Immune Evasion of G-CSF and GM-CSF in Lung Cancer

Chae Uk Chung, M.D., Ph.D.,Yeonhee Park, M.D., Ph.D. 대한결핵및호흡기학회 2024 Tuberculosis and Respiratory Diseases Vol.87 No.1

Tumor immune evasion is a complex process that involves various mechanisms, suchas antigen recognition restriction, immune system suppression, and T cell exhaustion. The tumor microenvironment contains various immune cells involved in immune evasion. Recent studies have demonstrated that granulocyte colony-stimulating factor(G-CSF) and granulocyte-macrophage colony-stimulating factor (GM-CSF) induce immuneevasion in lung cancer by modulating neutrophils and myeloid-derived suppressorcells. Here we describe the origin and function of G-CSF and GM-CSF, particularlytheir role in immune evasion in lung cancer. In addition, their effects on programmeddeath-ligand 1 expression and clinical implications are discussed.

Vitamin D-Cathelicidin Axis: at the Crossroads between Protective Immunity and Pathological Inflammation during Infection

Chae Uk Chung,Prashanta Silwal,Insoo Kim,Robert L. Modlin,조은경 대한면역학회 2020 Immune Network Vol.20 No.2

Vitamin D signaling plays an essential role in innate defense against intracellular microorganisms via the generation of the antimicrobial protein cathelicidin. In addition to directly binding to and killing a range of pathogens, cathelicidin acts as a secondary messenger driving vitamin D-mediated inflammation during infection. Recent studies have elucidated the biological and clinical functions of cathelicidin in the context of vitamin D signaling. The vitamin D-cathelicidin axis is involved in the activation of autophagy, which enhances antimicrobial effects against diverse pathogens. Vitamin D studies have also revealed positive and negative regulatory effects of cathelicidin on inflammatory responses to pathogenic stimuli. Diverse innate and adaptive immune signals crosstalk with functional vitamin D receptor signals to enhance the role of cathelicidin action in cell-autonomous effector systems. In this review, we discuss recent findings that demonstrate how the vitamin D-cathelicidin pathway regulates autophagy machinery, protective immune defenses, and inflammation, and contributes to immune cooperation between innate and adaptive immunity. Understanding how the vitamin D-cathelicidin axis operates in the host response to infection will create opportunities for the development of new therapeutic approaches against a variety of infectious diseases.

급성 호흡곤란 중후군 환자에서 염증 표지자의 예후 예측인자로서의 역할

정재욱 ( Chae Uk Chung ),황재희 ( Jae Hee Hwang ),박지원 ( Ji Won Park ),신지영 ( Ji Young Shin ),정선영 ( Sun Young Jung ),이정은 ( Jeong Eun Lee ),박희선 ( Hee Sun Park ),정성수 ( Sung Soo Jung ),김주옥 ( Ju Ock Kim ),김선영 ( S 대한결핵 및 호흡기학회 2008 Tuberculosis and Respiratory Diseases Vol.65 No.2

