백서 척수후근절로부터 슈반세포의 효과적인 체외 배양법

김성민,이종호,김남열,안강민,최원재,최시호,차미주,이주영,황순정,장정원,명훈,최진영,서병무,정필훈,김명진 大韓顎顔面成形再建外科學會 2003 Maxillofacial Plastic Reconstructive Surgery Vol.25 No.4

Schwann cells(SCs), an important component of the peripheral nervous system, intract with nerous to mutually support growth and replication for the peripheral nerve regentation. Recently, ading SCs to the lumen of guidance channel is widely tried to improve regeneration or to make regeneration possible over otherwise irreparable gaps. however, it is not easy to isolate and multiplicate SCs as much as enough to help the axonal regeneration. For the allogeneic SCs source for tubular nerve guidance, we developed a little bit improved technique of harvesting and multiplicating SCs. by culturing dispersed dorsal root ganglia in specially designed medium with growth factors and serial processing, we repeatedlly generate relatively homogenous SC cultures. Our technique was compared with other methods of literature using immunostaining methods such as GFAP, S100, BDNF and the total SC count assessment at different time interval after primary culture.

서울의 Penicillinase Producing Neisseria gonorrhoeae 발생빈도(1998)

김재홍,김준호,반재용,이정우,황성주,정준규,정성태,강진문,조흔정,홍창의,정혜신,이한승,김이선,이봉길,이종호,선영우,한기덕,윤성필,이성훈,안종성,박석범,문승현,조항래,김형섭,류지호,황재영,박준홍,손상욱 한양대학교 의과대학 2001 한양의대 학술지 Vol.21 No.1

In recent years, gonorrhea has been pandemic and remains one of the most common STDs in the world, especially in developing countries. For the detection of a more effective therapeutic regimen and assessing the prevalence of Penicillinase Producing Neisseria gonorrhoeae(PPNG), we have been trying to study the patients who have visited the Venereal Disease Clinic of Choong-Ku Public Health Center in Seoul since 1980 by menas of the chromogenic cephalosporin method. In 1998, 93 strians of N. genorrhoeae were isolated, among which 60(64.5%) were PPNG. The prevalence of PPNG in Seoul, which had been decreased to 39% in 1996 after a peak of 74.3% in 1993, is increased to 64.5% in 1998.

Antioxidant activity in vitro and mucosal protective effect of Rhei Rhizoma on reflux esophagitis induced in rats

Ah Reum Lee,Yu Ock Shin,Joo Young Lee,Min Yeong Kim,Sung Ho Shin,Bu-Il Seo,Young-Bae Seo,Man Hee Rhee,TakakoYokozawa,Chan Hum Park,Seong-SooRoh 한국약용작물학회 2015 한국약용작물학술대회 발표집 Vol.2015 No.05

Purpose Rhei Rhizoma (RR) is one of the herbal medicines traditionally used to treat diverse inflammatory diseases. The present study was undertaken to elucidate the antioxidant and anti-inflammatory activities of Rhei Rhizoma on experimental reflux esophagitis (RE) in rats. Methods The antioxidant activity of RR in vitro was measured in terms of radical scavenging capacity such as DPPH and ABTS. RE was produced by ligating both the pylorus and the transitional junction between the forestomach and the corpus. Rhei Rhizoma (125 and 250 mg/kg) were administered every day for 7 days, and its effect was estimated on comparison with RE control and normal rats. Results RR scavenged DPPH and ABTS effectively and IC50ofDPPH and ABTS radical scavenging activity of RR were 4.8 μg/ml and 15.75 μg/ml. The administration of RR decreased the elevated serum ROS in RE control rats. The RE control rats exhibited the down-regulation of antioxidant-related proteins such as Nrf2 and HO-1expression levels in the esophagitis; however, the level in the RR-treated RE rats was significantly higher than that in the RE control rats. Moreover, RE control rats exhibited the up-regulation of the protein expression related to oxidative stress at the esophagitis, but RR administration significantly reduced the expression of inflammatory proteins through the MAPK-independent signaling pathways. The expression of inflammatory mediators and cytokines by NF-κB activation was modulated through blocking the degradation of IκBα. In addition, the oral administration of RR regulated the gastric mucosal damage in RE rats. Conclusion The administration of Rhei Rhizoma effectively ameliorates the inflammatory damage of esophageal mucosa through radical scavenging activity and the activation of the Nrf2/HO-1 pathway.

