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구자충 ( Ja Chung Goo ),김병욱 ( Byeong Uk Kim ),정지인 ( Jee In Jeong ),한정호 ( Joung Ho Han ),채희복 ( Hee Bok Chae ),박선미 ( Seon Mee Park ),윤세진 ( Sei Jin Youn ),이호창 ( Ho Chang Lee ) 대한장연구학회 2010 Intestinal Research Vol.8 No.2
목적: 내시경 검사의 빈도가 늘면서 이전에는 매우 드물던 유암종의 빈도도 늘고 있다. 특히 대장 내시경을 시행하면서 우연히 발견되는 작은 유암종들은 내시경적 절제술 및 외과적 국소절제술을 통하여 비교적 간단히 치료되고 있다. 저자들은 이러한 하부위관 유암종의 임상적 특징과 치료 결과 및 재발 등에 대해 분석하고자 하였다. 대상 및 방법: 1999년 9월부터 2009년 9월까지 10년간 충북대학교병원에서 하부위장관의 유암종을 진단받은 41명의 환자를 후향적으로 조사하였다. 결과: 41명의 환자 중 남녀비는 1:0.64 이었고, 평균 연령은 47.4±12.4세였다. 41명의 환자 중직장 유암종이 38예(92.7%), 충수돌기 유암종이 2예(4.9%), S자결장 유암종이 1예(2.4%)였다. 내시경을 통한 유암종의 육안적 평균 크기는 9.4±4.8 mm였다. 초기치료를 시행받은 41명 중 수술적 절제를 시행받은 사람이 12명(29.3%), 내시경적 절제를 시행받은 사람이 29명(70.7%)이었다. 수술적 절제를 시행한 군의 평균 크기는 13.8±5.8 mm였고 내시경적 절제를 시행한 군의 평균 크기는 8.0±3.4 mm로 차이가 있었다 (P=0.011). 초기 치료 후 절제연 종양 양성을 보인 예는 총 41예 중 10예(24.4%)로 용종절제술을 시행하였던 28예 중에서 10예 모두가 발생(35.7%)하여 용종절 제술이 다른 치료방법에 비하여 유의하게 높은 치료후 절제연 종양 양성을 나타내었다(P=0.013). 41명의 환자 중 29명(70.7%)에서 추적 관찰이 이루어졌다. 이들의 평균 추적 관찰 기간은 19.2±14.5개월이었다. 재발은 추적 관찰하던 29명 중 직장 유암종으로 치료받았던 2명(6.1%)에서 발생하였다. 결론: 하부위장관의 유암종은 내시경적 절제술을 통해 쉽게 절제될 수 있으나 용종절제술의 경우 비교적 높은 절제연 종양 양성률(35.7%)을 보여 보다 신중한 치료적 접근이 필요하다. 또한 작은 크기의 직장 유암종도 재발의 가능성은 있으므로 추적 관찰은 반드시 시행되어야 하겠다. Background/Aims: The increase of colonoscopy procedures has led to an increase in the diagnosis of carcinoid tumors in the lower gastrointestinal tract. The purpose of this study was to identify the clinical and pathological characteristics that affect the treatment and recurrence of carcinoid tumors of the lower gastrointestinal tract. Methods: A 10-year (1999-2009) retrospective analysis of 41 patients with carcinoid tumors of the lower gastrointestinal tract at the Chungbuk National University Hospital was conducted. Patient and tumor characteristics, treatment and recurrence were analyzed. Results: The mean age was 47.4±12.4 (range, 22-79 years) and the male to female ratio was 1:0.64. The mean tumor size was 9.4±4.8 (3-20) mm. In the lower gastrointestinal tract, the rectum was the most frequent location of the lower gastrointestinal carcinoid tumors (92.7%). Twenty-nine out of 41 patients were treated by endoscopy (mean size of tumor: 8.0±3.4 mm) and 12 were treated by surgery (mean size of tumor: 13.8±5.8 mm)(P=0.011). Among the patients treated by endoscopy, only one patient had a complete resection. However, the histology showed that 10 patients treated by endoscopy had positive resection margins; all 10 cases (35.7%) had a polypectomy (P=0.013). The mean follow-up duration was 19.2±14.5 months, and there were two recurrences of rectal carcinoid tumors. Conclusions: Both endoscopic and surgical resections were effective methods for the treatment of lower gastrointestinal carcinoid tumors. However, endoscopic polypectomy should be carefully considered because of the possibility of more frequent incomplete histological resections. Moreover, even for small rectal carcinoid tumors, follow-up examination should be performed to evaluate for tumor recurrence. (Intest Res 2010;8:142-150)
Ja Un Moon,Joo Young Lee,Jae Wook Lee,Nack Gyun Chung,Bin Cho,In Goo Lee 대한소아신경학회 2021 대한소아신경학회지 Vol.29 No.3
Purpose: The aim of this study was to assess the incidence of seizures, clinical manifestations, and risk factors that could predict the occurrence of seizures after hematopoietic stem cell trans-plantation (HSCT) in children. Methods: The study group consisted of 543 patients (311 males and 232 females) registered at the Catholic University of Korea’s Seoul St. Mary’s Hospital who received HSCT before the age of 18 from January 2009 to January 2019. Their medical records and test results were retrospective-ly reviewed. Results: The incidence of seizure after HSCT was 6.6% and the average age of seizure patients was 8.33±5.5 years. The use of calcineurin inhibitors combined with methotrexate as prophylaxis for graft versus host disease (GVHD) was a statistically significant risk factor for seizures (P=0.006). Pediatric patients with grade 2–4 acute GVHD (P=0.003) also showed a higher incidence of seizures than those with grade 0–1 acute GVHD after HSCT. Conclusion: Our findings indicate that among pediatric patients who underwent HSCT, using calcineurin inhibitors with methotrexate as a conditioning regimen and a higher grade (≥2) of acute GVHD are risk factors of seizures.
