http://chineseinput.net/에서 pinyin(병음)방식으로 중국어를 변환할 수 있습니다.
변환된 중국어를 복사하여 사용하시면 됩니다.
불균질 대수층에서 유선 시뮬레이션을 이용한 다수 오염원의 용질 이동 모사
정승필,최종근,Jung Seung-Pil,Choe Jong-Geun 한국지하수토양환경학회 2005 지하수토양환경 Vol.10 No.3
2차원 불균질 대수층에서 다수의 오염원이 있음 경우 오염물의 거동을 모사할 수 있는 방법을 제시하였다. 이 방법은 유선 시뮬레이션을 기반으로 하며 다차원의 계산을 다수의 일차원으로 분해하여 계산하는 방법으로서 불균질한 매질에서 수두 계산을 한 후, 관심영역에 유선을 분포시키고 그 유선을 띠라 오염물이 전파되는 농도를 계산한다. 개발된 모델을 Visual MODFLOW를 이용하여 검증하였고 시간에 따른 농도 분포나 관측정에서의 용질 도달 곡선이 잘 일치함을 확인할 수 있었다. 개발된 모델은 시뮬레이션 수행 시간에 대한 효율 면에서 Visual MODFLOW보다 뛰어나 많은 연산을 필요로 하는 대규모 대수층의 용질거동 예측이나 반복 계산을 필요로 하는 역산 모델링에서 효과적으로 사용될 수 있다. This study presents a contaminant transport model suitable for a 2-dimensional heterogeneous aquifer with multiple contaminant sources. It uses a streamline simulation, which transforms a multi-dimensional problem into multiple 1dimensional problems. It runs flow simulation, streamline tracking, and calculation of contaminant concentrations by turns. The model is verificated with a Visual MODFLOW by comparing contaminant concentration distributions and breakthrough curves at an observation well. Due to its fast simulation, it can be applied to time consuming simulations such as in a fine-grided aquifer, an inverse modeling and other applications.
정승필,허성모,이세경,김상민,최민영,배수연,김지영,김민국,길원호,최준호,김정한,김지수,남석진,배정원,이정언 한국유방암학회 2013 Journal of breast cancer Vol.16 No.1
Purpose: IBTR! 2.0 is a web-based nomogram that predicts the 10-year ipsilateral breast tumor recurrence (IBTR) rate after breast-conserving therapy. We validated this nomogram in Korean patients. Methods: The nomogram was tested for 520 Korean patients, who underwent breast-conserving surgery followed by radiation therapy. Predicted and observed 10-year outcomes were compared for the entire cohort and for each group, predefined by nomogram-predicted risks: group 1, <3%; group 2, 3% to 5%; group 3, 5% to 10%; group 4, >10%. Results: In overall patients, the overall 10 year predicted and observed estimates of IBTR were 5.22% and 5.70% (p=0.68). In group 1, (n=124), the predicted and observed estimates were 2.25% and 1.80% (p=0.73), in group 2 (n=177), 3.95% and 3.90% (p=0.97), in group 3 (n=181), 7.14% and 8.80% (p=0.42), and in group 4 (n=38), 11.66% and 14.90% (p=0.73), respectively. Conclusion: In a previous validation of this nomogram based on American patients, nomogram-predicted IBTR rates were overestimated in the high-risk subgroup. However, our results based on Korean patients showed that the observed IBTR was higher than the predicted estimates in groups 3 and 4. This difference may arise from ethnic differences, as well as from the methods used to detect IBTR and the healthcare environment. IBTR! 2.0 may be considered as an acceptable nomogram in Korean patients with low- to moderate-risk of in-breast recurrence. Before widespread use of this nomogram, the IBTR! 2.0 needs a larger validation study and continuous modification.
