열공형과 비열공형 피질하 혈관성 치매에서 위험인자의 차이에 관한 비교 연구

배희준,정지향,유경호,나덕렬,김상윤,최경규,양동원,손의주,이상도,김재우,박경원,김응규,이재홍,박미영,한일우,함동석,최문성,하충건,최성혜,이애영,이병철,한설희 대한치매학회 2003 Dementia and Neurocognitive Disorders Vol.2 No.2

Backgrounds and Objectives: Vascular dementia is a group of dementing disoders arising from various stroke syndrome. Among these. subcortical ischemic vascular dementia (SIVD) is regarded as a relatively distinct clinical entity. However, MRI patterns of SIVD are not homogenous. In some patients, lacunes are dominant, and in others, subcortical white matter changes are. This study was designed to compare risk factor profiles between SIVD with and without multiple lacunes. Methods: We divided 47 subjects (22 males, mean age. 68 years) recruited from VADAPET (Multicenter Trial For Evaluation Of The Changes In the PET Images Of Subcortical Vascular Dementia Patient) study into two groups one with more than 5 lacunes in deep gray matter (lacune group) and the other with 5 or less(non-lacune group) Clinical characteristics and laboratory findings of two groups were compared. Results: Nineteen of 47 patients (40%) belonged to the lacune group. The lacune and non-lacune groups d d not differ in the following variables: age, hypertension, diabetes mellitus, hyperlipidemia heart disease, history of stroke or TIA, history of trauma or major surgery, family history of hypertension stroke, or dementia, age at diagnosis of dementia, body mass index, white blood cell count, ESR, CRP, fibrinogen, hemoglobin A1C, total cholesterol. LDL cholesterol creatinine, proteinuria, glucosuria, and microhematuria. However, male sex, smoking alcohol. hemoglobin, and HDL cholesterol were possibly associated more with lacune group SIVD than with non-lacune group (p<0 1) Multivariate analyses revealed that smoking, hemoglobin, and HDL cholesterol were independent predictors of SIVD with multiple lacunes Conclusion: Our study suggests that SIVD with multiple lacunes may be significantly different in smoking habits hemoglobin, and HDL cholesterol from SIVD without multiple lacunes.

