경구용 약물수송체로서의 팔미토일 치환 다당체로 코팅된 리포좀

한양희,이정우,최영욱,Hahn, Yang-Hee,Yi, Jung-Woo,Choi, Young-Wook 한국약제학회 1994 Journal of Pharmaceutical Investigation Vol.24 No.2

Applications of liposomes as a drug carrier for the oral delivery of poorly-absorbable macromolecular drugs have been limited, because of their instability in gastrointestinal environments including pH, bile salts, and digestive enzymes. Two polysaccharides, dextran(DX) and pullulan(PL), were introduced to the preformed liposomes in order to enhance the stability. Palmitoyl derivatives of polysaccharides, palmitoyldextran(PalDX) and palmitoylpullulan(PalPL), were synthesizd and introduced to the liposomes during preparation for the same purpose of stability. The effects of these polysaccharides coating were evaluated basically by physical properties of particle size distribution and optical microscopy, then compared with uncoated liposomes by the observations of both in vitro stability and in vovo absorption characteristics. The geometric mean diameters of polysaccharide-coated liposomes were greater than that of uncoated liposome, showing the outermost polysaccharide-coated layer under the optical microscopy. In vitro stabilities of uncoated or polysaccharides-coated liposomes were measured by turbidity changes in various pH buffer solutions containing sodium choleate as bile salts. While uncoated liposome was very sensitive to bile salts, polysaccharides-coated liposomes were stable in relatively higher concentrations of sodium choleate, giving the results of better stability of PalDX- and PalPL-coated liposomes than that of DX- and PL-coated liposomes. After liposomal encapsulation of acyclovir(ACV), an antiviral agent as a model drug, it has been administered orally to rats as dose of ACV 40 mg/kg. Plasma concentrations of ACV were assayed by HPLC and analyzed by model-independent pharmacokinetics. Pharmacokinetic parameters of Cmax, tmax, and [AUC] have been compared.

반딧불

한양희 이화여자대학교 음악대학 작곡과 1971 멜로디 Vol.- No.6

Pullulan으로 흡착코팅시킨 리포좀의 물리적 특성 및 담즙산염용액에서의 안정성

한양희,김상헌,양수근,최영욱 중앙대학교 약학연구소 1993 약학 논총 Vol.7 No.-

Liposomes have been used as drug carriers for the delivery of peptide, anticancer agent, hormones, and etc. Another possibiltity of liposome as an effective carrier for the oral administration of drugs which are unstable in gastrointestinal tract has been extensively studied in recent years, in the viewpoint of protection of liposome against pH, bile salts and pancreatic lipase in physiological circumstances. Pullulan, a hydrophilic polysaccharide and a coating agent for foods and drugs, was employed in this experiment to coat the DMPC liposomes (MLVs) by adsorption technique. Physical properties of pullulan-coated liposomes were investigated with TEM and particle size analyzer. Turbidity changes were measured and expressed as a relative turbidity (A_t/A_0), in order to compare the stability of uncoated or pullulan-coated liposomes against both pH shock and bile salts attack. The stability of liposomes was independent of pH, since turbidities of liposomes were unchanged for 8 hours in various pH buffer solutions from pH 1.2 to 7.4. On the other hand, from the observations in pH 5.6 or 6.8 buffer solution, pullulan-coated liposomes showed comparative stability against sodium choleate upto 0.15% concentration, although neither uncoated nor pullulan-coated liposomes revealed enough stability against the bile salt at 0.15% or higher concentration. Therefore, it is possible to conclude that pullulan-coated liposmes might be useful as a drug carrier for oral delivery, because of the enhanced stability in gastrointestinal environment. It is still necessary, however, to find out better selections for polymers and coating methods for the purpose of further stabilization of liposomes.

The Area Of a Pythagorean Triangle and the Number Six.