2012년 특별관측 자료를 이용한 동해안 겨울철 강수 특성 분석
정승필,임윤규,김기훈,한상옥,권태영 한국지구과학회 2014 한국지구과학회지 Vol.35 No.1
The special observation using Radiosonde was performed to investigate precipitation events over the east coast of Korea during the winter season from 5 January to 29 February 2012. This analysis focused on the various indices to describe the characteristics of the atmospheric instability. Equivalent Potential Temperature (EPT) from surface (1000 hPa) to middle level (near 750 hPa) was increased when the precipitation occurred and these levels (1000~750 hPa) had moisture enough to cause the instability of atmosphere. The temporal evolution of Convective Available Potential Energy (CAPE) appeared to be enhanced when the precipitation fell. Similar behavior was also observed for the temporal evolution of Storm Relative Helicity (SRH), indicating that it had a higher value during the precipitation events. To understand a detailed structure of atmospheric condition for the formation of precipitation, the surface remote sensing data and Automatic Weather System (AWS) data were analyzed. We calculated the Total Precipitable Water FLUX (TPWFLUX) using TPW and wind vector. TPWFLUX and precipitation amount showed a statistically significant relationship in the north easterly winds. The result suggested that understanding of the dynamical processes such as wind direction be important to comprehend precipitation phenomenon in the east coast of Korea. 겨울철 동해안 강수 현상에 대한 규명을 위하여 라디오존데를 활용한 특별관측을 2012년 1월 5일부터 2월 29일까지 실시하였고, 이 연구는 대기의 불안정을 나타내는 다양한 변수를 활용하여 강수 사례의 분석을 수행하였다. 그결과, 강수가 발생할 때 지표면(1000 hPa)에서 중층(약 750 hPa)까지의 상당온위가 증가하는 것을 볼 수 있었고, 이러한 대기층(1000~750 hPa)은 불안정을 일으키기에 충분한 수준의 수증기를 함유하고 있었다. 대류가용잠재에너지의 시간적인 변화를 살펴본 결과 강수가 발생하였을 때 증가하는 것을 볼 수 있었고, 연직바람쉬어의 경우에서도 대류가용잠재에너지와 마찬가지로 강수 기간 동안 상승하여 일정수준 이상의 값을 유지하는 것을 확인할 수 있었다. 강수에 따른 대기 구조의 상세한 분석을 위하여 지상 원격 탐사 자료와 지상 관측 자료를 활용하여 분석을 수행하였다. 또한 가강수량과 바람벡터를 이용하여 가강수량플럭스를 계산하였다. 가강수량플럭스와 강수량은 북동풍 계열의 바람이 발생하였을때 높은 관계성을 보였다. 그 결과 동해안영역에서 발생하는 강수 현상에서는 풍계와 같은 역학적인 작용의 이해가 중요한 것으로 판단되었다.
가족집적성을 보이는 B형간염 바이러스 만성보유자에서 바이러스 유전자의 돌연변이와 주조직접합체 양상 - 질병발현 형태와의 관련성을 중심으로 -
정승필,이효석,김정룡,안윤옥,Jung, Seung-Pil,Lee, Hyo-Suk,Kim, Chung-Yong,Ahn, Yoon-Ok 대한예방의학회 2000 Journal of Preventive Medicine and Public Health Vol.33 No.3
Objectives : Chronic HBsAg carriers are the principal source of infection for other susceptible people, and are themselves at high risk of developing serious liver diseases. In Korea, it has been estimated that 65-75% of the HBsAg positives remained as persistent carriers. Additionally, familial clustering of MBV infection has frequently been observed among carriers. Some would become progressive, chronic hepatitis patients, and others would not. The aim of this study was to evaluate the association between various factors, such as the duration of infection, type of virus, mutation of precore/core region in HBV, major histocompatibility class-I, and developing chronic liver diseases among familial HBV carriers. Methods : Chronic carrier status was identified by repeated serological tests for HBsAg at intervals of six months or more. A familial chronic carrier was defined when the disease was observed in a family member over two generations. Two families were recruited, among which a total of 20 chronic HBsAg carriers(11 carriers in No.1, and 9 in No.2 family) were identified. Data on the general characteristics and liver disease status were collected. Identification of the HBV-DNA was successful only for 13 subjects among the 20 carriers. Analysis of viral DNA in terms of subtype, pre-core and core region mutations was carried out. The type of major histocompatibility class-1 for the 13 subjects was also analysed. Results & Conclusions : Seven of 10 chronic HBV carriers of the 1st generation and one of 10 of the 2nd generation were clinical patients with chronic hepatitis, the others, three of the 1 st and nine of the 2nd generation, were asymptomatic carriers. This data indicates that the duration of HBV carriage is one of the major factors for disease severity. The subtype of HBsAg analysed using MBV-DNA identified in 13 carriers were adr, and the pattern of precore nonsense mutation in HBV-DNA was identical among family members, which meads that the same virus strains were transmitted between the family members. The association between the precore or core mutations in HBV-DNA and the disease severity was not observed. While it was suggested that a specific type of MHC class-I may be related to disease progression.