디지털 및 일반 측방두부규격방사선사진에서 측정 방법에 따른 계측치의 비교

김미자,허경회,이원진,허민석,이삼선,이진구,안병근,최순철 대한구강악안면방사선학회 2005 Imaging Science in Dentistry Vol.35 No.1

Purpose : To compare cephalometric measurement between measuring methods in digital and conventional lateral cephalometric radiograph. Materials and Methods : Twenty digital and conventional lateral cephalometric radiographs were selected. In digital group, cephalometric measurements were performed manually using hardcopies and automatically using VCeph^(TM) program on the monitor. In conventional group, the same measurements were performed manually on conventional films, and for automatic measurement conventional films were digitized by scanner. All measurements were performed twice by 4 observers, and 24 cephalometric variables were calculated and the time spent for each measurement was recorded. The differences in measurements data and the time spent for each measurement were compared within each group. Intra-observer and inter-observer comparisons were performed. Results : In both groups, no statistically significant difference between manual and automatic measurements was observed and most of the variables didn’t show statistically significant differences between methods. The observer with less experience tended to show statistically significant differences of measurements between methods, and differences from other observers. The differences of measurements between methods in digital group were lesser than those of conventional group with statistical significance in 8 variables out of 24. With automatic method and in digital group, the spent time was shorter. Conclusion : With direct digital radiograph, automatic method using manually idenitified landmarks can be preferable in cephalometric analysis.

한국산 시궁쥐(Rattus norvegicus)와 곰쥐(Rattus rattus)의 mtDNA RFLPs

김회숙,유선아,백상기,김영진 충남대학교 기초과학연구소 1996 忠南科學硏究誌 Vol.23 No.2

RFLPs(restriction fragment length polymorphisms) of mitochondrial DNA(mtDNA) of Rattus norvegicus and Rattus rattus in Korea were observed. All of the mtDNA of R. norvegicus individuals were shown no variatioin by the single digestion with EcoR Ⅰ, Hind Ⅲ, Ksp Ⅰ, Hind Ⅱ and Cfo Ⅰ as well as the double digestion with BamH Ⅰ/Sac Ⅰ or Hpa Ⅰ/Xba Ⅰ. Morph-1(18.75%) and morph-2(81.25%)) were observed by digestion with Hind Ⅱ in mtDNA of R. norvegicus. Morph-1(91.70%) and morph-2(8.30%) were observed by digestion with Cfo Ⅰ in mtDNA of R. norvegicus. In the mtDNA obtained from 3 R. rattus individuals, no variants were observed. The types of mtDNA obtained from 48 R. norvegicus individuals were four types(RN 1, RN 2, RN 3 and RN 4). The frequency of RN 1, RN 2, RN 3 and RN 4 was 66.67%, 14.58%, 6.25% and 12.50%, respectively. The value range of nucleotide diversity in mtDNA of R. norvegicus was between 0.0059 and 0.0153, and the value of nucleotide diversity of mtDNA between R. norvegicus and R. rattus was 0.13. The divergence time between the two species is believed to be 6.5 million years ago.

폐경 후 여성에서 체성분과 골밀도와의 관계

채진욱,김일희,권우성,이근미,정승필,문용 영남대학교 의과대학 2003 Yeungnam University Journal of Medicine Vol.20 No.1

Background: Body weight is an important factor that influence the bone density in postmenopausal women except estrogen dificiency. However, different results are reported about the relationship between body composition and bone density in the postmenopausal women. We have studied the relationship between age, body weight, body mass index (BMI), waist hip ratio (WHR), muscle mass, fat mass, fat free mass and bone density. Materials and Methods: We have studied 127 persons of postmenopausal women who visited university medical center and examined the inbody 3.0 and Dual Energy X-ray Absorptiometry (DEXA) from Jan, 2001 to Jun, 2002. they didn't have any disease and didn't received homone therapy, osteoprosis therapy or other medication that influence the bone density. Results: The numbers of study subjects is total 127 persons. Mean age is 56.9±5.14, mean weight is 59.3±8.7 kg, mean BMI is 25.37±3.16 (kg/㎡), mean fat mass is 20.02±5.05 kg, mean muscle mass is 37.49±4.50 kg, mean fat free mass is 39.80±4.70, mean BMD is 0.828±0.148 (g/㎠). In the result of linear regression analysis, age, height, weight, muscle mass, fat free mass, fat mass, BMI are significant determinants of BMD. In stepwise multiple regression analysis, age is the most significant determinant of BMD and besides age, fat mass is the most significant determinant of BMD among body composition. Conclusion: In postmenopausal women, age, height, weight, BMI, muscle mass, fat free mass, fat mass are significant determinants of BMD and besides age, fat free mass is the most significant determinant of BMD among the body composition. So, diet and exercise that increase fat free mass will contribute to bone density increment.

