Multi‑tissue lipotoxicity caused by high‑fat diet feeding is attenuated by the supplementation of Korean red ginseng in mice

Seon‑A Jang,Seung Namkoong,이성률,Jin Woo Lee,Yuna Park,Gyeongseop So,Sung Hyeok Kim,Mi‑Ja Kim,Ki‑Hyo Jang,Alberto P. Avolio,Sumudu V. S. Gangoda,Hyun Jung Koo,Myung Kyum Kim,Se Chan Kang,Eun‑Hwa Sohn 대한독성 유전단백체 학회 2020 Molecular & cellular toxicology Vol.16 No.1

Background Excessive intake of fat, one of the causes of obesity, is associated with low-grade infammation in various susceptible organs and eventually causes tissue toxicity. This study examines the multifaceted suppressive efects of Korean red ginseng extract (KRG) on high-fat diet (HFD)-induced lipotoxicity and infammatory responses in the aorta, liver, and brain. Methods Male C57BL/6 mice were fed HFD with or without KRG for 12 weeks. The improvement efect in KRG on lipotoxicity and infammatory potential was determined in the blood and the aorta, liver, and brain tissues. Results KRG signifcantly inhibited 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase activity by >20% in vitro. KRG supplementation suppressed HFD-associated body weight gain, lipid profle changes, and excessive fat deposition in the liver and increased leptin, insulin, and ALT levels in the blood. Infammatory markers in the aorta, liver, and brain were also signifcantly reduced by KRG treatment. In microvascular endothelial cells, the 15% cyclic stretch-mediated upregulation of ICAM-1 and vascular cell adhesion protein-1 (VCAM-1) expression was signifcantly attenuated in the presence of KRG. Conclusion KRG supplementation attenuates HFD-mediated body weight gain, lipid profle changes, and multi-tissue infammatory responses.

Proteomic Approach to Analyzing Flooding Stress in Soybean (Glycine max(L.) Merr.)

Kim,Tae-Seon,Cho,Seong-Woo,Lee,Jae-Eun,Kim,Yook-Han,Cho,Kun,Choi,Jong-Soon,Chung,Keun-Yook,Song,Beom-Heon,Jong,Seung-Keun,Kim,Hong-Sig,Woo,Sun-Hee 한국작물학회 2005 한국작물학회 학술발표대회 논문집 Vol.2005 No.-

두경부 마사지가 중환자실 환자의 수면과 불안에 미치는 효과

김미용,전선영,송윤희,최은진,김재희,김미성,주명순,김남선 병원간호사회 2006 임상간호연구 Vol.11 No.2

Purpose: This study was to apply head and neck massage to patients in intensive care unit and to inventigate the effect of that massage on sleep and state anxiety. Method: The subjects in this study were 27 patients who were admitted in medical intensive care unit. The study was performed from June thru September of 2005 on the One-group pretest-posttest design and the sleep, state anxiety of the subjects were measured before and after head and neck massage. For data analysis, paired t-test and Pearson correlation coefficient were utilized. Result: The first hypothesis that the subjects might have a better sleep after being exposed to head and neck massage was accepted. The second hypothesis that the subjects might feel less state anxiety afrer being exposed to head and neck massage was accepted. The third hypothesis that the sleep of the ICU patients maight be correlated to their anxiety was accepted, as there appeared correlation between their sleep and anxiety. Conclusion: Head and neck massage is identified as one of independent nursing interwentions to improve the sleep of ICU patients and ease their anxiety, and it is necessary to apply it to clinical practices.

기관내관 소독방법 개선에 따른 간호업무 시간단축 및 비용 절감 효과

이행선,김해리나,김은숙,김보람,성선숙 한국의료QA학회 2008 한국의료질향상학회지 Vol.14 No.1

Background: The purposeof innercannula is to protect the upperair wayand permitair to pass freely, in addition, to provideendotrachealsuction, artificial respiration and to maintain adequate oxygensaturation. The tubeneeds to be sterilizedformaintenanceand cleannessof air wayand forprevention of bronchospasm. However, it has been reportedthat there is no guideline forsterilization and manyhospitalsconducttheirown sterilization methods, forexample, oncea day(13's generalhospital), three timesa day(TheCatholic University of Korea STMary's hospital) or evenno cleansing. Consequently, the QI team of our hospitalsuggested the SOP(standard operatingprocedure) of sterilization and evaluate cost and timeeffect in nursing. Method: 1) Benchmarking of 13's neurosurgery departmentof generalhospital in Seoul 2) Investigation of test recordsof sputumculture from patientswith intubation for tracheotomy 3) Checkof resultsof 02 Sat. monitoring to confirm of maintainingopenedair way Result : 1) Improvement of process: decrease of excess sterilization of inner cannula (from 3 timesa day to oncea day) 2) Costeffects: saving over10 million wonper oneyear 3) Providing better nursing: time effects (30 mina day) permit to conductmorenursing activities Conclusion: Itcan get Costand timeeffectsin nursing withimproved sterilization methodof innercannula It needs to do researchon improvement of the monthly exchangeprotocol of outercannula and providesupportingdata forthe properexchangeschedule. The resultof additionalmicroorganism detection frompatients withnewprocessneeds to be evaluated furthermore.