원발성 유방암에서 Sodium Iodide Symporter의 발현과 ^(99m)Tc-MIBI 유방스캔의 관계

석주원,김성장,곽희숙,이창훈,김인주,김용기,배영태,김동수 대한핵의학회 2002 핵의학 분자영상 Vol.36 No.6

목적: hNIS는 갑상선 조직 외에 다른 조직들에서도 발현된다고 알려져 있다. 유방암 세포는 그런 조직들 중에 하나이며, 그에 의한 유방암의 방사성옥소치료의 가능성이 제시되고 있다. 본 연구에서는 유방암 조직에서 hNIS의 발현정도를 알아보고, ^99mTc-MIBI 유방스캔과 hNIS의 발현 정도와의 관계를 조사하여 보았다. 대상 및 방법: 본 연구에서는 유방암으로 수술을 시행했던 56명의 환자를 대상으로 하였다. hNIS의 발현은 면역조직화학염색에 의해서 평가되었으며, 그 결과를 ^99mTc-MIBI 유방스캔의 판정 결과와 비교하였다. 결과: 전체 56명의 환자에서 hNIS의 발현율은 41.1%였다. 병리학적 진단에 의해 침윤성관상피암종이었던 49명에서의 발현율은 42.9%, 관상피내암종이었던 7명에서의 발현율은 28.6%였다. ^99mTc-MIBI 유방스캔에서 국소섭취 소견이 관찰되었던 41명에서의 hNIS의 발현율은 31.7%였다. 비정상적인 섭취 소견이 관찰되지 않았던 15명의 환자에서의 hNIS의 발현율이 의미있게 높게 관찰되었다(66.7%, p>0.05). 결론: 유방암 환자에서의 hNIS의 발현율은 그다지 높지 않았다. ^99mTc-MIBI 유방스캔에서 섭취증가 소견이 없을 때 hNIS의 발현율이 더 높았다. Purpose: Human Na^+/I- symporter (hNIS) is known to be expressed in many tissues other than thyroid gland. The breast cancer cells are one of them and the possibility of radioiodine therapy in treatment of the breast cancer may be suggested. We investigated the expression rate of hNIS and the relationship between the expression of hNIS and the finding of 99mTc-MIBI scintimammography in the breast cancer. Materials and Methods: Surgically proved 56 patients with breast cancer were the subjects of this study. The expression of hNIS were evaluated by immunohistochemistry and the results were compared to the findings of 99mTc-MIBI scintimammography. Results: Overall expression rate of hNIS was 41.1% in 56 patients. According to the pathologic diagnosis, it was 42.9% in 49 patients with invasive ductal carcinoma and 28.6% in the 7 patients with ductal carcinoma in situ. The expression rate of hNIS in the 41 cases with a focal increased uptake at he breast lesion on 99mTc-MIBI scintimammogram was 31.7%. That in the 15 cases without any abnormal uptake on the scan was significantly higher(66.7%, p<0.05). Conclusion: The expression rate of hNIS in the patients with breast cancer was not so high. The rate was higher in the patients with no increased uptake at the breast lesion on 99mTc-MIBI scintimammography. (Korean J Nucl Med 2002;36;325-32)

전이금속촉매에 의한 환상중합고분자의 합성에 관한 연구

김윤희,문성배,김영인,정경규 부산대학교 1997 科學敎育硏究報 Vol.24 No.-

The cyclopolymerization of 4-ethyl-4-hydroxy-1,6-heptadiyne was carried out by transition metal catalysts such as MoCl_(5) or WCl_(6)-based catalysts. The catalytic activity of MoCl_(5) for this cyclopolymerization was greater than that of WCl_(6). The polymerization of 4-ethyl-4-hydroxy-1,6-heptadiyne by MoCl_(5) alone gives a quantitative yield of polymer. WCl_(6)-based catalyst system was not effective in this polymerization. The obtained polymer was generally insoluble in common organic solvents. The IR spectrum of poly (EHH) showed the stretching band of the carbon-carbon double bond at 1590-1650 cm^(-1) indicate a high conjugation. The thermal properties and oxidative stability of poly(EHH) were also studied. The electrical conductivity of the I2 doped poly(EHH) was 1.2 - 2.5 × 10^(-4) Scm^(-1). 본 연구에서는 4-위치에 에틸기와 히드록실기를 동시에 갖는 1,6-heptadiyne 유도체를 합성하여 이를 여러가지 전이 금속 촉매를 사용하여 합성하였다. MoCl_(5) - 단독 촉매를 사용할 경우 가장 높은 중합수율을 보였으며 WCl_(6)- 계 촉매의 경우 중합체가 얻어지지 않았다. 합성된 고분자는 여러 가지 분광 법으로 확인한 결과 주 사슬에 6각형 고리 구조를 가지면서 공액이중결합을 구조를 갖는 것으로 확인되었다. 중합된 고분자는 치환기의 효과로 여러 용매에 쉽게 용해되었으며 산화안정성도 높은 것으로 확인되었다. 합성된 고분자를 요오드로 도핑 시켜 전도도를 조사한 결과 1.2 - 2.5×10^(-4) Scm^(-1)를 갖는 것으로 확인되었다.

