암 환자의 혈장 Transforming Growth Factor-β1 농도

박병규,하우송,이시은,이수진,박순태,박찬후,전지현,장정순 THE KOREAN SOCIETY FOR BIOMEDICAL LABORATORY SCINE 1999 Journal of biomedical laboratory sciences Vol.5 No.2

한국인의 대표적인 성인 고형 종양인 위암, 간암, 유방암과 소아 백혈병 및 2종의 소아 고형 종양 환자로부터 혈장 transforming growth factor-ß1 (TGF-ß1) 농도를 sandwich ELISA 분석법을 이용해 측정함으로써 TGF-ß1을 이 질환들에 대한 새로운 종양표지자 (tumor marker)로 사용할 수 있는지 검토하였다. 또한 연령 및 성별에 따른 혈장 TGF-ß1 농도의 정상치를 조사하였다. 신생아에서 70대까지 혈장 TGF-ß1 농도의 차이는 없었고 남녀간의 차이도 없었다. 위암 환자의 혈장TCF-ß1 농도는 16.0±6.8 ng/ml (평균 ±표준편차)로 정상 대조군의 TGF-ß1 농도 (8.3 ±5.0 ng/ml) 보다 유의하게 높았으나 간암, 유방암 환자의 혈장 TGF-ß1 농도는 대조군과 차이가 없었다. 그리고 위암 환자 16명, 간암 환자 8명, 유방암 환자 7명 중 각각 7명 (43.7%), 1명 (12.5%), 1명 (14.3%)에서만 혈장 TGF-ß1 농도가 증가되었다. 5명의 소아 백혈병 환자에서는 관해 (remission) 여부와 상관없이 혈장 TGF-ßl 농도가 모두 정상 범위에 있었으나 2명의 소아 고형암 환자에서는 종양 절제 전에는 혈장TGF-ß1 농도가 높았다가 절제 후 정상으로 떨어졌다. 결론적으로 1)정상인의 혈장 TGF-ßl 농도는 연령 및 성별에 따른 차이가 없다는 것을 알 수 있었고, 2)성인 고형암인 위암, 간암, 유방암에서는 낮은 민감도로 인해 TGF-ß1을 진단을 위한 선별 검사로 이용하기에는 부적절한 것으로 판단되었으며, 3) 정상 대조군보다 혈장 TGF-ß1 농도가 높았던 위암 환자와 종양 절제 전후로 혈장 TGF-ß1 농도가 민감하게 변했던 소아 고형 암 환자에 대해서는 향후 표본 수를 늘려 부가적인 연구를 해 야 할 것으로 사료된다. To evaluate the usefulness of transforming growth factor-ß1 (TGF-ß1)as a new tumor marker, we determined the plasma TGF-ß1 levels using sandwich ELISA assay in cancer patients. Patients with three most common adult cancers in Korea (stomach, liver and breast cancer) and children's cancers (leukemia and two kinds of solid tumor) were enrolled for the study. Furthermore, 39 individuals were subjected to age and sex-stratified plasma TGF-ß1 analysis. No statistical difference was demonstrated with respect to age or sex. The mean plasma TGF-ß1 level (16.0 ng/ml) of stomach cancer patients was significantly higher than that (8.3ng/ml) of controls. However, there was no difference among the mean plasma TGF-ß1 levels of liver, breast cancer patients and controls. Seven of 16 patients (43.7%) with stomach cancer, one of 8 (12.5%) with liver cancer, and one of 7 (14.3%) with breast cancer showed higher TGF-ß1 levels compared to controls. Plasma TGF-ß1 concentrations of five leukemic children remained in the normal range regardless of the remission state. In contrast, initial high TGF-ß1 levels from two children with solid tumors returned to normal range on surgical resection of tumors. From the above results, we could conclude that plasma TGF-ß1 levels of apparently healthy individuals seem to be rather constant irrespective of difference in age or sex, and the plasma TGF-ß1 has the limited value as a screening test for the diagnosis of aforementioned adult cancers because of its low sensitivity. Finally, additional studies need to be pursed for the large number of stomach cancer and pediatric solid tumor patients in order to reach a secure conclusion on the usefulness of plasma TGF-ß1 as a tumor marker in these patients.

