Factors associated with the risk of colorectal neoplasia in young adults under age 40

Ilsoo Kim,Han Hee Lee,Young Jae Ko,Ho Eun Chang,Dae Young Cheung,Bo-In Lee,Young-Seok Cho,Jin Il Kim,Myung-Gyu Choi 대한내과학회 2022 The Korean Journal of Internal Medicine Vol.37 No.5

Background/Aims: Recent epidemiologic studies have shown a continued increase in colorectal cancer incidence among younger adults. Little is known about the factors that contribute to the development of young-onset colorectal neoplasia (CRN). Methods: A cross-sectional analysis was performed for individuals younger than 40 years who underwent colonoscopy in Seoul St. Mary’s Hospital and its affiliated health screening center. High-risk CRN was defined as adenoma or sessile serrated lesion ≥ 10 mm, with three or more adenomas, villous histology, high grade dysplasia, or carcinoma. Results: Of these 13,621 included participants, 2,023 (14.9%) had one and more CRN. Young patients with CRN tended to be elderly, male, obese, smoker, having a habit of drinking, and having comorbidities such as hypertension, dyslipidemia, diabetes, and chronic kidney disease. In a multivariate analysis adjusted for age, sex, obesity, smoking status, and alcohol intake, old age (odds ratio [OR], 1.086; 95% confidence interval [CI], 1.054 to 1.119), male sex (OR, 1.748; 95% CI, 1.247 to 2.451), obesity (OR, 1.439; 95% CI, 1.133 to 1.828), and smoking (OR, 1.654; 95% CI, 1.287 to 2.127) were independent risk factors for overall CRN. Obesity and smoking as two modifiable factors increased the risk for high-risk CRN even more than for overall CRN (OR, 1.734; 95% CI, 1.168 to 2.575 and OR, 1.797; 95% CI, 1.172 to 2.753, respectively). Conclusions: Obesity and smoking were modifiable risk factors for CRN in young adults. They increased the risk for highrisk CRN even more than for overall CRN. A colonoscopy might be beneficial for young individuals with these factors.

영골(靈骨).강압혈(降壓穴) 자극(刺鍼)이 혈압(血壓)에 미치는 영향(影向)

임영남,심성용,한지완,고호연,박종형,한양희,전찬용,김동우,Yim, Young-Nam,Sim, Sung-Yong,Han, Ji-Wan,Ko, Ho-Yeon,Park, Chong-Hyeong,Han, Yang-Hee,Chun, Chan-Yong,Kim, Dong-Woo 대한한방내과학회 2004 大韓韓方內科學會誌 Vol.25 No.2

Objective : The purpose of this study is to evaluate the clinical effect of the non-pharmacological anti-hypertension method, acupuncture, for hypertensive patients. Methods : 26 patients diagnosed with hypertension were each treated by one of three methods: an anti-hypertension drug(adalat soft capsule), venepuncture, and acupuncture. In cases of rising blood pressure, patients were treated by their one of the three methods, and blood pressure was measured at regular intervals. Result : As for the group of acupuncture treated patients on Young-gol(ling-gu) and Gang-ap-hyul(jiang-ya-xue), readings dropped 18.0mmHg in systolic blood pressure and 6.50mmHg in diastolic blood pressure. This was a greater effect than that seen in the venepuncture treated patients. Blood pressure checked one hour after acupuncture treatment showed a greater difference than blood pressure checked after thirty minutes. Conclusion : Safe reductions in blood pressure were observed through the non-pharmacological method of acupuncture on Young-gol(ling-gu) and Gang-ap-hyul(Jiang-ya-xue).

