펄스 옥시미터 시스템 구현에 관한 연구

유동주,허 웅,김근이,이호재,임현수 明知大學校 産業技術硏究所 1992 産業技術硏究所論文集 Vol.11 No.-

In this paper, we implemented a pulse oximeter system which is measured oxygen saturation coefficient of a human blood in vivc We use the Beer-Lambert Law to measure the percentage of hemoglobin is oxygen saturation. The oximeter sensor are consisted of two LED(RED and INFRARED LED) and a single photodiode. The photodiode measures lights which transmitted through the tissue from two light source alternately, We calculated a ratio of light transmittance between two LEDs and then, it applied for the oxygen saturation coefficient calculation to formula. As a result, the oxygen saturation coefficient that measured from normal conditions men was 96.43[%]

대퇴동맥을 통한 경피적 관동맥 중재시술 환자의 천자부위 지혈을 위한 Angioseal^(�) 사용과 고식적 용수 압박법의 비교 : 전향적 연구

김용훈,권현철,김필호,안석진,유철웅,최진호,이상철,김준수,김덕경,전은석,이상훈,홍경표,박정의,서정돈 대한내과학회 2004 대한내과학회지 Vol.66 No.5

목적 : 경피적 관동맥 중재술은 최근 양적 및 질적으로 급격한 발전을 보였지만 시술 시 천자부위의 혈관 합병증은 아직 해결해야 할 문제점이다. 저자들은 대퇴동맥을 통한 경피적 관동맥 중재술을 환자에게 천자부위 지혈을 위한 혈관폐쇄기구인 안지오실의 안전성과 유용성을 고식적인 용수 압박법과 비교 연구하고자 하였다. 방법 : 2002년 4월부터 2003년 5월 사이에 삼성서울병원 심장혈관센터에서 대퇴동맥을 통한 경피적 관동맥 중재술을 성공적으로 시행한 200명의 환자(안지오실 사용군: A군, 100명, 고식적 용수압박법 사용군 B군, 100명)를 대상으로 시술 후 주요 합병증 및 경한 합병증, 지혈 후 환자가 자리에 앉기까지의 시간, 보행개시 가능시간, 총 재원 기간과 시술 1주 후의 합병증을 전향적으로 조사하여 비교 연구하였다. 결론 : 두 군에서 연령, 성별, 기저질환, 심혈관 질환의 위험요소, 시술의 종류, 시술 중 사용한 헤파린의 양, clopidogrel의 양, ticlopidine의 양, 지혈 시 수축기와 확장기혈압, ACT (activated clotting time)는 차이가 없었다. A군이 B군에 비해 시술 후 자리에 앉기까지의 시간 (A군: 4.3±0.3시간, B군: 13.7±0.8시간, p=0.004) 및 보행개시까지의 시간(A군: 6.8±0.5시간, B군: 18.8±2.1시간, p=0.013)이 유의하게 짧았다. 시술 후 주요 합병증은 두군 모두에서 관찰되지 않았으며, 경한 합병증의 전체발생은 A군에서 유의하게 적었다(A군: 28명, B군: 19명, p=0.003). 반상출혈의 경우는 A군에서 유의하게 낮았지만(A군: 3명, B군: 12명, p=0.01), 혈종, 출혈의 발생은 두군간에 차이가 없었다. 총 재원기간에는 두 군간에 차이가 없었다(p=0.239). 시술 1주 후 경과관찰에서 주요합병증은 역시 두 군 모두에서 관찰되지 않았으며, 경한 합병증의 전체발생은 두 군에서 차이가 없었다(A군: 15명, B군: 13명 p=0.418), 반상출혈의 빈도는 차이가 없었지만 혈종의 발생은 A군에서 더 낮았다(A군: 2명, B군:6명, p=0.004). 두 군 모두에서 출혈은 발생하지 않았다. 결론 : 대퇴동맥을 통한 경피적 관동맥 중재술을 시행한 환자에서 안지오실의 사용은 고식적 용수 압박법에 비해 환자의 침상 안정시간을 줄여 조기 활동개시가 가능하게 하였으며 국소합병증의 위험도를 일부 낮추어, 시술에 따른 환자의 불편을 현저하게 감소시킬 수 있다고 할 수 있을 것으로 기대된다. Background : Although the number and the quality of percutaneous coronary intervention have been recently increased dramatically, the vascular complication at puncture site is still the major cause of patients' morbidity. We evaluated the safety and efficacy of newly of newly-developed collagen-based arterial closure device, Angioseal after transfemoral percuatenous coronary intervention. Methods : This study was designed as a prospective single center non-randomized comparative study. A total 200 patients undergoing transfemoral percutaneous coronary intervention were enrolled between April 2002 and May 2003. They were divided into two groups; Angioseal group (group A, n=100) and manual compression group (group B, n=100). The baseline clinical and angiographic characteristics were reviewed. The time to sit up, the time to ambulation, the duration of hospital stay, major and minor vascular puncture site complications were monitored. The patients were followed-up for 1 week after procedure by telephone. Results : The baseline clinical characteriwtics, clinical diagnosis, cardiocascular risk factors, typesof procedure, doses and numbers of anticoagulants were similar between two groups. The blood pressure and activated clotting time were also similar. The time to sit up (group A: 4.3±0.3 hours, group B: 13.7±0.8 hours, p=0.004) and the time to ambulation (group A: 6.8±0.5 hours, group B: 18.8±2.1 hours, p=0.013) were shorter in group A. No major vascular complications were noted. The incidence of hematoma and bleeding were not significantly different between two groups. The incidence of ecchymosis, however, was significantly lower in group A (group A:12%, group B: 3%, p=0.001) The duration of gospital stay was similar between groups. During 7 days of follow-up period incidence of hematoma was significantly lower in group A (p=0.004). Although the incidence of ecchymosis was not significantly different between two groups. Conclusion : The angioseal may be associated with earlier ambulation and less patients' morbidity with low incidence of local complication rate compared to manual compression after transfemoral percutaneous coronary intervention.

