Direct effectiveness of pneumococcal polysaccharide vaccine against invasive pneumococcal disease and non-bacteremic pneumococcal pneumonia in elderly population in the era of pneumococcal conjugate vaccine: A case-control study

Kim, Jong Hun,Chun, Byung Chul,Song, Joon Young,Kim, Hyo Youl,Bae, In-Gyu,Kim, Dong-Min,Choi, Young Hwa,Jun, Yoon Hee,Choi, Won Suk,Kang, Seong Hee,Kwon, Hyun Hee,Jeong, Hye Won,Kee, Sae Yoon,Hur, Jia Elsevier Ltd. 2019 Vaccine Vol. No.

<P><B>Abstract</B></P> <P><B>Background</B></P> <P>While herd effects and serotype replacement by childhood pneumococcal protein conjugated vaccines (PCVs) continues to accumulate worldwide, direct effectiveness of 23-valent pneumococcal polysaccharide vaccine (PPV23) against pneumococcal diseases in the elderly has been challenged. We estimated the direct effectiveness of PPV23 in the elderly population.</P> <P><B>Methods</B></P> <P>For a hospital-based case-control study, cases of invasive pneumococcal disease (IPD) and non-bacteremic pneumococcal pneumonia (NBPP) (adults ≥ 65 years) were identified in 14 hospitals participated in the pneumococcal surveillance program from March 2013 to October 2015, following implementation of PPV23 national immunization program (NIP) for the elderly in the Republic of Korea. Controls matched by age, sex, and hospital were selected at ratios of 1:2 (IPD) or 1:1 (NBPP). Clinical data and vaccination records were collected. Vaccine effectiveness was calculated as (1-adjusted odds ratio) × 100.</P> <P><B>Results</B></P> <P>We enrolled 148 IPD and 557 NBPP cases, and 295 IPD and 557 NBPP controls for analyses. Overall effectiveness of PPV23 against IPD was 28.5% [95% confidence interval (CI) −5.8%–51.6%] and against NBPP was 10.2% (-15.1-30.6) in all patients ≥ 65 years. However, in subgroup analysis of patients aged 65–74 years, PPV23 was protective against IPD [effectiveness 57.4% (19.4–77.5)] and against NBPP [effectiveness 35.0% (2.3–56.7)]. Furthermore, serotype-specific effectiveness of PPV23 against IPD was 90.6% (27.6–98.8) for PPV23-unique serotypes and 81.3% (38.6–94.3) for PPV23 serotypes excluding serotype 3.</P> <P><B>Conclusions</B></P> <P>This study indicates that PPV23 with broad serotype coverage might be beneficial in preventing IPD and NBPP due to non-PCV13 serotypes in the young-elderly, with potentially increasing effectiveness in the setting of childhood PCV NIP.</P> <P><B>Highlights</B></P> <P> <UL> <LI> National immunization program for PPV23 for the elderly was implemented in Korea. </LI> <LI> PPV23 was effective against IPD and NBPP for young elderly patients aged 65–74. </LI> <LI> Effectiveness of PPV23 against IPD was higher for PPV23 unique serotypes. </LI> <LI> PPV23 was non-protective against IPD caused by PCV13 serotypes. </LI> </UL> </P>

L-형 장골이식을 이용한 구순열 비변형의 수정

유선열,박홍주,손영휘,윤천주,박충열,송종운,이용욱 대한악안면성형재건외과학회 2000 Maxillofacial Plastic Reconstructive Surgery Vol.22 No.6

Patients with a cleft lip nasal deformities hope for a pleasing nasal profile, a well-defined angular nasal tip, and symmetry of the nose. The main objective of the correction of cleft lip nasal deformity is to achieve nasal symmetry and an improved nasolabial relationship. The present study was carried out to assess the effect and prognosis of correction of cleft lip nasal deformity with L-shaped iliac bone graft. We performed correction surgery of the severe cleft lip nasal deformity with the autogenous L-shaped iliac bone graft in five patients and described the technique of correction. The columella portion of the L-shaped graft provided stabilization, eliminating the see-saw effect of the bridge on the bony fulcrum of the bony bridge, The disadvantage of this technique was stiffening of the nasal tip, which included the distal end of the grafted bone. However, the nasal tip gradually becomes softer, probably due to resorption of the bony edge several months after the operation. We obtained stable and symmetric reconstruction of the supporting elements of the nose. These results suggest that L-shaped iliac bone graft is stable and esthetic reconstruction method for correction of the severe cleft lip nasal deformity