흔치않은 대상포진 치험 2예 : 비전형적 부위와 다른 부위로 재발한 예 Unusal Dermatome and Recurs Other Dermatome

김정미,조은경,조정선,최용석,한영수,한정호,김두응,최진영 건국대학교 의과학연구소 2004 건국의과학학술지 Vol.14 No.-

Herpes zoster is well known as an acute, self-limited disease of unilateral sensory dermatome caused by varicella-zoster virus and characterized by grouped vesicular skin eruption and pain over several dermatomes as well as single. This virus usually affects the thoracic dermatome and there are a few reports that this virus involves lower lumbar or sacral area, and recurrent cases. We experienced 2 cases that zoster virus involved L4 or S2 dermatome and left typical skin lesions, of which one was a recurrent case involving different dermatome at an interval of 8 years and the other was a rare case involving sacral dermatome.

치위생사의 전산화에 대한 지식,태도,행위조사

김은숙,나동진,임도선 서울보건대학 1997 서울보건대학 부설 병원경영연구소 논문집 Vol.3 No.1

본 연구의 이상과 같은 결론에서 다음과 같은 제언을 하고자 한다. 첫째, 치위생사들의 많은 부분이 근무하는 보건기과(보건소, 보건지소 등)의 치위생사들에 대한 실태 및 비교연구가 필요하다. 둘째, 치과의사를 대상으로 치과업무 전산화에 대한 비교연구가 필요하다. 셋째, 치위생사들이나 치위생과 학생들에 대한 컴퓨터관련 교육에 대한 연구가 필요하다. 넷째, 치과운영에 전산화가 주는 도움에 대한 지속적인 연구가 필요하다. This Study was to analyze the Hygienist's knowledge, attitude and behavior on computerization in dental clinics. The period of this research was for 6 months in which data collection were carried out. For this study 323 questirnaires were distributed to the dental Hygienists in dental Clinics and 80 cases were collected and used for analysis. Data were analyzed by frequency, T-test, Pearson correlation using the SPSS PC package program. The results of this analysis are as follows: 1. The mean of dental hygienist's knowledges of computer was low. 2. The mean of dental hygienist's attitudes toward computer was positive, but use of computerization was not positive. The more education for computer and computerization of dental Clinics, the more positive the attitudes toward computer. 3. The mean of dental hygienist's behaviors of computer was positive. 4. The more duration of computerization, the more knowledge of computerization. 5. The more decrease with manual work, the more positive attitude toward computerization. 6. The more income of dental clinics, the more postive attitude and behavior of computerization. 7. There were some correlations between attitude and behavior of computerization.

200m 달리기시 곡선 구간과 직선 구간 동작의 운동학적 변인 비교 분석

김용운,정철수,은선덕,이영석 한국운동역학회 2000 한국운동역학회지 Vol.10 No.1

본 연구는 단거리 달리기(200 m)의 곡선 구간과 직선 구간의 동작을 비교 · 분석하여, 운동학적 변인의 차이를 규명하고, 곡선 구간의 동작 메카니즘에 대한 기초적인 정보를 제공하기 위해, 서울체육고등학교의 100 m 및 200 m 달리기 선수 5명을 대상으로 하여, 3차원 영상 분석법을 통하여 동작을 분석하였다. 본 연구에서 도출된 결론은 다음과 같다. 1. 신체중심의 높이는 직선 구간이 곡선 구간보다 높았으며, 신체중심 변위의 변화는 곡선 구간에서 더 컸다. 2. 신체중심의 수평속도는 곡선 구간이 직선 구간보다 컸으며, 곡선 구간에서 내측 스트라이드 국면이 외측 스트라이드 국면보다 컸다. 3. 신체중심의 수평 측면속도는 평균값에서 곡선 구간과 직선 구간이 차이가 없었으나, 속도의 절대값에서는 곡선 구간이 직선 구간보다 컸다. 4. 곡선 구간 내, 외측 스트라이드 국면의 이지, 착지시 접선속도는 차이가 없었다. 5. 스트라이드 길이는 곡선 구간의 외측 스트라이드가 가장 길었으며, 직선 구간, 곡선 구간의 내측 스트라이드 순서로 길었다. 6. 스트라이드 빈도는 곡선 구간과 직선 구간에서 차이가 없었다. 7. 상체 전경각의 평균값은 곡선 구간과 직선 구간에서 차이가 없었으나, 범위는 곡선 구간이 직선 구간보다 컸다. 8. 상체 측경각은 평균값에서 곡선 구간이 직선 구간보다 컸으나, 범위는 차이가 없었다. 9. 상완의 운동범위는 곡선 구간과 직선 구간에서 차이가 없었다. 10. 무릎거양각은 곡선 구간이 직선 구간보다 운동범위가 컸다. 이상의 결과, 단거리 달리기의 곡선 구간에서 직선 구간과는 차별화된 수행 형태를 보였으며, 내, 외측 스트라이드 간에도 상이한 수행 형태를 보였다. This study was conducted to make a comparative analysis of running motion and to examine the differences of kinematice in curved and straight track portion during the 200m sprinting. In this study, five skilled male sprinters of high school served as subjects. The running motions were analyzed using the method of three-dimensional cinematography The conclusions of this study were as follows. 1. Height of the center of gravity in straight portion was higher than that in curved portion, but displacement of the center of gravity in curved portion was higher than that in straight portion. 2. Horizontal velocity of the center of gravity in curved portion was faster than that in straight portion, and in curved portion that of left stride phase was faster than that in fight stride phase. 3. There was no difference in mean value of lateral component of horizontal velocity between both portions, but absolute value of that in curved portion was faster than that in straight portion. 4. There was no difference in tangential velocity at the instant of touchdown and takeoff of both strides on curved portion. 5. Stride length in right stride of curved portion was the longest, and next to that, that of straight portion was, and left stride of curved portion was the shortest. 6. There was no difference in stride frequence between curved and straight portion. 7. There was no difference in mean value of forward lean angle between both portions, but active range of that in curved portion was larger than that in straight portion. 8. Mean value of inward lean angle in curved portion was larger than that in straight portion, but no difference in active range of that between both portions. As the conclusion of this study, it was clear that there were significantly different running patterns between curved and straight portion, and between left and right stride of curved portion.

