Bisphenol A exposure through receipt handling and its association with insulin resistance among female cashiers

Lee, Inae,Kim, Sunmi,Kim, Ki-Tae,Kim, Sungkyoon,Park, Suhyun,Lee, Hyojin,Jeong, Yunsun,Lim, Jae-Eun,Moon, Hyo-Bang,Choi, Kyungho Elsevier 2018 Environment international Vol.117 No.-

<P><B>Abstract</B></P> <P>Bisphenol A (BPA) is one of the most widely used chemicals in various consumer products. In thermal papers such as receipts and tickets, BPA is used as a heat-activated developer. Cashiers are therefore suspected to be a vulnerable group of exposure to BPA, but neither contribution of receipt handling to the total body burden of BPA among cashiers, nor related health effects are well characterized. Female cashiers (n = 54) were recruited from seven retail shops of a major supermarket chain in Korea, and urinary levels of BPA and metabolic syndrome (MetS) related biomarkers were measured. In order to estimate the contribution of receipt handling to the body burden of BPA, an intervention was designed on the use of gloves: the subjects were asked not to wear gloves during the work for one week, and in the following week, to wear gloves. Urine samples were collected at pre-shift and post-shift for the first two consecutive days in each week, and urinary BPA concentrations were measured. In cashiers without gloves, about a two-fold increase in urinary BPA concentrations was observed after work-shift. When the cashiers wore gloves, however, urinary BPA levels showed no changes. Higher urinary BPA concentrations were associated with greater levels of fasting insulin and insulin resistance. Our observation shows that receipt handling among the cashiers could double the BPA exposure levels at post-shift compared to those at pre-shift, and use of simple protective equipment such as gloves could effectively reduce the BPA exposure levels.</P> <P><B>Highlights</B></P> <P> <UL> <LI> Contribution of receipt handling to body burden of BPA was determined in cashiers. </LI> <LI> Without gloves, urinary BPA levels increased by two folds following work-shift. </LI> <LI> Use of gloves could efficiently prevent occupational exposure to BPA. </LI> <LI> Urinary BPA levels were associated with increased insulin levels and resistance. </LI> </UL> </P>

Association of urinary phthalate metabolites and phenolics with adipokines and insulin resistance related markers among women of reproductive age

Lee, Inae,Kim, Sunmi,Park, Suhyeon,Mok, Sori,Jeong, Yunsun,Moon, Hyo-Bang,Lee, Jangwoo,Kim, Sungkyoon,Kim, Hai-Joong,Choi, Gyuyeon,Choi, Sooran,Kim, Su Young,Lee, Aram,Park, Jeongim,Choi, Kyungho Elsevier BV 2019 Science of the Total Environment Vol.688 No.-

<P><B>Abstract</B></P> <P>Chemicals such as phthalates and phenolics have been associated with metabolic markers in humans. However, most studies have only looked at a limited number of chemicals, and little is known about their potential effects on adipokines in humans. In the present study, the associations between dozens of urinary chemicals, including phthalate metabolites and phenolics, and markers related to insulin resistance as well as major adipokines, were assessed among the women of reproductive age (<I>n</I> = 459, between 20 and 48 years of age) recruited from major cities in Korea between 2015 and 2016. Adipokines such as adiponectin and leptin, and insulin resistance related markers such as glucose and insulin, were analyzed in serum. Associations between urinary chemicals and the adipokines or insulin resistance related markers were assessed in two steps. First, ordinary least squares (OLS) regression was used to assess the association of each urinary chemical with the adipokines or insulin resistance related markers (single-pollutant model). Second, several chemicals were selected using elastic net regression and were subsequently analyzed with OLS regression model (multi-pollutant model), considering simultaneous exposure to multiple chemicals. In both single- and multi-pollutant models, several urinary chemicals consistently showed significant associations with adipokines or the insulin resistance related markers. The sum of di-(2-ethylhexyl) phthalate metabolites (ΣDEHPm) and ethyl paraben (EtP) were associated with increased serum adiponectin levels. Urinary ΣDEHPm levels also showed positive associations with fasting glucose. Moreover, urinary mono-methyl phthalate (MMP), mono-isobutyl phthalate (MiBP), and bisphenol S (BPS) levels showed positive associations with the homeostasis model assessment for insulin resistance (HOMA-IR). Interestingly, urinary propyl paraben (PrP) levels showed a negative association with HOMA-IR, in both models. Our observations show that among many consumer chemicals, phthalates may affect serum adipokines, and thus glucose, and insulin resistance in adult females. Further confirmation is warranted in other populations.</P> <P><B>Highlights</B></P> <P> <UL> <LI> Urinary chemicals and metabolism related markers were measured in women of reproductive age. </LI> <LI> Multiple chemicals were considered in statistical models for adipokines and insulin resistance. </LI> <LI> Sum of DEHP metabolites and EtP were positively associated with serum adiponectin levels. </LI> <LI> Sum of DEHP metabolites was significantly associated with increased fasting glucose. </LI> <LI> MiBP was significantly associated with for increased HOMA-IR. </LI> </UL> </P> <P><B>Graphical abstract</B></P> <P>[DISPLAY OMISSION]</P>

