개에 있어서 耳根部의 Lidocaine 水針에 의한 全身 無痛覺의 誘發

권현주,유건주,이상은,이정연,송근호,김명철,정성목,박성준,김덕환 충남대학교 수의과대학 동물의과학연구소 2004 動物醫科學硏究誌 Vol.12 No.-

Twelve clinically healthy mongrel dogs were used to clarify the possibility of general analgesia induction by lidocaine aquapuncture to auricular root area in the present study. The experimental animals were devided into control (6 heads) and experimental groups (6 heads), respectively. Physiological salines (3 ml/kg) were injected into both auricular root areas in control group. Lidocaine hydrochlorides (3 ml/kg) were injected into both auricular root areas in experimental group. Superficial pain, the changes of vital signs and blood leukocytes, and PCV were examined on pre, 5 min., 15 min., 30 min, and 60 min. after injection in control and experimental groups, respectively. Analgesia was not detected at all in control group, however, all experimental animals were recumbent and analgesia was generally detected in the auricles, noses, dorsal parts, ventral areas, limbs and tails from 5 to 30 minutes after injection with lidocaine hydrochloride into auricular root areas in experimental group. As for the change of vital signs, body temperature showed decreasing tendency from 5 minutes after lidocaine injection in experimental group. Heart rates and respiration rates were increased on 5 minutes after lidocaine injection and then they showed decreasing tendency in experimental group. No significant difference were found among groups. As for the changes of hematological findings, the numbers of blood leukocytes were increased till 15 minutes after lidocaine injection and then they showed decreasing tendency. PCV values were increased on 5 minutes after lidocaine injection, and then they showed decreasing tendency. However, no significant differences were observed among groups. Considering the above findings, it was thought that general analgesia was possible by aquapuncture with lidocaine hydrochloride into auricular root areas and lidocaine aquapuncture didn’t affect so much to the changes of vital signs and blood.

1,2-벤조디아진-3-카복서마이드 유도체 합성 및 진통작용

권순경,송윤신,장은성,이명숙 德成女子大學校 藥學硏究所 1997 藥學論文誌 Vol.8 No.1

Seven new 7-H(or bromo)-4-hydroxy-2H(or methyl)-N-(5-aralkyl-3-aminohydantoinyl) -1,2-benzothiazine-3-carboxamide-1,1-dioxide derivatives were synthesized through the condensation of 7-H(or bromo)-4-hydroxy-2H(or methyl)-1,2-benzothiazine-3-carboxylic acid methyl ester 1,1-dioxides with 5-substituted-3-aminohydantoins. The analgesic activities of the synthesized compounds were investigated by Randall-Selitto assay. Most compounds exhibited lower activities but compound 6 and 7 showed higher analgesic activities than piroxicam.

Ti첨가 및 균질화 처리가 원심주조한 Cu-Zn-Al계 고력황동의 기계적 성질에 미치는 영향

권영한,허성강,김창규,윤재홍 國立 昌原大學校 産業技術硏究所 1997 産技硏論文集 Vol.11 No.-

Effects of Ti addition and homogenizing treatment on the mechanical properties in Cu-Zn-Al system high strength brass were investigated. Grain refinement was successfully achieved by Ti addition: The microstructure, which was composed of island or fine feather-like branched Ti compounds was changed to feather-like eutectic microstructure as the content of Ti increased. The highest hardness values was obtained for 0.5wt% Ti specimen and the second was Ti non-added specimen in as-cast conditions. Maximum tensile strength was obtained for 0.5wt% Ti specimen. Dueing to the presence of cast defects and worse castability, tensile strength decreased as the content of Ti increased. Elongation was increased with increasing homogenizing time and temperature: remarkable increase was obtained for 400℃ homogenizing temperature in the 0.5wt% Ti specimen. For 500℃ and 600℃ homogenizing temperature, high elongation was obtained in 2 and 4wt% Ti specimen.

