Multiple myeloma 환자에서 Bortezomib치료 후 발생한 마비성 장폐색증 1례

김준영,이원식,손창학,박성길,진한영,박석주,조영완,정은욱,강명주,박정하,주영돈 인제대학교 2006 仁濟醫學 Vol.27 No.-

Bortezomib is the first clinically available proteasome inhibitor that is clinically effective in the treatment of multiple myeloma. A proteasome inhibitor acts through multiple mechanisms to arrest tumor growth, tumor spread, and angiogenesis. The main adverse effects of bortezomib are gastrointestinal symptoms, cytopenia, fatigue, and peripheral neuropathy. To date, severe paralytic ileus has not been reported as a toxic effect of bortezomib treatment in multiple myeloma. Bortezomib is a novel agent that has only been used clinically for 30 months, so a need exists to further evaluate its toxicity. We report a case of grade Ⅲ (NCI CTCAE v3.0) or grade Ⅳ(SWOG toxicity criteria) paralytic ileus in a 65-year-old man with relapsed multiple myeloma who underwent one cycle of single-agent bortezomib treatment scheduled in a 21-day cycle (1.3 mg/㎥ as a single i.v. bolus on days 1, 4, 8, and 11).

급성심근경색증을 가진 한국인에 있어 Chlamydia Pneumoniae 감염의 영향에 대한 연구

이은미,오동주,황교승,안정천,송우혁,임도선,박창규,김영훈,서홍석,심완주,노영무,정희진,김우주,김종헌,송기준 대한순환기학회 2000 Korean Circulation Journal Vol.30 No.4

Repellent efficacy of essential oils and plant extracts against Tribolium castaneum and Plodia interpunctella

Lee Hwa‐Eun,Hong Su Jung,Hasan Najmul,Baek Eun Joo,Kim Jun Tae,Kim Young‐Duk,Park Mi‐Kyung 한국곤충학회 2020 Entomological Research Vol.50 No.9

This study was conducted to investigate the repellent efficacy of essential oils (Origanum vulgare, Pimpinella anisum, and Tanacetum cinerariifolium) and four plant extracts (Agastache rugosa, Capsicum annuum, Citrus reticulata, and Ginkgo biloba) against Tribolium castaneum (adults and larvae) and Plodia interpunctella (larvae). Gas chromatography/mass spectrometry analysis revealed the presence of carvacrol, anethole, and jasmolin I as the predominant constituent in O. vulgare, P. anisum, and T. cinerariifolium, respectively. Furthermore, ethyl hexopyranoside, 9,12‐octadecadienoic acid, cyclopentanol, and 2‐cresol were identified in A. rugosa, C. annuum, C. reticulata, and G. biloba, respectively. The repellent efficacy of each essential oil, plant extract, and the combination of oils was evaluated using a specially designed cylinder trap for 120 h. Among the three oils, O. vulgare and T. cinerariifolium had greatest repellent efficacy against P. interpunctella larvae. T. cinerariifolium exhibited effective repellence against the adults and larvae of T. castaneum. Therefore, O. vulgare (O) and T. cinerariifolium (T) were selected for further investigation of combined effects. Two essential oils were mixed in three different ratios of OT1 (1:3), OT2 (1:1), and OT3 (3:1). The repellent efficacies of OT1 and OT2 against the adults of T. castaneum were significantly greater than that of OT3. OT1 was effective against the larvae of T. castaneum, whereas OT2 was effective against the larvae of P. interpunctella. OT1 enhanced the repellent efficacy by approximately five times against larvae of T. castaneum, compared with that of T. cinerariifolium. Overall, OT1 was selected as the best repellent substance against all the tested insects.

암치료에 있어서 체질과 항암효과에 관한 한의학적 연구

성현제,신현규,박갑주,강봉주,은영아,김은해,정세영 한국한의학연구원 1997 한국한의학연구원논문집 Vol.3 No.1

As one of the chemical and experimental study on cancer treatment in Korea oriental medical hospital. Furthermore, we carried out the cytotoxicity test of extracts of herbal medicine. The results are as follows : About Clinical Aspects of the Oriental Medical Cancer Treatment - (1) Clinical experience is that 420 Oriental medical hospital were surveyed. Number of cancer patient treated by one oriental medical doctor was under 10(about 60%) or from 10 to 20(about 30%). (2) Diagnostic Procedure is that more than 80% of cancer patients were diagnosed by medical doctor of western hospital. (3) Therapeutic Method is that combination of oriental and western medical treatment was used in oriental medical hospital. (4) Relationship between cancer and constitutions is that to the relationship between cancer and constitutions, about 75% responded and most were considered to be Um. About Experimental Study - to evaluate the direct cytotoxicity of hot water and methanol extracts of 34 oriental medical presciptions on stomach cancer cell, SRB assay was carried out. (1) The IC50 value of water extract of Samsoum was 19㎍/㎖ and that of methanol extract was 15㎍/㎖, so that we confirmed Samsoum has a strong direct cytotoxicity. (2) The IC50 values of water extract of Coptidis Rhizoma, methanol extract of Caesalpiniae Lignum and Draba Semen were 10㎍/㎖, 19㎍/㎖ and 12.5㎍/㎖ respectively, so that we confirmed Coptidis Rhizoma, Caesalpiniae Lignum and Draba Semen have a strong direct cytototoxicity. (3) The IC50 value of combinatory prescription of Rhei Rhizoma, Forsythie Fructus and Caesalpiniae Lignum was about 40㎍/㎖.