Gradual phase transition from ferromagnetic tetragonal to antiferromagnetic cubic states in Mn_<i>x</i>Ga (1.80 ≤ <i>x</i> ≤ 3.03) thin films

Jang, Yunsun,Yoo, Woosuk,Bang, Hyun-Woo,Kim, Chungman,Lee, Young Haeng,Lee, Kyujoon,Jung, Myung-Hwa Elsevier 2019 JOURNAL OF ALLOYS AND COMPOUNDS Vol.810 No.-

<P><B>Abstract</B></P> <P>The structural, magnetic, and electronic properties of Mn<SUB> <I>x</I> </SUB>Ga thin films are investigated as varying the Mn composition (1.80 ≤ <I>x</I> ≤ 3.03). The variation of <I>x</I> in Mn<SUB> <I>x</I> </SUB>Ga films dramatically changes the crystal structure as well as the magnetic properties. With increasing <I>x</I>, we observe the gradual phase transition from a ferromagnetic tetragonal state to an antiferromagnetic cubic state. The structural characterization reveals that the D0<SUB>22</SUB> tetragonal structure of Mn<SUB>2</SUB>Ga is slowly transformed to the L1<SUB>2</SUB> cubic structure of Mn<SUB>3</SUB>Ga. Two phases coexist around <I>x</I> = 2.4. The magnetization is systematically reduced as <I>x</I> increases, ending to an antiferromagnetic state of cubic Mn<SUB>3</SUB>Ga, and the electrical resistivity increases with <I>x</I>. Such highly tunable magnetic and electronic properties in Mn<SUB> <I>x</I> </SUB>Ga phase simply by the variation of the Mn/Ga ratio provide advantages to be used for spintronic device applications.</P> <P><B>Highlights</B></P> <P> <UL> <LI> Phase transition in Mn<SUB> <I>x</I> </SUB>Ga from ferromagnetic tetragonal to antiferromagnetic cubic structure. </LI> <LI> Comparison to other previous studies on tetragonal Mn<SUB> <I>x</I> </SUB>Ga with only magnetic transition. </LI> <LI> Dramatic changes in the magnetic and electronic properties as well as the crystal structure in Mn<SUB> <I>x</I> </SUB>Ga. </LI> </UL> </P>