私立大學生의 成長發育 및 營養狀態에 關한 硏究 : 中學校 入試有無過程을 通한 比較

朴淳永,具燾書,朴良元,金振浩,南炳執,朴昌植,朴喆斌 慶熙大學校 1980 論文集 Vol.10 No.-

In order to ascertain any possible changes in the physical and the nutritional status of Korean high school students before and after the abolishment of college entrance examination system, an intensive survey was conducted on the physical conditions of the incoming freshmen students (9532 males and 3428 females) of Kyung Hee University from 1972 to 1980. The finding are as below. 1. Physical growth conditions In each of the average physical dimensions of body height, body weight, chest girth and sitting height, a remarkable improvement was recorded for all age groups after the matriculation was abolished. 2. Physical and nutritional indices Relative body weight showed constant values of 35.0 in male and 32.0 in female. Relative chest girth showed the normal chest girth style in all age groups of both sexes. Relative sitting height showed a constant value of 54 for both sexes. The values of vervaeck index of th nutritional status were shown to be between 86-87 in male and 83-94 in female, Pelidisi index 91 and 92-93, Rohrer index of physical status 121-125 and 130-132, and Kaup index 206-211 and 202-210, respectively.

이면성 및 도플러 심초음파도를 이용하여 진단한 선천성 거대 좌회선지-좌심실 관동맥루

진승원,박준철,이영중,유병현,박현옥,김용주,윤호중,김재형,홍순조,최규보,권종범,원용순,박건 대한순환기학회 2000 Korean Circulation Journal Vol.30 No.4

개에서 이중 결찰법을 통한 동맥관 개존증의 완치 예

윤헌영,정순욱,박희명,박철,정만복,김준영,한현정,황민,노병국,박상혁,장하영,박정윤 한국임상수의학회 2004 한국임상수의학회지 Vol.21 No.1

A ten months old, female Yorkshire terrier weighing 2.88 kg referred to veterinary teaching hospital of college of veterinary medicine, Konkuk University because of syncope, cough and dyspnea. First hematological and serum chemical test revealed thrombocytopenia, mild anemia, and increase of concentration of ALP (195 U/L). On 57 days later, second hematological and serum chemical test revealed polycythemia, increase of concentration of ALP (211 U/L), and Tchol (387 mg/dl). Right atrium enlargement, main pulmonary artery bulge and cardiomegaly (VHS = 11.5) were observed in radiographic findings. Ultrasonographic images showed both right and left ventricular dilation and turbulent flow between the descending aorta and the main pulmonary artery in color Doppler imaging. ECG showed left ventricular enlargement, SA block, and electrical alternant. Thoracotomy was performed through left fourth intercostal incision under isoflurane anesthesia. Patent ductus arteriosus was double ligated with 1-0 silk. Cough and dyspnea disappeared on 5 days after operation. Turbulent flow was not found in color doppler imaging of ultrasonography on 10 days after operation. Ten months later after the operation, syncope could not exist any more.

등단면-I형 곡선보의 영향선에 관한 연구

박정용,장병순 釜山大學校生産技術硏究所 1997 生産技術硏究所論文集 Vol.53 No.-

단면이 일정한 곡선보의 거동은 ��綢�효과를 고려한 Vlasov 이론식으로 표시할 수 있다. 본 논문에서는 I-형 곡선보에 대한 지배미분 방정식을 유한차분방정식으로 정식화한 후, 단위수직하중 및 단위비틂모멘트가 작용할 때 부재력을 계산할 수 있는 영향선을 구하였다. 실하중에 의한 부재력은 본 연구에서 구한 영향선을 이용하면 쉽게 계산되어 진다. The general behavior of curved girder with constant cross section is formulated by series of differential equations postulated by Vlasov including the warping effects. After shear force, bending moment, pure torsion, warping torsion, and bimoment for curved I-girder in the paper are analyzed by the difference method, the influence lines of them due to unit vertical load an unit torsional moment for it are obtained by using the finite difference method. The internal forces of the curved girder under an actual load can be calculated using the influence line obtained from this study.

白金의 比色定量에 關한 硏究

朴茂淳,孫炳贊,金演斗 순천향의과대학 1978 Journal of Soonchunhyang Medical Science Vol.1 No.1

It has been observed that Pt(IV) in Hydrochloric acid solution, when treated with Tin(II) chloride give a orange color and the color that is due to chloroplatin-ous acid, is stable reproducible and quantitative. Thus it is possible to determine platinum by use of spectrophotometer. This method saves time in determination of Pt and is applied to estimation of small amounts of Pt in its ores and alloys.

