2003년 국내 중증급성호흡기증후군 진료 현황 및 문제점 분석

이진수,김은실,정문현,백제중,정선화,안주희,최영화,이선희,고철우,김성범,김민자,박승철,기현균,송재훈,최상호,김양수,이상오,조용균,박영훈,정숙인,김연숙,이흥범,손창희,장성희,정희진,김우주 대한감염학회 2004 감염과 화학요법 Vol.36 No.3

목적 : 2002년 말 중국에서 SARS가 발생한 이후 국내에서도 2003년 10월까지 총 3명의 추정환자, 17명의 의심환자가 보고되었다. 향후 추가적인 SARS의 유행이 우려되는 상황에서, 그간의 SARS 환자 진료에 있어서의 실질적인 준비사항, 진료 현황 등에 대한 조사를 통해 문제점을 파악하여, 향후 더 나은 대비가 될 수 있도록 개선점을 제시하고자 하였다. 재료 및 방법 : SARS로 의심되는 환자를 진료 경험이 있는 병원의료진을 대상으로 2003년 10월에 설문조사를 실시하였다. 설문에는 SARS 환자 진료 시의 실질적인 조치, 진료 현황, 병실, 응급실 및 외래에서의 격리 시설과 준비사항, 보건당국의 관리와 지원에 관한 사항을 포함하였다. 결과 : 대상이 되는 22개 병원 중 17개(17/22, 77.2%) 병원이 설문에 응하였다. SARS 환자를 위한 격리실은 응급실, 외래, 일반병실 및 중환자실에서 각각 9개(9/17, 52.9%), 5개(5/17, 29.4%), 15개(15/16, 93.7%), 4개(4/16, 25%) 병원에서 음압처리가 되어있지 않은 일인실 혹은 다인실이 사용되었고, 1개(1/16, 6.3%) 병원에서만 일반병실에서 음압격리실이 운영되었다. 입원환자의 진찰 시 개인보호구의 착용은 거의 모든 의료기관에서 이루어졌다. 보건당국에서 SARS지정병원의 시설 등을 사전에 확인한 곳은 1곳(1/12, 8.3%)이였고, 14개 병원(14/15, 93.3%)에서는 보건당국에 의뢰한 검사결과를 통하 받지 못하였다. 결론 : 의료기관에서 SARS 환자용 격리실뿐만 아니라 기존의 격리실 설비 등이 미흡하였으며, 특히 중환자실 및 외래의 준비가 더욱 부족하였다. 보건당국의 의료기관에 대한 종합적인 지원이 부족하였고, 병원과의 원활한 연계가 잘 이루어지지 않았다. SARS 만이 아닌 격리를 필요로 하는 질환의 적절한 진료를 위해 향후 병원 시설의 정비와 정부차원에서의 보다 구체적이고 실질적인 대책마련이 필요하다. Background : There was an worldwide outbreak of the Severe Acute Respiratory Syndrome (SARS) originated from China in late 2002. During that period three cases of suspected SARS and 17 cases of probable SARS were reported in Korea. With the concerns about the reemergence of SARS-coV transmission, it is important to be prepared for any possibility. So, this study is aimed to analysis the past measures in managing SARS and propose the amendatory plans to improve the preparedness. Materials & Methods : Questionnaires were collected among clinicians with any experience in managing the probable or suspected SARS cases in Oct. 2003. 17 out of 22 hospitals responded to the questionnaire. The contents in the questionnaire were practical activities, personal equipments, response plans, isolation facilities in emergency centers, outpatient clinics, general wards and intensive care units, and relationship with the public health department. Results : The dedicated isolation rooms in emergency centers, outpatient clinics, general wards, and intensive care units were prepared in 9 (9/17, 52.9%), 5 (5/17, 29.4%), 15 (15/16, 93.7%), and 4 (4/16, 25.0%) hospitals, respectively. Except for one hospital that newly made negative pressure room for SARS, single or multi-bed rooms without airborne infection control were used in all the other hospitals. The personal precaution principles were kept quite well in general wards. Before the designation of SARS hospital by the public health department prior evalution to see if the hospital was suitable for managing SARS was conducted in only 1 (1/12, 8.3%) hospital. The results of laboratory diagnosis were reported back in 1 (1/15, 6.6%) hospital. Conclusions : The isolation facilities which can control airborne infection were almost deficient not only for SARS but also for other respiratory transmissible diseases. For the infection control of transmissible diseases including SARS, more investment is needed on medical facilities and comprehensive support from the public health department required.