희망기업의 취업의향에 영향을 미치는 주요 요인에 관한 탐색적 연구

이윤선(Yunsun Lee) 한국진로창업경영학회 2021 한국진로창업경영학회지 Vol.5 No.4

본 연구는 취업률 향상을 위해 일하고 싶은 기업으로 정의된 선호기업의 개념과 구직자가 일하기를 희망하고 일을 통해 만족감을 얻을 수 있는 기업을 희망기업으로 정의하여, 취업준비생인 대학생을 대상으로 희망기업의 취업의향에 영향을 미치는 주요 요인을 살펴보았다. 추가로 대학교에서 제공하는 취업지원프로그램에 적극적으로 참여한 대학생들과 상대적으로 참여가 낮은 대학생들 간에 취업의향에 영향을 미치는 주요 요인들도 살펴보았다. 특히 희망기업 선택의 주요 요인으로 적성중요도, 고용안정중요도, 임금중요도, 기업규모중요도, 통근거리 중요도와 희망기업의 취업의향과의 인과관계를 살펴보았다. 연구설계로 희망기업에 대한 사전조사를 진행하고, 희망기업 선택 시 고려하는 요인들과 취업의향에 영향을 미치는 변수들의 중요도를 통해 주요 요인을 확인하였다. 연구결과 적성중요도, 고용안정중요도가 희망기업의 취업의향에 정(+)의 영향을 미치고, 임금중요도, 기업규모중요도는 취업의향에 영향을 미치는 않는 것으로 나타났다. 이는 임금과 기업규모의 중요도보다는 구직자 자신의 적성과 고용안정이 주요변수로 인지하고 있음을 알 수 있었다. 또한 통근거리 중요도의 경우 통근거리가 멀수록 취업의향에 부(-)의 영향을 미치는 것으로 나타났다. 연구문제 2를 검증하기 위해 희망직무와 연관하여 필요한 취업지원프로그램인 진로탐색, 현장실습 및 인턴 연계 프로그램에 3회 이상 참여한 학생집단에서는 임금의 중요도와 기업규모 중요도가 희망기업의 취업의향에 영항을 미치는 것으로 나타났다. 이러한 결과는 취업지원프로그램에 참여도가 높은 학생들의 경우, 임금의 중요도와 기업규모 중요도가 통계적으로 유의하였으며, 통근거리에 대해서는 통계적으로 한계적 유의성을 보였다. This study defined the concept of a preferred workplace, defined as a workplace where they would like to work, and a workplace where job seekers hope to work and obtain satisfaction through work as a desired company. This is an exploratory study that examines the major factors that influence the employment intentions of students and examines the causal relationship among students who actively participated in the employment support program provided by the university. In particular, the causal relationship between the importance of aptitude, the importance of job security, the importance of income, the importance of company size, the importance of commuting distance, and the intention of employment of the desired company as major factors in selecting the desired company was examined. The research design conducted a previous survey of the desired company, and major factors were identified through the factors considered when selecting the desired company and the importance of the variables affecting the employment intention. As a result of the study, it was found that the importance of aptitude and the importance of job security had a positive (+) effect on the employment intention of the desired company, while the importance of income and the importance of the company size did not affect the employment intention. The results present that job seekers aptitude and job security are perceived as major variables rather than the importance of income and company size. Also, in the case of the importance of commuting distance, it was found that the longer the commuting distance, the negative (-) effect on the employment intention. In addition, in the group of students who participated in the career search, field training, and internship program, which are necessary employment support programs related to the desired job, more than 3 times, the importance of the income and the importance of the company size were found to affect the intent of the desired company to be employed. These results showed that in the case of students with high participation in the employment support program, the importance of income and the importance of company size were statistically significant, and the commuting distance was limitedly significant.

농대학생의 연상반응 분석

이윤선(YunSun Lee),원성옥(SeongWok Won),김지숙(JiSook Kim) 한국언어청각임상학회 2007 Communication Sciences and Disorders Vol.12 No.2

Background & Objectives: It has been known that deaf individuals tend to have limited mental lexicon, and that it takes longer time for them to access semantic knowledge of a given word. The purpose of this study was to investigate the responses in word association tasks(word association set, association motif, word class) in college students who were deaf or were not. Methods: The subjects included 30 deaf college students and 29 normal-hearing(NH) college students. Each student had to read 12 word cards and also had to write down words associated with a given stimulus word within 10 seconds. Results: Firstly, there was a significant difference between the deaf and the NH students in the size of the associative set for a given word and the strength of the most frequently occurred response. Secondly, there was no significant difference between the two subject groups regarding association motif. Thirdly, both groups frequently associated noun responses to the noun stimulus. Discussion & Conclusion: These findings imply that deaf students should improve their lexical competence based on organization and use of their mental lexicon. 배경 및 목적: 단어연상하기 과제에서 농학생들은 어휘집이 작고, 단어의 의미에 접근하는데 더 오랜 시간이 걸린다. 본 연구는 농대학생과 건청대학생이 단어연상과제에서 보인 명사자극어에 대한 연상반응(단어연상, 연상동기, 자극어에 따른 단어부류)을 알아보는데 목적이 있다. 방법: 연구대상은 같은 대학교에 재학하고 있는 농학생 30명과 건청학생 29명이다. 학생들은 제시된 자극어를 읽고 10초 내에 연상되는 단어를 적었다. 결과: 첫째, 농대학생과 건청대학생이 보인 총반응수와 연상강도에서는 통계적으로 유의미한 차이가 있었다. 둘째, 단어연상의 동기에 따라서 언어적 연상과 경험적 연상으로 분류하였는데, 두 집단간에 유의미한 차이가 없었다. 셋째, 명사자극어에 대한 반응어의 단어부류에 있어서 농학생과 건청학생 모두 명사자극어에 대해 명사로 연상하는 경우가 높았다. 논의 및 결론: 이러한 연구결과를 통해 농학생들의 어휘집특성을 고려하여 어휘량을 증대시킬 필요가 있음을 확인하였다.