연구배경: ARDS는 다양한 원인으로 초래되는 급성 염증성 폐 질환으로서 인공호흡기 치료 등의 여러 의학적 발전에도 불구하고 사망률이 40~60%로 예후가 좋지 않다. 이러한 환자들의 예후를 예측하는 방법으로 APACHE, SPAPS, MAM 등 방법이 있지만 간편하지가 않아서, ARDS가 염증성 폐질환이란 점에 착안하여서 염증 지표로 흔히 사용하는 ESR, CRP의 ARDS 환자에서 예후 인자로서의 역할을 평가해 보고자 하였다. 방법: 87명의 ARDS 환자들의 중환자실 입원 당시의 ESR, CRP 결과와 APACHE II score 그리고 추적 검사한 결과를 확인하였다. 또한 대상 환자를 생존한 군과 사망한 군으로 나누어서 생존한 환자군에서 총 입원기간, 중환자실 입원기간, 인공 호흡기 치료 기간과 ESR, CRP, APACHE II score들과의 상관관계 및 ESR, CRP의 변화 추이와 사망률과의 상관 관계에 대해서 연구하였다. 결과: 중환자실 입원 당시의 ESR, CRP로는 ARDS 환자의 사망률을 예측하기가 어렸다. 하지만 CRP는 ARDS로 중환자실 치료 후 생존했던 환자군에서 사망했던 환자군에 비해서 치료 초기에 유의하게 감소하였으며, 중환자실 입원 당시 ESR이 높을수록 ARDS 환자들의 총 입원 기간 및 중환자실 입원기간이 길었다. 결론: CRP의 초기 변화 및 중환자실 입원 당시의 ESR은 ARDS 환자의 예후를 예측하는데 도움이 될 수 있다. Background: Acute respiratory distress syndrome (ARDS) is ultimately an inflammatory state. The erythrocyte sedimentation rate (ESR) and C-reactive protein (CRP) level are inflammatory markers. The aim of this study was to evaluate the value of the ESR, CRP and APACHE II score as prognostic factors for patient with ARDS. Methods: We retrospectively analyzed the medical records of 87 ARDS patients. The predictors (APACHE II score, ESR and CRP) and outcomes (mortality and length of the total hospital stay, the ICU stay and mechanical ventilator care) were obtained from the patients` records. The patients were grouped according to survival as the Survivor and Non survivor groups. We compared the APACHE II score, the ESR and the CRP level between the survivor group and the nonsurvivor group. We evaluated the correlation between the predictors and the outcomes. The initial ESR, CRP level and APACHE II score were checked at the time of ICU admission and the second ESR and CRP level were checked 3.3±1.2 days after ICU admission. Results: Thirty-eight (43.7%) patients remained alive and 49 (56.3%) patients died. The APACHE II score was significantly lower for the survivor group than that for the non survivor group (14.7±7.6 vs 19.6±9.1, respectively, p=0.006). The initial ESR and CRP level were not different between the survivor and non-survivor groups (ESR 64.0±37.8 mm/hr vs 63.3±36.7 mm/hr, respectively, p=0.93, CRP 15.5±9.6 mg/dl vs 16.3±8.5 mg/dl, respectively, p=0.68). The decrement of the CRP level for the survivor group was greater than that for the non survivor group (-8.23±10.0 mg/dl vs -1.46±10.1 mg/dl, respectively, p=0.003). Correlation analysis revealed the initial ESR was positively correlated with the length of the total hospital stay and the ICU stay (correlation coefficient of the total hospital days: R=0.43, p=0.001, correlation coefficient of the ICU stay: R=0.39, p=0.014). Conclusion: The initial APACHE II score can predict the mortality of ARDS patients, and the degree of the early CRP change can be a predictor of mortality for ARDS patients. The initial ESR has positive correlation with the ARDS patients` duration of the total hospital stay and the ICU stay. (Tuberc Respir Dis 2008;65:99-104)

대량출혈을 동반한 십이지장 이소성 췌장 1예

정인식,박두호,차상복,장기육,최규용,오수혁,채현석 대한소화기내시경학회 1997 Clinical Endoscopy Vol.17 No.2

Ectopic pancreas is commonly located at stomach, duodenum and jejunum. It is a relatively rare entity and is usually of no clinical importance which especially is a very rare source of massive upper gastrointestinal bleeding. We have recently experienced a case of an ectopic pancreas in the second portion of the duodenum which was proven to be a source of massive gastrointestinal bleeding by duodenoscopy and was confirmed by surgical exploration.

