경막외에 침범한 과립구성 육종 1예

최완영,김인순,최일영,정태준,이영열,고영혜,김남규 대한내과학회 1992 대한내과학회지 Vol.42 No.4

본 저자들은 백혈병으로 진단 받지 않은 환자에서 경막외에 침범하여 척수를 누르고 있고 수술후 방사선 치료로 증상이 좋아진 과립구상 육종을 경험하였기에 이에 보고하는 바이다. Granulocytic sarcoma is an uncommon tumor composed of immature cells of the granulocytic series, occuring in patients with AML and blast crisis of CML. It may rarely precede an acute myelogenous leukemia with an uniformly fetal course. We experienced a case of granulocytic sarcoma of extradural space presenting as spinal cord compression in a 31 years old female with no evidence of leukemia on the bone marrow and periphera1 blood. The tumor was located to the T₁-T₃ having narrowing pole after decompression laminectomy, patient received local irradiation to the residual tumor bed, and being followed at the OPD without evidence of leukemia.

흡입물질의 위생학적 연구 : 본드 흡입이 흰쥐의 폐 및 기타 장기의 효소 활성에 미치는 영향 The Effect of Bond Inhalation on the Enzyme Activity of Lung and Other Organs in Rat

윤수홍,박은주,이주영,서혜령 효성여자대학교 부설 한국환경위생연구소 1991 환경위생연구 Vol.1 No.1

Toluene, alcohol및 vinylester류 등을 함유하고 있는 bond를 이용하여 휘발성 물질이 생체에미치는 영향을 관찰하기 위하여 rat에 일정 농도의 bond를 일정 시간 흡입시킨 뒤 각 조직에대하여 효소의 생화학적 시험과 celluloseacetate electrophoresis를 실시하여 다음과 같은 결과를얻었다. 1. Bond 흡입은 시간이 증가함에 따라 혈청, 심장, 신장, 근육, 뇌의 ChE 활성을 억제하였으며특히 폐와 간장의 ChE활성에 가장 큰 영향을 나타내었다. 2. Bond 흡입에 의해 혈청 및 각 조직 중에서 LDH활성이 증가되었으며 특히 폐와 심장,근육에서 그 영향이 현저히 나타났다. 3. Celluloseacetate electrophoresis를 통한 각 조직의 LDH isozyme pattern에는 차이가 나타났으며 bond 흡입에 의해 band의 소멸과 선명도의 감소가 일어 났는데 특히 폐에 대한 독성이가장 현저했으며 근육에 대한 독성도 큰 것으로 나타났다. Acute poisoning with organic solvents and other volatile compou-nds now usually follows deliberate inhalation(volatile substance abuse) or inges-tion of these compounds. The effect of bond inhalation was analyzed for serum, liver, lung, brain,heart, kidney and muscle. And the observations are revealed on rat cholinesterase activity, lactatedeh-ydrogenase activity and electrophoretic pattern of lactatedehydrogenase isozyme. The results are as follows ; 1. The rat cholinesterase activity on serum, heart, muscle, kidney and brain showthe decrease by increasing of inhalation time of bond, in particular the lungand liver cholinesterase activity was greatly affected. 2. Bond inhalation brough out the lactatedehydrogenase activity increased ofthe serum and the tissues and had an important effect especially in both thelung and muscle lactatedehydrogenase activities. 3. Each tissue was found to have a characteristic distribution of lactatedehydro-genase isozymes on celluloseacetate elelctrophoresis and the development ofinhalation time is shown the disappearence and diffusion of band.

Plyometric Training과 비타민 C 투여가 남고생의 체력, 혈중 젖산, 암모니아 및 젖산탈수소효소에 미치는 영향

장준원,김세종,이현미,서혜림,조현숙,고정림,염종우,예정복,백영호 釜山大學校 附設 體育科學硏究所 2003 體育科學硏究所 論文集 Vol.19 No.-

The purpose of this was to examine the effect of plyometric training and vitamin C ingestion on physical fitness and fatigue substance....

n-CdS_(0.46)Se_(0.54)/p-Cu_92-x)S_(0.46)Se_(0.54) 이종접합 태양전지의 제작과 그 특성에 관한 연구

유상하,최승평,이상열,홍광준,서상석,김혜숙,전승룡,윤은희,문종대,신영진,정태수,신현길,김택성,유기수 全北大學校 基礎科學硏究所 1994 基礎科學 Vol.16 No.-