모바일 쇼핑 경험 향상을 위한 UX 디자인 개선 연구: 쇼핑 앱 ‘위시버킷’을 중심으로

강윤선(Yunsun Kang),김효원(Hyowon Kim),이소현(Sohyeon Lee),이주현(Juhyeon Lee),조의뢰(Uiroe Cho),김유진(Yu-Jin Kim) 한국디자인학회 2023 한국디자인학회 학술발표대회 논문집 Vol.2023 No.10

Whole Exome Sequencing in Patients with Phenotypically Associated Familial Intracranial Aneurysm

Song Yunsun,Lee Jong-Keuk,Lee Jin-Ok,Kwon Boseong,Seo Eul-Ju,Suh Dae Chul 대한영상의학회 2022 Korean Journal of Radiology Vol.23 No.1

Objective: Familial intracranial aneurysms (FIAs) are found in approximately 6%–20% of patients with intracranial aneurysms (IAs), suggesting that genetic predisposition likely plays a role in its pathogenesis. The aim of this study was to identify possible IA-associated variants using whole exome sequencing (WES) in selected Korean families with FIA. Materials and Methods: Among the 26 families in our institutional database with two or more IA-affected first-degree relatives, three families that were genetically enriched (multiple, early onset, or common site involvement within the families) for IA were selected for WES. Filtering strategies, including a family-based approach and knowledge-based prioritization, were applied to derive possible IA-associated variants from the families. A chromosomal microarray was performed to detect relatively large chromosomal abnormalities. Results: Thirteen individuals from the three families were sequenced, of whom seven had IAs. We noted three rare, potentially deleterious variants (PLOD3 c.1315G>A, NTM c.968C>T, and CHST14 c.58C>T), which are the most promising candidates among the 11 potential IA-associated variants considering gene-phenotype relationships, gene function, co-segregation, and variant pathogenicity. Microarray analysis did not reveal any significant copy number variants in the families. Conclusion: Using WES, we found that rare, potentially deleterious variants in PLOD3, NTM, and CHST14 genes are likely responsible for the subsets of FIAs in a cohort of Korean families.

내한성 분화용 철쭉류 신품종 육성

이정식(Jeongsik Lee),이성춘(Sungchun Lee),장윤진(Yunjin Chan),홍훈기(Hoonki Hong),김유선(Yunsun Kim) 한국원예학회 2005 한국원예학회 학술발표요지 Vol.2005 No.5

Development of Transient Cytosine and Adenosine Base Editing System in Plants

Eun-Bin Lee,Yunsun Kim,Minju Kim,Donghui Lee,Beum-Chang Kang 한국원예학회 2023 한국원예학회 학술발표요지 Vol.2023 No.10

실내 먼지 중 프탈레이트 인체노출평가

이효진(Hyojin Lee),김선미(Sunmi Kim),정윤선(Yunsun Jeong),강하병(Habyeong Kang),손주혜(Juhye Son),이고운(Gowwon Lee),신혜진,문효방(Hyobang Moon),최경호(Kyungho Choi),김기태(Kitae Kim) 환경독성보건학회 2016 한국독성학회 심포지움 및 학술발표회 Vol.2016 No.6