구강점막 부착용 케토프로펜 고분자 필름의 제조 및 평가

박진석,이상은,강봉석,이경록,이은주,박정숙 충남대학교 약학대학 의약품개발연구소 2014 藥學論文集 Vol.29 No.-

Abstract – The objective of this study was to prepare ketoprofen-loaded buccal adhesive patch. The adhesive patch was formulated by casting method using aqueous soluble polymer povidone K17 (PVP 17PF) as film-forming agent and hydroxypropylmethylcellulose (HPMC) as adhesive agent. To compare the effect of HPMC type, different molecular weight of K4M and K15M HPMC was used. The physicochemical properties of patches such as appearance, thickness, in vitro release, and adhesiveness were investigated. The concentration of ketoprofen was determined spectrophotometrically at a wavelength of 233 nm. The appearance of prepared patches was semi-transparent, light-yellow or almost colorless, and odorless. Thickness of each patches (n=6) was 0.895 ± 0.033 mm for K4M patch and 0.727 ± 0.036 mm for K15M patch. In vitro release test, both K4M and K15M patches showed over 20% release within 30 min. At 120 min, K4M and K15M patches demonstrated 95% and 67.5% release of ketoprofen, respectively, and up to 240 min, both patches released drug completely. Maximum adhesive force of K4M and K15M patches was 6.571 ± 2.703 gf and 2.735 ± 1.151 gf, respectively. Moreover, it took 28.29 ± 0.38 sec and 28.30 ± 0.34 sec for K4M and K15M patch to peel off them after adhesion, showing no significant difference. In conclusion, thickness, in vitro release, and maximum adhesive force could be modulated by alteration of polymer types.

Inoue Balloon을 이용한 PMV의 장·단기 결과 분석

진은선,이연아,전숙,김현숙,정승묵,박상선,최락경,임달수,홍석근,황흥곤 대한순환기학회 2003 Korean Circulation Journal Vol.33 No.11

민간 경호·경비원들의 의식구조와 가치관에 관한 연구

박준석,최현식,정성숙,김진환,정석현 한국스포츠리서치 2004 한국 스포츠 리서치 Vol.15 No.4

The aim of this study was to investigate Consciousness and Value on Private Bodyguard and Security. I started to search from 7. January. 2004 to 20. May. 2004. so totally I searched for 5month, As a result, I got 526 papers of questionnaire and dropped 26 papers of them because of insincere answers from responders, So I used 500 papers for the research that I am doing. The method of One-Way ANOVA was used to verify the mean ratio and LSD multiple range test was also used for the verification when there was a slight difference among the objected group, All data were analyzed by SPSS 11.0 producer. The results of this study are like the below: 1) The result In the case of ages showed that significant difference(p<.05) companies consciousness were Private Bodyguard and Security for structure of consciousness. 2) The result In the case of Educational Credentials showed that no significant difference self consciousness, welfare conscious ness, social consciousness, companies consciousness were Private Bodyguard and Security for structure of consciousness. 3) The result In the case of work duration showed that significant difference(p<.05) self consciousness were Private Bodyguard and Security for structure of consciousness. 4) The result in the case of monthly income showed that no significant difference self consciousness, welfare conscious ness, social consciousness, companies consciousness were Private Bodyguard and Security for structure of consciousness. 5) The result in the case of working time showed that significant difference(p<.05) self consciousness, social consciousness, companies consciousness were Private Bodyguard and Security for structure of consciousness.

성인여성의 체지방분포유형과 혈청성분, 식사행동및 열량섭취간의 관련성에 관한 실태조사

김석영,윤진숙 啓明大學校生活科學硏究所 1992 科學論集 Vol.18 No.-

This study was intended to figure out the interrelationship among body fat distribution type, serum components, eating style and energy intake. One hundred forty four female adults from Jinju area were participated in this study. The survey was conducted between December 17, 1990~February 27, 1991. Subjects were divided into two groups by WHR ratio (Waist/Hip girth ratio). Body fat content, fasting serum insulin level, serum lipids, eating style, and energy intake of two groups were compared. When subjects were classified into upper body type and lower body type women, age, weight, BMI(Body Mass Index), body fat ratio were significantly higher in upper body type women. While serum triglyceride and total cholesterol were also significantly higher, HDL-cholesterol was significantly lower in upper body type women. However, there was no significant difference in eating style. Total daily energy expenditure was significantly higher in upper body type women. These results suggested that body fat distribution would be relevant to chronic metabolic diseases.

