뇌성마비와 소아마비 환자에서 succinylcholie 사용후 혈중 전해질 농도의 변화

이강창,이환봉 圓光大學校 醫科學硏究所 1999 圓光醫科學 Vol.15 No.1

Background: Succinylcholine(Sch)-induced hyperkalemia occurs in patients with burn, severe trauma, uremia and neuromuscular diseases. Cerebral palsy and poliomyelitis are categorized into these neuromuscular diseases. This study was to exam the change of serum electrolyte after the administration of Sch in patients with cerebral palsy and poliomyelitis. Materials and Methods: 60 patients were devided into three groups. Group 1 (n=20) was composed of cerebral palsy patients with age range 1-4years. Group 2 (n=20) was composed of cerebral palsy patients over 4 years. Group 3(n=20) was composed of patients with poliomyelitis. To establish the effect of Sch in patients with cerebral palsy and poliomyelitis, serum potassium, sodium, calcium and chloride were measured prior to administration of Sch, and 2, 5, 10 and 30 minutes after injection of it. Results: Fine fasciculation on the hand (grade 1 by Cullen's grading) occurred 4, 6, 13 in Group 1, 2 and 3, respectively. In Group 3, 2 patients showed minimal contraction of the trunk and extremities. There was no significant increase in the concentrations of potassium after the administration of Sch. Conclusion: Succinylcholine seems to have no relation to hyperkalemia in patients with cerebral palsy and poliomyelitis over 1 year.

Vitamin E가 酸素中毒耐性에 미치는 影響에 關한 實驗的 硏究

李宇爀,車喆煥,李元暢 고려대학교 의과대학 1975 고려대 의대 잡지 Vol.12 No.3

In order to study the preventive measure of an oxygen toxicity under higher oxygen pressure, rats were given vitamin E and then exposed to at 2 atmospheres of 100% oxygen. Comparison group which was not administered with vitamin E was also exposed to at 2 atmospheres of 100% oxygen. Time required to evoke convulsion, correlation between treated dosage of vitamin E and time required to evoke convulsion, half-lethal time and its mean, correlation between treated dosage of vitamin E and fatal time, ratio of lung weight to body weight, and histo-pathological findings of the lungs were carefully examined. Some interesting results acquired through this study were thus: 1) Average time required to evoke convulsion of rats exposed to at 2 atmospheres of 100% oxygen was 103.7±2.5 min in comparison group and 179.0±9.5 min. or 202.1±2.7 min. in experimental groups administered with 25㎎ or 35㎎ of vitamin E per day respectively. Time required to evoke convulsion in experimental groups administered with vitamin E was longer than in comparison group. Higher correlation between time required to evoke convulsion and treated dosage of vitamin E was shown as r=+0.998 (p<0.01). 2) Average half-lethal times were 210 min. in comparison group and 325 min., 335 min. in groups administered with 25㎎, 35㎎ of vitamin E per day respectively. Statistically high correlation between treated dosage of vitamin E and half-lethal time was reported as r=+0.852(p<0.01). 3) Weight ratio of lung to body was significantly higher in experimental group exposed to high oxygen tension than control group not exposed to high oxygen tension, but there was no significant difference among experimental groups. 4) Lung damage was more severe in half-lethal group than in servival group during experiment. Histological changes of the lungs were that of vascular congestion, hemorrhage, pulmonary edema and emphysematous change. And the degree of changes was rather marked in experimental group than in comparison group. There was no difference in the degree of changes by the doses of vitamin E administered in experimental groups. 5) Vitamin E would be an effective agent for the prevention of oxygen poisoning under the high oxygen pressure. Effect of vitamin E administration before exposing to hyperbaric oxygen tension must be pondered to utilize in the "hyperbaric medicine".