한양희 이화여자대학교 자연과학대학 1970 梨花 自然 Vol.1 No.-

삼각형이 변의 길이가 x,y,z일 때 피타고라스의 삼각형이 되기 위한 필요충분조건은 x,y,z가 모두 양의 정수이고 x²+y²=z² 이다. 피타고라스의 삼각형에 관한 몇 개의 흥미있는 사실들이 성립되고 있으나 상대적으로 알려지지 않은 것도 있다. 피타고라스의 삼각형의 면적과 number six에 관한 것 중의 하나가 표1에서 제시되고 있다.

재생지 품질 향상을 위한 종이류 재활용 체계 분석 및 사례 연구-한국과 일본 사례를 중심으로-

한양희,신재욱 한국일러스아트학회 2022 조형미디어학 Vol.25 No.2

One day, because resources are not source of all resources are consumed in the future, we must find new resources or substitutes.In addition, continuing resource consumption is There is also the problem of environmental pollution.Progressing research continues to find a substitute, but still completely substitute that can replace an existing resources should not exist, and substitutes the present situation it is difficult as a complete solution for a limited duration.For this reason, to start the limited resources started recycling for human beings. Therefore, this study analyzed the status of paper recycling based on the laws and recycling systems of Korea and Japan, analyzed what differences affect the quality differences in the recycling systems of the two countries, and conducted a study to find out the development direction of Korea's paper recycling system. First, Korea's tributary recycling system was analyzed based on the separate discharge application of my hand made by the Ministry of Environment and the Korea Environment Corporation, the packing material and structure evaluation system of the Korea Packaging Recycling Business Credit Union, and the Resource Conservation and Recycling Promotion Act. Next, the paper recycling system in Japan was analyzed based on the container packaging recycling method and the highland recycling certification system. In this study, it is meaningful to compare and analyze how laws related to paper recycling are stipulated and implemented by country, and to find out what differences in the recycling system affect the quality difference on recycled paper. However, since the separate collection of notices for recycling cannot be achieved through individual efforts, it is expected that the national level will supplement the loopholes in the system and increase the ratio of recycled paper. 자원은 무한히 존재하지 않기 때문에, 언젠가의 미래에 모든 자원이 소모되면 인류는 새로운 자원이나 대체재를 찾아 나서야 한다. 더불어 계속되는 자원 소모는 환경오염의 문제도 있다. 대체재를 찾는 연구는 계속해서 진행되고 있지만 아직 기존 자원들을 완벽히 대체할 수 있는 대체재는 존재하지 않다고 봐야 하며, 대체재가 현 상황의 완전한 해결책이라고 보기에는 어렵다는 한계점이 있다. 이러한 이유로 한정되어있는 자원을 아껴 쓰기 위해 인류는 재활용을 시작하였다. 이에 본 연구에서는 한국과 일본의 재활용 관련 법률과 재활용 체계를 바탕으로 종이류 재활용 현황을 분석하고, 두 나라의 재활용 체계에 어떤 차이점이 재생지에 품질 차이에 영향을 미치는지 알아보고자 한다. 궁극적으로 우리나라의 종이류 재활용 체계의 발전 방향을 알아보고자 연구를 진행하였다. 먼저 환경부와 한국환경공단에서 제작한 내 손안의 분리배출 어플리케이션과 한국 포장재 재활용 사업공제조합의 포장재 재질·구조 평가제도, 한국 순환자원유통 지원센터의 자원의 절약과 재활용촉진에 관한 법률을 토대로 대한민국의 지류 재활용 체계에 대해 분석하였다. 다음으로 용기포장 리사이클법과 고지 재활용 인증 제도를 토대로 일본의 종이류 재활용 체계에 대해 분석하였다. 본 연구에서는 국가별로 종이류 재활용 관련 법률이 어떻게 규정되고 시행되고 있는지 비교 분석하고 재활용 체계의 어떤 차이점이 재생지에 품질 차이에 영향을 미치는지를 알아보는 데에 의의가 있다. 다만 재활용을 위한 고지의 분별 회수는 개인의 노력으로 이룰 수 없는 부분이기 때문에 국가 차원에서 제도의 허점을 보완해주기를, 그리고 더욱 재생지의 사용 비율이 늘어나기를 기대한다.