부부 문제에 대한 인지행동적 접근

김진숙,권석만 서울大學校 社會科學大學 心理科學硏究所 2003 心理科學 Vol.12 No.1

최근 이혼율과 더불어 가정파탄을 초래하는 부부 문제가 급증하고 있다. 이 글에서는 부부 문제를 이해하고 해결하기 위한 인지행동적 접근과 최근의 연구동향을 개관하였다. 이를 위해서 우선 부부 문제가 개인과 가정에 미치는 부정적인 영향을 제시하고 부부 문제의 구체적인 갈등내용을 살펴보았다. 이러한 부부 문제를 초래하고 악화시키는 다양한 인지행동적 요인들, 즉 부부관계와 배우자에 대한 역기능적인 신념과 기대, 배우자의 행동에 대한 인지적 왜곡, 부부관계에서 나타나는 부적응적인 행동방식 등을 소개하였다. 아울러 부부 갈등을 설명하는 인지행동적 설명모형으로서 Ellis의 합리적-정서 모형, Beck의 인지행동적 모형, Baucom과 Epstein의 인지 모형 및 Bradbury와 Fincham의 맥락 모형을 개관하였다. 마지막으로, 한국인이 나타내고 있는 부부 문제를 이해하고 해결하기 위한 인지행동적 접근과 앞으로의 연구과제를 제시하였다. Korean people are suffering from the soaring divorce rate and frequent marital problems. The purpose of this article is to introduce the recent research trend on marital problems from the cognitive-behavioral perspective. The important cognitive-behavioral factors resulting in marital problems, i.e., dysfunctional beliefs on marital relationship, unrealistic expectations to spouse, cognitive distortion to spouse's behavior, and maladaptive behaviors in marital relationships were reviewed on the basis of recent investigations. In addition, the major contents and issues of marital conflict were reviewed with the negative influences of marital problems on the married persons and their family. Lastly, the cognitive-behavioral approach and future research tasks for understanding and solving marital problems of Korean couples were discussed.

완전 포상기태 이후 발생한 지속성 융모질환의 치료경험 2례.

이진희,류은석,김윤숙,김종수,최승도,선우재근,배동한 순천향의학연구소 2005 Journal of Soonchunhyang Medical Science Vol.11 No.1

Persistent tumor develops in approximately 20% of patients with a complete mole, and chemotherapy is required to achieve remission. Following evacuation of hydatidiform mole, careful hCG monitoring is mandatory since it is the most reliable and sensitive method for the early detection of gestational trophoblastic disease. In carefully selected patients in whom the risk of developing gestational trophoblastic disease is significant or when the availability of hCG testing is suboptimal, chemoprophylaxis has been shown to decrease the risk of gestational trophoblastic tumor. We report here two cases of patient, 16-year-old and 45-year-old women who experienced unusual course after the evacuation of a complete mole and markedly elevated serum β-hCG levels. The patient developed persistent gestational trophoblastic disease and were successfully treated with EMA-CO and hysterectomy.