법랑질 접착에 대한 습윤 효과

고근호,조영곤,진철희,유상훈,김종욱,박병철,기영재,최희영,김종진 大韓齒科保存學會 2004 Restorative Dentistry & Endodontics Vol.29 No.3

This study evaluated the microleakage and interfacial gap between enamel and composite resin under the dry and wet condition of the enamel surface, V shaped class 5 cavities were prepared on the occlusal portion of extracted human molars. Samples were divided into three groups: D group (air dry for 10-15s), BD group (blot dry with moist cotton pellet), and DR group (air dry for 10-15s and rewet with Aqua-Prep F for 20s). Cavities were filled using Aelitefil composite resin after applied One-Step. Microleakage was tested by 2% methylene blue dye solution and the data were statistically analysed by Kruskal-Wallis test and Mann-Whitney test. Also Enamel-resin interface was observed under SEM. Group BD showed statistically lower microleakage than group D (p〈0.05). but there was no statistically significant difference between group BD and DR (p)0.05). At the enamel-resin interface, group D showed the gap of 2 ㎛ thickness, but group BD and DR showed close adaptation. In conclusion, the use of blot dry and rewetting agent (Aqua-Prep F) resulted in decreased microleakage and improved adhesion between enamel and resin when using One-Step.

활동치료학과 교육과정 개발 연구

양광희,고영애,조희,양선희,안은숙,전미영 적십자간호전문대학 2000 적십자간호전문대학논문집 Vol.22 No.-

심한 골병변으로 발현된 기능성 낭종성 부갑상선 선종

전숙,김영희,박지영,고관표,박철영,김덕윤,우정택,김성운,김진우,김영설,고석환 대한내분비학회 2003 Endocrinology and metabolism Vol.18 No.2

낭종성 부갑상선 선종과 심한 골병변을 동반한 부갑상선 기능항진증은 매우 드문 질환으로서, 저자들은 양측 고관절의 통증을 초기 주소로 내원한 환자에서 고칼슘혈증과 부갑상선 호르몬 증가, 골병변의 방사선적 소견을 통해 부갑상선 기능항진증을 진단하고, 경부 초음파와 컴퓨터 단층 촬영, 부갑상선 스캔검사 및 수술중 부갑상선 낭종액 검사 등을 통해 기능성 부갑상선 낭종의 한 종류인 낭종성 부갑상선 선종을 진단하고 수술적 제거를 통하여 정상화된 1예를 경험하였다. A cystic parathyroid adenoma is rare. A case of primary hyperparathyroidism, with the cystic formation of a parathyroid adenoma and a severe bony lesion, is reported. A 52-year-old male was admitted due to pain in both hips and for evaluation of hypercalcemia. The plasma level of the intact parathyroid hormone (iPTH) was elevated to 1424 pg/mL. Ultrasonography and the computed tomography revealed a parathyroid cyst on the left thyroid lower pole. Parathyroid scintigraphy detected a parathyroid adenoma. A radiograph showed a subperiosteal bone resorption on the phalanges, and a brown tumor (osteitis fibrosa cystica) on the femur shaft was noted. A surgical excision of the parathyroid adenoma was performed. The PTH level in the cystic fluid was increased. A histological examination confirmed a cystic parathyroid adenoma. The PTH level was normalized after the operation (J Kor SOC Endocrinol 18:214-220, 2003).