서울의 PPNG 발생 빈도(1991-1992)

김재홍,윤기범,박평원,김영진,전경민,김영태,김중환,곽호,구상완,송민석,유옥,지혜구,김동원,문상은,박영립,정승호,성범진,성순제,엄주용,황정열,이기홍,이주협,전태진 대한화학요법학회 1994 대한화학요법학회지 Vol.12 No.1

The prevalence of PPNG among pretreated gonorrhea cases isolated at the STD clinic of Choong-Ku Public Health Center in Seoul has been studied and reported annually since 1981. In 1991, 123 strains of N.gonorrhoeae were isolated, among which 58(47.1%) were PPNG. In 1992, 98 starains of N.gonorrhoeae were isolated, among which 51(52.0%) were PPNG. In all, 109(49.3%) strains were found to be PPNG among 221 strains isolated between 1991-1992. The prevalence of PPNG in Seoul showed increased tendency till 1989, thereafter, it has been stationary or slightly decreasing.

만선신부전 환자에서 관상동맥조영술 소견에 관한 연구

한대희,김성구,박상호,김성한,조원영,방덕원,조윤행,정의룡,은영근,권영구 순천향의학연구소 2003 Journal of Soonchunhyang Medical Science Vol.9 No.1

Background : Patients with chronic renal fialure have a substantially elevated risk of death from cardiovascular diseases than do the general population. the patients with chronic renal failure are at significantly increased freqeuncy of hypertension, hyperlipidemia, and diabetes mellitus which are known to the risk factors of the coronary artery diseases, and the prevalence of the coronary artery diseases in chronic renal failure patients is highly associated with the hemodynamic disorder and metabolic abnormalities. therefore we expected that the coronary angiographic findings in patients with chronic renal failure should be different from the general population (control groups) and investigated the risk factors contributing to coronary artery diseases. Method : we have retrospectively compared the coronary angiographic findings of 44 patients with chronic renal failure on hemodialysis with that of 88 patients in the general population and investigated the factors contributing to the development and acceleration of coronary artery diseases in patients with chronic renal failure Result : Hypertension and diabetes mellitus which is risk factors for coronary artery disease is significantly increased in patients with chronic renal failure, in coronary angiographic finding the severity of the lesion is worse. the incidence of PCI or CABG of patients with chronic renal failure is more than that of control group but statistically no difference between patients with chronic renal failure and control group. the sex, the duration of disease, the duration of dialysis, serum creatinine in patients with chronic renal failure have no correlation to the prevalence of coronary artery disease and severity of lesion. hyperglycemic patients with chronic renal failure have high incidence of coronary artery disease and are worse in the severity of lesion Conclusions : There is significantly increased the pevalence and severity of involving multiple coronary artery diseses in hyperglycemic patients with CRF.

자가지방을 이용한 성대주입술

손영익,박주현,이은경,신준호,추광철 대한이비인후과학회 1999 대한이비인후과학회지 두경부외과학 Vol.42 No.12

일반인에서 자율신경계 기능 평가

심영주,정호중 고신대학교의과대학 2008 고신대학교 의과대학 학술지 Vol.23 No.1

Background : To evaluate the autonomic nervous system functions, sympathetic skin response (SSR) and R-R interval variation (RRIV) were tested in general persons. Methods : The SSR and the RRIV were evaluated in 24 subjects with a mean age of 39.56 year (24 ~ 56 year). Bilateral SSRs were recorded on the palm and sole with stimulation of median and tibial nerves. The RRIVs were estimated at rest, during deep breathing and valsalva maneuver. Results : The SSR and the RRIV were obtained from all subjects. The mean latencies of SSR recorded from both palms and soles were 1.41 ± 0.05 sec (right palm), 1.28 ± 0.03 sec (left palm), 1.80 ± 0.09 sec (right sole) and 1.75 ± 0.11 sec (left sole). The mean amplitudes of SSR were 5.98 ± 0.67 mV (right palm), 5.70 ± 0.06 mV (left palm), 3.17 ± 0.45 mV (right sole) and 2.23 ± 0.15 mV (left sole). The mean values of RRIV at rest, during deep breathing and valsalva maneuver were 1.14 ± 0.05, 1.18 ± 0.09 and 1.27 ± 0.22. Conclusion : Functional status of autonomic nervous system is obtained easily with SSR and RRIV. Our results can be a useful basis of control values.

