결핵환자에 있어서 세포성 면역의 변화 (1)

김주옥,김선영 충남대학교 의과대학 지역사회의학연구소 1991 충남의대잡지 Vol.18 No.2

It is well established that cell-mediated immunity including T cell activation is the most important mechanism for the host defence against Mycobacterium tuberculosis. There are some indices for describing the mitogen-induced lymphocyte transformation such as stimulation index (SI). Recently curnmulative index (CI) was suggested to describe lymphocyte blastogenic function more accurately. To evaluate the abnormalities of cell-mediated immunity and usefulness of CI, we measured the T cell subsets and compared the indices (SI and CI) of lymphocyte transformation of peripheral mononuclear cells in patients with tuberculous patients (17 with pulmonary tuberculosis, 5 with tuberculous pleurisy). The postitive scores of skin test using CMI multitest kit were significantly decreased in patients group compared to normal controls. The percentage of total T lymphocytes in patients was not significantly different from normal controls, but that of helper T cells was significantly decreased and that of suppressor T cells was significantly increased, resulting significant decrease in T_4/T_8 ratio in patients group. The SI in patients was not significantly different from controls because of wide standard deviation, but CT was significantly decreased in patients group. As a result of this study, we could confirm the abnormal cell-mediated immunity in tuberculous patients and suggest that CI is a more useful parameter for describing the mitogen-induced lymphocyte transformation.

객혈의 임상적 고찰 및 기관지 내시경의 역할

김주옥,이종진,서지원,김선영 충남대학교 의과대학 지역사회의학연구소 1995 충남의대잡지 Vol.22 No.2

118 patients with hemoptysis were reviewed retrospectively to identify etiologic factors, clinical features, and treatment and to evaluate the usefulness of fiberoptic bronchoscopy. 63 cases (53.4%) were blood-tinged sputum, 2 cases (1.7%) were more than 600ml a day in amount of hemoptysis. Pulmonary tuberculosis was 37 cases (31.36%), the most common cause of the known etiologic factors. Lung cancer was 6 cases (5.09%). 6 patients (5.09%) were treated with bronchial artery embolization, 1 patient (0.85%) treated with right lower lobectomy. 1 (4.3%) of 23 patients with hemoptysis and normal chest roentgenogram was found to have lung cancer. We suggest that in patients with hemoptysis and normal chest roentgenogram, routine fiberoptic bronchoscopy is not necessary to exclude malignancy.

폐암환자에 있어서 T 세포 매개성 면역의 변화(Ⅰ)

김주옥,김선영 충남대학교 의과대학 지역사회의학연구소 1990 충남의대잡지 Vol.17 No.2

Cell-mediated immunity (CMI) was evaluated in 30 patients with lung cancer by in vivo and in vitro methods. These included skin test with CMI multitest kit, determination of peripheral T lymphocytes, and lymphocyte response to phytohemagglutinin (PHA) and concanavalin A (Con A). The positive scores of skin test were significantly lower in lung cancer group than controls (p<0.05), and there were no significant differences in T cell subsets. The response to PHA and Con A were greatly depressed in lung cancer and it was more apparent in advanced stage. But there was no difference in stimulation index (SI) between cancer patients and normal controls. The cumulative index (Cl) was more significant difference in cancer patients and advanced stage. These results suggest that depressed CMI in patients with lung cancer might be caused by lymphocytic dysfunction and cumulative index is more accurate to describe lymphocyte blastogenic function than stimulation index.

PCR을 이용한 Rat 기관지 세척액에서의 Pneumocystis carinii DNA의 검출 : 기초실험 A pilot study

김주옥,홍석철,한표성,이종진,김선영,이영하,신대환 충남대학교 의과대학 지역사회의학연구소 1994 충남의대잡지 Vol.21 No.1

Background: Pneumocystis carinii (PC) is a opportunistic pathogen causing serious pneumonia (Pneumocystis carinii pneumonia : PCP) in immunosuppressed patients including AIDS. Laboratory diagnosis of PCP is dependent on microscopic demonstration of the PC by using cytochemical staining or by immunocytochemical staining with monoclonal antibodies. However, these staining methods are not highly sensitive. The development of the polymerase chain reaction (PCR) has made it possible to detect very small numbers of pathogens in clinical specimens. To establish the usefulness of PCR for detection of PC DNA, We performed PCR as a pilot study. Methods: PCP was induced on Spraque-Dawley rats with prednisolone 5mg IM twice a week. Bronchial lavages, impression smears, and permanent sections were performed from the 3rd week to 7th week of cortisonized rats. PC DNA was extracted with bead beater / 10% CTAB method. Results: Impression smears showed PC cyst after the 4th week (100%, 28/28 rats), and permanent sections showed 27/28 rats. Control rats showed some PC cysts (2/7). PCR result was positive only one case among the 6th week rats (1/7), But positive 6 cases at the 7th week rats, (6/7). Among control rats. 2 cases were positive (2/7). ??This data is a pilot study for the PC DNA detection using a PCR. PCP were successfully cortisonized rats. If adequate bronchial washing technique will be used, PCR can be a sensitive for PC DNA detection.