CNC 자동선반용 고속,소형 회전형 공구헤드(Swivel Tool Head)의 설계 및 성능시험
구자함 ( Ja Ham Koo ),정성원 ( Sung Won Chung ),박종민 ( Jong Min Park ),김종순 ( Jong Soon Kim ),김인환 ( In Hwan Kim ),권순구 ( Soon Goo Kwon ) 한국경영공학회 2012 한국경영공학회지 Vol.17 No.3
It has been required that a small-size high-speed swivel tool head be improved for productivity of a CNC automatic lathe. It has been a growing interest in shorter machining times with an increasing cutting speed. However, the increase in a rotating speed of a swivel tool head causes adverse effects: vibration and noise from a swivel tool head system. In this study, the fatigue life and contact pressure of a swivel tool head system were calculated, and its static and dynamic characteristics, such as vibration, noise, and precision, were measured using a reliable test device. With all these results, we developed a new prototype of a small-size high-speed swivel tool head, showing less noise and better precision than those of conventional ones.
Youn-Kyoung Goo,Won-Sik Shin,Hye-Won Yang,So-Young Joo,Su-Min Song,Jae-Sook Ryu,Won-Myung Lee,Hyun-Hee Kong,Won-Ki Lee,Sang-Eun Lee,Won-Ja Lee,Dong-Il Chung,Yeonchul Hong 대한기생충학열대의학회 2016 The Korean Journal of Parasitology Vol.54 No.1
This study explored epidemiological trends in trichomoniasis in Daegu, South Korea. Wet mount microscopy, PCR, and multiplex PCR were used to test for Trichomonas vaginalis in vaginal swab samples obtained from 621 women visiting 2 clinics in Daegu. Of the 621 women tested, microscopy detected T. vaginalis in 4 (0.6%) patients, PCR detected T. vaginalis in 19 (3.0%) patients, and multiplex PCR detected T. vaginalis in 12 (1.9%) patients. Testing via PCR demonstrated high sensitivity and high negative predictive value for T. vaginalis. Among the 19 women who tested positive for T. vaginalis according to PCR, 94.7% (18/19) reported vaginal signs and symptoms. Notably, more than 50% of T. vaginalis infections occurred in females younger than 30 years old, and 58% were unmarried. Multiplex PCR, which simultaneously detects pathogens from various sexually transmitted infections, revealed that 91.7% (11/12) of patients were infected with 2 or more pathogens. Mycoplasma hominis was the most prevalent co-infection pathogen with T. vaginalis, followed by Ureaplasma urealyticum and Chlamydia trachomatis. Our results indicate that PCR and multiplex PCR are the most sensitive tools for T. vaginalis diagnosis, rather than microscopy which has been routinely used to detect T. vaginalis infections in South Korea. Therefore, clinicians should take note of the high prevalence of T. vaginalis infections among adolescent and young women in order to prevent persistent infection and transmission of this disease.
Singh, Sarbjit,Goo, Ja-Il,Noh, Hyojin,Lee, Sung Jae,Kim, Myoung Woo,Park, Hyejun,Jalani, Hitesh B.,Lee, Kyeong,Kim, Chunsook,Kim, Won-Ki,Ju, Chung,Choi, Yongseok Elsevier 2017 Bioorganic & medicinal chemistry Vol.25 No.4
<P><B>Abstract</B></P> <P>Astrocytes play a key role in brain homeostasis, protecting neurons against neurotoxic stimuli such as oxidative stress. Therefore, the neuroprotective therapeutics that enhance astrocytic functionality has been regarded as a promising strategy to reduce brain damage. We previously reported that ciclopirox, a well-known antifungal <I>N</I>-hydroxypyridone compound, protects astrocytes from oxidative stress by enhancing mitochondrial function. Using the <I>N</I>-hydroxypyridone scaffold, we have synthesized a series of cytoprotective derivatives. Mitochondrial activity assay showed that <I>N-</I>hydroxypyridone derivatives with biphenyl group have comparable to better protective effects than ciclopirox in astrocytes exposed to H<SUB>2</SUB>O<SUB>2</SUB>. <I>N</I>-hydroxypyridone derivatives, especially <B>11g</B>, inhibited H<SUB>2</SUB>O<SUB>2</SUB>-induced deterioration of mitochondrial membrane potential and oxygen consumption rate, and significantly improved cell viability of astrocytes. The results indicate that the <I>N</I>-hydroxypyridone motif can provide a novel cytoprotective scaffold for astrocytes via enhancing mitochondrial functionality.</P> <P><B>Graphical abstract</B></P> <P>[DISPLAY OMISSION]</P>