遠隔制御用컴퓨터인터페이스에 관한 硏究

송철,박종백,이웅기,이강현,양원일 조선대학교 동력자원연구소 1988 動力資源硏究所誌 Vol.10 No.1

This paper deals with the computer interface for the remote control in factory automation, and the concatenated IBM PC, designed interface card, temperature sensors and displayer. As the results 1. easy to expand and maintain the objects of upgrade levels. 2. easy to measure the temperature of product lines. 3. applications can be extended by using IBM PC and its function.

위암세포주에서 Recombinant Human Interferon-r와 Adriamycin의 투여순서가 항암효과에 미치는 영향

홍원선,손영숙,김창민,강윤구,이춘택,김유철,임영혁,남현석,이진오,강태웅 大韓免疫學會 1993 大韓免疫學會誌 Vol.15 No.-

Numerous previous studies, both in vitro and in vivo, have demonstrated that the cytotoxicity can be enhanced by the combination of chemotherapeutic agent and interferons(IFNs) in various types of cancer cells. We have previously reported that combined treatment of MKN-45, human gastric adenocarcinoma cells, with adriamycin(ADM) and recombinant human interferon-r(rh-IFN-r) increased in the cytotoxicity. In this study, the effects of combination timing of rh-IFN-r and ADM on the cytotoxicity against MKN-45 were investigated using MTT assay. MKN-45 was treated with rh-IFN-r and ADM in vitro on three schedules : Treat A ; rh-IFN-r and ADM were treated simultaneously, Treat B ; rh-IFN-r was treated 24 hours after the treatment with ADM, Treat C ; rh-IFN-r was treated for 72 hours and followed by the treatment with ADM. The survival of MKN -45 was inhibited by ADM dose-dependently. 102 and 103U/ml of rh-IFN-r significantly inhibited the survival of MKN-45(% survival : 35.1 ±-1.2% and 34.4 ±1.1% in Treat A and 42.5 ± 2.1% and 45.9-±2.5% in Treat C, respectively). However no difference in the survival was observed between 102 and 103U/ml of rh-IFN-r. Combined treatment with rh-IFN-r and ADM significantly augmented the cytotoxicity at low concentrations of ADM. Combined effects of rh-IFN-r and ADM were evaluated using IC30(,ag/ml) to ADM. IC30s of MKN-45 in Treat A, B and C at 102 U/ml of rh -IFN-r _ were 0.019 -?- 0.003, 0.045 :I:0.001 and 0.054 ± 0.012, respectively, while IC30 of MKN-45 treated with ADM alone was 0.052±0.004. IC30s of MKN-45 in ADM alone group, Treat A, Treat B and Treat C at 103U/ml of rh-IFN-r were 0.047 ±0.003, 0.004 -±0.001, 0.031 ±0.004 and 0.056 0.008, respectively. These results indicate IC30s of Treat A and B were significantly lower than those of ADM alone(p<0.05) and IC30s of Treat A was significantly lower than those of Treat B(p <0.01). IC30s of Treat C, however, were not different from those of ADM alone. From these results demonstrating that cytotoxic effects were increased by the combination of rh-IFN-r and ADM in the order, Treat A > Treat B> Treat C, it can be concluded that the simultaneous administration of rh-IFN-r and ADM may be the most effective method to combine these two therapeutic modalties.