미세절제술과 비교 유전자 보합법에 의한 각종 종양에서의 유전자 변화에 관한 연구

구선회,신소영,임춘화,전영미,이윤이,김진만 충남대학교 의과대학 지역사회의학연구소 2000 충남의대잡지 Vol.27 No.2

For the evaluation of oncogenesis, progression and prognosis of cancer, CGH is an important technique, because this technique is economic due to utilization of only one probe and lack of culture, screening mathod of whole genome and possibility of retrospective and prospective study. By the CGH, genornic variation of 20 breast cancer tissues, 23 stomach cancer tissues and 16 bladder cancer tissues were analyzed. The results were as followes ; 1. breast cancers The CGH results showed gains on chromosomes 8q(40%), lq(30%), 17q(15%), 20q(15%), 18q (15%), 5p(15%), and 13q(15%). The Deletions were on chromosomes 17p(45%) and 22q(20%). High-level amplifications(green/red ratio >1.5) were noted on chromosomes 1p31, iq, 3q25-qter, 5p, 7q31-qter, 8q, 9q22-qter, 10p, l1p, 11q22-qter, 12p, 12q24, 14g21-qter, 15q23-qter, 17q, 18p, 18q12-qter, 20p, and 20q. By comparison with infiltrating ductal carcinoma, the two medullary carcinomas showed high-level amplification on chromosomes iq3l, lq, 8q, 10p, 11p and 12p. 2. stomach cancers 1) Usual amplification sites of genome were lq, 13q, 17q, 20p,q. 2) 17p was the most common deletion site. The other sites of the deletion were lq, 4q. 3) In intestinal type of stomach cancer, genomic variation is more common than diffuse type. 4) In the cases of no evidence of lymph node metastasis, deletion of 17p is absent but amplification of 8q is obvious in the case of lymph node metastasis. 3. bladder cancers Common amplification of copy numbers of DNA sequences by CGH were seen at 1q, 3q, 4q, 5p, 6pq, 7p, 8q, 11q, 12q, 13q, 17q, 18q and 20pq(more than 20% of cases). High level amplification was noted at 1p32, 3p2l, 3q24, 4q26, 8q21-ter, 11q14-22, 12q15-21, 12q21-24, 13q 21-31, 17q22, and 18q22. Deletions were noted at 2q21-qter, 4q13-23, 5q, 8p12-22, 9pq, 11p13-15 (more than 20% of cases).

하악골 골절후의 골치유과정에 있어서 방사선학적 추적조사

최진영,김명호,허경희,서병무,이종호,정필훈,김명진 대한악안면성형재건외과학회 2000 Maxillofacial Plastic Reconstructive Surgery Vol.22 No.5

The results of radiographic study of healing of fractured mandible are often inconsistent with clinical evaluation of bone healing pattern of it. In addition, there is inconsistency between radiographic studies. We think if such inconsistency is resolved, clinical assessment combined with radiologic evidence can be used to guide to more accurate clinical management. The purpose of this study is to evaluate radiological healing pattern of mandible, and to apply its result to clinical use. Panoramic view was used to analyze the change of radiographic finding in 35 patients (27 male, 8 female, ranging 17 to 53 years old) treated for mandibular fracture at the department of oral & maxillofacial surgery, SNUH in the period 1991 to 1998, Patients are all treated by rigid internal fixation using monocortical miniplate. Within 9 weeks, no change is observed at fracture site. Osteogenic change is observed at various time interval (3 to 21 weeks). We have found radiographic change of healing is observed 4 to 6 weeks later to clinical healing, According to this result, we recommend radiographic follow-up at 4 week, 10 week, 10 month.