승화방법에 의해 CdS_0.46Se_0.54 단결정을 성장하여 결정구조를 조사하고, Van der Pauw 방법으로 Hall effect를 측정하여 carrier density의 온도 의존성과 mobility의 온도 의존성을 조사하였다. 성장된 CdS_0.46Se_0.54 단결정을 치환반응하여 n-CdS_0.46Se_0.54/p-Cu_2-xS_0.46Se_0.54 이종접합 태양전지를 제작하였다. Spectral response, 전류-전압특성 및 전력변환 효율을 조사하여 그 결과로부터 개방전압은 0.48V, 단락 전류 밀도는 21mA/㎠, fill factor와 전력변환효율은 각각 0.75와 9.5%를 얻었다. CdS_0.46Se_0.54 single crystal was grown by a sublimation method. The crystal structure and the temperature dependence of carrier density and mobility of CdS_0.46Se_0.54 single crystal were studied. Heterojunction solar cells on n-CdS_0.46Se_0.54/p-Cu_2-xS_0.46Se_0.54 were fabricated by the substitution reaction. The spectral response, the J-U characteristics and the conversion efficiency of the n-CdS_0.46Se_0.54/p-Cu_2-xS_0.46Se_0.54 heterojunction solar cells were studied. The open-cricuit voltage, short-circuit density, fill factor and conversion efficiency of n-CdS_0.46Se_0.54/p-Cu_2-xS_0.46Se_0.54 heterojunction solar cells under 80mW/㎠ illumination were found to be 0.48V, 21mA/㎠, 0.75 and 9.5%, respectively.

대사공학에 의해 개발된 코리네박테리움 글루타미컴에 의한 4-히드록시벤질 알코올 생산

김부연 ( Bu-yeon Kim ),정혜빈 ( Hye-bin Jungji-yeong Lee ),이지영 ( Lenny Ferrer ),페러레니 ( Henry Syukur Purwanto ),푸완토헨리슈쿠르 ( Jin-ho Lee1 ),이진호 한국미생물생명공학회(구 한국산업미생물학회) 2020 한국미생물·생명공학회지 Vol.48 No.4

4-Hydroxybenzyl alcohol (4-HB alcohol)은 두통, 경련 행동, 현기증과 같은 신경계 질환에 유익한 효과를 나타내며 천마의 주요 생리활성 성분 중의 하나이다. 대사공학을 통해 4-hydroxybenzoate (4-HBA)를 생산하는 균주로부터 4-HB alcohol을 생산하는 재조합 Corynebacterium glutamicum을 개발하였다. 먼저 4-HBA를 생산하는 APS809로부터 염색체 내 NCgl2922 유전자에 Methanocaldococcus jannaschii 유래의 aroK 유전자를 삽입한 APS963을 개발하였다. 4-HBA의 카로복실 산을 4-hydroxybenzaldehyde (4-HB aldehyde)로의 환원을 촉매하는 Nocardia iowensis 유래의 car 유전자를 염색체에서 발현하는 균주를 개발하기 위해 NCgl1112 유전자 일부 단편에 car 유전자가 삽입된 GAS177를 개발하였다. 더 높은 농도의 4-HB alcohol을 생산하기 위해 4-HB alcohol을 aldehyde로 산화를 촉매하는데 관여하는 creG 유전자를 염색체상에서 제거된 GAS255를 개발하였다. 최종적으로 chorismate를 4-HBA로 전환하는 효소의 유전자 ubiC^pr을 pcaHG에 삽입된 GAS355를 개발하였으며, 80 g/l 포도당을 함유한 삼각플라스크에서 발효하여 생산성을 평가한 결과, 2.3 g/l 4-HB alcohol이 생산되었으며 부산물로 0.32 g/l 4-HBA, 0.3 g/l 4-HB aldehyde가 축적되었다. 4-Hydroxybenzyl alcohol (4-HB alcohol) is one of the major active components of Gastrodia elata Blume, with beneficial effects on neurological disorders such as headache, convulsive behavior, and dizziness. Here, we developed a metabolically engineered Corynebacterium glutamicum strain able to produce 4-HB alcohol from 4-hydroxybenzoate (4-HBA). First, the strain APS963 was obtained from the APS809 strain via the insertion of aroK from Methanocaldococcus jannaschii into the NCgl2922-deleted locus. As carboxylic acid reductase from Nocardia iowensis catalyzes the reduction of 4HBA to 4-hydroxybenzaldehyde (4-HB aldehyde), we then introduced a codon-optimized car gene into the genome of APS963, generating the GAS177 strain. Then, we deleted creG coding for a putative short-chain dehydrogenase and inserted ubiCpr encoding a product-resistant chorismate-pyruvate lyase into the pcaHG-deleted locus. The resulting engineered GAS355 strain accumulated 2.3 g/l 4-HB alcohol with 0.32 g/l 4-HBA and 0.3 g/l 4-HB aldehyde as byproducts from 8% glucose after 48 h of culture.