A Comparison of Lyophilized Amniotic Membrane with Cryopreserved Amniotic Membrane for the Reconstruction of Rabbit Corneal Epithelium

Ahn Jae-Il,Jang In-Keun,Lee Doo-Hoon,Seo Young-Kwon,Yoon Hee-Hoon,Shin Youn-Ho,Kim Jae-Chan,Song Kye-Yong,Lee Hee-Gu,Yang Eun-Kyung,Kim Ki-Ho,Park Jung-Keung The Korean Society for Biotechnology and Bioengine 2005 Biotechnology and Bioprocess Engineering Vol.10 No.3

Many researchers have employed cryopreserved amniotic membrane (CAM) in the treatment of a severely damaged cornea, using corneal epithelial cells cultured on an amniotic membrane (AM). In this study, two Teflon rings were made for culturing the cells on the LAM and CAM, and were then used to support the AM, which is referred to in this paper as an Ahn's AM supporter. The primary corneal epithelial cells were obtained from the limbus, using an ex-plantation method. The corneal epithelium could be reconstructed by culturing the third­passage corneal epithelial cells on the AM. A lyophilized amniotic membrane (LAM) has a higher rate of graft take, a longer shelf life, is easier to store, and safer, due to gamma irradiation, than a (AM. The corneal epithelium reconstructed on the LAM and (AM, supported by the two­Teflon rings, was similar to normal corneal epithelium. However, the advantages of the LAM over that of the (AM make the former more useful. The reconstruction model of the corneal epithelium, using AM, is considered as a good in vitro model for transplantation of cornel epithelium into patients with a severely damaged cornea.

Reconstruction of Rabbit Corneal Epithelium on Lyophilized Amniotic Membrane Using the Tilting Dynamic Culture Method

Ahn, Jae-Il,Lee, Doo-Hoon,Ryu, Yang-Hwan,Jang, In-Keun,Yoon, Mun-Young,Shin, Youn Ho,Seo, Young-Kwon,Yoon, Hee-Hoon,Kim, Jae-Chan,Song, Kye-Yong,Yang, Eun-Kyung,Kim, Ki-Ho,Park, Jung-Keug Blackwell Publishing Inc 2007 Artificial Organs Vol.31 No.9

<P>Abstract: </P><P>Rabbit corneal epithelium was reconstructed using tilting dynamic culture with a self-manufactured, amniotic membrane (AM) supporter and a lyophilized amniotic membrane (LAM). Rabbit corneal epithelial (RCE) cells were cultured and cryopreserved after isolation from the limbus. The second- and third-passage RCE cells were plated onto the epithelial side of the LAM of Ahn's AM supporter. Two days later, the air–liquid interface culture was maintained with third-passage RCE cells for 6 days and second-passage corneal epithelial cells for 9 days. The average viability of thawed RCE cells, assessed using trypan blue dye exclusion, was 77.42%. The reconstructed corneal epithelium was characterized by histological (hematoxylin and eosin) and immunohistochemical staining (proliferating cell nuclear antigen) for light microscopy, and by reverse transcriptase-polymerase chain reaction, glucose assay, and transmission electron microscopy. The basal layer of the reconstructed corneal epithelium was well formed, and the epithelium was tightly constructed due to the increase in cell proliferation and differentiation caused by the tilting dynamic culture, as opposed to static culture. Tilting dynamic culture was useful for the reconstruction of the epithelium using easily damaged epithelial cells and resulted in more stratum cell layers. Moreover, cytokeratin (CK3) mRNA expression in tilting dynamic cultured third-passage RCE cells seeded onto AM was greater than in static cultured third-passage RCE cells. The morphology of the reconstructed corneal epithelium on LAM by tilting dynamic culture for 9 days resembled that of the skin epidermis. This was thought to be because the tilting dynamic culture not only accelerated the proliferation and differentiation of cells by physical or mechanical stimulation, but also ensured that the supply of medium was delivered to the basal cells more efficiently. Thus, the reconstruction of the corneal epithelium using LAM and tilting dynamic culture was considered to be a good in vitro model for autologous or allogeneic transplantation of corneal epithelium and skin epidermis in patients with damaged epithelia. </P>

隔壁의 傾斜에 따른 箱子桁의 硏究

鄭熺孝,安光列,李承烈,朴泳珏 경상대학교 생산기술연구소 2002 工學硏究院論文集 Vol.2 No.-

The box girder has became a popular bridge type for long span or curved bridges because of its structural advantage of torsional stiffness. Generally box girder have inner diaphragms. The purpose of diaphragms is to prevent the deformation of cross section shape. Most diaphragms are parallel to cross section but it is necessary at present to adapt the design of bridge structures to transport requirement and the restrictive conditions of environment. City bridges, bridges spanning railway lines and stations, skew crossing of streets and highways, etc., require an irregular arrangement of internal supports. If diaphragms are applied, they are usually skew. It is advantageous to use a box girder as the basic component for a bridge of this kind because the box girder provides a high torsional stiffness, a favorable stresses, and due to the small shear stresses arising due to torsion. This paper deal with the analysis of the function of irregularly situated support and skew diaphragms and with their influence on the resulting state of stress of the box girder and compare with vertical deflections, horizontal deflections, longitudinal stresses, distortional stresses according to the angle of diaphragms.