The Quality Improvement of Emulsion-type Pork Sausages Formulated by Substituting Pork Back fat with Rice Bran Oil

Hyeon-Woong Yum,Jin-Kyu Seo,Jin-Yeon Jeong,Gap-Don Kim,M. Shafiur Rahman,Han-Sul Yang 한국축산식품학회 2018 한국축산식품학회지 Vol.38 No.1

The effects of pork back fat (PBF) substitution with various concentrations of rice bran oil (RBO) (50%, 45%, 40% and 35%) on the physicochemical characteristics and sensory attributes of emulsion-type pork sausages were studied. The modified pork sausages were compared with control sausages produced using PBF only. The sausages with RBO had significantly lower (p<0.05) moisture content than the control sausages. Sausages made from PBF substituted with 40% RBO showed the lowest cooking loss. Substitution of PBF with RBO had no significant effect on the emulsion stability of pork sausages. All sausages with RBO showed significantly lower (p<0.05) hardness values than control sausages. Sausages with RBO also had significantly higher values (p<0.05) of unsaturated fatty acid and polyunsaturated to saturated fatty acid contents than the controls. RBO substitution had no effect on the flavor intensity of sausages, but it improved the tenderness and produced a softer texture.

Efficacy of Initial Treatment with Clevudine in Naive Patients with Chronic Hepatitis B

( Hyeon Woong Yang ),( Byung Seok Lee ),( Tae Hee Lee ),( Heon Young Lee ),( Kwan Woo Nam ),( Young Woo Kang ),( Hee Bok Chae ),( Seok Hyun Kim ),( Seok Bae Kim ),( Hyang Ie Lee ),( An Na Kim ),( Il H 대한내과학회 2010 The Korean Journal of Internal Medicine Vol.25 No.4

Background/Aims: Clevudine, a pyrimidine nucleoside analogue, has potent antiviral effects in patients with chronic viral hepatitis B (CHB). We report the efficacy of initial treatment with clevudine in naive patients with CHB living in Daejeon and Chungcheong Province, South Korea. Methods: One hundred five adults with CHB were administered 30 mg of clevudine per day for an average of 51 weeks. We evaluated viral markers and liver biochemistry retrospectively every 3 months. Results: Alanine aminotransferase (ALT), aspartate aminotransferase (AST), and hepatitis B virus (HBV) DNA before the treatment were 184 ± 188 IU/L, 150 ± 138 IU/L, and 7.1 ± 1.2 log copies/mL, respectively. Undetectable rates (< 60 IU/mL) of DNA were 36.2%, 68.9%, 83.6%, 76.2%, and 75.8% at 12, 24, 36, 48, and 60 weeks, respectively. Seroconversion rates were 9.1%, 13.6%, 24.6%, 26.5%, and 26.1% and ALT normalization rates were 64.5%, 78.1%, 87.9%, 90.0% at 12, 24, 36, and 48 weeks, respectively. Six patients (5.7%) had a viral breakthrough. Conclusions: Clevudine is a useful drug in the initial treatment of patients with CHB, with a potent antiviral effect and low incidence of viral breakthrough. (Korean J Intern Med 2010;25:372-376)

Niclosamide improves the anti-proliferative effect of gemcitabine on pancreatic cancer by inducing the ubiquitination of Β-catenin in wnt/β-catenin signaling

Hyeon Woong KANG,Daeun LEE,Myeong Jin KIM,So Yi KIM,YunSun LEE,Jung Min LEE,Hyung Sun KIM,Hyo Jung KIM,Joon Seong PARK 한국간담췌외과학회 2022 Annals of hepato-biliary-pancreatic surgery Vol.26 No.-

Brunner’s Gland Hyperplasia: Treatment of Severe Diffuse Nodular Hyperplasia Mimicking a Malignancy on Pancreatic-Duodenal Area