우리나라 은행의 효율적인 M&A전략에 관한 연구

송영렬 안양대학교 사회과학연구소 1997 社會科學硏究 Vol.5 No.-

Recently, we know that the banking industry in Korea will be faced with a period of renovation for the restructuring of the industry. In other words, it is needless to say that the commercial banks in Korea will have to grow its assets size for the achievement of the economy of scale in order to have its competition power against the foreign banks in the developed countries as well as to have its internal renovation before the complete opening of the korea financial markets. Then there are two ways for the Korean Banks to grow its assets: First, to achieve the internal growth through the increase of its capital. Secondly, to achieve its growth through the merger and acquisition of the other banks. Then the Korean banks have to find its ways to grow its assets through the merger and acquisition of inter-banks, and also it becomes the center of public interest that the Korean banks will be able to achieve its object in the difficult conditions of the Korea financial markets. And also, it is a matter of primary concern that the Korea banks will be satisfied with the results of the merger and acquistion of the other banks even if they really do. In these urgent circumstances, this paper shows the effects and influences of the merger and acquisitions between financial institutions at home and abroad in the past. In a result, we can see that in this papers, there is an economy of scale and span in a merger and acquisition between Korean banks in the industry.

WTO 체제하에서 한국산업부문의 대응방안에 관한 연구

송영열 안양대학교 사회과학연구소 1996 社會科學硏究 Vol.4 No.-

This article is analyze the new challenge of WTO(world trade organization) and it's effect to korean economy. For this. First, this article is try to find out it's effect to korean economy and to korean business throught agreement. Second, this article is try to find out the commercial problems with the settlement of WTO. Third, this article is find out the influencement to korean industries with the WHO andto find out appropriate countermeasure.

주가지수선물의 가격결정 및 투자전략에 관한 연구

송영열 안양대학교 사회과학연구소 1995 社會科學硏究 Vol.3 No.-

Abstract The government has decided to introduce the stock index futures in regard to KOSPI 200 starting from 1996. As futures markets are being opened, stock holders and would-be stock holders can hedge the risk of the variation of stock price with the use of futures markets. Future price can be found due to hight equity and trust as the participants in futures market collect, analyze and predict the information about stock price so that price of stock index futures can be done through price competition. It is expected that new investment means may be offered due to the profit rate corresponding to the investment principal as large-scale deals are available with pretty small margin. It is also predicted that liquidity may become enlarged and spot price may get settled with the active intervention of arbitragy traders using the temporary price difference between futures market and spot market. Therefore, these studies aim to promote the stable management and balanced development of stock market and stock index futures market and protect investors by examining how to make stock indices and investigating the pricing principle of stock index futures and the investment strategy with the use of stock index futures.

산업용로봇과 CNC 가감속을 위한 FPGA 설계

하영열,전재욱 成均館大學校 科學技術硏究所 1997 論文集 Vol.48 No.1

Many techniques for velocity profiles of industrial robots and CNC machine tools have been proposed in order to make industrial robots and CNC machine tools perform given tasks efficiently. Since they should be calculated in a limited time, most of them are not computationally intensive. In particular, some of the previous techniques calculate velocity profiles with hardware techniques for the reduction of calculation time of velocity profiles. However, these techniques cannot generate velocity profiles having some kinds of velocity profiles. This paper proposes a FPGA design to be able to generate velocity profiles which cannot be generated by previous hardware techniques as well as velocity profiles generated by them. Simulation results of VHDL programs for FPGA will be explained how to generate typical velocity profiles for the given condition.

응력-변형 거동 예측을 위한 탄소성 구성모델의 비교

문창열,박병수,조영묵 三陟大學校 1999 論文集 Vol.32 No.2

This paper is results of numerical analysis to investigate stress-strain behavior of sandy soils. Tree different constitutive relationships of Modified cam-Clay Model, Hyperbolic Model and Lade's Double-Work-Hardening Model were applied to predict stress-strain behavior of them. For each model, constitutive relations as well as parameters governing stress-strain behavior were programmed numerically. Weathered granite soil, tests were carried out with rich in Korea, and Ju Mun Jin Standard Sand were used as specimen of sandy soil. Stress-strain behaviors of these soils were obtained by performing isotropic compression and drained triaxial compression tests. For Weathered granite soil, tests were carried out with three different water contents determined on the basis of compaction test results. Four different relative densities were used with Ju Mun Jin Standard Sand. Numerically Predicted results with three different models were compared with tested results. Therefore applicability and problems of each model were discussed. Numerical analysis about sensitivity of parameters was also performed to investigate how these parameters influenced stress-strain behavior of sandy soils.