Novel Methylation Biomarker for Non-invasive Diagnostics in Lung Cancer

오태정,( Chang Hun Lee2 ),( Min Ki Lee ),( Yeul Hong Kim ),( Sang Yull Lee ),( Hyo Sung Jeon ),( Shin Yup Lee ),( Seung Soo Yoo ),( Jae Yong Park ),( Sung Whan An ) 대한결핵 및 호흡기학회 2012 대한결핵 및 호흡기학회 추계학술대회 초록집 Vol.114 No.-

To identify aberrantly hypermethylated DNA in lung cancer cells we established a genome-wide analysis for hypermethylation sites, namely Methyl DNA Isolation and Amplification (MeDIA) coupled-CpG microarray analysis. In the comprehensive methyaltion profiling analysis between human lung cancer, A549 cells and normal NHBE cells, we observed that several clusters of genes show a significant level of aberrancy in CpG island methylation pattern in cancer cells compared to normal cells. We further identified PCDHGA12 gene as a new marker of non-invasive diagnostics for lung cancer based on followings. 1) Transcription of PCDHGA12 gene is reactivated after treatment of A549 cells with demethylating agent. 2) Bisulfide clonal-sequencing reveals that CpG island of PCDHGA12 shows a distinctive differential methylation between two cell lines. 3) Pyrosequencing-based quantitative methylation assay for such region in tumor and non-tumorous tissues from lung cancer patients shows aberrant hypermethylation in 37 (92%) of the 40 tumor tissues. In clinical validation by pyrosequencingin induced-sputum of lung cancer patients (n=87) and healthy controls (n=51), we observed aberrant hypermethylation incident at significantly elevated level in samples derived from lung cancer patients. According to the optimal threshold calculated by ROC curve analysis, sensitivity and specificity of PCDHGA12 was 86.2% and 82.4%, respectively. PCDHGA12 methylation status could be a potential methylation biomarker alone or combined with others for the screen and the detection of relapse of lung cancer.

Arsenazo I-XAD-2 킬레이트수지를 이용한 U(VI) 이온의 분리 및 농축에 관한 연구

엄태윤,김인환,이창헌,강창희,이시은,이원,임재희 濟州大學校 基礎科學硏究所 1994 基礎科學硏究 Vol.7 No.1

Aresenazo I-XAD-2 킬레이수지를 합성하고 이 수지에 대한 U(VI)이온의 흡착 거동을 조사 검토하였다. 킬레이트수지는 Arsenazo I 킬레이트제와 Amberlite XAD-2의 디아조늄짝지움 반응에 의해서 합성하였으며 원소 분석법과 적외선 분광법으로 확인하였다. U(VI)이온흡착의 최적 조건을 찾기 위해서 pH, U(VI) 이온농도와 진탕 시간에 관해서 조사하였다. U(VI)이온에 대한 킬레이트수지의 전체 흡착능은 pH 4.0∼4.5 범위에서 0.39mmol U(VI)/g resin이었고, pH값이 증가함에 따라 흡착능이 증가하였다. Arsenazo I-XAD-2 킬레이트 수지에 대한 U(VI)이온의 흡착 메카니즘은 U(VI)이온과 H+ 이온 사이의 경쟁반응임을 확인하였다. 컬럼법으로 구한 U(VI) 이온의 돌파점 부피와 전체 흡착능은 각각 600ml, 0.38mmol U(VI)/g resin 이었다. 3M HNO₃와 3m Na₂CO₃의 탈착용액을 사용하여 구한 회수율은 90∼96%였다. 따라서 본 연구에서는 합성한 Arsenaso I-XAD-2 킬레이트수지는 자연수 바닷물 중에 함유된 U(VI)이온의 분리와 농축에 매우 유용함을 알았다. Some sorption behaviors of U(VI) ion on Arsenazo I-XAD-2 chelating resin were investigated. This chelating resin was synthesized by the diazonium coupling of Amberlite XAD-2 resin with Arsenazo I chelating reagent and characterized by elementary analysis method and IR spectrometry. The optimum conditions for the sorption of U(VI) ion were examined with respect to pH, U(VI) ion concentration and shaking time. Total sorption capacity of this chelating resin on U(VI) ion was 0.39 mmol U(VI)/g resin in the pH range of 4.0∼4.5. This chelating resin was showed increased sorption capacity on the increased pH value. It was confirmed that sorption mechanism of U(VI) ion on the Arsenazo I-XAD-2 chelating resin was competition reaction between U(VI) ion and H+ ion. Breakthrough volume and overall capacity of U(VI) ion measured by column were was 600ml and 0.38 mmol U(VI)/g resin, respectively. The desorption of U(VI) ion was showed recovery of 90∼96% using 3M HNO₃and 3M Na₂CO₃as a desorption solution. The separation and concentration of U(VI) ion from natural water and sea water was performed successfully by Arsenazo I-XAD-2 chelating resin.