말더듬 아동과 일반 아동의 유창성 특성 비교

고영옥,전희숙,권도하 대구대학교 특수교육재활과학연구소 2007 再活科學硏究 Vol.25 No.2

The purpose of this study was to investigate characteristics of stutter children on the speech task. The speech task was automatic speech, reading, and monologue. we collect speech sampling during of task. In the study participated seven stuttering children of 7 to 12years old(4 males, 3 females) and seven nonstuttering children(5 males, 2 females). The results of this study were as following. First, there was not significant difference between stuttering children and nonstuttering in the articulation rate. On the automatic speech task, stuttering children articulation rate was mean 171.60(SPM) and nonstuttering children articulation rate was mean 168.34(SPM). On the reading task, stuttering children articulation rate was mean 225.82(SPM) and nonstuttering children articulation rate was mean 218.09(SPM). On the monologue task, stuttering children articulation rate was mean 195.58(SPM) and nonstuttering children articulation rate was mean 191.95(SPM). Second, In the stutter children, dysfluency syllable number varied on the speech task. Also, stutter children, dysfluency syllable rate varied on the speech task. On the automatic, monologue task, dysfluency syllable number was mean 8.57syllable (SD=9.71), 20.71syllable (SD=13.47). On the automatic, monologue task, dysfluency syllable rate was mean 15.85%(SD=32.98), 29.00%(SD=19.74). 본 연구의 목적은 말더듬 아동이 각기 다른 구어 과업에서 유창하게 말할 때의 구어 특성을 알아보는 것이었다. 본 연구의 대상은 7~12세의 말더듬 아동 7명(남자 4명, 여자 3명)과 일반 아동7명(남자 5명, 여자 2명)이었다. 자동구어와 독백 과업을 실시하는 동안 구어샘플 수집하였다. 연구의 결과는 다음과 같다. 첫째, 말더듬 아동과 일반 아동의 유창한 구어의 속도에는 차이는 없었다. 자동구어 및 독백 과업 모두 유의한 차이가 없었다. 둘째, 과업별 말더듬 아동의 비유창한 음절수는 구어과업에 따라 다양하게 나타났다. 그리고 비유창한 음절 비율도 구어과업에 따라 다양하게 나타났다. 자동구어, 읽기, 독백과업에서 말더듬 아동의 비유창한 음절수는 평균 8.57음절(SD=9.71), 27.57음절(SD=23.47), 20.71음절(SD=13.47)이었다. 비유창한 음절비율은 자동구어, 독백과업에서 평균 15.85%(SD=32.98), 61.35%(SD=106.08), 29.00%(SD=19.74)이었다.

쪽파의 callus 배양에 의한 변이체 유기

고영은,고찬훈,임순희,김현정,안장순 全南大學校 農業科學技術硏究所 1998 農業科學技術硏究 Vol.33 No.-

A. wakegi Araki의 배발생 캘러스 유도에는 2,4-D의 단독 첨가가 보다 효과적이었으나 2,4-D의 농도가 높을수록 기형배의 배발생율이 높았다. BA를 혼합첨가하였을 때는 기형배가 보다 많이 발생하였다. 외식편의 부위별로는 경정, 인편, 엽조직 중, 경정이 배형성을 위한 외식편으로 가장 좋았으며 그 다음 인편, 엽조직 순으로 정상적인 배도 가장 많이 발생하였다. Sucrose 7%에서 배발생 callus 유도가 가장 좋았지만 기형 배의 발생율도 가장 높았다. 재분화 식물체의 염색체 변이는 인편유래 callus에서보다 경정유래 callus에서 높았다. Explant source, growth regulators and sugar contents in the culture media suitable for in vitro plant regenerations through somatic embryogenesis in Allium wakegi Araki were examined. Adition of 2,4-D alone was more effective on embryogenic callus induction than its addition in combination with BA. The embryogenic calluses induced on the media containing 2,4-D at high concentration or 2,4-D in combination with BA produced abnormal embryos at high frequency. Stem apex was the best explant source for normal embryo production, followed in order by scale and in vitro leaf segments. sucrose at 7% resulted in the best embryogenic callus induction though the callus produced abnormal embryos at highest frequency. The highest level of chromosomal variation was shown in the regenerants from the shoot apex-derived embryogenic callus.