서울의 PPNG 발생 빈도(1991-1992)

김재홍,윤기범,박평원,김영진,전경민,김영태,김중환,곽호,구상완,송민석,유옥,지혜구,김동원,문상은,박영립,정승호,성범진,성순제,엄주용,황정열,이기홍,이주협,전태진 대한화학요법학회 1994 대한화학요법학회지 Vol.12 No.1

The prevalence of PPNG among pretreated gonorrhea cases isolated at the STD clinic of Choong-Ku Public Health Center in Seoul has been studied and reported annually since 1981. In 1991, 123 strains of N.gonorrhoeae were isolated, among which 58(47.1%) were PPNG. In 1992, 98 starains of N.gonorrhoeae were isolated, among which 51(52.0%) were PPNG. In all, 109(49.3%) strains were found to be PPNG among 221 strains isolated between 1991-1992. The prevalence of PPNG in Seoul showed increased tendency till 1989, thereafter, it has been stationary or slightly decreasing.

자가지방을 이용한 성대주입술

손영익,박주현,이은경,신준호,추광철 대한이비인후과학회 1999 대한이비인후과학회지 두경부외과학 Vol.42 No.12

장기간 보관한 멸균물품의 오염 상태에 관한 연구

주홍순,조순덕,정재심,신동분,임바올라,노은지,이선희,송영미,최정화,백병윤,김미나 대한병원감염관리학회 2003 의료관련감염관리 Vol.8 No.1

교사 학습공동체 내 지식창출 활동의 성격 및 촉진요인에 대한 사례 연구

주영주,조은아 이화여자대학교 사범대학 교과교육연구소 2006 교과교육학연구 Vol.10 No.1

지식기반사회를 맞아 지식과 학습의 관계에 대한 다양한 논의가 이루어지고 있는데, 그 중 사람들간의 협력적 관계나 실제 활동을 통해 생산되는 역동적 지식의 창출과 공유를 위해 현재 활발하게 시도되고 있는 학습방법 및 지식관리전략 중 하나가 학습공동체라 할 수 있다. 기업의 지식경영 영역에서 뿐만 아니라, 교육현장에서의 새로운 전문성과 경쟁력을 제고하는 방법으로서도 학습공동체를 통한 지식창출이 중요한 이슈가 되고 있다. 학습공동체에 대한 논의는 이미 교육현장에서부터 시작되어 왔으나, 그 실행에 있어 교육청의 행정적 관여로 인해 교사들의 자발적 참여가 확신되지 못했고, 교사들의 요구를 충족시키지 못했다는 문제점들이 있었다. 이에 본 연구는 문화관광부의 지원대상이 되며 문화예술분야의 교사들을 대상으로 구축된 학습공동체인 '교사자율연구모임'의 사례를 통해, 교사 학습공동체의 유형과 공동체 내에서 이루어지는 지식창출 활동의 성격을 분석하고, 교사의 지식창출 환경으로서의 학습공동체 촉진요인을 도출해 보고자 하였다. '교사자율연구모임'을 분석한 결과, 동 학습공동체는 동일 분야의 동료 교사들과 상호협력적 학습을 통해 지식을 공유함으로써 교사로서의 자신의 전문성을 개발하는 것이 주요 목적인 전문성을 위한 학습 공동체로 파악되었다. 또한 학습공동체들은 대부분 연구와 현장활동을 병행하고 있었다. 교사자율연구 모임 내에서 습득, 공유되는 지식과 경험은 주로 교육콘텐츠의 제작 및 창작 활동, 연구 및 이론 개발, 공동의 문제해결을 위한 학습으로서의 연수활동 등이었다. 교사자율연구모임을 활성화시키기 위해 공동체로서의 목표공유, 참여에 대한 자발성, 동료의식 등 사회적 요인 등이 주요 촉진 요인으로 도출되었다. 특히 공동체 의식, 동료의식 등 정의적 영역의 요인들이 교과연구를 통한 인지적 성과달성에 비해 실제 교사 학습공동체의 지식창출 및 공유활동을 촉진시키는 요인으로 도출되었다. Learning Community is the learning method and knowledge management strategy which is actively attempted of collaborative learning and creation and sharing of knowledge being produced in authentic context. Knowledge creation through Learning Community has become an important issue not only in the fi디d knowledge management, but also in the educational field. Many studies on Learning Community have already begun in the field of education. But, there has been some obstacles to voluntary participation of teachers due to administrative intervention of educational offices. Accordingly, this study tries to analyze the type of teachers' Learning Community and the characteristics of knowledge-creating activities occurring in Learning Community, and to discover promotive elements of Learning Community as teachers' knowledge-creating environment, by example of "Teachers' Voluntary Research Group", which is a Learning Community aimed at teachers in the field of arts and culture, supported by the Ministry of Culture and Tourism. After analyzing the "Teachers' Voluntary Research Group", I concluded; the group was considered as a Learning Community aimed at developing their competency as teachers, by sharing knowledge through collaborative learning with colleagues belonged to the same field. Also, most of communities conducted researched and practices at the same time. The main knowledge and experience being acquired and shared in the "Teachers' Voluntary Research Group" was production of educational contents, research and developing theory and collaborative learning for problem-solving. Major promotive elements of the "Teachers' Voluntary Research Group" were social elements such as joint enterprise of community, voluntary participation and sense of colleagues. Especially, the sense of community and the sense of colleagues were indicated as more effective elements to promote knowledge creation and sharing of teachers' learning community, rather than cognitive ones.