서울의 Penicillinase Producing Neisseria Gonorrhoeae 발생빈도(1996)

김재홍,황동규,전재홍,김윤석,김중환,김용준,이창균,임동진,김현수,조창근,김경문,박상훈,전우형,김희성,이호정,차명수,김갑형,김형석,김석우,황지환,박병순,권오상,이민수,송기훈,성소영,이인섭,부태성 대한화학요법학회 1999 대한화학요법학회지 Vol.17 No.2

Background : In recent years, gonorrhea has been panedemic and remains one of the most commom STDs in the world, especially in developing countries. Objective & Methods: For the detection of a more effective therapeutic regimen and assessing the prevalence of PPNG, we have been trying to study the patients who have visited the VD Clinic of Choong-Ku Public Health Center in Seoul since 1980 by means of the chromogenic cephalosporin method. Results: In 1996, 139 strains of N. gonorrhoeae were isolated, among which 53(39.0%) were PPNG. Conclusion: Our results suggests that after a peak of 74.3% in 1993, the prevalence of PPNG in Seoul is gradually declining.

한국어 음성 인식에 관한 연구

이창섭,차일환,김영일 연세대학교 산업기술연구소 1984 논문집 Vol.16 No.2

In this study, a system is proposed which can be used for recognition of Korean single vowels "ㅏ, ㅓ, ㅗ, ㅜ, ㅡ, ㅣ, ㅐ, ㅔ, ㅚ" and automatic recognition is processed using μ-computer. 3 men of not-being-studied are participated in this experiment. Using the period of vowels, one part of the steady state is selected for high speed recognition, and LPC, PARCOR and formant are used for parament of recognition. Formant is obtained by peak picking method using LPC, and then vowels are recognized by LPC, PARCOR, formant. As a result, recognition rates are 93.1% for LPC, 100% for PARCOR, 88.8% for using formant.

建築工業敎育科 敎育改善에 관한 硏究 : 敎育課程을 中心으로 Focused on the development of curriculum

李昌甲,朴萬植,延吉煥,崔武革,李基男 충남대학교 공업교육연구소 1981 論文集 Vol.4 No.1

Due to the radical change of society and the technological innovation, it is inevitable to rearrange the educational objective of the Department of Architectural Engineering Education and to reorganize the curriculum responding to the objective. In this study, all the current curricula of architectural institutions have been analized to identify problems, and the educational objective of the department of architectural engineering education have been established based on the objective of the College of Industrial Education. As the result of the above studies, the model curriculum for the major subjects have been developed in order to have following characteristics. 1. The required subjects were limited to the basic fields in order to cover the education in the technical high school. 2. The elective subjects were organized into three fields, namely, architecture, structural engineering, and building materials and construction to meet the diversified demands to a possible maximum extent.