사춘기 초기 적응 교육과정 개발을 위한 요구 분석

고영희,홍후조 안암교육학회 2012 한국교육학연구 Vol.18 No.2

본 연구의 목적은 초등학교 고학년 사춘기 초기 적응을 위한 교육과정을 개발하기 위하여 요구를 파악하고, 향후 초등학교 고학년 사춘기 초기 적응을 위한 교육과정 기준을 마련하 기 위함에 있다. 이를 위해 사춘기의 개념과 선행연구를 간략히 개관하고, 초등학교 6학년 (276명), 고등학교 1-2학년(271명), 초등학교 5-6학년 담임교사(196명), 초등학교 6학년 학 부모(150명)를 대상으로 설문조사를 실시하였다. 연구 결과, 사춘기 초기 적응을 위한 교육 과정 내용으로 건강관리, 마음 다스리기, 정서.심리 변화, 사춘기의 자기 관리와 장래 설 계가 중요하다고 파악되었다. 사춘기 초기 적응을 위한 교육과정 내용의 가르칠 비중에서 는 친구 관계 향상 방법과 사춘기의 자기 관리와 장래 설계가 높게 수용되었다. The purpose of this study was to investigate the needs for development of early adolescence adaptation curriculum in Elementary school students in higher grades, and to suggest criteria of early adolescence adaptation curriculum for school teachers and parents. This study reviewed the concepts of puberty and prior studies about adolescent. Survey was carried out by asking a series of questions in the form of a questionnaire distributed to a group of the sixth grade students(276 persons), the eleventh-twelfth grade students(271 persons), the fifth-sixth grade teachers(196 persons) and parents of the sixth grade students(150 persons). The major findings of this study were as follows: It is concluded that early adolescence adaptation curriculum needs to be focused on health management, mind control, emotional and psychological change, self-management, and planning for the future. And proportion of teaching time is to be taken more for friend relationship, self-management, and planning for the future.

마이크로센서 응용을 위한 실리콘 미세가공 기술

고희선,김영민,권대혁,도양희,이광만 제주대학교 산업기술연구소 1999 尖端技術硏究所論文集 Vol.10 No.2

Silicon micromachining technology can be used to build microsensors and actuators by using tools derived from standard IC processing. For the silicon micromachining the etching characteristics of tetramethyl ammonium hydroxide (TMAH) by dissolving silicon powder or silicic acid have been studied. The 3, 5 and 10wt.% TMAH solutions, with dissolved silicon powder (6g/l) or with dissolved silicic acid(Si(OH)4, 16g/l) were used. And ammonium peroxydisulfate (APODS, 2g/l) dissolved in the solutions were also used. The etch rates of silicon and the etched surface roughness were observed with various etching conditions. The crystallographical aspect on the crystal orientation of silicon have been studied. With sufficiently fresh solutions, these TMAH concentration and combination of etchants, provide repeatable etch properties, does not attack exposed aluminum or silicon dioxode, and provide smooth (100) silicon surfaces.

청국장의 제조방법에 따른 향미 증진 효과

고한수,조대희,황성연,김영만 한국식품영양학회 1999 韓國食品營養學會誌 Vol.12 No.1

청국장 제조를 위한 분리균은 포자형성율이 높은 Bacillus subtilis로 대사력이 활발한 대수증식기의 것을 콩에 1,000CFU/g 이상의 균수를 접종하여 40℃와 상대습도 90%에서 배양하면 발효가 빠르게 진행되었다. 발효가 종료되면 포자형성율이 95% 이상 되어야 저온의 후숙과정에서 재번식이 쉽게 일어나지 않았으며 발효취는 발효 중에서만 형성되었다. 중립콩과 대립콩의 발효율이 가장 좋았다. 저온의 후숙과정은 5℃에서 1∼2일 후 경과하면 Bacillus subtilis는 더 이상의 증식이 일어나지 않고 발효취가 소멸되므로 저온의 유통과정을 거쳐야 불쾌취가 없는 구수한 청국장의 맛을 유지할 수 있었다. The strain isolated for making chungkuk-jang was Bacillus subtilis, which formed spore with 98% ratio. Logarithmical culture was inoculated (1,000 CFU /g) to the steamed soybeans and at the optimum fermentation conditions(40℃, RH 90%), fermentation progressed very rapidly and synchronously. Fermentation time was 24 hours on the optimum fermentation conditions. During activated fermentation, chungkuk-jang's aroma and flavor created. After finishing the fermentation, the spore forming ratio was 95% and replenishment was not occured easily during aging at the below 5℃.