수소화붕소 리튬을 이용한 카르복시산의 환원

朴昞洙,車震淳,金鍾大 嶺南大學校附設 基礎科學硏究所 1981 基礎科學硏究 Vol.1 No.-

Carboxylic acids are readily reduced to the corresponding alcohols with borane-THF solution (or diborane) at 0°, whereas with lithium borohydride in THF solution the rate of reaction is very sluggish even at room temperature. In this study the possibility for the direct reduction of carboxylic acids to the corresponding alcohols by lithium borohydirde itself have been investigated, forming the reactive acyloxyborane in situ in the reaction mixture of acyloxyborohydride with methyl iodide. Thus, aliphatic acids were reduced rapidly to the alcohols, however, aromatic acid was reduced in a slow rate at room temperature. And in the reaction of α,β-unsaturated carboxylic acids with this reducing system the rduction on carboxylic group and the hydroboration on double bond were occurred competitively. Amino acid and dicarboxylic acid were reduced cleanly to the amino alcohol and diol, respectively. However, amino dicarboxylic acid was inert to this reducing system.

상관논리 활동을 통한 중학생들의 상관논리 유형 변화

박종윤,김지영,남정희,이상권,최병순 한국과학교육학회 2002 한국과학교육학회지 Vol.22 No.4

본 연구에서는 우리나라 중학교 학생들의 상관논리형성정도와 그 유형을 알아보고, 상관논리 활동을 통하여 학생들의 상관논리에 어떤 변화가 있는가를 알아보고자 하였다. 이를 위하여 중학교 2학년 학생 111명을 실험집단으로, 55명을 통제집단으로 선정하였다. 사전 검사에서는 두 집단 모두 상관논리의 형성률이 낮았으며, 집단간 차이는 없었다. 사후 검사에서는 실험집단의 상관논리 형성률이 유의미하게 증가하였으며, 통제집단의 경우는 사전 검사와 차이가 없는 것으로 나타나 상관논리 활동이 상관논리 형성에 도움이 되는 것을 알 수 있었다. 그러나 사후 검사에서도 실험집단의 정답률이 객관식 문항에서는 27%, 서술형 문항에서는 6% 정도로 나타나 상관논리가 완전히 형성된 학생들의 비율은 상당히 낮은 것으로 나타났다. The main purpose of this study is to investigate whether the correlational reasoning activities could improve middle school students' correlational reasoning abilities. The subjects were 8th grade students, and the correlational reasoning activities of the CASE(cognitive acceleration through science education) program was intervened to the experimental group(m=111) during science class while usual science instruction was given to the control group(m-55). The correlational reasoning test was administered before and after the intervention. The pre-test results showed that most of subjects performed poorly in correlation problems and no significant differences were found between the two groups. In the post-test, the experimental group showed enhanced performance while the control group did not. Therefore it can be concluded that CASE program activities help the students to improve correlational reasoning ability. However, the proportions of students gave correct response were not so high: 27% for the multiple-choice item and about 6% for the essay-type items.

E. coli 과량발현을 통한 B형 간염 바이러스 preS1 유도체의 안정한 동위원소 N의 치환

박병관,김세하,한규훈,김선영,홍요정,이시형,한동설,김순종,박진구 木浦大學校基礎科學硏究所 1997 基礎科學硏究誌 Vol.15 No.-

We have used molecular biology technique to label the side chains and backbone of HBV preS1(1-56) with stable isotope (??) during E. coli over-expression and purified the protein to near homogeneity. The expression level of ?? labelled preS1(1-56) seems to be ∼15% of the total protein. to characterize the secondary structure of the labelled protein, circular dichroism was used. In different buffer conditions including pH 3.3 and pH 7.4 the protein seems to be devoid of any stable secondary structure probably suggesting that the N-terminal portion (preS1(1-56)) of HBV preS1 might be unstructured before binding to its target cells.

세딸의 죽음을 초래한 三重精神病 治驗 一例

朴斗秉,金純範,李大熙,金裕光 大韓神經精神醫學會 1981 신경정신의학 Vol.20 No.4

Recently the auther had the opportunity to examine a case of folie a trois involving mother and two dauthers. Because of their shared delusions of constant threat to their virginity from men the mother had killed her three daughters by drawing vinyl cover over their faces while restraints were applied to the victims, extremities to prevent any physicical resistance. Two victims were partners of the infector the mother, and the remaining one daughter was diagnosed as schizophrenia. From this case presentation, it was thought that evolution and transference of paranoid symptoms are influenced by psychological-environmental factors rather than genetic-constitutional one, necessisating psychiatric approaches of this disorder should consider these aspects.