서식지 특성에 따른 조류군집의 차이

채진확,김정수,구태회 경희대학교 환경연구소 2002 環境硏究 論文集 Vol.11 No.-

This study was carried out to analyze difference of bird communities in Mt. Dae-ryong and Mt. O-eum with habitat characteristics. The number of species and individuals of bird observed in Mt. Dae-ryong and Mt. O-eum were 27 and 309, 26 and 123, respectively. The nesting guild was higher at canopy and bush nesting guild(41% and 30%) compared with hole and water nesting guild(22% and 7%) In Mt. Dae-ryong. The nesting guild was higher at hole and canopy nesting guild(35% and 34%) compared with bush nesting guild(31%) in Mt. O-eum. The forage guild was higher at canopy and bush foraging guild than at water and outside foraging guild in all studied areas. Based on the results, habitat condition was major factor to bird communities because the difference of guilds in this studied areas caused the change of bird communities.

몬테카를로 방법에 의한 수소분자의 기저상태 에너지의 수치 해석적인 계산

양해정,양회룡,정진,김미정,최승평,장차익 조선대학교 기초과학연구소 2000 自然科學硏究 Vol.23 No.1

Numerical methods that are known as Monte as Monte Carlo methods can be loosely described as statistical simulation methods, where statistical simulation is defined in quite general terms to be any method that utilizes sequences of random numbers to perform the simulation. Monte Carlo methods are now used routinely in many problems, the simulation of the esoteric subnuclear processes in high energy physics experiments, cellular automata, self-organized critical phenomena, the Ising spin glass, the simulation of a Bingo game, etc. The physical processes are simulated directly, and there are no needs to even write down the differential equations that describe the behaviors of the systems. The only requirement is that the physical systems be described by probability density functions. We consider with the Monte Carlo variational method and the Monte Carlo path integral method(MCPI). These methods are used to calculate the energy of the ground states of H2 molecule by the formal similarity between the Schroedinger equation and the multi-dimensional diffusion equation.

He 원자의 가장 낮은 들뜬 상태 에너지의 수치 계산

차혁렬,양해정,김미정,정진,양회룡,최승평,장차익 조선대학교 기초과학연구소 1999 自然科學硏究 Vol.22 No.1

The one-electron theory of atoms, molecules, and crystals have enjoyed a wide success in many branches of physics. This theory provides a physically appealing description of the electronic structure of many-electron systems. In addition, this theory gives a convenient basis for performing the detailed calculation on specific many-electron systems. In such calculations, it is usually necessary to introduce many simplified assumptions in order to make a progress. Since the principal computational difficulty supposed by the Hartree-Fock equations is the treatment of the exchange term, it would be very desirable to simplify the treatment of these terms by using Slater's average of the exchange potential. The first order correction of energy in the lowest excited states of He atom is calculated by using the unperturbed wave function obtained with the Hartree-Fock-Slater approximation and compared with the result obtained by the simple analytical method. The numerical results agrees with an experimental results for the lowest excited states of He atom with tolerance 3.22%, 2.16%, 2.94% and 3.41%. These results show that the numerical analysis can be applied to other multielectron atoms with the personal computer.

흰쥐 경동맥 풍선손상 모델에서 리포좀 전달체를 이용한 에스트로겐의 국소전달 효과

윤영섭,장양수,정광회,박요석,김형관,강웅철,권진욱,정보영,조상호,김성순 대한순환기학회 1998 Korean Circulation Journal Vol.28 No.8

골격근 근형질세망의 ATP유도 ^45Ca-uptake에 대한 Thapsigargin및 Vanillylnonanamide의 영향

황의강,배소현,홍장희,허강민,김진회,이재흔,석정호 충남대학교 의과대학 지역사회의학연구소 1999 충남의대잡지 Vol.26 No.2

To investigate the effect of thapsigargin(THP) and vanillylnonanamide(VN), derivative of capsaicin, on the ATP-induced ^45Ca-uptake in the sarcoplasmic reticulum(SR) of the skeletal muscle, the SR vesicles were prepared from the back muscle of the rabbit, and ^45Ca-uptake was carried out. The results as follows: ATP-induced ^45Ca-uptake of skeletal muscular SR was significantly increased by 1 mM ATP. It was significantly blocked by 5 μM THP, but slightly decreased by 20 μM VN. The combined effect of THP and VN on the 45Ca-uptake of the SR vesicles was much potentiated than the sum of each effect of them. The above results suggest that the action of VN, being slightly influential to ATP-induced Ca-uptake but potentiating the effect of THP on the Ca-uptake, might be related with direct perturbation of the SR membrane or exposure of the THP-binding site.