유행 스타일의 결정과 확산에 대한 설명모형 연구 : 추구가치의 양면성을 중심으로 Based on Ambivalence of Pursuit Values

김선숙,이은영 한국의류학회 1995 한국의류학회지 Vol.19 No.4

The purpose of the study was to develop a model to explain how a fashion style is determined within a society and how the style diffuses. The research was carried out in two stages, theoretical study followed by empirical study. In the theoretical study, explanatory model about decision of fashion style and diffusion was developed and then fashion diffusion theories and fashion phenomenon of postmodern society were explained by the model developed. The theoretical framework of the explanatory model was constructed in that fashion changes by ambivalence of pursuit values within an individual as well as within a society. The empirical study was carried out to validate the model by looking into fashion phenomenon in the postmodern society. A questionnaire was developed including style image, pursuit value, preference style and administered to 19 to 30 year-old women living in Seoul area. Frequency distribution, discriminant analysis, one-way ANOVA. were used for the statistical analysis. As pursuit values differed in each style preference group, and pursuit value coincided with image of preference style it was confirmed that clothing selection behavior was determined by pursuit value. In a postmodern society where variety of values are pursued, appearance of various products and preference of all styles altogether considered, it could assume that subcultural collective selection phenomenon appeared.

Effects of 27.12 MHz Radio Frequency on the Rapid and Uniform Tempering of Cylindrical Frozen Pork Loin (Longissimus thoracis et lumborum)

Eun Ji Choi,Hae Woong Park,Hui Seon Yang,Jin Se Kim1,Ho Hyun Chun 한국축산식품학회 2017 한국축산식품학회지 Vol.37 No.4

Quality characteristics of frozen cylindrical pork loin were evaluated following different tempering methods: 27.12 MHz curved-electrode radio frequency (RF) at 1000 and 1500 W, and forced-air convection (FC) or water immersion (WI) at 4ºC and 20°C. The developed RF tempering system with the newly designed curved-electrode achieved relatively uniform tempering compared to a parallel-plate RF system. FC tempering at 4°C was the most time-consuming process, whereas 1500 W RF was the shortest. Pork sample drip loss, water holding capacity, color, and microbiological quality declined after WI tempering at 20°C. Conversely, RF tempering yielded minimal sample changes in drip loss, microstructure, color, and total aerobic bacteria counts, along with relatively uniform internal sample temperature distributions compared to those of the other tempering treatments. These results indicate that curved-electrode RF tempering could be used to provide rapid defrosting with minimal quality deterioration of cylindrical frozen meat block products.

국내외 저명학술지에 발표된 무작위대조연구 초록의 질적 연구

김효선,김은영 충남대학교 약학대학 의약품개발연구소 2012 藥學論文集 Vol.27 No.-

In this study, the quality of reporting the Randomized Controlled Trial (RCT) abstracts was investigated. It was compared between abstracts in four major Korean medical journals, covered by SCI(E), and in the New England Journal of Medicine (NEJM), the most cited medical journal in 2010 (IF=53.484), published from 2007/01 to 2011/06. There were 57 abstracts in Korean SCIs and 50 in NEJM included in the investigation; among them, three from Korean SCIs and one from NEJM were excluded. A modification of CONSORT for abstract was used as criteria, including 16 checklist items. The conformity of the abstracts to each item was assessed, and the χ2 (chi-square) analysis was used to analyze the significance of difference between the two. As a result, the two groups of journals were statistically equivalent in six items; Korean journals were significantly better in two items, and NEJM were in eight. In conclusion, the quality of reporting of RCT abstracts was better in general in NEJM than in Korean SCIs. This does not mean the full RCT reports of NEJM are superior to that of Korean SCI; rather, it highlights the need for Korean journals to adopt the CONSORT for abstracts in reporting of RCT in abstracts.