국내에서 파상풍의 연령별 면역혈청학적 역학연구

강진한,허재균,김종현,이경일,박수은,마상혁,이명숙,반상자,홍성화,조대현,이성호 대한감염학회 2001 감염 Vol.33 No.2

Background : The incidence of tetanus in adults and neonatal tetanus have been markedly reduced by world-wide use of DTP vaccines. But, tetanus is still one kind of major health problems in many developing countries, and several serosurvey stduies in developed ountries revealed that substantial proportions of adult opulation may lack immunity against tetanus and imunity level against tetanus is continuously decreasing by age. In Korea, tetanus outbreaks have been disappeared since the 1980s by high acceptant DTaP vaccination rates. Annually, few tetanus patient has been reported since 1990s. But, there knave been no seroepide-miological studies to tetanus, no trials to assess tetanuts immunizations. And we do not use Td vaccine in adults for maintaning tetanus immunity. In this aspect, we conducted age related survey of immunity to tetanus and indirectly assessed the immunogenecity of tetanus vaccines, used in Korea. Methods : For the evaluation of age related sero-survey of tetanus immunity in Korean population, study subjects were classified into 16 groups (A∼J group; below 10 years with one year interval, K∼O group; 11~60 yrs with 10 years interval, p group; over 60 yrs). The numbers of each group were 100, and sex distributions of each group were almostly equal. And far the indirect assessment of tetanus immunization in Korean children, children under 15 years old age were classified into 6 groups (I∼VI) according to the status of DTaP vaccination. The numbers of this each group were 50, and sex ratio was almostly equal. Specific IgG antibody to tetanus toxin were detected by ELISA. And the ANOVA repeated t-test was used to compare antibody levels in study groups. Results : In age related groups, the antibody levels to tetanus toxin were well maintained until 20 years old age group (L group), but thereafter the titers abruptly decreased below 0.1 IU/mL and over 75% populations among the groups over 30 years old age needed maintenance of protective immunity to tetanus. The antibody level of male was statistically higher than that of female in P group. In the groups related DTaP vaccination status, the antibody titer was very low in pre-vaccination group (I), but the titers after primary vaccinations were sharply increased and highly maintained until 15 years. Conclusion : The results of our study revealed that the immunity to tetanus was dramatically decreased in age groups over 30 years old. This result indicates that Td vaccination program in adults should be considered for maintenance of immunity to tetanus. And our study indicate that DtaP vaccination programs and vaccines, used in Korea, are effective for acquisition and maintenance of tetanus immunity in Korean children. (Korean J Infect 33:104~111, 2001)

한국 소아에서 보행발달 과정의 삼차원 동작분석 특성

박창일,박은숙,김유철,신지철,조상현,박진석 大韓再活醫學會 1998 Annals of Rehabilitation Medicine Vol.22 No.6

고식적 검사로 간외 전이를 진단하지 못한 원발성 간암 환자에서 간이식 전에 시행한 전신 FDG-PET의 역할

이원우,류진숙,양유정,김재승,여정석,문대혁,이승규 대한핵의학회 2002 핵의학 분자영상 Vol.36 No.6

목적: 원발성 간암의 치료를 위해 간이식이 시행되고 있으나, 8-54%의 환자에서는 이식 후 원격 전이로 인한 재발이 보고 되고 있다. 이 연구는 간이식 예정인 원발성 간암 환자들에서 고식적인 검사로 진단하지 못한 간의 전이 진단에 있어서 FDG-PET의 유용성을 평가하고자 시행되었다. 대상 및 방법: 2001년 8월 이후 본원에서 간이식을 계획하고 전신 FDG-PET을 시행한 환자 중, FDG-PET 검사 이전에 복부 초음파와 CT, 흉부 x선 검사와 CT, 골스캔 등의 고식적인 검사를 시행하여 전이의 증거가 없거나(n=22), 애매한 이상 소견이 있었던(n=4) 원발성 간암 환자 26명(남:여=23:3), 평균 나이 55.7세)을 조사하였다. FDG-PET에서 양성을 보인 결과는 조직 검사나 임상적인 추적 검사로 전이 여부를 확인하였다. 결과: 고식적 검사에서 애매한 이상 소견이 있었던 환자 4명 중 3명의 6개 병변이 FDG-PET에서 국소 대사 항진을 보였고, 전이로 확인되어 간이식을 시행하지 않았다. 이 중 5 병변들은 의심되지 않았던 부위에서 새로 발견된 것이었다. 다른 1명은 PET에서 음성 소견으로 간이식을 시행하였다. 고식적인 검사에서 전이를 의심할 만한 소견이 없었던 22명 중에서는 5명의 환자에서 7개의 간의 국소 대사항진 병변들이 FDG-PET에서 발견되었는데, 이들 줄 1명은 2 개의 전이 병변이 확인되어 간이식을 시행하지 않았다. 다른 4명의 환자들에서 보인 5개의 국소 대사항진 병변들은 양성병변으로 확인되었고 이 중 3명은 간이식을 시행하였다. 요약하면, FDG-PET으로 4명의 환자에서 고식적인 검사로 찾지 못하던 전이 병변을 찾아 불필요한 간이식을 피할 수 있었다. 모두 17명에서 간이식이 시행되었다. 간의 조직 검사 소견과 비교하였을 때 생존 원발성 간암을 진단하는 FDG-PET의 민감도는 55.6% (5/9)이었고, 특이도는 87.5% (7/8)이었다. 결론: FDG-PET 전신 스캔은 간이식 예정인 원발성 간암 환자들에서 이전에 시행한 고식적인 검사들로 진단하지 못한 전이 병소들을 추가로 진단하여 불필요한 간이식 수술을 줄이는데 기여할 수 있었다. Purpose: Liver transplantation (LT), one of the therapeutic options of primary liver cancer has been suffering from recurrence caused by metastasis in 8-54% of patients. This study was performed to investigate whether FDG-PET is useful for detecting hidden metastasis in LT candidates. Materials and Methods: Twenty-six patients (male:female=23:3, mean age 55.7 year) underwent FDG-PET. Their previous conventional diagnostic studies (CDS) like a abdomen US and CT, chest x-ray and CT, and bone scan were negative (n=22) or equivocal (n=4) for metastasis. Positive FDG-PET findings were confirmed by biopsy or clinical follow-up. Results: Among 4 patients with equivocal metastatic lesions on CDS, 3 had 6 hypermetabolic lesions on FDG-PET, which were confirmed as metastasis and subsequently LTs were cancelled. Of these, 5 lesions were initially negative on CDS. Remained 1 patient underwent LT with a negative FDG-PET result. Among 22 patients without metastasis on CDS, 5 had 7 hypermetabolic lesions on FDG-PET. One of these patients proved to have 2 metastatic lesions, and LT was cancelled. The other 4patients had 5 hypermetabolic lesions on FDG-PET, which were confirmed as benign lesions, and 3 patients of them underwent LT. In summary, FDG-PET was useful in avoiding 4 unwarranted LT by detecting unsuspected metastatic lesions on CDS. A total of 17 patients underwent LT. In comparison with pathology, the sensitivity and specificity of FDG-PET for detecting viable primary liver cancer were 55.6% (5/9) and 87.5% (7/8), respectively. Conclusion: FDG-PET can detect additional hidden metastasis and contribute to reducing unwarranted LT in the patients with primary liver cancer. (Korean J Nucl Med 2002;36;368-80)

