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정신분열증과 주요 우울장애에서 Natural Killer Cell 수와 백분율 변화NK cell
윤장봉,이재우,박두병 大韓神經精神醫學會 1996 신경정신의학 Vol.35 No.5
The purpose of this study was to compare the number and percentage of natural killer cell in schizophrenic and major depressive patients with those in normal healthy subjects 15 Schizophrenic patients, 15 major depressive patients and 16 healthy subjects were included in this study There was no statistical difference in the age and sex between patients and control subjects. All of these patients were drug-free for at lest two weeks before this study. The results of this study were as follows : 1) In schizophrenic patients, the number and percentage of natural killer cell of the group with below-mean score of general psychopathology were significantly lower than those of the group with above-mean score(p<.05). The number but not the percentage of natural killer cell of the group with below-mean BPRS score was significantly lower than that of the group with above-mean BPRS score(p<.05). 2) The number of natural killer cell showed statistically negative correlation with generalpsychopathology score or BPRS score(p<0.05). In conclusion, these findings suggest that the number and percentage of natural killer cell is not significantly changed in schizophrenia and major depressive disorder, but in schizophrenic patients, severe psychopathology in the rating scales is associated with suppression of the number and percentage of natural killer cell.
응급실 내원 정신과 환자의 조치경로에 미치는 변인 연구
이종훈,이길홍,박두병 大韓神經精神醫學會 1995 신경정신의학 Vol.34 No.5
In this study the author tries to elucidate any determinants concerning the disposition of visitors in a psychiatric emergency room by analyzing 667 psychiatric patients who had been visited the Chung-Ang University Hospital Emergency Room from 1991.6.1 to 1992.5.31. 1) Hospitalization rates were higher in men, rural residents, those making a second visit and in the spring. In addition, these patients had psychotic symptoms, were psychoactive substance users, showing violent behavior, had personality disorders, having familial problems and were accompanied by a family member. 2) In general, out patient department follow up(OPD F/U) was the result of the majority of the emergency room visits. The rates of OPD F/U were higher in women, urban residents, visits during summer and autumn and evidenced neurotic symptoms such as somatization, anxiety, depressive symptoms, adjustment difficulties due to transient situational problems and marital problems. 3) Discharges against medical advice were represented mainly in cases of acute neurotic symptoms, financial problems, organic mental disorders and visitors who came with friends.
김용희,이재광,박두병 大韓神經精神醫學會 1997 신경정신의학 Vol.36 No.3
주요 우울 질환 환자에서 전반적인 면역상태를 알아보고 연령, 성별, 우울증의 심도와의 상관성을 검토해보기 위해 저자들은 30명의 주요 우울장애 환자군과 32명의 정상 대조군을 비교하여 다음의 결과를 얻었다. 1) 환자군과 대조군 간의 면역지표 중 총백혈구 수, 총임파구 수와 백분률, 자연 살 세포 수와 백분률, T 임파구의 수와 백분률, B 임파구의 수와 백분률, helper T 임파구의 수, supressor T 임파구의 수, helper T임파구/supressor T 임파구 비에 있어 통계적으로 의미있는 차이를 보이지 않았고 supressor T 임파구 백분률만 의미있게 감소되어 있었다. 혈청 면역글로블린은 환자군과 대조군 간에 IgG와 IgM은 통계적으로 의미있는 차이는 없었지만 IgA는 환자군이 대조군에 비해 의미있게 증가되어 있었다. 2) 환자군에서 임파구 총 수, B 임파구 수와 백분률, IgA가 남자가 여자보다 감소되어 있었다. 연령에 따른 비교에서 환자군에서 연령과 임파구 백분률 사이에 정적 상관 관계를 보였고 대조군에서는 T 임파구 백분률, helper T 임파구의 수와 백분률에서 정적 상관 관계를 보였다. 환자군에서 HDRS로 평가된 증상의 심각도에 따라 IgM이 부적 상관 관계를 보였다. The authors compared 30 depressive patients with 32 normal controls to see the change of immunity in major depressive disorder and study the relationship between altered immunity and variables such as sex, age, and symptom severity. The results of this study were as follows : 1) Percent of suppressor T cell in depressive patients was significantly lower than that of normal controls and IgA concentration of depressive patients was significantly higher than that of normal controls. 2) In the depressive patient group, male patients showed significantly lower number in total lymphocyte, number and percentage of B cell, and IgA concentration than in the female patients. 3) In depressive patient group, a positive correlation was found between percentage in lymphocyte and age and in control group, positive correlations were found among percent of T lymphocyte, number and percentage of helper T cell and age. Negative correlation between IgM and the symptom severity assessed by HDRS was observed in depressive patient group.