M-Commerce에서 Secure Card 기반의 결제 프로토콜 설계

김성열,조성지,유성진,배용근 조선대학교 전자정보통신연구소 2002 電子情報通信硏究所論文誌 Vol.5 No.2

In order to provide a reliable M-Commerce, a payment solution with security functions should be required. User's mobile terminals used in M-Commerce services are diversifying to cellular phone, PDA, Smart phone etc. Among them, integration of PDA's interface and mobile connection overcomes the weak point of existing cellular phone depending on information via the internet. In this paper, the Secure Card based protocol for a credit card transaction on PDA using ECC is presented. Secure Card module on this protocol encrypts user's information such as private information, delivery information and credit card information and stores it on PDA in order to free from inputting information whenever it is used. This scheme also offers security services on M-Commerce including authentication, confidentiality, integration, non-repudiation and so on.

정수공정에서 이취미물질 제거에 관한 연구

김지태,한명애,곽현,배성렬 漢陽大學校 工學技術硏究所 2000 工學技術論文集 Vol.9 No.1

이취미물질중에서 페놀, Geosmin, 2-MIB를 선정하여 응집제(PACS)와 흡착제(PAC) 및 산화제(Cl2, ClO2)로 처리하였을 때 제거율을 알아보았다. 페놀의 경우 이산화염소(ClO2)와 분말활성탄(PAC)으로 처리하였을 때 제거효율이 높았고, Geosmin과 2-MIB는 분말활성탄(PAC)으로 처리하였을 때 제거효율이 높았다. 그러나 페놀, Geosmin, 2-MIB 모두 응집제(PACS), 염소(Cl2)로 처리하였을 경우에는 제거효율이 거의 없음을 알 수 있었다. The removal ratio of phenol, geosmin, and 2-MIB selected in odor and taste causing materials was investigated, when water was treated with coagulant(PACS), adsorbent(PAC), and oxidants(Cl2, ClO2). Phenol was removed at a relatively higher rate by the treatment with CIO2 and PAC(Powder Activated Carbon). The other side, geosmin and 2-MIB were removed at a higher rate by the treatment with PAC. But it was found that the treatment with coagulant(PACS) and chlorine(Cl2) for the removal of phenol, geosmin and 2-MIB was little removal efficiency.

鍾大黃의 皮膚塗布로 인한 白鼠의 火傷 皮膚組織과 血淸 內 호중구 Chemokine 의 生成抑制 效果

金成培,康秉秀 대한본초학회 2000 大韓本草學會誌 Vol.15 No.2

The present study was conducted to determine whether local production of neutrophil chemoattractant cytokines preceded the influx of neutrophils following dermal scald burn injury. In order to inhibit the influx of neutrophils, we examined the effect of Undulati Rhubarb(R. undulatum L.) to spread on scald skin. Dermal KC, human IL-8 family, level was elevated significantly at 24 h postburn and the level was higher at 72 h postburn than at 24 h postburn. Rhubarb markedly decreased the KC level by skin spread postburn. At 24 h postburn, KC was significantly increased in serum, Rhubarb decreased KC centent. However Rhubarb did not affect to protein concentration in serum at early stage within a 24 h postburn. This suggests that Undulati Rhubarb should be possible to alter neutrophil accurnulation at the wound site by inhibition of the local chemokine production.