부의 양육참여와 아동의 사회적 능력과의 관계에 관한 고찰

은주영,류도희,이귀옥 경성대학교 2001 論文集 Vol.22 No.1

This paper reviewed the father's influence on his children's social ability. Traditional fathers were firm and demanding, authoritarian, and possessed the bulk of the power in their families. Recently, father's role on his family has been changed in that more fathers get involved in their children's bringing up. Fathers' instrumental role has negative effects on the emotional lives of fathers and their children, while when fathers show more affective and acceptive in fathering, their children develop highly in their social and intellectual ability. In order to increase paternal involvement, social supports is needed such as more flexible work schedule.

한국 Drosophila아속 10종에 대한 유전적 유연관계

주은영,이양숙,김남우 경산대학교 기초과학연구소 2001 基礎科學 Vol.5 No.2

한국산 Drosophila아속 10종(D. virilis, D. tsigana, D. lacertosa, D. angularis, D. brachyephros, D. curvispina, D. kuntzei, D. nigromaculata, D. takadai, D. unispina)의 계통관계를 알아보기 위하여 동위효소와 수용성 단백질 분석을 실시하였다. 15종류의 동위효소 분석에서 18개의 loci가 검출되었다. 18개 loci중 Mdh-2, Got, Me, Ao, G6pd, Adh, Fum은 종내 변이가 없었으며, 특히 Ao, Fum은 종간에서도 변이가 없이 monomorpic하였다. 이 동위효소 분석에서 D. lacertosa와 D. nigromaculata가 가장 낮은 유연관계를 보였다. 2DE에 의한 수용성단백질 분석에서는 D. nigromaculata와 D. brachynephros가 가장 낮은 유연관계를 보였으며, D. angularis와 D. brachynephros가 가장 높은 유연관계를 보였다. 이상의 결과를 종합하여 보면 한국산 Drosophila아속 10종은 D. virilis, D. tsigana, D. lacertosa의 group과 D. angularis, D. brachynephros, D. curvispina, D. kuntzei, D. nigromaculata, D. takadai, D. unispina의 group으로 나눌 수 있으며, D. virilis가 속한 group이 더 primitive하다고 하겠다. 그러나 이 group이 다른 group에 직접적인 ancestor는 아니며 다른 ancestor가 있었을 것으로 생각된다. Phylogenetic relationships among the 10 species of the subgenus Drosophila in Korea, which is D. virilis, D. lacertosa, D. tsigana, D. angularis D. brachnephros, D. curvispina, D. kuntzei, D. nigromaculata, D. takadai and D. unispina were investigated using 18 loci found from analysis of 15 allozymes and soluble proteins analysis. Mdh-2, Got, Me, Ao, G6pd, Adh and Fum showed monomorphic patterns in each species, and specially Ao and Fum are the same alleles. As for the genetic relationships based on the results from the allozymes analysis, D. curvispina and D. unisina were found to have the closest relationship (0.851), and D. lacertosa and D. kuntzei showed the reverse (0.198). the average genetic similarity of the 10 species by allozyme analysis was 0.458. Soluble proteins from the 10 species of subgenus Drosophila were analyzed by 2DE method. Genetic distance between D. angularis and D. brachynephros was closer (0.168) than any other species. D. curvispina and D. unispina, and D. kuntzei and D. takadai were grouped as related species. The allozyme and soluble protein analysis showed similar. The average genetic distance of the 10 species by 2DE analysis was 0.386, indicating that the subgenus Drosophila can be grouped into two classes; the one class in D. virilis, D. lacertosa, D. tsigana and the other D. angularis, D. brachynephros, D. curvispina, D. kuntzei, D. nigromaculata, D. takadai and D. unispina.