소프트웨어 아키텍처 기반 프레임워크 개발에 관한 연구

이창훈,김태균,이경환 중앙대학교 정보통신연구소 1999 정보통신연구소논문집 Vol.1 No.1

소프트웨어 개발에 있어 재사용의 필요성은 오랫동안 주장되어 왔고, 코드 수준의 재사용에서 지식 수준의 재사용을 목적으로 한 프레임워크를 통한 어플리케이션 개발 기술로까지 이어져 왔다. 프레임워크는 기본적으로 소프트웨어 개발 시 얻어진 생산물들을 상위레벨의 추상화 과정을 통해 그 분석 및 설계 정보의 재사용을 통해 소프트웨어의 재사용 범위를 넓히고자 하는 시도이다. 그러나 이 프레임워크는 역호출관계를 통한 어플리케이션 개발 시스템이기 때문에 어플리케이션에 대한 아키텍처 정보를 모두 가지고 있어야 한다. 기존의 프레임워크의 경우 이런 아키텍처 정보는 설계 수준에서만 머물고 바로 코드 수준에서 정의, 사용되는 형태를 가져왔다. 그래서 프레임워크의 확장이나 컴포지션 시 코드를 재 설계하고 구현해야 하는 문제점이 있다. 즉 아키텍처 정보를 설계 수준과 코드 재사용 수준의 중간 형태인 언어로서 개발, 사용해야할 필요성이 생겼다. 이에 본 논문에서는 다음과 같은 연구에 중점을 두었다. 첫째로 아키텍처 정보를 보다 구체화하는 방법으로 ADL을 통한 표현 방법에 대해 정의하였다. 둘째로 기존의 추상화된 컴포넌트 기반 프레이워크 개발 공정을 아키텍처 정보를 구체화하여 개발하는데 적합하도록 그 공정을 개선하였다. 셋째로 ADL로 표현된 아키텍처 정보를 프레임워크를 통한 어플리케이션 개발에 필요한 정보로 활용하여 개발할 수 있도록 제안하였다. 전체적으로 논문에서 연구된 내용은 아키텍처 기반 프레임워크를 개발하고자 할 때 필요한 개념의 ADL을 통한 표현과 개발 방법을 정의하는 것이다. The need of reuse has been emphasized in the process of software development, so the current reuse technology is able to provide reuse of the analysis and designing process, and the reuse of code by providing reusable class and component library. The reuse by using framework is proposed to improve productivity. It is a set of usable and expandable classes and their connectivity. But frameworks are described with programming languages, it is hard for developers to learn the collaborative patterns of a framework by reading it. Patterns are one approach to improving the documentation. But this should be redesigned to expand and redefine the framework. The necessity of the formal description of architecture information is being proposed to relate to programming language. This paper support the following points. First of all, it has been proposed the description of the needed elements when developing a framework using ADL. Secondly, the current development process has been refined to be suitable for developing the domain framework. Thirdly, it has been proposed the development of a application using a framework implemented by an architecture information described with ADL. Overally, the main contents of this research is defining the ideas of a description and development of an architecture framework using ADL.

전국 형광등 제조 사업장의 수은 오염원에 대한 조사연구

이창주,김광종,차철환 大韓産業醫學會 1990 대한직업환경의학회지 Vol.2 No.1

This research was conducted to study the correlations between the airbone mercury concentration and each independent variable to detect the source of mercury contamination in a total of 11 fluorescent lamp manufacturing factories. The mercury concentration in air was measured and informations about production management (operation hour, overtime, vacuum exhaustion system, number of droppers, number of vacuum exhaustion pumps, frequency of mercury infusion, mercury consumption per lamp, number of lamps producted, number of inferior lamps producted, number of breakage lamps, local exhaust ventilation system) were collected from January 1988 to March 1989. The results were as follows: 1. Among the airborne mercury concentrations according to the sampling point the highest mean concentration was 0.162mg/㎥(0.016-0.635mg/㎥) at the workeplace floor, and 0.074mg/㎥ at the vaccum exhaustion pump site, and 0.66mg/㎥ at the breathing zone in order. 2. The correlation between airborne mercury concentration and each independent variable was significant in a following order : the number of inferior lamps producted(0.485), vacuum exhaustion system(-0.405), number of breakage lamps (0.344), operation hour (0.341), number of vacuum exhaustion pumps(0.337) and local exhaust ventilation system(0.331). 3. The result of stepwise multiple regression analysis that the airborne mercury consumption was affected by number of inferior lamps producted, frequency of mercury infusion, overtime, ventilator, mercury consumption amounts per lamp, local exhaust ventilation system in order. And these six variables explained 36.7% of the variance of airborne mercury concentration.

천공성 충수돌기염 환자의 창상세척과 일차봉합에 대한 고찰

이환봉,이강창 圓光大學校 醫科學硏究所 1999 圓光醫科學 Vol.15 No.1

Background: Under the principle that, the more the removal of pathogens from the contaminated wound, the lesser the chance of wound infection, we tried massive saline irrigation and primary closure in order to compare with the generalized wound management method of delayed primary closure. Methods: From September 1997 to Desember 1998, we operated 318 cases of appendicitis and 64 cases of them presented with perforated appendicitis on operative field. By the same method and the same surgeon, all patients of perforated appendicitis underwent appendectomy and had intraperitoneal closed suction drainage from the peluic cavity and massive (1.0L) saline wound irrigation after peritoneal approximation. A penrose drain was also left in primarily closed operative wound for several days in all patients. Results: Postoperative suppurative wound infection in 5 patients (7.8%) which in eluded 2 cases of wound infections after reoperation due to intraabdominal abscesses appeared as the result of above management. Conclusions: Because of painful time consuming method of delayed primary closure, primary closure of operative wound in perforated appendicitis seems to be acceptable as management method especially in children.