Human Adipose Stem Cells Improve Mechanical Allodynia and Enhance Functional Recovery in a Rat Model of Neuropathic Pain

Lee, Hye Yeong,Lee, Hye-Lan,Yun, Yeomin,Kim, Jin-Su,Ha, Yoon,Yoon, Do Heum,Lee, Soo-Hong,Shin, Dong Ah Mary Ann Liebert 2015 Tissue engineering. Part A Vol.21 No.13

<P>Stem cells are a promising source of tissue engineering due to their differentiation potential. Today, direct transplantation of stem cells for cell therapy is commonly performed. However, in cases of nerve injury, direct transplantation of cells could lead to secondary nerve damage. Male Sprague-Dawley rats were randomized into four groups: the phosphate-buffered saline epineural transplantation (PBS-ENT) group, the PBS intraneural transplantation (PBS-INT) group, the human adipose-derived stem cells epineural transplantation (hASCs-ENT) group, and human adipose-derived stem cells intraneural transplantation (hASCs-INT) group. Transplantation was conducted 1 week later after inflicting a crush injury with subsequent observation for 5 weeks. To evaluate pain, each group was examined with regard to paw withdrawal latency and evoked potentials. The sciatic functional index (SFI) was calculated to estimate functional recovery. The sciatic nerve was also examined histologically. The hASCs-ENT group showed a more rapid paw withdrawal threshold and SFI recovery than the other groups (p<0.05). The hASCs-ENT group also showed shorter initial latencies in both somatosensory evoked potential (SSEP) and motor evoked potential (MEP) than the PBS-INT group (p<0.05). In addition, the N1 latency of the MEP and the N1 and P1 latencies of the SSEP were significantly shorter than those of the PBS-INT group (p<0.05). Histological examination revealed that the transplanted groups showed better neural recovery and remyelination than the groups injected with PBS. These results show that the transplantation of hASCs into the injured sciatic nerve improved mechanical allodynia and functional recovery as determined by the paw withdrawal test, SFI analysis, and electrophysiological studies. ENT is superior to INT in terms of invasiveness and better outcomes.</P>

가시 근적외선 분광법을 이용한 참외 숙도 판별 모델 개발

이혜인 ( Hye-in Lee ),김민지 ( Min-jee Kim ),이보영 ( Bo-young Lee ),이정은 ( Jeong-eun Lee ),이홍구 ( Hong-gu Lee ),박수환 ( Soo-hwan Park ),양하은 ( Ha-eun Yang ),유우형 ( Woo-hyeong Yu ),이아영 ( Ah-yeong Lee ),모창연 ( Changye 한국농업기계학회 2023 한국농업기계학회 학술발표논문집 Vol.28 No.2

참외는 한국의 여름철 대표 과일 중 하나로 후숙하지 않는 과일이다. 최근에는 수확에서 출고까지의 회전이 빨라 저장고를 거치지 않고 수확 즉시 유통하고 있다. 그러므로 참외의 수확 시기와 수확 직후의 상태는 참외 품질에 중요한 영향을 미친다. 특히 참외의 숙도는 상품성과 직결되는 당도에 가장 큰 영향을 주는 인자로써 미숙과일수록 당도가 낮아진다. 현재 참외를 재배하는 농가에서는 참외의 숙도를 외관 색깔만으로 판단하고 있다. 참외가 미숙에서 적숙으로 넘어가기 직전 시기에는 적숙과와 같은 노란색을 띠기 때문에 작업자는 수확 적기를 구분하기 어려워진다. 따라서 수확 후 품질 균일화를 위해서는 작업자의 주관적인 육안 판별보다 객관적인 품질 판정 기술이 필요하다. 본 연구에서는 참외의 숙도 판별을 위하여 가시 근적외선(VNIR) 분광 기법의 적용 가능성을 평가하고자 한다. 본 연구의 목적은 참외의 당도, 숙도 간의 상관관계와 VNIR 분광 스펙트럼 특성을 구명하고 참외 숙도 판별모델을 개발하는 것이다. 시료는 성주에서 수확한 참외로 미숙과 100개, 적숙과 132개를 이용하였다. 이는 착과 시기와 색도에 따라 미숙과-초록(stage 1), 미숙과-노랑(stage 2), 적숙과(stage 3)의 3단계로 분류하였다. 색도를 기준으로 더 익은 면을 앞면으로 설정하여 장축을 2부분으로 나누었으며, 단축은 꼭지부, 중앙부, 배꼽부 3부분으로 나누어 한 개체당 총 6 부위의 스펙트럼을 획득하였다. 분광 스펙트럼은 100W의 할로겐 광원과 USB4000 분광기(Ocean Optics, USA)를 이용하여 투과식으로 측정하였다. 참외 숙도 판별을 위하여 부분최소제곱 판별분석(Partial Least Squares-Discriminant Analysis, PLS-DA)모델을 개발하였으며, 분석에는 472~1,100nm의 파장 대역을 사용하였다. 그 결과, 판별 정확도 0.80의 우수한 성능을 보였다. 따라서 VNIR 분광 스펙트럼을 이용한 참외의 숙도 판별이 가능할 것으로 판단된다. 본 연구의 결과는 향후 참외의 수확 후 품질 균일화 및 품질 정보 제공 기술로 활용할 수 있을 것으로 기대된다.