기관지경 생검상 확진된 폐암환자에서 기관지세척 세포진과 다른 지표들과의 관계

김주옥,서지원 충남대학교 의과대학 지역사회의학연구소 1989 충남의대잡지 Vol.16 No.2

Bronchoscopic examination is an essential tool for diagnosis and treatment of the lung cancer. Various method with bronchoscopy are possible, such as cytologic examination (washing, brushing, bronchoalveolar lavage and transbronchial needle aspiration0, mucosal biopsy and transbronchial lung biopsy. There are many reports on the bronchial washing cytology, but there were few reports on the relations between bronchial washing cytology and other various parameters(age, sex, celltype, bronchoscopic location and shape of lesion). To evaluate the relationships between washing cytologic yield, age, sex, celltype, bronchoscopic location and shape of lesion in lung cancer, we have studied in 189 patients(males 170, females 19; ages, mean 60.7yrs) with histologically proven lung cancer who showed direct signs of lung cancer bronschoscopically. All cases were collected washing cytology specimens simultaneously. :There were no significant relationship between age and washing cytology positivity, celltype or bronchoscopic shape of lesion, between sex and washing cytology positivity, bronchoscopic location or shape of lesion, There was significant relationship between sex and celltype, that is, NSCLC in male vs SCLC in female. There were no significant relationship between cytology positivity and celltype, bronchoscopic location or shape of lesion. There was significant relationship between celltype and bronchoscopic location of lesion, that is, squamous and SCLS in both upper lobes va adenocarcinoma in RLL. There was no significant relationship between bronshoscopic location and shape of lesion, but significant between celltype and shape of lesion.(mass in squamous vs non-mass in SCLC). In conclusion, lung cancer has more prevalent in older males than females and both upper lobes, and squamous cell carcinoma has more mass-shaped and SCLS has more infiltrated lesion bronchoscopically. The cytologic positivity was not depended on the bronchoscopic shape of lesion.

모바일 특성화 고등학교의 응용프로그래밍 수업 모형 개발

김주옥,전영국 순천대학교 교육과학연구소 2020 현장수업연구 Vol.1 No.1

Recently, the NCS curriculum has been introduced in specialized high schools aiming to cultivate practical skills such as knowledge, skills, and attitudes that are needed in industrial fields. This paper explored a model development for improving practical competencies of students in a K specialized high school in the area of information and communication based on the NCS curriculum. The curriculum of applied computer programming among the NCS practical courses is composed of the lessons for software production such as development environment, user requirements analysis, application building and testing, and maintenance. However, it is one of the most difficult subjects for learners, and the students of specialized high school due to the students’ different competency levels in their understanding of programming and their logical thinking, which makes them less interested in learning and lowers their academic achievement. In this study, we focused on developing teaching and learning materials that can develop creative problem-solving methods by adopting ‘Design Thinking’ techniques to enhance learner-oriented teaching and learning. Considering the students’ lack of concentration and learning comprehension as a whole, the curriculum model and teaching materials were organized in order to raise their interests through hands-on and creative problem solving activities. The prototype of developed model and instructional materials was implemented in the second year class of K specialized high school. At the end, we suggest directinos for improving the model and instructional materials based on interviews with expert teachers. 최근 특성화고등학교에 도입된 NCS 교육과정은 실제 산업 현장에서 필요한 지식, 기술, 태도 등의 실무 능력을 함양하는 것을 각 교과의 목표로 삼고 있다. 이 연구의 목적은 경기도에 소재한 K 특성화 고등학교에서 정보컴퓨터 분야의 응용프로그래밍 교과의 수업지도안과 모형 개발에 따른 수업자료를 적용한 사례를 고찰하고 응용 프로그래밍의 실무 능력을 함양하는데 있다. 특성화 고등학교에서 개설되고 있는 응용프로그래밍 교과는 모든 과정이 실습으로 구성되어 있고 프로그래밍 언어 뿐 아니라 개발환경 구축, 사용자 요구분석, 애플리케이션 구축 및 테스트, 유지 보수와 같이 소프트웨어 제작을 위한 전 과정을 다루는 특징을 갖고 있다. 하지만 학습자에게는 매우 난이도가 높은 교과 중 하나이며 특성화고 학생들의 경우 프로그래밍에 대한 이해도와 논리적인 사고력에 편차가 커서 일반적인 교수·학습 방법을 적용했을 때 학습에 대한 흥미가 떨어지고 학업성취도가 낮은 편이다. 따라서 이 연구는 학습자의 흥미를 높이고 배움 중심의 교수·학습이 이루어 질 수 있도록 디자인 사고(Design Thinking) 기법을 도입하여 창의적인 문제 해결 방법을 기를 수 있는 교수-학습 자료를 개발하는데 중점을 두었다. 실습과 모둠 단위의 프로젝트 학습을 통해 응용 프로그래밍 교과 학습에 대한 관심과 흥미를 높일 수 있도록 개발된 교수-학습 지도안과 수업 자료는 K 고등학교 모바일컨텐츠과 2학년 학생들을 대상으로 한 수업에 일부 적용되었다. 마지막에 전문가 교사 면담을 통한 모델 개발에 대한 수정 사항과 수업 적용에 관한 향후 방향을 제시하였다.