재활의학과적 검사 결과가 임상증상과 차이를 보인 잠수병 환자

심영주,정호중,김기찬 고신대학교 의과대학 2010 고신대학교 의과대학 학술지 Vol.25 No.2

Decompression sickness is divided into 2 types based on clinical symptoms and severity. Type I decompression sickness involves usually the musculoskeletal system and cardiopulmonary system. Type II decompression sickness involves commonly the central nervous system. We experienced a case of type II decompression sickness involving cervical spinal cord. The patient showed hypesthesia below C5 dermatome and quadriplegia. But the whole spinal magnetic resonance image revealed high signal of the spinal cord below T2 levels and electrodiagnostic study showed thoracic cord level lesion. In decompression sickness, diagnosis of injured spinal cord levels is very delicate problem because in some cases clinical symptoms can be unmatched with magnetic resonance findings and electrodiagnostic study. In this kind of case there are little studies of diagnostic tools and prognostic factors. Therefore, focusing on clinical symptoms need to help more proper treatment and provide better prognosis to decompression sickness patients

환경규제강화와 생산성 분석 : 간접효과와 직접효과를 중심으로 focusing on indirect and direct productivity effects

조주현,이영수,차근호 한국산업조직학회 2004 産業組織硏究 Vol.12 No.1

환경규제의 생산성에 대한 영향은 긍정적일 수도, 부정적일 수도 있다. 본 연구는 환경규제의 생산성 효과를 직접효과와 간접효과로 나누어 환경규제가 생산성에 부정적인 영향만을 주는 가에 대해서 실증분석하는 것을 연구목적으로 한다. 이에 본 연구에서는 우리나라 제조업을 대상으로 1983년~1997년 기간의 산업별 자료를 이용하여 환경규제강화와 생산성이 어떠한 관계를 갖는가에 대해 실증분석 하였으며, 환경규제강화의 생산성 효과를 비용함수를 이용하여 직접효과와 간접효과로 나누어서 분석하였다. 실증분석 결과 환경규제가 강화된 기간에 환경규제의 생산성에 대한 부정적인 영향이 감소하는 것으로 추정되었다. 이러한 실증분석 결과로부터 환경규제강화가 단지 기업의 비용 상승으로 인한 생산성 감소로 이어지지 않고 오히려 경쟁력을 강화시켜 환경오염의 감소와 경쟁력 강화라는 두 마리 토끼를 잡을 수 있다는 측면에서 정책적으로 시사하는 바가 크다. Productivity effects of environmental regulation implementation can be positive or negative. The purpose of this paper is to analyse whether the environmental regulation productivity effects can be negative or not by estimating the direct and indirect productivity effects of that. We test the empirical relationship between environmental regulation and productivity by Korean manufacturing industries using industrial-level data during the 1983-1997 period. And we analyse the direct and indirect productivity effects of environmental regulation using a flexible functional form cost function. We find that the negative productivity effects of environmental regulation decrease as regulatory activity increase, around the time of the 1990. Our empirical results are suggestive in that the environmental regulation implementation not only enhance the competitiveness but also reduce the pollution.

덕성여대생들의 생활스트레스에 관한 연구

김정호,김선주,오영희 덕성여자대학교 학생생활연구소 1995 學生生活硏究 Vol.11 No.-

본 연구에서는 덕성여대생들이 어느 부분에서 가장 많은 생활스트레스를 받고 있으며, 이 경향이 학년과 소속단과대학별로 차이가 있는지를 살펴 보았다. 그 결과, 전반적으로 덕성여대생들은 당면과제인 학과공부와 졸업후 진로문제로 가장 많은 스트레스를 겪고 있으며, 대인관계에서 오는 스트레스는 비교적 적은 것으로 나타났다. 학년별로 볼 때, 모든 학년에서 학업과 진로에 대한 스트레스가 큰 것으로 나타났고, 특히 학년이 올라가면서 장래진로에 대한 스트레스가 상대적으로 많아지는 결과를 보였다. 또한 2학년은 4학년보다 가족, 가치-종교, 학업 및 경제 영역에서 더 많은 스트레스를 받고 있는 것으로 나타났다. 단과대학 별로 볼 때, 예술대를 제외한 모든 단과대학 학생의 가장 큰 스트레스 요인 역시 학업과 진로로 나타났다. 예술대 학생들 역시 학업 스트레스를 많이 겪는 것으로 나타난 반면, 진로 스트레스는 다른 단과대학 학생들에 비해 적었다. 학업과 관련해서는 특히 자연대학 학생들이 가장 많은 스트레스를 경험하고 있는 것으로 나타났다. 이 결과에 대한 논의와 함께 본 연구의 제한점이 지적되었다. This study examined the life stress of students from Duksung Women's University. More specifically, it investigated (1) What kinds of life events are the most stressful ones to the students ; (2) Do these differ according to grade level or college. The results are as follows. First, study and career after graduation turned out to be the two most stressful life events to the students. Second, even though study and career were the most stressful in all grades, career stress relatively increased as grade became higher. In addition, sophomores experienced more life stress than seniors in some areas. Third, all students except those from College of Art experienced study and career as most stressful. Art students also experienced serious study stress, but career stress were less serious than the students from other colleges. The students from College of Natural Science experienced more study stress than students from other colleges.