은 3.1개월(1-10개월)이었고 생존기간의 중앙값은 8.2개월 (1-23개월) 그리고 1년 생존율은 35%였다. 항암화학요법에 의한 독성은 3도 이상의 중성구 감소가 12%, 오심과 구토가 12.5% 였다. 결론 : 일차 치료에 반응이 없거나 재발한 비소세포 폐암환자의 이차 치료로 gemcitabine과 vinorelbine 혼합요법은 효과적이라고 생각되며 향후 3상 연구를 통한다른 약제와의 비교 연구가 필요하다고 생각된다.

동기발전기 여자시스템용 고주파 PWM 컨버터 설계

장수진,류동균,원충연,이진국,배기훈,김수석 성균관대학교 2003 학술회의지원논문목록집 Vol.2003 No.-

A synchronous generator is equipped with an automatic voltage regulator(AVR), which is responsible for keeping the output voltage constant under normal operating conditions at various levels. The output voltage of Synchronous Generator is regulated constantly by field voltage control in excitation system. High frequency PWM converter (Buck converter) type excitation system for synchronous generator that can sustain proper output voltage level even at the fault condition happened. The proper operation of the proposed excitation system was verified through the simulations and the experiments.