흰쥐 뇌줄기에 분포하는 Nitric Oxide Synthase 신경세포에 관한 면역조직화학적 연구

나준희,허영범,박찬,김정혜,유진화,안희경,이원규 대한해부학회 1999 Anatomy & Cell Biology Vol.32 No.2

심신관계의 인과성 문제

안형관,박정희 대구효성가톨릭대학교 현대사상연구소 1998 현대사상연구 Vol.8 No.-

The mental seems to be distinct from the physical. However, as long as we acept the existence of causation between the mental and the physical, we cannot regard them as two discernible domains. Therefore it will be hard to explain the mental apart from the physical, if we see the domains with one sided perspective. Mind-body problem is to harmonize the mental distinguished from the physical. In other word the mind-body is the problem how to get the mental have causal roles in the physical world. The concept of psychophysical supervenience which has been so far regarded as an effective theory in philosophy of mind is not so satisfactory for explaining the relation between the mental and the physical.

공급사슬관리의 전략적 과제에 관한 탐색적 연구

안병훈,이승규,정희돈,안현수 한국경영과학회 1997 經營 科學 Vol.14 No.1

This study addresses strategic issues related to the question of "how can a supply chain become more competitive?" We examine several cases of manufacturing supply chains. Results show that each constituent firm is required to maintain different manufacturing capabilities and to play different roles by its position (up/mid/down-stream) in a chain. Furthermore, there are patterns of required capabilities by the positions in a chain. These findings imply that the "position in a chain" should be treated as one of the strategic factors when discussing the buyer-seller relationship. It is also shown that different action programs are required for building different manufacturing capabilities of individual firms in a supply chain. Additionally, we argue that some programs need to be done simultaneously, by all the members of the chain, while some need to be carried out by only a small group or an individual firm. Finally, we propose a direction for a theoretical framework for analyzing supply chain structures and strategies.

경기력을 향상시키는 역도선수들의 영양관리 및 식이섭취에 대한 문헌 연구

안효작,신정희 한국체육대학교 2000 敎養敎育硏究所 論文集 Vol.- No.5

서론 Ⅰ. 평상기 영양관리 1. 근력 향상을 위한 식사 2. 잊어서는 안될 체지방 체크 Ⅱ. 역도 선수들에게 효과적인 ergogenic aids 1. 아미노산 ergogenis aids 2. 무기질 ergogenis aidser 3. 비타민 ergogenis aids 4. 기타 ergogenis aids 5. ergogenis aids의 안전성 Ⅲ. 체중감량 식이 1. 체중감량 2. 부산을 예방하는 효과적 식사법 3. 피로회복 식사 4. 시합전의 올바른 식사법 결론 * 인용문헌 * ABSTR The purpose of this is to research nutritional management and ergogenic aids which may improve competitive performance of weight-lifter. Increased protein intake for the weight-lifters is significantly important during training for increasing muscle mass. The optimal protein intake for weight-lifter tranining may be 2g/kg. Moderate dose of arginine and ornithine may have enhanced body fat loss associated with resistance training an attribute partially modulated by somatotropin. Thus, it is recommended to intake arginine/ornithine during weigh-lifter training. Nutrition considerations for weight loss recommends daily low-fat, high protein diet since short-term weight loss decreases muscle mass. Continuous efforts for food pattern and ergogenic aids are needed to improve competitive performance.

급성 자발성 척추 경막외 혈종 1예

안경희,김민정,김희상,오진주,윤동환,유승돈 경희대학교 2003 慶熙醫學 Vol.19 No.2

Golgi 염색 기법에 대한 연구

안병권,박매자,김은희,배용철,홍해숙,조희중,주강 慶北大學校 醫科大學 1990 慶北醫大誌 Vol.31 No.4

여러 Golgi methods 중에서 본 실험실 환경에 적합한 방법을 확립하기 위해서, Golgi Method, Golgi-Kopsch modification, silver-chromate Golgi method 그리고 Rapid Golgi method의 네가지 방법을 실제로 실시했는데 그 중 Adam의 silver-chromate Golgi method에서 가장 좋은 결과를 얻었는데 그 결과는 다음과 같다. 1) 착색에 소요되는 시간이 약 7일 정도였다. 2) 대뇌피질, 시상하부, 뇌간의 모든부위 등 실험을 실시한 거의 모든 부위에서 착색된 신경세포를 관찰할 수 있었다. 3) 착색된 신경세포는 세포체 뿐만 아니라 축삭돌기, 수상돌기 그리고 수상돌기소극 등의 미세구조도 잘 관찰되었으며, 규칙적인 분포를 하였다. 4) 착색된 신경교세포와 혈관은 저밀도로 관찰되었다. Four modifications of the Golgi method, i. e. Golgi method, method, Golgi-Kopsch modification, silver-chromate Golgi method and rapid Golgi method were tested to find out most reliable method. Compared to another 3 modifications, Adams' silver chromate Golgi method was found to have several advantages as follows. 1) It took 7 days for impregnation procedure. 2) Neurons were well impregnated and their axons, dendrites and spines could be identified very clearly. 3) Impregnated neurons formed few clusters. 4) Glias and vessels showed very minimal impregnations.