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홍해숙,변영순,나연경 대한기초간호자연과학회 2003 Journal of korean biological nursing science Vol.5 No.1
The purpose of this study was to investigate and analyse current educational requirements related to genetics curriculum(from June 2002 to September 2002) established at nursing institutions and to provide the basic data for the development of genetics science program at the undergraduate. Subjects of this study were comprised of twenty three colleges of nursing in 4-year baccalaureate and thirty colleges in 3-year diploma programs. The results of this study were as follows : 1) 32 colleges offer courses related to genetics. 29 among 32 colleges have that integrated. Three schools have established completely independent courses of genetics. 21 colleges do not have any courses dealing with genetics. 2) The contents of courses related to genetics include:Congenital abnormalities, chromosomal aberrations, congenital metabolic disease, prenatal diagnosis and genetic counseling, genes and chromosomes, immune genetics, blood type and genetics, rule of genetics, variation in gene expression, the map of the human gene, gene linkage genetics, interaction of genes, single inheritance in order and genetic biochemistry. 3) For course credit, 14colleges(48.3%) offered at most 1 credit per course. The grade of student who can take the course, 51.7% were in their second year while 37.9% were in their third year. The majors of nursing faculty who taught the course were nursing(51.7%) and basic nursing science(17.2%). 4) As far as the need of opening the courses related to genetics, 36 colleges(67.0%) have made a ‘need’, 12 schools(22.6%) state ‘dose not need’. The reason for need were the following:development of bio engineering, increase number of patients who are related to genetics, recognition of the need in clinical nursing. 7 schools(13.2%) agreed to offer independent course in genetics but 39 schools(73.6%) are in disagreement with that. When the school offers the course with other courses, 27 schools(50.0%) are opening basic nursing science and 14 schools(26.4%) are opening nursing as an integrated courses. If the name of course was either genetic nursing(34.0%) or genetics(28.3%), the credits for the course was one or 2 credits. 33 schools(62.3%) students were in the first or second years. 41 schools(84.9%), the majors of the faculty who had taught the course were either basic nursing science(35.8%), nursing(28.3%) or basic medicine(24.5%). The contents of the course should include in that order:Chromosome aberrations, prenatal diagnosis and genetic counseling, congenital metabolic disease, congenital abnormalities, genes and chromosomes, the rules of genetics, immune genetics, interaction of genes, variation in gene expression, etc. The results and discussions of the study indicate that the entire curriculums need to be investigated with respect to contents of education, nursing curriculums and name of courses because of the increasing need of knowledge related to genetics in the clinical practice.
BudR편입法과 ^3H-thymidine autoradiography에 의한 不活性 X-染色體의 判別
홍해숙,주강,강�형 慶北大學校 醫科大學 1988 慶北醫大誌 Vol.29 No.4
The mechanism of X-chromosome replication is not yet fully defined. One of the key question concerning the control of mammalian X-chromosome differentiation is whether the process in one of inactivating a previously active X, or of a activation a single X, leaving any other inactive. It is well established that facultatively heterochromatic and late replicating X is not present until a blastocyst stage in such mammalian species as have been investigated by Lyon, et al. Thus, identification of inactive and active X-chromosome is one of interesting subject in the human genetics. Inactive X-chromosome has been detected by means of BudR Incorporation and ^3H-thymidine autoradiography. The result obtained that the: ·percentage of Barr body appearance was 30∼40%. ·autoradiography was heavily labelled on inactive X-chromosome. ·R-band was lightly stained on inactive X-chromosome. Therefore, identification of inactive X-chromosome would be important to evalute the correlations of sex linked abnormalities.
Duchenne Muscular Dystrophy에 관한 세포유전학 및 분자유전학적 연구
홍해숙 기초간호학회 2005 Journal of korean biological nursing science Vol.7 No.1
Purpose ; 본 연구는 X-염색체와 관련된 장애 중에서 흔하고 심한 Duchenne Muscular Dystrophy(DMD)의 세포유전학 및 분자유전학적 특성을 설명하기 위해서 DMD에 영향을 받고 있는 두 가계의 13명을 대상으로 가계도 분석과 염색체 분석 및 DNA 분석을 하였다. Method ; DNA분석은 DNA probe을 이용한 Southern blotting method로써 RFLPs와 DMD유전자 부위의 exon소실 유무를 조사하여 아래와 같은 결과를 얻었다. Conclusion ; A. 염색체 분석 : 말초혈액과 양수를 표본으로 High-Resolution GTG염색에서 A가계의 염색체 분석에서 12명의 염색체는 정상 X-염색체였으나 B가계의 Ⅰ-2(DMD여성)에서 46, x, -x, +t(2x)(q 21.1 : p21.2)로 나타난다. B. DNA분석3 : 1) RFLPs의 분석 J66,XJ-1.1,754-11로써 B가계의 RELPs(Restriction Fragment Length Polymorphisms)에서 J66/Pst Ⅰ은 l.7hb(E), 1.6kb(e)을 보여 주었고 XJ-1.l/Taq Ⅰ은 3.6kb(F), 3.0kb(f), 754-11/EoR Ⅰ은. 4.2kb(G), 2.0kb(g)의 대립인자를 나타내었다. 이상의 결과를 바탕으로 영향을 받고 있는 남자 (Ⅱ-2_의 haplotype는 보인자인 어머니의 한쪽 인자를 받았으며 어머니와 딸은 보인자이고 임산부의 태아는 남아였고 태아의 인자들은 그의 할아버지로부터 물려받아 DMD에 영향을 받지 않은 것으로 진단되었다. 2) DMD 유전자의 exon 소실에 대한 분석 cDNA probe 8과 cDNA probe 2b-3으로써 소실에 대한 진단은 영향을 받은 남자(Ⅱ-2)는 cDNA probe 8에서 12, 7.3, 6.6, 4.2kb에 소실이 있고 cDNA 2b-3d은 l.7kb에 소실에 나타났다.
출산장려인구교육프로그램에 참여한 미혼남녀의 결혼, 자녀 및 성역할 가치관 변화
홍해숙,김미예,최연희,박완주 한국모자보건학회 2011 한국모자보건학회지 Vol.15 No.2
Objectives: The purpose of this study was to investigate the effect of community population education program for improving values of marriage, childbearing and gender equality among unmarried youth. Methods: Data was collected by questionnaires from 1,598 unmarried workers at 35 different facilities. Outreach education program was conducted 6 sessions for each facility from June to November in 2010. The collected three family values about marriage, childbearing, and gender equality were respectively analyzed by descriptive statistics, paired t-test, ANOVA, Pearson correlation coefficient using SPSS 17.0. Results: Value of marriage (t=14.98, p<.001) and childbearing (t=11.53, p<.001) had significant differences between pre-test and post-test after education about reconstructing their family values but no difference in gender equality. Conclusions: The results of this study reveal that community outreach education program can reform the reasonable and righteous value with family-friendly perspectives. Considering enriched population education for unmarried youth or premarital couples, creating the proper atmosphere is very important by using fully tailored access strategies to meet their needs. Therefore, when population educations for overcoming the falling birth rate are developed, tailored community outreach education program should be considered. Gender equality is still big issue how to solve it by education in our society.