매립지 침출수내의 Ca^2+, Fe^2+,3+, 휴믹물질 동반제거에 관한 연구

김지태,고명욱,배성렬 漢陽大學校 工學技術硏究所 2002 工學技術論文集 Vol.11 No.-

탄산칼슘(CaCO_3) 결정화 석출과 수산화철(Fe(OH)_3)의 결정화 석출을 위해 반회분식 장치를 이용하였으며, 반응온도는 25±2℃로 유지하였고 교반속도는 40∼80rpm으로 교반하였다. 매립 침출수내에 함유되어져 있는 Ca^2+와 Fe^2+, Fe^3+를 응집 침전물로 결정화한 후, 활성탄에 흡착시켰다. 휴믹물질을 금속 이온 물질과 배위 결합시켜 함께 제거할 수 있었다. 침출수 처리의 적정pH 범위는 9∼10이었고, 약 90%이상의 Ca^2+, 휴믹물질이 동반제거됨을 알 수 있다. 그러나 Fenton 산화처리 이후에 활성탄 흡착에 의한 Fe^2+,3+, 휴믹물질의 동반제거에 있어서 충분한 처리방법이 되지 못함을 관찰할 수 있다. Batch reactor was used in this study for treating CaCO_3 and Fe(OH)_3, temperature was maintained at 25±2℃ and stirring speed was 40∼80rpm. Ionic metals such as Ca^2+, Fe^2+ and Fe^3+ in leachate were precipitated and adsorbed by activated carbon. Subsequently ionic metals and humic substances that combined with Ca^2+, Fe^2+ and Fe^3+ are removed. The removal efficiency of humic substances was varied with pH value. At the pH 9∼10 range in the treated leachate, Ca^2+, humic substances was removed over 90%. but removal of Fe^2+,3+, humic substances didn't show that the efficient treatment was absorbed by activated carbon after Fenton treat.

멀티 프레임 PRA를 이용한 움직임 추정

김형종,이성순,최영일,조금배,한승조 조선대학교 동력자원연구소 1997 動力資源硏究所誌 Vol.19 No.1

We discuss the theory of motion estimation and motion compensation. The proposed algorithm uses more information from the input video image sequence than the traditional two-frame pel-recursive algorithms. And it uses fewer assumptions on the motion vectors among different video frame pairs. This paper shows two three-frame pel-recursive algorithm for predictive motion compensation which can estimate the d₁(from the previous frame f_t-1 to current frame, f_t) and d₂(from the frame before the previous frame f_t-2 to the previous frame, f_t-1) simultaneously, and three frame information to update the motion vector d₁when the past motion vector d₂is available.

연취급 근로자들의 사회 심리적 스트레스가 연노출 수준에 미치는 영향

김용배,황보영,김화성,이성수,안규동,이병국 순천향의학연구소 2004 Journal of Soonchunhyang Medical Science Vol.10 No.1

Objectives : This study was carried out to assess psychosocial distress of lead workers and to examine the effect of psychosocial distress on lead exposure indices. Methods : The study design was cross-sectional and research subjects were 246 lead workers in primary smelting industry. General characteristics, job characteristics and social support were obtained by self-administered questionnaire and history taking. Psychosocial distress was measured using PWI(Psycosocial Well-being Index), a 45-item self-administered instrument. Blood lead(PbB), zinc protoporphyrin(ZPP), δ-aminolevulinic acid in urine(ALAU) were selected as indicators of lead exposure. Results : The crude odds ratio of group whose PbB was 20-39 ㎍/㎗ was 3.475(95% CI : 1.243-6.404) and that of group whose PbB was above 40 ㎍/㎗ was 7.586(95% CI : 1.487-15.611). The odds ratio of each group adjusted age, wages, job characteristics, social support, smoking and alcohol drinking habit were still significant. Conclusions : Our results supported the association between lead exposure and psychosocial distress. The inclusion of psychosocial distress measurement as a special health examination for lead workers is highly recommended for the effective prevention of stress in lead workers.

보존적 치료로 회복된 망경색에 의한 급성복증 1예

김정념,이숭환,김정식,김진호,배윤오,박성규,윤상정,한현영,이헌영 충남대학교 의과대학 의학연구소 2003 충남의대잡지 Vol.30 No.1

Omental infarction, the end result of impaired perfusion to the greater omentum, is a rare benign self-limiting clinical entity. The main clinical symptom is non-specific localized abdominal pain with a moderately raised white blood cell and erythrocyte sedimentation rate. These findings often mimic an abdominal surgical emergency. This condition is often misdiagnosed as acute appendicitis or cholecystitis. The characteristic feature of CT scan and ultrasonography provide non-invasive diagnosis in most patients with omental infarction. We report a case of patient whose CT scan showed the characteristic finding of omental infarction. The patient was improved spontaneously only with conservative care.