Bacillus sp. KCM-101에 의한 내열성 α-amylase의 생산 및 효소학적 성질

강상모,최유정,황윤영,이동희,권태종 건국대학교 산업기술연구원 2000 건국기술연구논문지 Vol.25 No.-

A strain isolated from soil was able to produce thermostable α-amylase. The strain (KC-101) was identification as Bacillus sp. Bacillus sp. KC-101 was treated NTG(N-methyl-nitro-nitrosoguanidine). The mutant KCM-101 increased α-amylase activity and decreased pretease activity. The condition for production, purification, and properties of α-amylase were investigated. α-Amylase production was maximized when was grown on soluble starch 2.0%, yeast extract 0.5%, K2HPO4 0.1% and MnCl2 0.02% for 24hrs at 37℃, and initial pH 7.0. The enzyme production was also increased by the addition of 0.01% Triton X-100. The enzyme was purified by ultrafiltration(MW 10,000), 80% ammonium sulfate precipitation, and Sephadex G-75 gel chromatography and it's yield 15.0%, The characteristics of purified α-amylase were as follow : MW 55,000, optimal pH and temperature were 7.0 and 95℃, respectively. The enzyme was activated by Ca++ and Mn++ ion but inhibited Co++, Cu++, Hg++, and Pb++ ion. The enzyme was stable at 95℃ and it's thermostability was greatly increased by the addition of Ca++. In kinetic studies, the Km value of α-amylase for soluble starch was 0.93mg/mL.

生體實驗用 900 MHz 電磁波의 인가장치 설계연구

김윤명,권용일,문병기,성주영 단국대학교 1999 論文集 Vol.34 No.-

In this paper, we made the space 900 ㎒ electromagnetic field, using the strip line which has been applied to EMC test for communication equipments and vehicles etc.. We analyzed electromagnetic distribution and scattering parameters of strip line to obtain the characteristic of this designed strip line, using the numerical method of FDTD(Finite Difference Time Domain).

실험동물에서의 내분비계 교란물질인 DEHP, DBP의 생체내 영향

정지윤,이성호,박영석,박병권,김병수,김상기,박창식,강경선,이영순 충남대학교 형질전환복제돼지연구센터 2007 논문집 Vol. No.10

The major protocol features of the rodent uterotrophic assay have been evaluated using a range of reference chemicals. The protocol variables considered include the selection of the test species and route of chemical administration, the age of the test animals, the maintenance diet used, and the specificity of the assay for estrogens. The rodents were ovariectomized under general anesthesia via bilateral flank incisions and randomly assigned to groups of 5 animals. This study investigated the estrogenic effects of phthalates, which are DEHP and DBP, suspected as endocrine disruptors. It is concluded that three daily subcutaneous administration of test chemicals, which are di-ethylhexyl phthalate(DEHP) and di-n-butyl phthalate(DBP), to 9 week-old rodents. The results revealed that DEHP & DBP show similar uterotrophic activity in the rat and the mouse, using subcutaneous administration. DEHP and DBP failed to affect any of these parameters, which are body weight, mammary gland, vaginal and uterus histopathology. but, DBP increased uterus weight to only one rat of 1.0 g/kg group. The results conform the need for rigorous attention to experimental design and criteria for assessing estrogenic activity.