토지소유권에 대한 공법적 규제

김주옥 관동대학교 1994 관동법학 Vol.3 No.-

‘대칭적 인류학(anthropologie symétrique)’ 논의와 ‘사운드스케이프(soundscape)’ 작품을 통해 본 기술과 예술의 생태학

김주옥 현대미술사학회 2018 현대미술사연구 Vol.0 No.44

The purpose of this paper is to reconsider the humanistic attitude by discovering problems in the modern anthropocentric view of the world based on a discussion of ‘symmetric anthropology’, a term proposed by Bruno Latour(1947-) in his book, We Have Never Been Modern. The Great Animal Orchestra, written by Bernie Krause, and which is analyzed in this paper, presents an auditory landscape using ‘soundscape’, which is a compound word made up of ‘sound-landscape’. This soundscape reveals the actual conditions of environmental pollution that cannot be easily recognized by just using our ordinary senses. NEUROSCAPE, a soundscape design system of RETRIEVER that uses deep learning AI technology, shows how sound, image and text information, using the multi-modal method based on meta data search, is restructured into a soundscape collage. By presenting such an example, this paper aims to ecologically look at nature and the environment, which human beings can not see, from an egocentric view of the world and to explore the possibility of reestablishing the host-guest relationship between the subject and others, which had been recognized by separating that dualistic existence from the human environment which surrounds technology, media and the arts. 본 논문은 인본주의적 견해로 분리된 인간/비-인간 구도를 탈피할 수 있는 방법에 대해‘대칭적 인류학’의 논의로 연구해본다. 기술-미디어를 사용한‘ 사운드스케이프(soundscape)’ 작업을 살펴봄으로써 기술적 주체의 등장과 함께 인간이 타자화했던 기술에 대한 이분법적 구도가 달라지는 것을 확인하며, 과연 예술은 인간 주체에 의해서만 생산 가능한 것인지 반문해본다

급성 세균성 감염증에 대한 Cefotetan(Yamatetan^ⓡ)의 임상적 효과

김주옥,안원전,박종훈,노흥규,박종우 충남대학교 의과대학 지역사회의학연구소 1987 충남의대잡지 Vol.14 No.1

Total 20 cases of infectious diseases were treated with Cefotetan at the Dept. of internal medicine, Chung Nam National University Hospital, Dae Jeon, Korea, from January 1985 to April 1985. Among 20 cases, 6 were the patients with acute pyelonephritis, 7 were pneumonia, 2 were acute cholecystitis, 2 were chronic bronchitis, 2 were cellulitis and 1 was lung abscess. The response was good in 16 cases, and poor in 4 cases. The laboratory tests were normal except I which was reversible. (mild elevation of SGOT and SGPT) The side effects were noted in 2 cases, such as skin eruption and drug fever, which were improved with supportive care. Cefotetan was thought to be useful against acute bacterial infections of respiratory, urinary, biliary tracts and cutaneous tissue.

Interventional Pulmonology : Photodynamic Therapy(PDT) in Lung Cancer

김주옥,정미경 대한결핵 및 호흡기학회 2006 워크샵 Vol.24 No.-