휴경답에서의 토양의 이화확적 특성 , 주요 영양분 및 잡초종의 변화

정갑채,구자옥,천상욱,한성욱,이희재 한국환경농학회 1998 한국환경농학회지 Vol.17 No.3

휴경답에서의 휴경년한에 따른 토양의 이화학적 특성과 주요 영양분의 변화 및 잡초종의 식생 변화를 조사하였다. 휴경년한이 경과할수록 휴경답 토양의 유기물 함량이 증가하였으며 pH는 휴경후 3년까지는 변화가 없었으나 이후로는 다소 증가하였다. 토양의 양이온치환용량 및 치환성 N, K, Ca, Mg의 함량은 휴경후 3년까지는 감소하였으나 휴경년한이 길어지면서 증가하였다. 유효 P₂O_5의 함량은 휴경년한이 길어지면서 지속적으로 감소한 반면 유효 SiO₂의 함량은 3년까지는 변화가 없었으나 그이후로는 증가하였다. 휴경답에서의 잡초종 구성은 초기에는 화본과, 사초과 및 국화과가 주종을 이루었으며 휴경년한이 경과할수록 마디풀과와 골풀과의 잡초 발생이 증가하는 반면 콩과, 물옥잠과, 닭의장풀과, 바늘꽃과의 잡초 발생이 점차 감소하였다. 그러나 화본과의 사초과의 잡초종은 휴경년한의 경과와는 관계없이 항상 우점종으로 발생하였다. 일반적으로 휴경화가 진전될수록 일년생 잡초종에 비해 다년생 잡초종의 발생 비율이, 또한 논 잡초종에 비해 밭 잡초종의 발생 비율이 높아지는 경향이 뚜렷하였다. Changes in physico-chemical properties and major nutrient contents were investigated in the soil of paddy fields during fallow period. Weed vegetation change in the fallow paddy fields was also examined. As the fallow period became longer, organic matter content in the paddy soil has gradually increased. Soil pH of the paddy fields has not changed until three years of fallow period and thereafter slightly increased. Cation exchange capacity of the paddy soil, and exchangeable N, K, Ca and Mg contents in the soil tended to decrease until three years of fallow period and then increase with the prolonged fallow period. As the fallow period became longer, available P₂O_5 content in the paddy soil has continuously decreased. Available SiO₂content in the paddy soil has not changed until three years of fallow period and thereafter increased. The vegetation in the fallow paddy fields have mostly been occupied by the weeds of the Gramineae, Cyperaceae, and Compositae. As the fallow period became longer, the weeds of the Polygonaceae and Juncaceae have increased, whereas the weeds of the Leguminosae, Commelinaceae, Pontederiaceae, and Onagraceae have gradually disappeared. However, the weeds of the Gramineae and Cyperaceae have always been dominant in the paddy fields during the fallow paddy period.

내시경 절제술로 진단한 표재성 낭종성 위염 2예

조욱 ( Uk Jo ),정명화 ( Myung Hwa Jung ),강경환 ( Kyung Hwan Kang ),박지영 ( Ji Young Park ),정회훈 ( Hoe Hoon Chung ),김선용 ( Sun Yong Kim ),김민경 ( Min Kyung Kim ),채정민 ( Jung Min Chae ),이은정 ( Eun Jung Lee ),김정욱 ( Jun 전북대학교 의과학연구소 2011 全北醫大論文集 Vol.35 No.1

Gastritis cystica superficialis (GCS) is an uncommon benign lesion which is characterized by hyperplastic foveolar epithelia and multi-cystically dilated glands, especially within the mucosa. It is usually observed in patients who had done stomach surgery before, but also infrequently found in an unoperated stomach. We report two cases of GCS, which occurred in patients who had never undergone stomach surgery. The first case was a 63 years old male with GCS accompanying with gastric adenoma, which was confirmed by endoscopic resection. The second case was a 55 years old female with GCS diagnosed by endoscopic resection, who had been misdiagnosed as raised erosive gastritis but did not respond to H2blocker treatment. Therefore, endoscopic resection is a safe and useful procedure to confirm the histological diagnosis of GCP.