기능성척추측만증에 근막이완요법 및 전침치료 증례

김성욱,강영화,이상훈,권혜연,조태성,송춘호,안창범 동의대학교 한의학연구소 2001 동의한의연구 Vol.5 No.-

목적 : 우리는 신체를 근막의 통합된 전체로 보는 근막이완요법과 TrP를 파괴하는 전침요법을 기능성 척추측만증에 적용시킬수 있는지 알아보았다. 방법 : 22세의 기능성 척추측만증을 가진 남성에게 다양한 형태의 근막이완요법을 적용하였고, 중둔근, 요방형근, 슬괵근에 전침요법을 적용하였다. 결과 : 3주시술후 다리길이차이, 근막구축, Cobb's 각과 척추회전변위가 감소되었고 흉부압박감 같은 전신적증상이 호전되었다. 결론 : 근막이완요법과 전침병행치료가 신체를 근막의 일체로 보는 관점으로 인체의 구조적불균형을 바로 잡아줄수 있는 새로운 치료법의 기능성을 찾았다. Objective: We investigated this study in order to see the adaptation capability of myofascial release that translating the body being integrated fascial totality and electroacupuncture treatment that breaking trigger points in functional scoliosis. Methods: We applied myofascial relase by three patterns and electroacupuncture in TrPs of gluteus medius, Quadratus lumborum and Hamstring muscle to 22 year-old who have had functional scoliosis. Results: After 3 weeks, The leg length, fascial restriction. Cobb's angle and rotation scoliosis are decreased. Systemic symptoms, for example; chest discomfort are improved. conclusion: Myofascial release and electroacupuncture treatment is new methods that treating the sturctural unbalance in view of body's fascial network.

인슐린 비의존성 당뇨병에 동반된 심상성 천포창 1 례

이상준,박진용,임태형,윤영호,권순대,남창욱,허규찬,박근용,구본식,김상표,장종억 啓明大學校 醫科大學 1997 계명의대학술지 Vol.16 No.3

저자들은 인슐린 비의존형 당뇨병 환자에서 통증성 구강내 미란 및 전신성 수포성 미란을 동반한 심상성 천포창 1예를 경험하였기에 문헌고찰과 함께 보고하는 바이다. Various skin conditions such as diabetic dermopathy, necrobiosis lipoidica diabeticorum, bullosis diabeticorum, granuloma annulare occur frequently in diabetes, although common lesions may be associated by chance. Pemphigus vulgaris(PV) is a blistering skin disease seen predominantly in elderly patients. This disorder is characterized by the loss of cohesion between epidermal cells with the resultant formation of intraepidermal blisters. These blisters rupture easily, leaving denuded areases that may crust and enlarge peripherally. In half or more of patients, lesions begin in the mouth: approximately 90% of patients have oromucosal involvement at some time during the course of their disease. But the relationship of this disorder with diabetes is not clear. We experienced a case of pemphigus vulgaris associated with NIDDM in 67 years old woman who was admitted due to painful oral ulcer and control of blood glucose, so we present this case with a review of literatures.

Ca^(2+)-감수성 증가기전과 평활근 수축

이연리,김보경,최원호,김태경,이창권,배영민,조성일 건국대학교 의과학연구소 2004 건국의과학학술지 Vol.14 No.-

Smooth muscle contraction is regulated by intracellular Ca^(2+) ([Ca^(2+)]_(i)) and the phosphorylation of myosin light chain (MLC). However, various kinds of vasoconstrictors induce a further contraction at a given [Ca^(2+)]_(i), and elicit a sustained contraction under Ca^(2+) -depleted conditions, referred to as "Ca^(2+) -sensitization", in intact and membrane-pen-neabilized smooth muscle. Previously, several molecules, including protein kinase C (PKC), RhoA, and mitogen-activated protein kinases (MAPK), have been suggested as candidate regulators of Ca^(2+) -sensitization. In the present review, we describe the role of PKC, RhoA, and MAPK in the regulation of Ca^(2+) -sensitization, and suggest a new model in research for the regulation of smooth muscle contraction.

뇌성마비 장애자를 위한 교육용 소프트웨어 제작에 관한 연구

이상윤,권중장 경성대학교 공학기술연구소 2002 공학기술연구지 Vol.9 No.-

In this paper, studied characteristics of students having cerebral infantile paralysis. And, suggest an implementation method of the educational software using multimedia informations such as text, icon(button), sound, image, etc and effective usages such as the types of the educational softwares, the composition of a picture, a teacher's control window, various working files, integrated teaching materials, games, songs. By experimental result, we know that the proposed method is very useful.