풍진항체 검사법의 신뢰도에 관한 연구 : Comparison of the Methods between the Abbott RUBAZYME kit and the Abboutt IMx Automated Analyzer

신영전,최보율,최은주,박항배 한양대학교 의과대학 1995 한양의대 학술지 Vol.15 No.2

Abbott Rubazyme and Abbott IMx, which are most used to prevent Rubella IgG and IgM thesedays, were evaluated for their reliability. Both methods were tested on 305 women, 287 and 18 number of each pregnant and non-pregnant women, in Yangpyong county from March 1993 through September 1993. In addition, they had 14. 3 weeks of pregnant period and 25.8 of average age. It appeared that there was a significant correlation between the titers of Rubazyme and IMx for Rubella IgG (Coefficient Correlation 0.6167, p=0.000) but not for IgM(C. C. 0.0668, p=0.245). Additionally, the correlation coefficient of the two methods for IgG titer of 1st and 4th quartile, 0.6829, p=0.000, were higher than that of 2nd and 3rd, 0.4600, p=0.000, So does IgM : 0.1081, p=0.181 for ist and 4th quartile and 0.0230, p=0.780 for 2nd and 3rd quartile. The agreement rate of positivity was 92.5% for IgG and 99.0% for IgM. The kappa index for IgG was 0.51338. The agreement point of titer, where the number of a people who showed positivity for IgG in IMx test and that in Rubazyme kit test became equal, was 31.3 IU/ml, which was 315% of the original point, 9.949 IU/ml. The agreement rate of both tests for 1gG was decreased to 92.13% but the kappa index was increased to 0.66869 in rasing cut off point of the IMx up to 31.3 IU/ml. Abbott Rubazyme and Abbott IMx tests play important roles in determining the infection of pregnant women and even the prevention of deformation of child and artificial abortion. However, since these two methods turns out not to be reliable to be used through this experiment, physicians should examine the reliability of both methods, and even the possibility of technical errors of them before actual use.

巨大卵巢囊腫 1例

최명률,이영주 순천향대학교 1986 논문집 Vol.9 No.1

In these days of highly-spread medical care, it is relatively rare to encounter huge ovarian cyst. This is a case study of a large known ovarian cyst in 73 years old woman. The tumor developed from left side ovary and was removed surgically under the general anesthesia. The tumor was 5.5kg in weight and mucinous cystadenoma on the finding of pathology. So we report with a brief review of literature.

공황장애에서 Paroxetine 단기약물치료가 심리적 상태에 미치는 영향

이소영,김지혜,김율리,강은호,이동수,유범희 大韓神經精神醫學會 2004 신경정신의학 Vol.43 No.3

Objectives : This study was designed to evaluate clinical effect of paroxetine treatment and to explore psychological Pre-dictors of treatment response. Methods : Patients (n=26) who met DSM-IV criteria for panic disorder with or without agoraphobia were treated by Pa-roxetine for 12 weeks. We assessed symptom improvement using Clinical Global Impression (CGI), and clinical characteristics using Anxiety Sen&itivity Index (ASI), Anxious Thoughts and Tendencies (AT & T), Agoraphobic Cognition Questionnaire (ACQ), Body Sensation Questionnaire (BSQ), Beck Anxiety Inventory (BAI), and Beck Depression Inventory (BDI). T-test, correlation analysis, and stepwise multiple regression analysis were performed. Results : Panic patients showed significant improvement in seventy of illness and each clinical characteristic after 12 weeks of paroxetine treatment. There were significant correlations among severity of illness, anxiety, and depression, and subjective seventy was related with catastrophic thoughts. The more catastrophic thoughts and the higher sensitivity of body sensation, Patients had the worse symptom improvement they shorved. Multiple regression analysis showed that catastrophic thought related to agoraphobia was the best predictor of symptom improvement (22%). Conclusion : This study suggests that short-term treatment of paroxetine is effective in panic disorder with or without ago-raphobia, and that catastrophic thought could be a predictor of poor treatment response. Thus cognitive intervention on Catastro-phic thoughts may play an important role in symptom improvement in panic disorder.