[산업보건] 초음파 전처리에 의한 용접 흄 중 6가 크롬의 분석

윤충식(Chung-Sik Yoon),백남원(Nam-Won Paik),김정한(Jeong-Han Kim),박동욱(Dong-Uk Park),최상준(Sang-Jun Choi),김신범(Shin-Bum Kim),채현병(Hyun-Byung Chae) 한국분석과학회 1999 분석과학 Vol.12 No.5

노인에서 정서 인식의 저하

이경욱,채정호,최인철,이해국,권용실,이정태 大韓神經精神醫學會 2005 신경정신의학 Vol.44 No.2

Objectives : The purpose of this study was to investigate whether elderly and young adults differ in their recognition of facial expressions of emotion. Methods : A total of 120 (elderly group 53, young group 67) subjects participated in this study. Korean facial expressions of emotion including happiness, sadness, fear, anger, disgust, surprise and neutral were used as stimuli for facial affect recognition test. Computerized facial affect recognition test that consists of facial affect discrimination test and facial affect intensity test was performed. Results : For facial affect discrimination test, there was a significant difference between two groups (F==3.986, P<.01) after controlling the effect of education. Elderly participants showed significantly less correct recognition rate with sadness, anger and disgust (p<.05). For facial affect intensity test, there was no significant difference between the groups in recognition of emotional intensity. Chi-square test or t-test was done according to the clinical variables. Multivariate analysis of covahance was done to test group differences of correct recognition rate and emotional intensity. Conclusion : This is the first report of differential decrease of facial affect recognition in elderly using Korean facial expressions. This study suggests that the decrement of facial affect recognition maye be a part of normal aging process.

Poster Exhibition : Genotypic Resistance to Entecavir in Chronic Hepatitis B Patients (초)

Byeong Uk Kim,Ja Chung Goo,Byeong Chul Park,Soo Ok Kim,Sun Pyo Hong,Won Joong Jeon,Hee Bok Chae,Seon Mee Park,Sei Jin Youn 대한간학회 2009 Clinical and Molecular Hepatology(대한간학회지) Vol.15 No.4(S)

Gilbert 증후군에서 열량 제한 시험과 Phenobarbital 자극 시험의 의의(14예)

이헌영,채경훈,정재훈,강윤세,김연수,문희석,박기오,이엄석,김선문,김석현,성재규,이병석,이강욱 충남대학교 의학연구소 2003 충남의대잡지 Vol.30 No.2