Woong Chul Lee,Hyeon Woong Yang,Yun Jung Lee,Sung Hee Jung,Gi Young Choi,Hoon Go,Anna Kim,Sang Woo Cha 대한의학회 2008 Journal of Korean medical science Vol.23 No.3

Brunner’s gland hyperplasia is a benign tumor of the duodenum and it is rarely associated with clinical symptoms. We report on a 64-yr-old man with Brunner’s gland hyperplasia who had undergone a duodenocephalo-pancreatectomy. The reason is that he presented upper gastrointestinal obstructive symptoms and the esophagogastroduodenoscopic finding revealed the lesion to be an infiltrating type mass on the second portion of the duodenum with luminal narrowing. An abdominal computed tomography showed a 2.5 cm-sized mass in the duodenal second portion with a suspicious pancreatic invasion and 7 mm-sized lymph node around the duodenum. Duodenocephalopancreatectomy was successfully performed. Histological examination revealed a Brunner’s gland hyperplasia. The final diagnosis was the coexistence of Brunner’s gland hyperplasia and pancreatic heterotopia with a pancreatic head invasion. The literature on Brunner’s gland hyperplasia is reviewed.

농업생산기반정비사업의 가뭄피해저감 효과 분석: 연산가능일반균형모형을 중심으로

김현웅 ( Hyeon-woong Kim ),성재훈 ( Jae-hoon Sung ) 한국농공학회 2023 한국농공학회 학술대회초록집 Vol.2023 No.0

정부는 농업생산기반정비사업을 통해 가뭄의 피해를 최소화하고 안정적인 농업생산을 유지하기 위해 지속적으로 노력하고 있다. 농업생산기반정비사업은 농지 정비를 통해 기계화 영농이 가능하도록 농지를 조성하며, 가뭄·홍수·수해 등 자연재해 예방을 위한 농촌용수 공급 수리시설을 설치 및 관리하는 사업이다. 특히, 농업생산기반정비사업에 속하는 농어촌용수개발 사업은 안정적인 농업용수공급기반 구축을 위해 가뭄상습지역에 저수지, 용수로 등의 수리시설을 설치하는 사업에 해당한다. 농어촌용수개발 사업을 통해 국내 수리안전답은 전체 논 면적의 63%까지 증가하였으며, 그 사업 비용 역시 2019년 5,698억 원까지 증가하였다. 또한, 최근 가뭄빈도 증가 등 기후변화에 대응하기 위하여 2030년까지 수리안전답률을 80% 달성할 것을 목표로 추진되고 있다. 하지만 이러한 많은 재원 투자에도 불구하고 농업생산기반정비사업의 가뭄저감효과에 대한 연구는 매우 제한적이다. 특히, 미래 기후변화를 고려한 농업생산기반정비사업의 가뭄저감효과와 경제적 파급효과는 매우 부족하다. 이에 본 연구에서는 문헌연구를 바탕으로 기후변화에 따른 농업생산기반정비사업의 가뭄저감효과를 식별하고, 연산가능일반균형모형을 통해 그 경제적 파급효과를 분석하였다. 분석 결과, 과거 2019년 수리안전답 수준을 가정할 경우, 2001년과 2010년 수리안전답 수준에 비해 단위면적당 쌀 생산량 피해가 10% 이상 줄어드는 것으로 나타났으며, 이러한 가뭄피해저감효과의 경제적 파급효과는 쌀 생산에 미치는 영향보다 큰 것으로 계측되었다. 또한, 이러한 경제적 효과는 가뭄의 강도와 빈도가 강해지는 기후변화로 인해 더욱 커지는 것으로 나타났다. 이는 농업생산기반정비사업의 가뭄저감효과의 경제적 효과가 직접적인 효과보다 더 크며, 중장기 기후변화를 고려한다면 그 경제적 효과는 더욱 증가할 수 있음을 의미한다. 다만, 본 연구의 결과는 농업생산기반정비사업의 가뭄저감효과만을 대상으로 하였기 때문에 전체 농업생산기반정비사업의 경제적 혜택을 계측하기 위해서는 추가적인 연구가 필요할 것으로 생각된다.

Basic : A case of jejunal variceal bleeding in Liver cirrhosis (초)

( Chan Woong Park ),( Sae Hee Kim ),( Hyeon Woong Yang ),( Yun Jung Lee ),( Sung Hee Jung ),( Hyang Ie Lee ),( An Na Kim ),( Sang Woo Cha ) 대한간학회 2011 Clinical and Molecular Hepatology(대한간학회지) Vol.17 No.3(S)