Successful Treatment of Tracheal Invasion Caused by Thyroid Cancer Using Endotracheal Tube Balloon Inflation under Flexible Bronchoscopic Guidance

한양희,임재민,정복현,권준성 대한결핵및호흡기학회 2014 Tuberculosis and Respiratory Diseases Vol.77 No.5

Tracheal invasion is an uncommon complication of thyroid cancer, but it can cause respiratory failure. A rigid bronchoscope may be used to help relieve airway obstruction, but general anesthesia is usually required. Tracheal balloon dilatation and stent insertion can be performed without general anesthesia, but complete airway obstruction during balloon inflation may be dangerous in some patients. Additionally, placement of the stent adjacent to the vocal cords can be technically challenging. An 86-year-old female patient with tracheal invasion resulting from thyroid cancer was admitted to our hospital because of worsening dyspnea. Due to the patient’s refusal of general anesthesia and the interventional radiologist’s difficulty in completing endotracheal stenting, we performed endotracheal tube balloon dilatation and argon plasma coagulation. We have successfully treated tracheal obstruction in the patient with thyroid cancer by using endotracheal tube balloon inflation and a flexible bronchoscope without general anesthesia or airway obstruction during balloon inflation.

Liver Metastasis of Early Gastric Cancer with Mixed Histology after Endoscopic Submucosal Dissection

한양희,박종규,권준성,김영돈,정우진,이상진,한군희,천갑진 대한소화기내시경학회 2015 Clinical Endoscopy Vol.48 No.3

The Japanese Classification of Gastric Carcinoma histologically classifies endoscopically resected gastric cancer into differentiated and undifferentiated types according to the presence or absence of tubular structures on histology. The former includes papillary adenocarcinoma and tubular types, and the latter includes poorly differentiated adenocarcinoma, signet ring cell carcinoma and mucinous adenocarcinoma. However, gastric cancer sometimes contains a mixture of differentiated and undifferentiated components, and the clinical outcomes of the histological mixture are unknown, especially following endoscopic resection of early gastric cancer (EGC). This case was within the guideline indications for endoscopic submucosal resection (ESD), although it contained a partly signet ring cell carcinoma component; it recurred after 19 months with multiple lymph node and liver metastases. This case shows that additional surgical resection after ESD should be performed for patients with any mixed signet ring cell component, even in mild or moderately differentiated EGC.

보리피리

한양희 이화여자대학교 음악대학 작곡과 1973 멜로디 Vol.- No.8

나그네 : 박목월 시

한양희 이화여자대학교 음악대학 작곡과 1972 멜로디 Vol.- No.7

카르보폴 - 젤라틴의 상분리법을 이용한 Acyclovir 마이크로캅셀 현탁액의 제조 및 생물학적 평가

한양희,조진호,이정우,최영옥 한국약제학회 1993 Journal of Pharmaceutical Investigation Vol.23 No.3

Microencapsulation of acyclovir, an effective antiviral agent which acts as a specific inhibitor of herpes DNA polymerase, by carbopol-gelatin complex coacervation has been carried out to develop an oral controlled release preparation, which could improve the absorption characteristics in GI tract. After dissolving carbopol and gelatin separately in distilled water at 40℃, gelatin solution was mixed with carbopol solution while stirring at the same temperature. The pH of the mixture was lowered gradually by dropwise addition of 10% HCl with continuous stirring, and then, at pH 3.5, positively charged gelatin molecules were attracted to negatively charged carbopol. These coacervation processes were observed by optical microscopy during preparation. Plasma concentrations of acyclovir in rats after an oral administration of microcapsule suspension were assayed by HPLC, and pharmacokinetic parameters were calculated based on the model-independent analyses. Two standard formulations, oral solution and intravenous bolus injection, were used as references to compare the bioavailability. It has been revealed that C_(max), t_(max), and MRT of microcapsule suspension were greater than those of oral solution, which results in about two-fold increases in bioavailability. Therefore, in conclusion, the carbopol-gelatin microcapsule of acyclovir might be evaluated as an effective oral controlled release preparation which could increase the bioavailability of acyclovir.