Gilbert 증후군은 인구의 7%에서까지 나타날 수 있는 매우 흔한 증후군으로서 비진행성인 양성의 만성적 경과를 치하며, 간질환의 증상과 징후가 없는 경한 비포합형 고빌리루빈혈증이 특징인 일종의 체질적인 증상으로서 혈장 빌리루빈 농도에 대한 사춘기의 영향 때문에 10대와 20대에 자주 진단이 된다. 따라서 임상적인 중요성은 미약하지만 높은 빈도가 예상되는 점에 그 중요성이 부여되어야 할 것이다. 따라서 적정한 임상적 진단법으로 기왕에 소개된 열량제한 시험과 phenobarbital 유도 시험을 시행하고 이들의 진단적 가치를 알아보기 위하여 본 연구를 시행하였다. 1990년 7월부터 1999년 4월까지 충남대학교병원에 내원하여 HBsAg, IgG anti-HBc 및 anti-HCV가 음성이고, 간 초음파 스캔에서 이상이 없으며, 혈청 AST, ALT 및 AP가 정상인 비음주자에서 경한 비포합형 고빌리루빈혈증이 있는 14예의 환자들을 대상으로 ^(99m)Tc-DISID 스캔을 시행하였으며, 기저 치 총빌리루빈 및 포합형 빌리루빈 치를 측정한 다음에 하루에 400Kcal로 48시간동안 제한한 열량 제한 시험을 시행하였고, phenobarbital을 하루 60mg씩 5일간 투여한 후에도 각각 총빌리루빈과 포합형 빌리루빈 치를 검사하여 비포합형을 구하였다. 대상 환자들은 모두 14예로서 남자가 11예(78.6%)였고 여자가 3예(21.4%)여서 3.7:1로 남자에서 많았으며, 20대가 6예(42.9%), 30대가 역시 6예(42.9%) 및 40대가 2예(14.2%)로서 2,30대가 대부분(85.8%)이었다. 열량 제한 시험 후의 총빌리루빈 치, 비포합형 및 포합형 빌리루빈 치들은 평균 각각 5.5±2.7, 4.2±2.3 및 1.3±10mg/dL 로서, 시험 전 치들인 3.0±0.8, 2.2±0.8 및 0.7±0.4mg/dL 보다 유의하게(p=0.001, p=0.001, p=0.023) 상승하였다. 포합형 빌리루빈 치도 유의하게 상승하였으나 비포합형의 상승보다는 훨씬 낮아서 주로 비포합형이 증가하였다. phenobarbital 투여 중 설사가 발생하여 중단한 1예를 제외한 13예에서 열량 제한 시험 후에 상승하였던 총, 비포합형 및 포합형 빌리루빈 치가 phenobarbital 유도 시험후에는 2.0±1.1, 1.5±0.8 및 0.5±0.4mg/dL로서 열량 제한 시험 결과보다 유의하게 낮아졌고(p=0.00, p=0.000, p=0.001), 열량 제한 시험 전의 기초치들인 3.0±0.8, 2.2±0.8 및 0.7±0.4mg.dL 보다도 더욱 낮아졌으며 유의한 차이(p=0.001, p=0.02, p=0.005)를 나타내었다. 14예에서 시행한 ^(99m)-Tc DISIDA 스캔에서 9예(64.3%)가 정상이었고, 5예(35.7%)에서는 심장 및 신장으로의 간외 섭취가 3예였고, 60분까지 소장 배출이 없는 배설 지연 예와 담낭 수축 불량 예가 각각 1예 씩 발견되었다. Phenobarbital 투여시험에서 민감도가 열량제한시험에 비해 더 높았다(92.3%와 50.0%). Gilbert 증후군에서 1일 400 Kcal로 48시간의 열량제한 시험과 1일 60mg의 phenobarbital을 5일간 투여하는 유도 시험은 편리하고 유용한 임상적인 진단법으로 이용할 수 있다고 생각된다. 그러나 열량 제한 시험에서는 증가 기준의 통일이 필요하다고 유추되며 phenobarbital 유도 시험이 민감도가 더 높은 것으로 생각된다. Gilbert's syndrome is very frequent and benign chronic process characterized by mild, intermittent, unconjugated hyperbilirubinemia without any symptom and sign of liver disease. Previously intoduced caloric restriction test and phenobarbital stimulation test as two appropriate clinical tests had been examined and their diagnostic values were reevaluated. Fourteen patients with mild, persistent, unconjugated hyperbilirubinemia were included. Subsequently caloric restriction has been applicated by 400 Kcal/day for 48 hours and phenobarbital has been prescribed by 60 mg/day for 5 days. Therafter serum levels of total and direct bilirubin were measured. Most of the patients were third and fourth decade(85.8%) and male predominant. Each basal serum levels of total, indirect and direct bilirubin were 3.0±0.8, 2.2±0.8 and 0.7±0.4 mg/dL. After caloric restriction test, each levels were increased significantly to 5.5±2.7, 4.2±2.3 and 1.3±1.0 mg/dL(p=0.001, p=0.001, p=0.023). After phenobarbital stimulation test for 13 patients had been practiced, increased levels of each bilirubin after caloric restriction test were decreased significantly to 2.0±1.0, 1.5±0.8 and 0.5±0.4 mg/dL(p=0.000, p=0.000, p=0.001) and these levels were significantly lower than basal levels(p=0.001, p=0.02, p=0.005). The sensitivities of caloric restriction test were 85.7%, 50.0%, and 71.4%, 35.7%(1.0, 1.5 mg increase of total bilirubin and 1.0, 1.5 mg/dL increase of indirect bilirubin). The sensitivities of phenobarbital stimulation test were 93.2% and 92.3% at criteria of 1.5 mg/dL increase of total bilirubin and indirect bilirubin. On the diagnosis of Gilbert syndrome, caloric restriction test and phenobarbital stimulation test are convenient and useful diagnostic tools in clinical face. And also phenobarbital stimulation test has higher sensitivity than caloric restriction test. Furthermore, standardization of bilirubin increment would be necessary in caloric restriction test.