위전절제시 단순공장간치술의 임상적 의의

노승무,배진선,정현용,이병석,조준식,신경숙,송규상,이태용 충남대학교 암연구소 2003 암연구소 업적집 Vol.3 No.-

Purpose: The aim of this study was to evaluate the short-term outcome of a jejunal interposition, by comparing it with a conventional Roux-en-Y gastrojejunostomy, after a total gastrectomy. Materials and Methods: For 28 patients (20 men and 8 women) with a gastric adenocarcinoma, who underwent an isoperistaltic simple jejunal interposition, weight, hemoglobin, hematocrit, serum protein and albumin, and cholesterol levels were checked before the operation and at 1 year and 2 years after the surgery. Also, endoscopy was performed to confirm reflux esophagitis. In this study, the data were collected between January 1993 and July 1999 at Chungnam National University Hospital, and the results were compared with those of the Roux-en-Y procedure. Results: The body weights at 1 year and 2 years after the surgery had returned to 86.0% and 87.6% of the recent original body weight in the jejunal interposition (Jl) group and to 90.8%, 87.0%, respectively in the Roux-en-Y (RY) group. The levels of hemoglobin (g/dl) were 13.3, 12.5, and 11.9 in the Jl group, and 13.8, 12.6, and 12.1 in the RY group at the time of the operation and at 1 year, and 2 years after the surgery, respectively. The total serum protein (g/dl) levels were 7.1, 7.2, and 7.5 in the Jl group and 7.1, 7.0, and 7.2 in the RY gropu at the time of the operation and at 1 year and 2 years after the surgery, respectively. The serum albumin (g/dl) levels were 4.2, 4.1, and 4.2 in the Jl group and 4.2, 4.2, and 4.2 in the RY group at the time of the operation and at 1 year, and 2 years after the surgery, respectively. The total serum cholesterol (mg/dl) levels were 186.5, 174, and 164 in the Jl group and 213.7, 171.1, and 141.0 in the RY group at the time of the operation and at 1 year and 2 years after the surgery, respectively. The endoscopic finding showed that reflux esophagitis occurred in 7.1% of the patients in the Jl group and in 3.5% in the RY group. Conclusion: We think that from the view point of quality of life, a jejunal interposition, as well as a Roux-en-Y procedure, is a useful reconstruction methods for a total gastrectomy. (J Korean Gastric Cancer Assoc 2001;1:210-214)