임신한 당뇨 환자에서의 당뇨병성 위병증 2예 보고

이정은 ( Lee Jeong Eun ),송은섭 ( Song Eun Seob ),박인해 ( Park In Hae ),이동현 ( Lee Dong Hyeon ),김혜미 ( Kim Hye Mi ),이종훈 ( Lee Jong Hun ),이지영 ( Lee Ji Yeong ),이우영 ( Lee U Yeong ) 대한산부인과학회 2004 Obstetrics & Gynecology Science Vol.47 No.1

Gastrointestinal complications of diabetes mellitus include diarrhea, constipation, small bowel bacterial overgrowth, and gastropathy. Diabetic gastropathy is well-described motility disorder probably caused by an automatic neuropathy of the upper gastroi

혈액 투석 환자에서 발생한 결핵성 척추염 치료

유혜영 ( Yu Hye Yeong ),신영신 ( Sin Yeong Sin ),우영식 ( U Yeong Sig ),최강현 ( Choe Gang Hyeon ),이정록 ( Lee Jeong Log ),이소영 ( Lee So Yeong ),박철휘 ( Park Cheol Hwi ),안명임 ( An Myeong Im ),장윤식 ( Jang Yun Sig ),방병기 ( 대한신장학회 2001 Kidney Research and Clinical Practice Vol.20 No.6

Patients undergoing maintenance dialysis show an increased susceptibility to tuberculosis because host immunity is decreased secondary to malnutrition, impaired cellular immunity, acidosis and etc. Extrapulmonary tuberculosis is more prevalent in patients with end stage renal disease than in normal subjects. Among the extrapulmonary tuberculosis in patients receiving hemodialysis, the diagnosis of tuberculous spondylitis is difficult because the symptoms are non specific and attributable to uremia, and the appearance of plain radiographs is often normal during the early phase of the disease. We experienced a case of tuberculous spondylitis in a hemodialysis patient. A 55 years old female admitted with fever, weight loss and back pain. Conventional radiograph of T-spine showed no definite abnormal finding. However, chest CT revealed heterogeneously enhancing soft tissue around the T8 vertebral body and T-spine MRI showed compatible finding to tuberculous spondylitis. She received radical excision of involved vertebra and confirmed tuberculous spondylitis with histologic finding from a surgical specimen. Following the administration of anti-tuberculosis medication(isoniazid, rifampin, pyraziamide, ethambutol) and radical excision, patient`s symptom and sign were improved. The patient is maintaining dialysis with anti-tuberculosis medication for 5 months.

Long-term cardiovascular events in hypertensive patients: full report of the Korean Hypertension Cohort

Jin Young Lee,Jean Kyung Bak,Mina Kim,Ho-Gyun Shin,Kyun-Ik Park,Seung-Pyo Lee,Hee-Sun Lee,Ju-Yeun Lee,Kwang-il Kim,Si-Hyuck Kang,Jang Hoon Lee,Se Yong Jang,Ju-Hee Lee,Kye Hun Kim,Jae Yeong Cho,Jae-Hye 대한내과학회 2023 The Korean Journal of Internal Medicine Vol.38 No.1

Background/Aims: This study evaluated the long-term cardiovascular complications among Korean patients with hypertension and compared them with that of controls without hypertension. Methods: The Korean Hypertension Cohort (KHC) enrolled 11,043 patients with hypertension and followed them for more than 10 years. Age- and sex-matched controls without hypertension were enrolled at a 1:10 ratio. We compared the incidence of cardiovascular events and death among patients and controls without hypertension. Results: The mean age was 59 years, and 34.8% and 16.5% of the patients belonged to the high and moderate cardiovascular risk groups, respectively. During the 10-year follow-up, 1,591 cardiovascular events (14.4%) with 588 deaths (5.3%) occurred among patients with hypertension and 7,635 cardiovascular events (6.9%) with 4,826 deaths (4.4%) occurred among controls. Even the low-risk population with hypertension showed a higher cardiovascular event rate than the population without hypertension. Although blood pressure measurements in the clinic showed remarkable inaccuracy compared with those measured in the national health examinations, systolic blood pressure (SBP) ≥ 150 mmHg was significantly associated with a higher risk of cardiovascular events. Conclusions: This long-term follow-up study confirmed the cardiovascular event rates among Korean hypertensive patients were substantial, reaching 15% in 10 years. SBP levels ≥ 150 mmHg were highly associated with occurrence of cardiovascular event rates.